JP2004509120A - カスパーゼ阻害剤およびそれらの用途 - Google Patents

カスパーゼ阻害剤およびそれらの用途 Download PDF

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Publication number
JP2004509120A
JP2004509120A JP2002526864A JP2002526864A JP2004509120A JP 2004509120 A JP2004509120 A JP 2004509120A JP 2002526864 A JP2002526864 A JP 2002526864A JP 2002526864 A JP2002526864 A JP 2002526864A JP 2004509120 A JP2004509120 A JP 2004509120A
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group
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disease
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ring
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JP2004509120A5 (enExample
Inventor
カリエール，　ジーン−ダミエン
ネテル，　ロナルド
モルティモア，　マイケル
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Publication of JP2004509120A publication Critical patent/JP2004509120A/ja
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Hematology (AREA)
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JP2002526864A 2000-09-13 2001-09-12 カスパーゼ阻害剤およびそれらの用途 Pending JP2004509120A (ja)

Applications Claiming Priority (2)

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US23257300P 2000-09-13 2000-09-13
PCT/US2001/028450 WO2002022611A2 (en) 2000-09-13 2001-09-12 Caspase inhibitors and uses thereof

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JP2008198860A Division JP2008297321A (ja) 2000-09-13 2008-07-31 カスパーゼ阻害剤およびそれらの用途

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JP2004509120A true JP2004509120A (ja) 2004-03-25
JP2004509120A5 JP2004509120A5 (enExample) 2008-09-25

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JP2008198860A Pending JP2008297321A (ja) 2000-09-13 2008-07-31 カスパーゼ阻害剤およびそれらの用途

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US (1) US6800619B2 (enExample)
EP (1) EP1317454B1 (enExample)
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004527548A (ja) * 2001-04-19 2004-09-09 バーテックス ファーマシューティカルズ インコーポレイテッド カスパーゼ阻害剤としての複素環ジカルバミド
JP2006502415A (ja) * 2002-10-10 2006-01-19 ベクトン・ディキンソン・アンド・カンパニー カスパーゼ阻害剤を有するサンプル収集システム
JP2008520620A (ja) * 2004-11-24 2008-06-19 テラプトシス エス アー カスパーゼ−２／−６二重阻害剤として有用な新規ペプチドおよびそれらの生物学的適用
JP2008297321A (ja) * 2000-09-13 2008-12-11 Vertex Pharmaceut Inc カスパーゼ阻害剤およびそれらの用途

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020058636A1 (en) * 1994-09-21 2002-05-16 Geoffrey P. Symonds Ribozymes targeting the retroviral packaging sequence expression constructs and recombinant retroviruses containing such constructs
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
FR2815541B1 (fr) * 2000-10-24 2008-02-29 Lipha Utilisation d'inhibiteurs de l'apoptose des pericytes pour le traitement et/ou la prevention de la retinopathie diabetique
JP4428926B2 (ja) * 2001-05-23 2010-03-10 バーテックス ファーマシューティカルズ インコーポレイテッド カスパーゼインヒビターおよびそれらの使用
CA2453531A1 (en) 2001-07-10 2003-01-23 Johnson & Johnson Research Pty Limited Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells
WO2003068242A1 (en) 2002-02-11 2003-08-21 Vertex Pharmaceuticals Incorporated Phospholipids as caspase inhibitor prodrugs
US7960398B2 (en) 2002-04-19 2011-06-14 Vertex Pharmaceuticals Incorporated Regulation of TNF-alpha
CN100366612C (zh) * 2002-12-20 2008-02-06 沃泰克斯药物股份有限公司 4-氧代-3-(1-氧代-1h-异喹啉-2-基乙酰氨基)-戊酸酯和酰胺衍生物及其作为天冬氨酸特异性半胱氨酸蛋白酶抑制剂的用途
PT1470818E (pt) * 2003-04-25 2006-11-30 Neuro3D Utilização de derivados de fenotiazina piperazina no fabrico de um medicamento com efeitos neuroprotectores e/ou neurotróficos no cns e/ou pns
AU2003902704A0 (en) * 2003-05-29 2003-06-19 Crc For Waste Management And Pollution Control Limited Of Unsw Process for producing a nanoscale zero-valent metal
WO2005117846A2 (en) * 2004-05-27 2005-12-15 Vertex Pharmaceuticals Incorporated Ice inhibitors for the treatment of autoinflammatory diseases
EP1718639A2 (en) 2004-02-27 2006-11-08 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
CA2768700C (en) * 2004-03-12 2014-04-29 Vertex Pharmaceuticals Incorporated Processes and intermediates for the preparation of aspartic acetal caspase inhibitors
US20060128696A1 (en) * 2004-05-15 2006-06-15 Annamaria Vezzani Treating seizures using ice inhibitors
US8012751B2 (en) * 2005-03-31 2011-09-06 Wisconsin Alumni Research Foundation Differentiation of pluripotent embryonic stem cells
ATE529430T1 (de) * 2005-07-28 2011-11-15 Vertex Pharma Caspase-hemmer-propharmaka
CA2632257A1 (en) 2005-11-30 2008-05-02 Massachusetts Institute Of Technology Pathogen-detecting cell preservation systems
EP2043672A4 (en) * 2006-07-07 2009-10-21 Univ Leland Stanford Junior SELECTIVE INHIBITORS OF CASPASES
US8828950B2 (en) * 2007-05-01 2014-09-09 Cedars-Sinai Medical Center Caspase inhibitors in the treatment of infection-associated preterm delivery
WO2009140765A1 (en) 2008-05-21 2009-11-26 New World Laboratories Inc. Selective caspase inhibitors and uses thereof
WO2010133000A1 (en) 2009-05-21 2010-11-25 New World Laboratories Inc. Selective caspase inhibitors and uses thereof
WO2011094426A1 (en) * 2010-01-29 2011-08-04 The United State Of America, As Represented By The Secretary, Department Of Health & Human Services Caspase inhibitors
CN102241627B (zh) * 2010-05-14 2014-07-02 中国人民解放军总医院 脲类化合物及其医药用途
JP6006908B2 (ja) 2010-11-05 2016-10-12 ブランダイス ユニバーシティＢｒａｎｄｅｉｓ Ｕｎｉｖｅｒｓｉｔｙ Ｉｃｅ阻害化合物およびその使用
WO2012140500A1 (en) 2011-04-15 2012-10-18 New World Laboratories, Inc. Selective cysteine protease inhibitors and uses thereof
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
SG11201609256SA (en) 2014-05-12 2016-12-29 Conatus Pharmaceuticals Inc Treatment of the complications of chronic liver disease with caspase inhibitors
WO2017079566A1 (en) 2015-11-05 2017-05-11 Conatus Pharmaceuticals, Inc. Caspase inhibitors for use in the treatment of liver cancer
US20190022043A1 (en) 2015-12-31 2019-01-24 Conatus Pharmaceuticals Inc. Methods of using caspase inhibitors in treatment of liver disease
AU2017311691B2 (en) 2016-08-18 2021-12-02 Vidac Pharma Ltd. Piperazine derivatives, pharmaceutical compositions and methods of use thereof
WO2018065902A1 (en) 2016-10-05 2018-04-12 Novartis Ag Combination compositions comprising fxr agonists for treating or preventing a fibrotic,cirrhotic disease or disorder
WO2022123062A1 (en) 2020-12-11 2022-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients
IT202300000834A1 (it) 2023-01-20 2024-07-20 Scylla Biotech Srl Inibitori selettivi della caspasi-8 ed usi degli stessi per potenziare le difese innate

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07500828A (ja) * 1991-11-04 1995-01-26 サンド・リミテッド ＩＬ−１β遊離を阻害するペプチド類
WO1995023222A1 (en) * 1994-02-25 1995-08-31 Khepri Pharmaceuticals, Inc. Irreversible cysteine protease inhibitors containing vinyl groups conjugated to electron withdrawing groups
WO1998016502A1 (en) * 1996-10-11 1998-04-23 Warner-Lambert Company ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME
WO1999047545A2 (en) * 1998-03-19 1999-09-23 Vertex Pharmaceuticals Incorporated Inhibitors of caspases
JP2008297321A (ja) * 2000-09-13 2008-12-11 Vertex Pharmaceut Inc カスパーゼ阻害剤およびそれらの用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0789951A (ja) * 1993-06-03 1995-04-04 Sterling Winthrop Inc インターロイキン−１β転換酵素阻害剤
US5843904A (en) * 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme
EA200000409A1 (ru) * 1997-10-10 2000-10-30 Сайтовиэ, Инк. Соединение, фармацевтическая композиция, способ ингибирования гибели клетки в одной клетке или ткани, способ лечения или снижения клеточной смерти, способ лечения или профилактики поликистозного заболевания почек или анемии/эритропоэза у животных, способ защиты органа или ткани млекопитающего от гибели клеток, способ снижения или профилактики гибели клеток в органе или ткани донора после их трансплантации, способ снижения или предотвращения гибели спермы или яйцеклеток
WO1999047154A1 (en) 1998-03-16 1999-09-23 Cytovia, Inc. Dipeptide caspase inhibitors and the use thereof
AU4213500A (en) * 1999-04-09 2000-11-14 Cytovia, Inc. Caspase inhibitors and the use thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07500828A (ja) * 1991-11-04 1995-01-26 サンド・リミテッド ＩＬ−１β遊離を阻害するペプチド類
WO1995023222A1 (en) * 1994-02-25 1995-08-31 Khepri Pharmaceuticals, Inc. Irreversible cysteine protease inhibitors containing vinyl groups conjugated to electron withdrawing groups
WO1998016502A1 (en) * 1996-10-11 1998-04-23 Warner-Lambert Company ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME
WO1999047545A2 (en) * 1998-03-19 1999-09-23 Vertex Pharmaceuticals Incorporated Inhibitors of caspases
JP2008297321A (ja) * 2000-09-13 2008-12-11 Vertex Pharmaceut Inc カスパーゼ阻害剤およびそれらの用途

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008297321A (ja) * 2000-09-13 2008-12-11 Vertex Pharmaceut Inc カスパーゼ阻害剤およびそれらの用途
JP2004527548A (ja) * 2001-04-19 2004-09-09 バーテックス ファーマシューティカルズ インコーポレイテッド カスパーゼ阻害剤としての複素環ジカルバミド
JP2006502415A (ja) * 2002-10-10 2006-01-19 ベクトン・ディキンソン・アンド・カンパニー カスパーゼ阻害剤を有するサンプル収集システム
JP2008520620A (ja) * 2004-11-24 2008-06-19 テラプトシス エス アー カスパーゼ−２／−６二重阻害剤として有用な新規ペプチドおよびそれらの生物学的適用
US8324173B2 (en) 2004-11-24 2012-12-04 Chiesi Farmaceutici S.P.A. Peptides useful as dual caspase-2/-6 inhibitors and their biological applications

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