JP2004513923A5 - - Google Patents
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- Publication number
- JP2004513923A5 JP2004513923A5 JP2002542393A JP2002542393A JP2004513923A5 JP 2004513923 A5 JP2004513923 A5 JP 2004513923A5 JP 2002542393 A JP2002542393 A JP 2002542393A JP 2002542393 A JP2002542393 A JP 2002542393A JP 2004513923 A5 JP2004513923 A5 JP 2004513923A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- use according
- bone mass
- mass loss
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 210000000988 bone and bone Anatomy 0.000 claims 4
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229940122355 Insulin sensitizer Drugs 0.000 claims 3
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 claims 3
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 claims 3
- 239000000556 agonist Substances 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 201000002980 Hyperparathyroidism Diseases 0.000 claims 2
- 208000010191 Osteitis Deformans Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 208000027868 Paget disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 208000027202 mammary Paget disease Diseases 0.000 claims 2
- 208000029725 Metabolic bone disease Diseases 0.000 claims 1
- 206010049088 Osteopenia Diseases 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 1
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 150000002688 maleic acid derivatives Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229960005095 pioglitazone Drugs 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 229960001641 troglitazone Drugs 0.000 claims 1
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 claims 1
- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0027783.0A GB0027783D0 (en) | 2000-11-14 | 2000-11-14 | Novel use |
| PCT/GB2001/005044 WO2002040020A1 (en) | 2000-11-14 | 2001-11-14 | Novel use of certain insulin sensitizers or ppar-gamma agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004513923A JP2004513923A (ja) | 2004-05-13 |
| JP2004513923A5 true JP2004513923A5 (enExample) | 2005-09-29 |
Family
ID=9903156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002542393A Pending JP2004513923A (ja) | 2000-11-14 | 2001-11-14 | ある種のインスリン感作剤またはｐｐａｒ−ガンマアゴニストの新規使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040266833A1 (enExample) |
| EP (1) | EP1335724A1 (enExample) |
| JP (1) | JP2004513923A (enExample) |
| AU (1) | AU2002215109A1 (enExample) |
| GB (1) | GB0027783D0 (enExample) |
| WO (1) | WO2002040020A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041691B1 (en) | 1999-06-30 | 2006-05-09 | Amgen Inc. | Compounds for the modulation of PPARγ activity |
| US20030171399A1 (en) | 2000-06-28 | 2003-09-11 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
| US20050054663A1 (en) * | 2003-08-13 | 2005-03-10 | Bennett Christina N. | GSK-3 inhibitors |
| US7223761B2 (en) | 2003-10-03 | 2007-05-29 | Amgen Inc. | Salts and polymorphs of a potent antidiabetic compound |
| US7435741B2 (en) * | 2006-05-09 | 2008-10-14 | Teva Pharmaceutical Industries, Ltd. | 2-N{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5476865A (en) * | 1994-07-06 | 1995-12-19 | Eli Lilly And Company | Methods of inhibiting bone loss |
| TWI249401B (en) * | 1999-04-14 | 2006-02-21 | Takeda Chemical Industries Ltd | Agent for improving ketosis |
| US6239157B1 (en) * | 1999-09-10 | 2001-05-29 | Osiris Therapeutics, Inc. | Inhibition of osteoclastogenesis |
-
2000
- 2000-11-14 GB GBGB0027783.0A patent/GB0027783D0/en not_active Ceased
-
2001
- 2001-11-14 AU AU2002215109A patent/AU2002215109A1/en not_active Abandoned
- 2001-11-14 US US10/416,599 patent/US20040266833A1/en not_active Abandoned
- 2001-11-14 WO PCT/GB2001/005044 patent/WO2002040020A1/en not_active Ceased
- 2001-11-14 JP JP2002542393A patent/JP2004513923A/ja active Pending
- 2001-11-14 EP EP01983684A patent/EP1335724A1/en not_active Withdrawn
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