JP2004511773A - アフィニティ捕捉タンデム質量分析を用いた分子相互作用の特性を決定する方法 - Google Patents

アフィニティ捕捉タンデム質量分析を用いた分子相互作用の特性を決定する方法 Download PDF

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Publication number
JP2004511773A
JP2004511773A JP2002534819A JP2002534819A JP2004511773A JP 2004511773 A JP2004511773 A JP 2004511773A JP 2002534819 A JP2002534819 A JP 2002534819A JP 2002534819 A JP2002534819 A JP 2002534819A JP 2004511773 A JP2004511773 A JP 2004511773A
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Japan
Prior art keywords
binding partner
probe
protein
binding
affinity capture
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Pending
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JP2002534819A
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English (en)
Japanese (ja)
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JP2004511773A5 (enExample
Inventor
ワインバーガー,スコット
モリス,タイ
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Aspira Womens Health Inc
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Ciphergen Biosystems Inc
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Application filed by Ciphergen Biosystems Inc filed Critical Ciphergen Biosystems Inc
Publication of JP2004511773A publication Critical patent/JP2004511773A/ja
Publication of JP2004511773A5 publication Critical patent/JP2004511773A5/ja
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2002534819A 2000-10-11 2000-10-12 アフィニティ捕捉タンデム質量分析を用いた分子相互作用の特性を決定する方法 Pending JP2004511773A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/028261 WO2002031484A2 (en) 2000-10-11 2000-10-11 Methods for characterizing molecular interactions using affinity capture tandem mass spectrometry

Publications (2)

Publication Number Publication Date
JP2004511773A true JP2004511773A (ja) 2004-04-15
JP2004511773A5 JP2004511773A5 (enExample) 2005-04-14

Family

ID=21741885

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002534819A Pending JP2004511773A (ja) 2000-10-11 2000-10-12 アフィニティ捕捉タンデム質量分析を用いた分子相互作用の特性を決定する方法

Country Status (7)

Country Link
US (1) US20030219731A1 (enExample)
EP (1) EP1327151A2 (enExample)
JP (1) JP2004511773A (enExample)
CN (1) CN1474944A (enExample)
AU (1) AU1199501A (enExample)
CA (1) CA2425434A1 (enExample)
WO (1) WO2002031484A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106415260A (zh) * 2014-06-13 2017-02-15 Dh科技发展私人贸易有限公司 使用质谱分析法分析脂质的方法
JP2017534052A (ja) * 2014-10-30 2017-11-16 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド イオン断片化のためのイオンを選択するための方法およびシステム

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0101555D0 (sv) * 2001-05-04 2001-05-04 Amersham Pharm Biotech Ab Fast variable gain detector system and method of controlling the same
US6946653B2 (en) * 2001-11-27 2005-09-20 Ciphergen Biosystems, Inc. Methods and apparatus for improved laser desorption ionization tandem mass spectrometry
US7846748B2 (en) * 2002-12-02 2010-12-07 The University Of North Carolina At Chapel Hill Methods of quantitation and identification of peptides and proteins
CN1314968C (zh) * 2004-03-11 2007-05-09 复旦大学 痕量多肽或蛋白质富集及其直接分析方法
CN100376895C (zh) * 2004-11-03 2008-03-26 中国科学院计算技术研究所 一种使用串联质谱数据鉴定肽的方法
CN100483394C (zh) * 2006-04-14 2009-04-29 中国科学院计算技术研究所 一种质谱数据处理中噪音基线识别方法
US7879799B2 (en) * 2006-08-10 2011-02-01 Institute For Systems Biology Methods for characterizing glycoproteins and generating antibodies for same
WO2012092281A2 (en) * 2010-12-28 2012-07-05 Quest Diagnostics Investments Incorporated Quantitation of insulin by mass spectrometry
GB201110272D0 (en) 2011-06-17 2011-08-03 Isis Innovation Metod of detection by mass spectrometry
CN203367223U (zh) * 2012-05-21 2013-12-25 核工业北京地质研究院 热电离飞行时间质谱仪
US10049868B2 (en) * 2016-12-06 2018-08-14 Rapiscan Systems, Inc. Apparatus for detecting constituents in a sample and method of using the same
CN114383984B (zh) * 2021-12-06 2022-09-23 浙江大学 一种捕获颗粒物并测量其相态、形貌和化学组分的系统

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288644A (en) * 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
US5202563A (en) * 1991-05-16 1993-04-13 The Johns Hopkins University Tandem time-of-flight mass spectrometer
US5144127A (en) * 1991-08-02 1992-09-01 Williams Evan R Surface induced dissociation with reflectron time-of-flight mass spectrometry
US5382793A (en) * 1992-03-06 1995-01-17 Hewlett-Packard Company Laser desorption ionization mass monitor (LDIM)
PT700521E (pt) * 1993-05-28 2003-10-31 Baylor College Medicine Metodo e espectrometro de massa para dessorcao e ionizacao de analitos
US6020208A (en) * 1994-05-27 2000-02-01 Baylor College Of Medicine Systems for surface-enhanced affinity capture for desorption and detection of analytes
US5538897A (en) * 1994-03-14 1996-07-23 University Of Washington Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases
US5498545A (en) * 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements
US5777324A (en) * 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
GB9717926D0 (en) * 1997-08-22 1997-10-29 Micromass Ltd Methods and apparatus for tandem mass spectrometry
US6348688B1 (en) * 1998-02-06 2002-02-19 Perseptive Biosystems Tandem time-of-flight mass spectrometer with delayed extraction and method for use
US6428956B1 (en) * 1998-03-02 2002-08-06 Isis Pharmaceuticals, Inc. Mass spectrometric methods for biomolecular screening
US6723564B2 (en) * 1998-05-07 2004-04-20 Sequenom, Inc. IR MALDI mass spectrometry of nucleic acids using liquid matrices

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106415260A (zh) * 2014-06-13 2017-02-15 Dh科技发展私人贸易有限公司 使用质谱分析法分析脂质的方法
CN106415260B (zh) * 2014-06-13 2021-04-06 Dh科技发展私人贸易有限公司 使用质谱分析法分析脂质的方法
JP2017534052A (ja) * 2014-10-30 2017-11-16 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド イオン断片化のためのイオンを選択するための方法およびシステム

Also Published As

Publication number Publication date
WO2002031484A3 (en) 2002-07-25
CN1474944A (zh) 2004-02-11
WO2002031484A8 (en) 2003-09-04
CA2425434A1 (en) 2002-04-18
EP1327151A2 (en) 2003-07-16
WO2002031484A2 (en) 2002-04-18
AU1199501A (en) 2002-04-22
US20030219731A1 (en) 2003-11-27

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