JP2004512810A5 - - Google Patents

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Publication number
JP2004512810A5
JP2004512810A5 JP2001520859A JP2001520859A JP2004512810A5 JP 2004512810 A5 JP2004512810 A5 JP 2004512810A5 JP 2001520859 A JP2001520859 A JP 2001520859A JP 2001520859 A JP2001520859 A JP 2001520859A JP 2004512810 A5 JP2004512810 A5 JP 2004512810A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001520859A
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English (en)
Japanese (ja)
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JP2004512810A (ja
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Publication date
Priority claimed from US09/474,432 external-priority patent/US6528640B1/en
Priority claimed from US09/476,387 external-priority patent/US6617438B1/en
Application filed filed Critical
Priority claimed from PCT/US2000/023998 external-priority patent/WO2001016312A2/en
Publication of JP2004512810A publication Critical patent/JP2004512810A/ja
Publication of JP2004512810A5 publication Critical patent/JP2004512810A5/ja
Pending legal-status Critical Current

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JP2001520859A 1999-08-31 2000-08-30 核酸に基づく遺伝子発現の調節剤 Pending JP2004512810A (ja)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US15171399P 1999-08-31 1999-08-31
US40664399A 1999-09-27 1999-09-27
US15646799P 1999-09-27 1999-09-27
US15623699P 1999-09-27 1999-09-27
US43643099A 1999-11-08 1999-11-08
US16910099P 1999-12-06 1999-12-06
US17361299P 1999-12-29 1999-12-29
US09/474,432 US6528640B1 (en) 1997-11-05 1999-12-29 Synthetic ribonucleic acids with RNAse activity
US09/476,387 US6617438B1 (en) 1997-11-05 1999-12-30 Oligoribonucleotides with enzymatic activity
US49882400A 2000-02-04 2000-02-04
US53102500A 2000-03-20 2000-03-20
US19776900P 2000-04-14 2000-04-14
US57822300A 2000-05-23 2000-05-23
US63638500A 2000-08-09 2000-08-09
PCT/US2000/023998 WO2001016312A2 (en) 1999-08-31 2000-08-30 Nucleic acid based modulators of gene expression

Publications (2)

Publication Number Publication Date
JP2004512810A JP2004512810A (ja) 2004-04-30
JP2004512810A5 true JP2004512810A5 (de) 2005-01-06

Family

ID=27585071

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001520859A Pending JP2004512810A (ja) 1999-08-31 2000-08-30 核酸に基づく遺伝子発現の調節剤

Country Status (4)

Country Link
EP (1) EP1212416A2 (de)
JP (1) JP2004512810A (de)
CA (1) CA2403243A1 (de)
WO (1) WO2001016312A2 (de)

Families Citing this family (49)

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US6528640B1 (en) * 1997-11-05 2003-03-04 Ribozyme Pharmaceuticals, Incorporated Synthetic ribonucleic acids with RNAse activity
US7179796B2 (en) 2000-01-18 2007-02-20 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
US20020055479A1 (en) * 2000-01-18 2002-05-09 Cowsert Lex M. Antisense modulation of PTP1B expression
US20030190635A1 (en) * 2002-02-20 2003-10-09 Mcswiggen James A. RNA interference mediated treatment of Alzheimer's disease using short interfering RNA
WO2003070983A1 (en) * 2002-02-20 2003-08-28 Sirna Therapeutics, Inc RNA INTERFERENCE MEDIATED INHIBITION OF PROTEIN KINASE C ALPHA (PKC-ALPHA) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US9994853B2 (en) 2001-05-18 2018-06-12 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
EP1390472A4 (de) * 2001-05-29 2004-11-17 Sirna Therapeutics Inc Nukleinsäurebehandlung von krankheiten oder leiden im zusammenhang mit ras-, her2- und hiv-niveaus
WO2003034985A2 (en) * 2001-10-22 2003-05-01 University Of Rochester Telomerase interference
US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
AU2003215161A1 (en) * 2002-02-20 2003-09-09 Ribozyme Pharmaceuticals, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF TELOMERASE GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
EP2108707A3 (de) * 2002-05-17 2010-04-14 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Molekulare Identifizierung der Aspergillus-Species
US7507808B2 (en) 2002-12-12 2009-03-24 Isis Pharmaceuticals, Inc. Modulation of endothelial lipase expression
US7618948B2 (en) 2002-11-26 2009-11-17 Medtronic, Inc. Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA
US7829694B2 (en) * 2002-11-26 2010-11-09 Medtronic, Inc. Treatment of neurodegenerative disease through intracranial delivery of siRNA
US7605249B2 (en) 2002-11-26 2009-10-20 Medtronic, Inc. Treatment of neurodegenerative disease through intracranial delivery of siRNA
FR2848573B1 (fr) * 2002-12-13 2005-04-08 Exonhit Therapeutics Sa Compositions et methodes pour la detection et le traitement de pathologies neurodegeneratives
US7994149B2 (en) 2003-02-03 2011-08-09 Medtronic, Inc. Method for treatment of Huntington's disease through intracranial delivery of sirna
US7846906B2 (en) 2003-02-28 2010-12-07 Isis Pharmaceuticals, Inc. Modulation of growth hormone receptor expression and insulin-like growth factor expression
US7803781B2 (en) 2003-02-28 2010-09-28 Isis Pharmaceuticals, Inc. Modulation of growth hormone receptor expression and insulin-like growth factor expression
AU2003225410A1 (en) 2003-03-21 2004-10-11 Academisch Ziekenhuis Leiden Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
US7534775B2 (en) * 2004-04-08 2009-05-19 Sangamo Biosciences, Inc. Methods and compositions for modulating cardiac contractility
US10508277B2 (en) 2004-05-24 2019-12-17 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
WO2006064519A2 (en) * 2004-12-14 2006-06-22 National Institute Of Immunology Dnazymes for inhibition of japanese encephalitis virus replication
AU2006222563A1 (en) 2005-03-08 2006-09-14 Biota Scientific Management Pty Ltd. Bicyclic nucleosides and nucleotides as therapeutic agents
US9133517B2 (en) 2005-06-28 2015-09-15 Medtronics, Inc. Methods and sequences to preferentially suppress expression of mutated huntingtin
US9273356B2 (en) 2006-05-24 2016-03-01 Medtronic, Inc. Methods and kits for linking polymorphic sequences to expanded repeat mutations
HUE037173T2 (hu) 2006-08-08 2018-08-28 Univ Bonn Rheinische Friedrich Wilhelms 5'-Foszfát-oligonukleotidok szerkezete és alkalmazása
US9375440B2 (en) 2006-11-03 2016-06-28 Medtronic, Inc. Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
NZ584793A (en) 2007-10-26 2012-05-25 Academisch Ziekenhuis Leiden Means and methods for counteracting muscle disorders
USRE48468E1 (en) 2007-10-26 2021-03-16 Biomarin Technologies B.V. Means and methods for counteracting muscle disorders
EP2119783A1 (de) 2008-05-14 2009-11-18 Prosensa Technologies B.V. Verfahren für effizientes Exon (44)-Skipping bei Duchenne-Muskeldystrophie und entsprechende Mittel
US9738680B2 (en) 2008-05-21 2017-08-22 Rheinische Friedrich-Wilhelms-Universität Bonn 5′ triphosphate oligonucleotide with blunt end and uses thereof
JP2012524540A (ja) 2009-04-24 2012-10-18 プロセンサ テクノロジーズ ビー.ブイ. Dmdを処置するためのイノシンを含むオリゴヌクレオチド
EP2512491B1 (de) 2009-10-16 2017-10-11 Glaxo Group Limited Hbv-antisense-hemmer
CN103140582A (zh) 2010-08-24 2013-06-05 默沙东公司 含有内部非核酸间隔子的单链RNAi试剂
ES2663009T3 (es) 2010-10-29 2018-04-10 Sirna Therapeutics, Inc. Inhibición de la expresión génica mediada por interferencia por ARN utilizando ácidos nucleicos de interferencia cortos (ANic)
MX2013005413A (es) 2010-11-15 2014-02-27 Univ Ramot Analogos de dipeptidos para el tratamiento de afecciones asociadas con la formacion de fibrillas amiloides.
EP2508530A1 (de) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Reinigung von triphosphorylierten Oligonucleotiden mit Einfang-Tags
US8658783B2 (en) 2011-04-13 2014-02-25 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
EP3816288A3 (de) 2011-04-21 2021-07-14 Glaxo Group Limited Modulation einer hepatitis-b-virus (hbv)-expression
EP2806900B1 (de) 2012-01-27 2021-12-15 BioMarin Technologies B.V. Rna-modulierende oligonukleotide mit verbesserten eigenschaften zur behandlung der duchenne- und becker-muskeldystrophie
WO2014017938A2 (en) * 2012-07-27 2014-01-30 BIAL - PORTELA & Cª, S.A. Process for the synthesis of substituted urea compounds
EP2712870A1 (de) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Neuartige RIG-I-Liganden und Herstellungsverfahren dafür
GB201408623D0 (en) 2014-05-15 2014-07-02 Santaris Pharma As Oligomers and oligomer conjugates
DE102015113038B3 (de) * 2015-07-13 2017-01-19 Simone Kann Oligonucleotide und deren Verwendung
WO2019079195A1 (en) * 2017-10-16 2019-04-25 University Of Pittsburgh - Of The Commonwealth System Of Higher Education GENETICALLY MODIFIED MESENCHYMAL STEM CELLS FOR USE IN CARDIOVASCULAR PROSTHESES

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WO1998049346A1 (en) * 1997-04-29 1998-11-05 The Scripps Research Institute Enzymatic dna molecules
WO1997026270A2 (en) * 1996-01-16 1997-07-24 Ribozyme Pharmaceuticals, Inc. Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules
AU721758B2 (en) * 1996-04-02 2000-07-13 Gene Shears Pty. Limited Asymmetric hammerhead ribozymes

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