JP2004504808A - 前立腺癌の治療及び診断のための組成物及び方法 - Google Patents
前立腺癌の治療及び診断のための組成物及び方法 Download PDFInfo
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Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53685700A | 2000-03-27 | 2000-03-27 | |
| US56810000A | 2000-05-09 | 2000-05-09 | |
| US09/570,737 US7202342B1 (en) | 1999-11-12 | 2000-05-12 | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US09/593,793 US7517952B1 (en) | 1997-02-25 | 2000-06-13 | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US60578300A | 2000-06-27 | 2000-06-27 | |
| US09/636,215 US6620922B1 (en) | 1997-02-25 | 2000-08-09 | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US09/651,236 US6818751B1 (en) | 1997-08-01 | 2000-08-29 | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US09/657,279 US6894146B1 (en) | 1997-02-25 | 2000-09-06 | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US09/679,426 US6759515B1 (en) | 1997-02-25 | 2000-10-02 | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US09/685,166 US6630305B1 (en) | 1999-11-12 | 2000-10-10 | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US70972900A | 2000-11-09 | 2000-11-09 | |
| PCT/US2001/009919 WO2001073032A2 (en) | 2000-03-27 | 2001-03-27 | Compositions and methods for the therapy and diagnosis of prostate cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004504808A true JP2004504808A (ja) | 2004-02-19 |
| JP2004504808A5 JP2004504808A5 (enExample) | 2008-05-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2001570749A Pending JP2004504808A (ja) | 2000-03-27 | 2001-03-27 | 前立腺癌の治療及び診断のための組成物及び方法 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1311673A2 (enExample) |
| JP (1) | JP2004504808A (enExample) |
| AU (1) | AU2001249549A1 (enExample) |
| CA (1) | CA2403909A1 (enExample) |
| WO (1) | WO2001073032A2 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009523431A (ja) * | 2006-01-17 | 2009-06-25 | バイオレックス セラピュティックス インク | ウキクサ科由来の発現制御因子 |
| JP4969444B2 (ja) * | 2005-06-14 | 2012-07-04 | ディナベック株式会社 | 抗体の作製方法 |
| JP2021040639A (ja) * | 2015-08-05 | 2021-03-18 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 前立腺がんおよびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドの組み合わせ |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030185830A1 (en) * | 1997-02-25 | 2003-10-02 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US7517952B1 (en) | 1997-02-25 | 2009-04-14 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| ES2324503T3 (es) | 1997-04-10 | 2009-08-07 | Stichting Katholieke Universiteit University Medical Centre Nijmegen | Pca3, genes pca3 y metodos de uso. |
| US20030149531A1 (en) | 2000-12-06 | 2003-08-07 | Hubert Rene S. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
| US6833438B1 (en) | 1999-06-01 | 2004-12-21 | Agensys, Inc. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
| US6329503B1 (en) | 1998-06-01 | 2001-12-11 | Agensys, Inc. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
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| US6943235B1 (en) | 1999-04-12 | 2005-09-13 | Agensys, Inc. | Transmembrane protein expressed in prostate cancer |
| US20060073150A1 (en) | 2001-09-06 | 2006-04-06 | Mary Faris | Nucleic acid and corresponding protein entitled STEAP-1 useful in treatment and detection of cancer |
| JP2003510075A (ja) | 1999-09-29 | 2003-03-18 | ディグノキュアー・インコーポレーテッド | 良性および悪性の前立腺組織におけるpca3メッセンジャーrna種 |
| US7361338B2 (en) | 1999-10-05 | 2008-04-22 | Agensys, Inc. | Methods to inhibit growth of prostate cancer cells |
| US7208280B2 (en) | 1999-10-05 | 2007-04-24 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 101P3A41 useful in treatment and detection of cancer |
| US6790631B1 (en) | 1999-10-05 | 2004-09-14 | Agensys, Inc. | G protein-coupled receptor up-regulated in prostate cancer and uses thereof |
| PT1517913E (pt) * | 1999-10-07 | 2007-05-31 | Corixa Corp | Sequência codificante de mycobacterium turberculosis para expressão de proteínas heterólogas. |
| AU6867801A (en) | 2000-06-20 | 2002-01-02 | Corixa Corp | Fusion proteins of mycobacterium tuberculosis |
| JP2004535765A (ja) | 2000-12-07 | 2004-12-02 | カイロン コーポレイション | 前立腺癌においてアップレギュレートされた内因性レトロウイルス |
| US7736654B2 (en) | 2001-04-10 | 2010-06-15 | Agensys, Inc. | Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers |
| CA2446788A1 (en) * | 2001-05-09 | 2002-11-14 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| CA2447564A1 (en) * | 2001-05-15 | 2002-11-21 | Agensys, Inc. | Nucleic acids and corresponding proteins entitled 101p3a11 or phor-1 useful in treatment and detection of cancer |
| US6897024B2 (en) | 2001-05-31 | 2005-05-24 | Stichting Katholieke Universiteit More Particularly The University Medical Centre Nijmegen | Nucleic acid molecules comprising the promoter for PCA3, and uses thereof |
| US7332290B2 (en) | 2001-08-02 | 2008-02-19 | The Regents Of The University Of Michigan | Dectection of AMACR cancer markers in urine |
| US7229774B2 (en) | 2001-08-02 | 2007-06-12 | Regents Of The University Of Michigan | Expression profile of prostate cancer |
| US7700293B2 (en) | 2001-08-02 | 2010-04-20 | The Regents Of The University Of Michigan | Expression profile of prostate cancer |
| US7494646B2 (en) | 2001-09-06 | 2009-02-24 | Agensys, Inc. | Antibodies and molecules derived therefrom that bind to STEAP-1 proteins |
| WO2003064602A2 (en) | 2002-01-25 | 2003-08-07 | The Regents Of The University Of California | Methods of modulating cold sensory perception |
| US20060147477A1 (en) * | 2002-06-11 | 2006-07-06 | Glaxo Group Limited | Immunogenic compositions |
| US20040081653A1 (en) | 2002-08-16 | 2004-04-29 | Raitano Arthur B. | Nucleic acids and corresponding proteins entitled 251P5G2 useful in treatment and detection of cancer |
| JP4824540B2 (ja) | 2003-02-07 | 2011-11-30 | ダイアノキュアー インク. | サンプル中の前立腺癌を検出する方法 |
| PT1742966E (pt) | 2004-04-22 | 2014-02-05 | Agensys Inc | Anticorpos e moléculas derivadas daí que se ligam às proteínas steap-1 |
| CA2491067A1 (en) | 2004-12-24 | 2006-06-24 | Stichting Katholieke Universiteit | Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer |
| JP2009508493A (ja) | 2005-09-19 | 2009-03-05 | ベリデックス・エルエルシー | すい臓がんを診断するための方法 |
| WO2007100568A2 (en) * | 2006-02-24 | 2007-09-07 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | T cell receptors and related materials and methods of use |
| US7820174B2 (en) | 2006-02-24 | 2010-10-26 | The United States Of America As Represented By The Department Of Health And Human Services | T cell receptors and related materials and methods of use |
| MX2009003938A (es) | 2006-10-27 | 2009-04-24 | Genentech Inc | Anticuerpos e inmunoconjugados y sus usos. |
| BR112019018767A2 (pt) | 2017-04-03 | 2020-05-05 | Hoffmann La Roche | anticorpos, molécula de ligação ao antígeno biespecífica, um ou mais polinucleotídeos isolados, um ou mais vetores, célula hospedeira, método para produzir um anticorpo, composição farmacêutica, usos, método para tratar uma doença em um indivíduo e invenção |
| EP4584297A1 (en) * | 2022-09-11 | 2025-07-16 | Yeda Research and Development Co. Ltd | Anti-klk4 antibodies and uses thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998037039A1 (en) * | 1997-02-19 | 1998-08-27 | Asahi Kasei Kogyo Kabushiki Kaisha | Granular fertilizer coated with decomposable coating film and process for producing the same |
| JP2002520054A (ja) * | 1998-07-14 | 2002-07-09 | コリクサ コーポレイション | 前立腺癌の治療及び診断のための組成物及び方法 |
| JP2003528591A (ja) * | 2000-01-14 | 2003-09-30 | コリクサ コーポレイション | 前立腺癌の治療及び診断のための組成物及び方法 |
| JP2004537252A (ja) * | 1999-11-12 | 2004-12-16 | コリクサ コーポレイション | 前立腺癌の治療及び診断のための組成物及び方法 |
| JP2005504513A (ja) * | 2001-05-09 | 2005-02-17 | コリクサ コーポレイション | 前立腺癌の治療及び診断のための組成物及び方法 |
| JP2006515749A (ja) * | 2002-11-12 | 2006-06-08 | コリクサ コーポレイション | 前立腺癌の治療および診断のための組成物および方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998037418A2 (en) * | 1997-02-25 | 1998-08-27 | Corixa Corporation | Compounds for immunodiagnosis of prostate cancer and methods for their use |
| AU7994200A (en) * | 1999-10-04 | 2001-05-10 | Corixa Corporation | Compositions and methods for therapy and diagnosis of prostate cancer |
-
2001
- 2001-03-27 EP EP01922786A patent/EP1311673A2/en not_active Withdrawn
- 2001-03-27 JP JP2001570749A patent/JP2004504808A/ja active Pending
- 2001-03-27 CA CA002403909A patent/CA2403909A1/en not_active Abandoned
- 2001-03-27 AU AU2001249549A patent/AU2001249549A1/en not_active Abandoned
- 2001-03-27 WO PCT/US2001/009919 patent/WO2001073032A2/en not_active Ceased
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998037039A1 (en) * | 1997-02-19 | 1998-08-27 | Asahi Kasei Kogyo Kabushiki Kaisha | Granular fertilizer coated with decomposable coating film and process for producing the same |
| JP2002520054A (ja) * | 1998-07-14 | 2002-07-09 | コリクサ コーポレイション | 前立腺癌の治療及び診断のための組成物及び方法 |
| JP2004537252A (ja) * | 1999-11-12 | 2004-12-16 | コリクサ コーポレイション | 前立腺癌の治療及び診断のための組成物及び方法 |
| JP2003528591A (ja) * | 2000-01-14 | 2003-09-30 | コリクサ コーポレイション | 前立腺癌の治療及び診断のための組成物及び方法 |
| JP2005504513A (ja) * | 2001-05-09 | 2005-02-17 | コリクサ コーポレイション | 前立腺癌の治療及び診断のための組成物及び方法 |
| JP2006515749A (ja) * | 2002-11-12 | 2006-06-08 | コリクサ コーポレイション | 前立腺癌の治療および診断のための組成物および方法 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4969444B2 (ja) * | 2005-06-14 | 2012-07-04 | ディナベック株式会社 | 抗体の作製方法 |
| JP2009523431A (ja) * | 2006-01-17 | 2009-06-25 | バイオレックス セラピュティックス インク | ウキクサ科由来の発現制御因子 |
| JP2021040639A (ja) * | 2015-08-05 | 2021-03-18 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 前立腺がんおよびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドの組み合わせ |
| JP7142957B2 (ja) | 2015-08-05 | 2022-09-28 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 前立腺がんおよびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドの組み合わせ |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2403909A1 (en) | 2001-10-04 |
| EP1311673A2 (en) | 2003-05-21 |
| WO2001073032A2 (en) | 2001-10-04 |
| WO2001073032A3 (en) | 2003-03-13 |
| AU2001249549A1 (en) | 2001-10-08 |
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