JP2004508372A5 - - Google Patents
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- Publication number
- JP2004508372A5 JP2004508372A5 JP2002525145A JP2002525145A JP2004508372A5 JP 2004508372 A5 JP2004508372 A5 JP 2004508372A5 JP 2002525145 A JP2002525145 A JP 2002525145A JP 2002525145 A JP2002525145 A JP 2002525145A JP 2004508372 A5 JP2004508372 A5 JP 2004508372A5
- Authority
- JP
- Japan
- Prior art keywords
- methylidene
- pyrrolo
- dihydro
- quinolin
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- CUKDYHBXPMRNNS-RGEXLXHISA-N (1z)-1-[[4-(diethylaminomethyl)anilino]methylidene]-3h-pyrrolo[3,2-f]quinolin-2-one Chemical compound C1=CC(CN(CC)CC)=CC=C1N\C=C/1C2=C3C=CC=NC3=CC=C2NC\1=O CUKDYHBXPMRNNS-RGEXLXHISA-N 0.000 claims 1
- DGJKYSIIGHMSAG-PDGQHHTCSA-N (1z)-1-[[4-(imidazol-1-ylmethyl)anilino]methylidene]-3h-pyrrolo[3,2-f]quinolin-2-one Chemical compound O=C1NC2=CC=C3N=CC=CC3=C2\C1=C\NC(C=C1)=CC=C1CN1C=CN=C1 DGJKYSIIGHMSAG-PDGQHHTCSA-N 0.000 claims 1
- AXUSEJMRCUNBKZ-RGEXLXHISA-N (1z)-1-[[4-(morpholin-4-ylmethyl)anilino]methylidene]-3h-pyrrolo[3,2-f]quinolin-2-one Chemical compound O=C1NC2=CC=C3N=CC=CC3=C2\C1=C\NC(C=C1)=CC=C1CN1CCOCC1 AXUSEJMRCUNBKZ-RGEXLXHISA-N 0.000 claims 1
- LNXCKELRDFMLII-HKWRFOASSA-N (1z)-1-[[4-(piperidin-1-ylmethyl)anilino]methylidene]-3h-pyrrolo[3,2-f]quinolin-2-one Chemical compound O=C1NC2=CC=C3N=CC=CC3=C2\C1=C\NC(C=C1)=CC=C1CN1CCCCC1 LNXCKELRDFMLII-HKWRFOASSA-N 0.000 claims 1
- DCPOLJJSVZYWLG-ZHZULCJRSA-N (1z)-1-[[4-[(4-hydroxypiperidin-1-yl)methyl]anilino]methylidene]-3h-pyrrolo[3,2-f]quinolin-2-one Chemical compound C1CC(O)CCN1CC(C=C1)=CC=C1N\C=C/1C2=C3C=CC=NC3=CC=C2NC\1=O DCPOLJJSVZYWLG-ZHZULCJRSA-N 0.000 claims 1
- OJBMUGXSHFSAFT-HKWRFOASSA-N (1z)-1-[[4-[(4-methylpiperazin-1-yl)methyl]anilino]methylidene]-3h-pyrrolo[3,2-f]quinolin-2-one Chemical compound C1CN(C)CCN1CC(C=C1)=CC=C1N\C=C/1C2=C3C=CC=NC3=CC=C2NC\1=O OJBMUGXSHFSAFT-HKWRFOASSA-N 0.000 claims 1
- XMRXEVIRZJNJPU-ATVHPVEESA-N (1z)-1-[[4-[(dimethylamino)methyl]anilino]methylidene]-3h-pyrrolo[3,2-f]quinolin-2-one Chemical compound C1=CC(CN(C)C)=CC=C1N\C=C/1C2=C3C=CC=NC3=CC=C2NC\1=O XMRXEVIRZJNJPU-ATVHPVEESA-N 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 102000003903 Cyclin-dependent kinases Human genes 0.000 claims 1
- 108090000266 Cyclin-dependent kinases Proteins 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23024100P | 2000-09-01 | 2000-09-01 | |
| PCT/US2001/020703 WO2002020524A1 (en) | 2000-09-01 | 2001-06-28 | Oxindole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004508372A JP2004508372A (ja) | 2004-03-18 |
| JP2004508372A5 true JP2004508372A5 (https=) | 2005-04-07 |
Family
ID=22864461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002525145A Pending JP2004508372A (ja) | 2000-09-01 | 2001-06-28 | オキシインドール誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6720332B2 (https=) |
| EP (1) | EP1313732B1 (https=) |
| JP (1) | JP2004508372A (https=) |
| AT (1) | ATE281455T1 (https=) |
| AU (1) | AU2001271611A1 (https=) |
| DE (1) | DE60106947T2 (https=) |
| ES (1) | ES2230337T3 (https=) |
| WO (1) | WO2002020524A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000071102A2 (en) * | 1999-05-19 | 2000-11-30 | Neurosearch A/S | Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders |
| ES2251677T3 (es) | 2002-01-22 | 2006-05-01 | Warner-Lambert Company Llc | 2-(piridin-2-ilamino)-pirido(2,3-d)pirimidin-7-onas. |
| ATE412650T1 (de) * | 2003-07-11 | 2008-11-15 | Warner Lambert Co | Isethionat salz eines selektiven cdk4 inhibitors |
| US20050171182A1 (en) * | 2003-12-11 | 2005-08-04 | Roger Briesewitz | Methods and compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases |
| US7304074B2 (en) * | 2005-04-05 | 2007-12-04 | Hoffmann-La Roche Inc. | Substituted 1,5-naphthyridine azolinones |
| EP3399026B1 (en) | 2010-06-14 | 2024-06-26 | The Scripps Research Institute | Reprogramming of cells to a new fate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9716557D0 (en) * | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| GB9904933D0 (en) * | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
-
2001
- 2001-06-28 ES ES01950642T patent/ES2230337T3/es not_active Expired - Lifetime
- 2001-06-28 AU AU2001271611A patent/AU2001271611A1/en not_active Abandoned
- 2001-06-28 US US10/362,744 patent/US6720332B2/en not_active Expired - Fee Related
- 2001-06-28 JP JP2002525145A patent/JP2004508372A/ja active Pending
- 2001-06-28 DE DE60106947T patent/DE60106947T2/de not_active Expired - Fee Related
- 2001-06-28 EP EP01950642A patent/EP1313732B1/en not_active Expired - Lifetime
- 2001-06-28 AT AT01950642T patent/ATE281455T1/de not_active IP Right Cessation
- 2001-06-28 WO PCT/US2001/020703 patent/WO2002020524A1/en not_active Ceased
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