JP2004510950A - 免疫免除された抗原に対する細胞性免疫の検出および調整のための方法および薬剤 - Google Patents

免疫免除された抗原に対する細胞性免疫の検出および調整のための方法および薬剤 Download PDF

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JP2004510950A
JP2004510950A JP2000557146A JP2000557146A JP2004510950A JP 2004510950 A JP2004510950 A JP 2004510950A JP 2000557146 A JP2000557146 A JP 2000557146A JP 2000557146 A JP2000557146 A JP 2000557146A JP 2004510950 A JP2004510950 A JP 2004510950A
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immunoimmune
antigens
modulation
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JP2004510950A5 (ja
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ダーネル　ロバート　ビー．
アルバート　マシュー　エル．
バードウェッジ　ニナ
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Rockefeller University
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Abstract

本発明は、免疫特権を有した抗体に対する個人毎の細胞免疫応答性の存在および程度を決定する方法に関する。この方法は細胞免疫応答性が病理学的な症状と直接もしくは間接的に関連する方法であり、個人の体液サンプルにおいて、免疫特権を有した抗体に特有のＴリンパ球の存在および程度を測定することからなる。

Description

【０００１】
【発明の属する技術分野】
政府によるサポート
本発明に関連する研究は、少なくとも一部が国防省、Ｂｒｅａｓｔ Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ａｗａｒｄ ＮＯ．ＤＡＭＤ０１７−９４−Ｊ−４２７７、Ｎａｔｉｏｎａｌ Ｉｎｓｔｉｔｕｔｅｓ ｏｆ Ｈｅａｌｔｈ Ａｗａｒｄ Ｎｏ．Ｍ０１ ＰＲ００１０２、および Ｎａｔｉｏｎａｌ Ｍｕｌｔｉｐｌｅ Ｓｅｌｅｒｏｓｉｓ Ｓｏｃｉｅｔｙ から許可を得て支持されている。このため、政府がこの発明について所定の権利を有する。
【０００２】
発明の分野
本発明は、免疫特権を有した抗体に対する細胞免疫およびその役割の開発に基づく診断および治療方法に関する。
【図面の簡単な説明】
【図１】
患者の血清およびＣＦＳ因子のウエスタンブロット解析結果を示す図である。

Claims (1)

  1. 免疫特権を有した抗体に対する個人毎の細胞免疫応答性の存在および程度を決定する方法であって、前記細胞免疫応答性が病理学的な症状と直接もしくは間接的に関連している方法が、前記個人の体液サンプルにおいて、免疫特権を有した抗体に特有のＴリンパ球の存在および程度を測定することからなることを特徴とする方法。
JP2000557146A 1998-06-30 1999-06-30 免疫免除された抗原に対する細胞性免疫の検出および調整のための方法および薬剤 Pending JP2004510950A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10797898A 1998-06-30 1998-06-30
PCT/US1999/014827 WO2000000825A2 (en) 1998-06-30 1999-06-30 Detection and modulation of cellular immunity to immune privileged antigens

Publications (2)

Publication Number Publication Date
JP2004510950A true JP2004510950A (ja) 2004-04-08
JP2004510950A5 JP2004510950A5 (ja) 2005-01-06

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JP2000557146A Pending JP2004510950A (ja) 1998-06-30 1999-06-30 免疫免除された抗原に対する細胞性免疫の検出および調整のための方法および薬剤

Country Status (4)

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JP (1) JP2004510950A (ja)
AU (1) AU4848899A (ja)
CA (1) CA2336382A1 (ja)
WO (1) WO2000000825A2 (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1092154A2 (en) 1998-06-30 2001-04-18 The Rockefeller University Detection and modulation of cellular immunity to immune privileged antigens
CN100352921C (zh) * 1999-05-06 2007-12-05 威克福雷大学 用于鉴定引起免疫反应的抗原的组合物和方法
US20020031787A1 (en) * 2000-02-04 2002-03-14 Maclaren Noel K. Compositions and methods for reducing autoimmunity
AU2002218019A1 (en) * 2000-11-03 2002-05-15 Nexell Therapeutics Inc. Methods for depleting and isolating alloreactive and antigen-reactive t cells from hematopoietic donor cells
EP1734663B1 (en) 2005-06-17 2011-06-15 Fujitsu Limited Multi-hop communication system
US7928190B2 (en) * 2007-07-05 2011-04-19 Darnell Robert B Methods and compositions for tumor vaccination and therapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1796492A (en) * 1991-04-25 1992-12-21 Sloan-Kettering Institute For Cancer Research Antigen recognized by antibodies associated with paraneoplastic opsoclonus and methods of use thereof
WO1993003375A1 (en) * 1991-08-09 1993-02-18 Washington University Autoantibodies and their targets in the diagnosis of peripheral neuropathies
US5753522A (en) * 1991-12-06 1998-05-19 Legacy Good Samaritan Hospital And Medical Center Purified protein for identifying a cancer-associated retinopathy autoantibody
US5686068A (en) * 1994-03-24 1997-11-11 Ludwig Institute For Cancer Research Isolated peptides derived from MAGE-2, cytolytic T cells specific to complexes of peptide and HLA-A2 molecules, and uses thereof

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WO2000000825A2 (en) 2000-01-06
WO2000000825A3 (en) 2000-02-10
AU4848899A (en) 2000-01-17
CA2336382A1 (en) 2000-01-06
WO2000000825A9 (en) 2000-05-25

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