JP2004508348A5 - - Google Patents
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- Publication number
- JP2004508348A5 JP2004508348A5 JP2002525087A JP2002525087A JP2004508348A5 JP 2004508348 A5 JP2004508348 A5 JP 2004508348A5 JP 2002525087 A JP2002525087 A JP 2002525087A JP 2002525087 A JP2002525087 A JP 2002525087A JP 2004508348 A5 JP2004508348 A5 JP 2004508348A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound according
- naphthyl
- carbamoyl
- naphthalene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 description 19
- 125000000217 alkyl group Chemical group 0.000 description 9
- 125000001624 naphthyl group Chemical group 0.000 description 6
- 125000001072 heteroaryl group Chemical group 0.000 description 5
- 239000001257 hydrogen Substances 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 125000000623 heterocyclic group Chemical group 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 125000003107 substituted aryl group Chemical group 0.000 description 4
- 0 *C(c1cc(C(N*)=O)cc(C(N*)=O)c1)=O Chemical compound *C(c1cc(C(N*)=O)cc(C(N*)=O)c1)=O 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 3
- 201000001421 hyperglycemia Diseases 0.000 description 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 3
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 150000002431 hydrogen Chemical class 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 125000003831 tetrazolyl group Chemical group 0.000 description 2
- ZQBWBMFQNDKJSC-UHFFFAOYSA-N 2-[[3,5-bis[(1-sulfonaphthalen-2-yl)carbamoyl]benzoyl]amino]naphthalene-1-sulfonic acid Chemical compound C1=CC2=CC=CC=C2C(S(=O)(=O)O)=C1NC(=O)C1=CC(C(=O)NC=2C(=C3C=CC=CC3=CC=2)S(O)(=O)=O)=CC(C(=O)NC=2C(=C3C=CC=CC3=CC=2)S(O)(=O)=O)=C1 ZQBWBMFQNDKJSC-UHFFFAOYSA-N 0.000 description 1
- KDEJOXKUTBZPNO-UHFFFAOYSA-N 4-[[3,5-bis[(4-sulfonaphthalen-1-yl)carbamoyl]benzoyl]amino]naphthalene-1-sulfonic acid Chemical compound C12=CC=CC=C2C(S(=O)(=O)O)=CC=C1NC(=O)C1=CC(C(=O)NC=2C3=CC=CC=C3C(=CC=2)S(O)(=O)=O)=CC(C(=O)NC=2C3=CC=CC=C3C(=CC=2)S(O)(=O)=O)=C1 KDEJOXKUTBZPNO-UHFFFAOYSA-N 0.000 description 1
- LXAIYNONPNXMJE-UHFFFAOYSA-N 5-[[3,5-bis[(5-sulfonaphthalen-1-yl)carbamoyl]benzoyl]amino]naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(NC(=O)C=3C=C(C=C(C=3)C(=O)NC=3C4=CC=CC(=C4C=CC=3)S(O)(=O)=O)C(=O)NC3=C4C=CC=C(C4=CC=C3)S(=O)(=O)O)=CC=CC2=C1S(O)(=O)=O LXAIYNONPNXMJE-UHFFFAOYSA-N 0.000 description 1
- ZPEKAAMNUZIGFQ-UHFFFAOYSA-N 5-[[3,5-bis[(6-sulfonaphthalen-1-yl)carbamoyl]benzoyl]amino]naphthalene-2-sulfonic acid Chemical compound OS(=O)(=O)C1=CC=C2C(NC(=O)C=3C=C(C=C(C=3)C(=O)NC=3C4=CC=C(C=C4C=CC=3)S(O)(=O)=O)C(=O)NC=3C4=CC=C(C=C4C=CC=3)S(=O)(=O)O)=CC=CC2=C1 ZPEKAAMNUZIGFQ-UHFFFAOYSA-N 0.000 description 1
- DXYNGOCUJLUQEI-UHFFFAOYSA-N 6-[[3,5-bis[(5-sulfonaphthalen-2-yl)carbamoyl]benzoyl]amino]naphthalene-1-sulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC2=CC(NC(=O)C=3C=C(C=C(C=3)C(=O)NC=3C=C4C=CC=C(C4=CC=3)S(O)(=O)=O)C(=O)NC=3C=C4C=CC=C(C4=CC=3)S(=O)(=O)O)=CC=C21 DXYNGOCUJLUQEI-UHFFFAOYSA-N 0.000 description 1
- KOJZXTNJSUUKEB-UHFFFAOYSA-N 6-[[3,5-bis[(6-sulfonaphthalen-2-yl)carbamoyl]benzoyl]amino]naphthalene-2-sulfonic acid Chemical compound C1=C(S(O)(=O)=O)C=CC2=CC(NC(=O)C=3C=C(C=C(C=3)C(=O)NC=3C=C4C=CC(=CC4=CC=3)S(O)(=O)=O)C(=O)NC3=CC4=CC=C(C=C4C=C3)S(=O)(=O)O)=CC=C21 KOJZXTNJSUUKEB-UHFFFAOYSA-N 0.000 description 1
- BGUFXDHVTHERDC-UHFFFAOYSA-N 8-[[3,5-bis[(7-sulfonaphthalen-1-yl)carbamoyl]benzoyl]amino]naphthalene-2-sulfonic acid Chemical compound C1=C(S(O)(=O)=O)C=C2C(NC(=O)C=3C=C(C=C(C=3)C(=O)NC=3C4=CC(=CC=C4C=CC=3)S(O)(=O)=O)C(=O)NC3=CC=CC4=CC=C(C=C43)S(=O)(=O)O)=CC=CC2=C1 BGUFXDHVTHERDC-UHFFFAOYSA-N 0.000 description 1
- KCRUJBHIGVXHHE-UHFFFAOYSA-N 8-[[3,5-bis[(8-sulfonaphthalen-1-yl)carbamoyl]benzoyl]amino]naphthalene-1-sulfonic acid Chemical compound C1=CC(S(O)(=O)=O)=C2C(NC(=O)C=3C=C(C=C(C=3)C(=O)NC=3C4=C(C=CC=C4C=CC=3)S(O)(=O)=O)C(=O)NC=3C=CC=C4C=CC=C(C=34)S(=O)(=O)O)=CC=CC2=C1 KCRUJBHIGVXHHE-UHFFFAOYSA-N 0.000 description 1
- WUDQSWQMDNZNLD-UHFFFAOYSA-N CNC(c1cc(C(NC)=O)cc(C(NC)=O)c1)O Chemical compound CNC(c1cc(C(NC)=O)cc(C(NC)=O)c1)O WUDQSWQMDNZNLD-UHFFFAOYSA-N 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23073800P | 2000-09-07 | 2000-09-07 | |
| PCT/US2001/028084 WO2002020464A2 (en) | 2000-09-07 | 2001-09-06 | Benzene tricarboxylic acid amides as insulin receptor activators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004508348A JP2004508348A (ja) | 2004-03-18 |
| JP2004508348A5 true JP2004508348A5 (es) | 2008-10-30 |
Family
ID=22866366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002525087A Withdrawn JP2004508348A (ja) | 2000-09-07 | 2001-09-06 | インスリン受容体アクチベーターとしてのベンゼントリカルボン酸誘導対体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6600069B2 (es) |
| EP (1) | EP1315695B1 (es) |
| JP (1) | JP2004508348A (es) |
| AR (1) | AR030620A1 (es) |
| AT (1) | ATE299491T1 (es) |
| AU (1) | AU8889101A (es) |
| CA (1) | CA2421581A1 (es) |
| DE (1) | DE60111948T2 (es) |
| DK (1) | DK1315695T3 (es) |
| ES (1) | ES2241867T3 (es) |
| TW (1) | TWI283660B (es) |
| WO (1) | WO2002020464A2 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1391474B1 (it) * | 2008-10-02 | 2011-12-23 | Università Degli Studi Di Roma La Sapienza | Derivati carbonilici a simmetria c3, loro preparazione e loro uso |
| KR101121954B1 (ko) | 2010-05-13 | 2012-03-09 | 아주대학교산학협력단 | 1,2,3-Ｂｅｎｚｅｎｔｒｉｃａｒｂｏｘｙｌｉｃ ａｃｉｄ를 유효성분으로 포함하는 당뇨병 예방 또는 치료용 조성물 |
| JP6255210B2 (ja) * | 2013-10-24 | 2017-12-27 | アーゼッド・エレクトロニック・マテリアルズ（ルクセンブルグ）ソシエテ・ア・レスポンサビリテ・リミテ | レジスト下層膜形成組成物 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4051176A (en) | 1976-05-10 | 1977-09-27 | American Cyanamid Company | Ureidophenylenebis(carbonylimino)dinaphthalenetrisulfonic acid compounds |
| US4046805A (en) | 1976-05-10 | 1977-09-06 | American Cyanamid Company | Substituted-hydroxy-naphthalenedisulfonic acid compounds |
| US4129591A (en) | 1976-10-27 | 1978-12-12 | American Cyanamid Company | Ureida-phenylenebis(substituted imino)multianionic substituted dinaphthalene sulfonic acids and salts |
| US4102917A (en) | 1977-06-01 | 1978-07-25 | American Cyanamid Company | Substituted phenyl naphthalenesulfonic acids |
| US4089974A (en) | 1977-06-13 | 1978-05-16 | American Cyanamid Company | 5-Carboxy-phenylenebis(carbonylimino)benzene carboxylic and dicarboxylic acids and salts |
| US4123455A (en) | 1977-06-13 | 1978-10-31 | American Cyanamid Company | Phenenyltris(carbonylimino) multi-anionic substituted triphenyl acids and salts |
| US4120895A (en) | 1977-06-29 | 1978-10-17 | American Cyanamid Company | S-phenenyltris (iminocarbonyl) triisophthalic acid salts |
| US4120891A (en) | 1977-07-01 | 1978-10-17 | American Cyanamid Company | Ureylene naphthalene sulfonic acids |
| US4118585A (en) | 1977-07-01 | 1978-10-03 | American Cyanamid Company | Anionic benzene tetrakis carbonylimino isophthalic acid salts |
| US4132730A (en) | 1977-07-29 | 1979-01-02 | American Cyanamid Company | Ureylene naphthalene sulfonic acids |
| US4229371A (en) * | 1977-07-29 | 1980-10-21 | American Cyanamid Company | Ureylene naphthalene sulfonic acid intermediates |
| CH654853A5 (de) | 1982-08-07 | 1986-03-14 | Sandoz Ag | Verfahren zum verdichten von anodisch oxydierten aluminiumoberflaechen. |
| DE4229182A1 (de) | 1992-09-02 | 1994-03-03 | Basf Ag | Metallchelate |
| US5599984A (en) | 1994-01-21 | 1997-02-04 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
| US5973076A (en) | 1995-05-31 | 1999-10-26 | New Japan Chemical Co., Ltd. | Polybutene-1 resin composition and a method of accelerating the crystal transformation thereof |
| US5565432A (en) | 1994-11-07 | 1996-10-15 | American Home Products Corporation | Smooth muscle cell proliferation inhibitors |
| CA2174583A1 (en) | 1995-05-05 | 1996-11-06 | Alexander Chucholowski | Sulfuric acid esters of sugar alcohols |
| JPH08333324A (ja) * | 1995-06-08 | 1996-12-17 | Terumo Corp | ベンゼン誘導体およびそれを含有する医薬製剤 |
| JP3836910B2 (ja) * | 1996-01-19 | 2006-10-25 | 富士写真フイルム株式会社 | ハロゲン化銀写真感光材料およびその処理方法 |
| EP1277790A3 (en) | 1998-03-04 | 2004-07-28 | Ciba SC Holding AG | Nucleators for crystallizable thermoplastic polymers |
| HUP0202168A3 (en) | 1999-07-29 | 2005-04-28 | Telik Inc South San Francisco | Novel naphthylsulfonic acids and related compounds as glucose uptake agonists |
-
2001
- 2001-09-06 JP JP2002525087A patent/JP2004508348A/ja not_active Withdrawn
- 2001-09-06 TW TW090122095A patent/TWI283660B/zh not_active IP Right Cessation
- 2001-09-06 AU AU8889101A patent/AU8889101A/xx not_active Withdrawn
- 2001-09-06 AT AT01968657T patent/ATE299491T1/de not_active IP Right Cessation
- 2001-09-06 US US09/949,165 patent/US6600069B2/en not_active Expired - Fee Related
- 2001-09-06 CA CA002421581A patent/CA2421581A1/en not_active Abandoned
- 2001-09-06 AR ARP010104240A patent/AR030620A1/es unknown
- 2001-09-06 WO PCT/US2001/028084 patent/WO2002020464A2/en active IP Right Grant
- 2001-09-06 DE DE60111948T patent/DE60111948T2/de not_active Expired - Fee Related
- 2001-09-06 ES ES01968657T patent/ES2241867T3/es not_active Expired - Lifetime
- 2001-09-06 EP EP01968657A patent/EP1315695B1/en not_active Expired - Lifetime
- 2001-09-06 DK DK01968657T patent/DK1315695T3/da active
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