JP2004504099A - 整形外科的構成要素用のモジュラー式接続具 - Google Patents
整形外科的構成要素用のモジュラー式接続具 Download PDFInfo
- Publication number
- JP2004504099A JP2004504099A JP2002513385A JP2002513385A JP2004504099A JP 2004504099 A JP2004504099 A JP 2004504099A JP 2002513385 A JP2002513385 A JP 2002513385A JP 2002513385 A JP2002513385 A JP 2002513385A JP 2004504099 A JP2004504099 A JP 2004504099A
- Authority
- JP
- Japan
- Prior art keywords
- concentric wall
- tapered portion
- orthopedic component
- wall
- concentric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000399 orthopedic effect Effects 0.000 title claims description 47
- 230000013011 mating Effects 0.000 claims description 17
- 238000005452 bending Methods 0.000 description 8
- 210000000988 bone and bone Anatomy 0.000 description 4
- 210000004394 hip joint Anatomy 0.000 description 4
- 210000000629 knee joint Anatomy 0.000 description 4
- 238000010276 construction Methods 0.000 description 3
- 230000008602 contraction Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000000689 upper leg Anatomy 0.000 description 2
- 210000000588 acetabulum Anatomy 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 1
- 229910001285 shape-memory alloy Inorganic materials 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
Classifications
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Landscapes
- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Prostheses (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Abstract
Description
【出願係属中の先の出願の参照】
本出願は次の出願の優先権を主張するものである。
(1)アルフレッド・S・デスプレスIII(Alfred S Despres III)らが2000年7月20日付けで出願した、モジュラー式整形外科接続具(MODULAR ORTHOPEDIC CONNECTION)という名称の出願係属中の先の米国仮特許出願第60/219,955号(弁護士事件番号HAYES−1 PROV);
(2)アルフレッド・S・デスプレスIIIらが2000年7月20日付けで出願した、強制的継手接続具(FORCE COUPLE CONNECTION)という名称の出願係属中の先の米国仮特許出願第60/219,963号(弁護士事件番号HAYES−2 PROV)。
【0002】
上記2つの特許出願の内容を本明細書に含めるものとする。
【0003】
【発明の分野】
本発明は、全体として、外科装置及び方法、より具体的には、整形外科的構成要素に関する。
【0004】
【発明の背景】
整形外科的構成要素は当該技術分野にて周知である。
例えば、関節置換外科手術において、関節の一部を長期間永続する機能及び痛み無しの可動性を提供し得るように整形外科的構成要素にて置換する。より具体的には、人工装具的全腰関節の場合、大腿骨の頂部は人工装具的大腿骨軸部構成要素と置換し、股臼窩は人工装具的股臼陥凹構成要素にて置換し、これにより人工装具的全腰関節を提供する。同様に、人工装具的全膝関節の場合、脛骨の頂部を人工装具的脛骨構成要素にて置換し、大腿骨の底部を人工装具的大腿骨構成要素にて置換し、これにより人工装具的全膝関節を提供する。
【0005】
整形外科的構成要素は、また多岐に亙るその他の方法にても使用されている。例えば、整形外科的構成要素は、骨折した骨を安定化させ又は2つの椎骨体を共に固着し又は骨移植片を骨に対し保持し、或いは柔軟な組織を骨に対して固着する等のために使用される。
【0006】
多くの状況にて、整形外科的構成要素は、互いに固着する必要がある2つ又はより多くの構成要素を備えることができる。一例として、人工装具的全腰関節の場合、人工装具的大腿骨軸部構成要素は、複数の別個の構成要素にて製造されることがあり、その場合、要素の各々は患者の身体部位に最も正確に近似し得るように独立的に選ぶことができ、また、別個の構成要素は、モジュラー式接続具(connection)を使用して互いに組み立て、その患者に対して可能な限り最良の人工装具的大腿骨軸部構成要素を提供することができる。同様に、人工装具的全膝関節の場合、人工装具的脛骨構成要素はまた、モジュラー式接続具を使用して組み立てられる複数の別個の要素にて形成される場合もある。更にその他の型式の整形外科的構成要素は、モジュラー式接続具を使用して複数の別個の要素を組み立てることを必要とし又はその組み立てによる利益を受けることができる。
【0007】
一度び患者の体内に配置されたならば、整形外科的構成要素、従って、別個の構成要素を互いに固着するモジュラー式接続具には、典型的に、軸方向荷重、曲げ荷重及び捩れ荷重が加わる。当該技術分野にて異なる型式のモジュラー式接続具が既知であるが、これら3つの型式の荷重、すなわち軸方向荷重、曲げ荷重及び捩れ荷重の全てに対処するのに理想的な既存の型式のモジュラー式接続具は全く存在しない。一例として、テーパー付き接続具は全体として軸方向(すなわち、圧縮)荷重に十分に対応するが、これらのテーパー付き接続具は全体として曲げ荷重及び捩れ荷重に特に十分には対応しない。更なる例として、同心状のシリンダ接続具は、全体として曲げ荷重に十分に対応するが、これらの接続具は全体として軸方向荷重及び捩れ荷重に特に十分には対応しない。
【0008】
【発明の概要】
その結果、本発明の1つの目的は、整形外科的構成要素を形成し得るように複数の別個の構成要素を共に接続する改良されたモジュラー式接続具を提供することである。
【0009】
本発明の別の目的は、改良された整形外科的構成要素を提供することである。
上記及びその他の目的は、本発明を提供し且つ使用することで実現される。
本発明の1つの形態において、整形外科的構成要素を形成し得るように複数の別個の要素を共に接続する改良されたモジュラー式接続具であって、テーパー付き接続具と、係合嵌め式接続具とを組み合わせて備えるモジュラー式接続具が提供される。
【0010】
本発明の別の形態において、第一の要素と、第二の要素とを備え、第一の要素及び第二の要素がモジュラー式接続具により互いに固着され、モジュラー式接続具が、テーパー付き接続具と、係合嵌め式接続具とを組み合わせて備える改良された整形外科的構成要素が提供される。
【0011】
本発明の上記及びその他の目的並びに特徴は、同様の部品を同様の参照番号で表示する添付図面と共に検討されるべきである、本発明の好ましい実施の形態に関する以下の詳細な説明からより完全に開示され又は明らかになるであろう。
【0012】
【好ましい実施の形態の詳細な説明】
先ず、図1を参照すると、本発明に従って形成された整形外科的構成要素5が図示されている。整形外科的構成要素5は、人工装具的全腰関節にて使用される型式のものであって、モジュラー式接続具を使用して組み立てられる複数の別個の要素を備える人工装具的大腿骨軸部構成要素を備えることができ、又は整形外科的構成要素5は、人工装具的全膝関節にて使用される型式のものであって、モジュラー式接続具を使用して組み立てられる複数の別個の要素を備える人工装具的頸骨構成要素を備えることができ、若しくは整形外科的構成要素5は、モジュラー式接続具を使用して複数の別個の要素を組み立てることを必要とし又はその組み立てによる利益を受けることができる任意のその他の型式の整形外科的構成要素を備えることができる。
【0013】
整形外科的構成要素5は第一の要素10及び第二の要素15とから主に成る。第一の要素10は、第二の要素15の一部分がその内部に伸びる開口20を有している。
【0014】
本発明によれば、第一の要素10及び第二の要素15は、完全な整形外科的構成要素5を形成し得るように改良されたモジュラー式接続具25を使用して互いに固着し得るようにされている。
【0015】
より具体的には、モジュラー式接続具25は、テーパー付き接続具30及び係合嵌め式接続具35という2つの荷重支承接続具を組み合わせて備えている。
テーパー付き接続具30は、第一のテーパー付き部分40を相応する第二のテーパー付き部分45と相互作用させることにより形成される。より具体的には、第一のテーパー付き部分40は第二の要素15の突起50に形成される。第二のテーパー付き部分45は、第一の要素の開口20を画成する側壁の一部分に沿って形成される。第一のテーパー付き部分40及び第二のテーパー付き部分45は、荷重支承テーパー付き接続具30を共に形成し得るように互いに対して強固に着座する。
【0016】
第一の同心状壁55が第二の同心状壁60と相互作用することにより係合嵌め式接続具35が形成される。より具体的には、第一の同心状壁55は第二の要素15の突起50上に形成される。好ましくは、第一の同心状壁55は第一のテーパー付き部分40と同軸状に且つ該第一のテーパー付き部分40の末端側にて突起50上に配置されている。第二の同心状壁60は、第一の要素の開口20を画成する側壁の一部分に沿って形成される。好ましくは、第二の同心状壁60が、第二のテーパー付き部分45と同軸状に且つ該第二のテーパー付き部分45の末端側にて第一の要素10上に配置されている。第一の同心状壁55及び第二の同心状壁60は、荷重支承係合嵌め式接続具35を形成し得るように互いに対して強固に着座する。
【0017】
一般に、係合嵌め式接続具35は拘束する第二の部材に対して圧力係止されるように1つの部材の変形によって安定性を実現する機械的な接続具である。この変形は、拡張(例えば、テーパー付きの拡張コレットにおけるように)又は収縮(例えば、強制嵌めの場合におけるように)とすることができる。この変形はまた、熱膨張又は熱収縮(例えば、ニチノール(Nitinol)等のような形状記憶合金の場合のように)にて行うこともできる。変形が実現される仕方に関係なく、形成される機械的接続具はこの変形の結果として互いに強制的に係合し、これにより、係合嵌め式接続具を確立する表面を有する。
【0018】
上述したように、荷重支承係合嵌め式接続具35を形成し得るように第一の同心状壁55及び第二の同心状壁60を互いに強固に着座させることのできる多数の方法が存在する。
【0019】
例えば、第一の同心状壁55を第二の同心状壁60に比して僅かに過大の寸法とし、第二の同心状壁60の内側にて第一の同心状壁55を強制嵌めする結果、係合嵌め式接続具35が形成されるようにすることができる。
【0020】
これと代替的に且つ本発明の1つの好ましい形態によれば、第二の要素の突起50の末端には凹部65を形成し、第三の要素70の基端が凹部65内に挿入される突起75を備えるようにすることができる。より具体的には、突起75は、凹部65に対して過大な寸法とされており、突起75を凹部65内に挿入すると、第一の同心状壁55が半径方向に拡張して第二の同心状壁60と係合し、これにより係合嵌め式接続具35を形成する。本発明の1つの好ましい形態において、凹部65及び突起75の双方にテーパーが付けられており、第二の要素15の末端は割り型コレットである。これと代替的に、第二の要素15の末端は、割らずに、第二の同心状壁60に係合するのに十分弾性的な材料で形成することができる。
【0021】
モジュラー式接続具25の独創的な構造のため、整形外科的構成要素5は、従来技術の装置よりも軸方向荷重、曲げ荷重及び捩れ荷重に良好に対応することができる。より具体的には、モジュラー式接続具25は、テーパー付き接続具30及び係合嵌め式接続具35という、2つの荷重支承接続具を同時に提供する。テーパー付き接続具30は軸方向(すなわち圧縮)荷重に極めて良好に対応する。これと同時に、係合嵌め式接続具35は曲げ荷重及び捩れ荷重に極めて良好に対応する。更に、係合嵌め式接続具35は曲げ荷重及び捩れ荷重に対してテーパー付き接続具30を安定化させる。2つの荷重支承接続具は、共に、従来技術の装置よりも十分良好に軸方向荷重、曲げ荷重及び捩れ荷重を全体として取り扱う。
【0022】
次に、図2を参照すると、別の構造の形態が図示されている。この場合、開口20は、第一の要素10に形成された盲穴を備えており、第三の要素70は第二の要素15に形成され且つ凹部65と連通する開口部80を貫通して伸び、一度び第一のテーパー付き部分40が第二のテーパー付き部分45に対して着座したならば、係合嵌め式接続具35が第三の要素70の上で基端方向に引っ張ることにより作動される。
【0023】
次に、図3を参照すると、別の代替的な構造の形態が図示されている。この場合、テーパー付き接続具30及び係合嵌め式接続具35は、図1及び図2に図示するように互いに同心状ではなくて互いに平行に配置されている。この目的のため、開口20は一対の平行な開口20を備え、突起50は一対の平行な突起50を備えている。
【0024】
次に、図4を参照すると、更に別の代替的な構造の形態が図示されている。この場合、テーパー付き接続具30及び係合嵌め式接続具35は、図2に図示した仕方にて軸方向に分離しているのではなくて、互いに同軸状に且つ少なくともある程度重なり合う状態に配置されている。
【0025】
次に、図5を参照すると、更に別の構造の形態が図示されている。この場合、第三の要素70は、リングの形態をしており且つ第一の同心状壁55と第二の同心状壁60との間で係合嵌め式接続具35を形成し得るように第二の要素15を内方に駆動するために使用される。好ましくは、このことは、第二の要素15に対しテーパー付き面85を設け且つ第三の要素70に対し相応するテーパー付き面90を設けることにより行われるようにする。使用時、第一のテーパー付き部分40が第二のテーパー付き部分45に係合し、また、第一の同心状壁55が第二の同心状壁60に隣接するように第一の要素10及び第二の要素15を共に接近させ、次に、テーパー付き面85がテーパー付き面90に係合し、第一の同心状壁55が第二の同心状壁60に強固に係合し、これにより係合嵌め式接続具35を作動させ得るように第三の要素70を第二の要素15に向けて移動させる。
【0026】
本発明の性質を説明するために本明細書にて記載して且つ図示した詳細、材料、ステップ及び部品の配置の多数の追加的な変更が、本発明の原理及び範囲から逸脱せずに当該技術分野の当業者により実現可能であることが理解されよう。
【図面の簡単な説明】
【図1】本発明に従って形成されたモジュラー式接続具の概略図的な分解側面図である。
【図2】本発明に従って形成されたモジュラー式接続具の別の形態を示す概略図的な分解側面図である。
【図3】本発明に従って形成されたモジュラー式接続具の更に別の形態を示す概略図的な分解側面図である。
【図4】本発明に従って形成されたモジュラー式接続具の更に別の形態を示す概略図的な分解側面図である。
【図5】本発明に従って形成されたモジュラー式接続具の別の形態を示す概略図的な分解側面図である。
Claims (34)
- 整形外科的構成要素を形成し得るように複数の別個の要素を共に接続するモジュラー式接続具において、テーパー付き接続具と、係合嵌め式接続具とを組み合わせて備える、モジュラー式接続具。
- 請求項1によるモジュラー式接続具において、前記テーパー付き接続具が、第一のテーパー付き部分が第二のテーパー付き部分と相互作用することにより形成される、モジュラー式接続具。
- 請求項2によるモジュラー式接続具において、前記第二のテーパー付き部分が、第一の要素に開口を画成する側壁の一部分に沿って形成され、前記第一のテーパー付き部分が第二の要素の突起上に形成される、モジュラー式接続具。
- 請求項1によるモジュラー式接続具において、前記係合嵌め式接続具が、第一の同心状壁が第二の同心状壁と相互作用することにより形成される、モジュラー式接続具。
- 請求項4によるモジュラー式接続具において、前記第二の同心状壁が、第一の要素内を伸びる開口を画成する側壁の一部分に沿って形成され、前記第一の同心状壁が第二の要素の突起上に形成される、モジュラー式接続具。
- 請求項1によるモジュラー式接続具において、
前記テーパー付き接続具が、第一のテーパー付き部分が第二のテーパー付き部分と相互作用することにより形成され、前記第二のテーパー付き部分が第一の要素の開口を画成する側壁の一部分に沿って形成され、前記第一のテーパー付き部分が、第二の要素の突起上に形成され、
前記係合嵌め式接続具が、第一の同心状壁が第二の同心状壁と相互作用することにより形成され、前記第二の同心状壁が第一の要素内を伸びる開口を画成する側壁の一部分に沿って形成され、前記第一の同心状壁が、第二の要素の突起上に形成される、モジュラー式接続具。 - 請求項6によるモジュラー式接続具において、前記第一の同心状壁が、前記第一のテーパー付き部分と同軸状に且つ該第一のテーパー付き部分の末端側にて第二の要素の突起上に配置される、モジュラー式接続具。
- 請求項7によるモジュラー式接続具において、前記第二の同心状壁が、前記第二のテーパー付き部分と同軸状に且つ第二のテーパー付き部分の末端側にて第一の要素上に配置される、モジュラー式接続具。
- 請求項4によるモジュラー式接続具において、前記第一の同心状壁が前記第二の同心状壁の内側に配置される、モジュラー式接続具。
- 請求項9によるモジュラー式接続具において、前記第一の同心状壁が、前記第二の同心状壁に対して圧力係止されるように変形される、モジュラー式接続具。
- 請求項10によるモジュラー式接続具において、前記第一の同心状壁が、前記第二の同心状壁に対して圧力係止されるように拡張される、モジュラー式接続具。
- 請求項11によるモジュラー式接続具において、前記第二の同心状壁が、第一の要素に開口を画成する側壁の一部分に沿って形成され、前記第一の同心状壁が第二の要素の突起上に形成され、前記第一の同心状壁が、第三の要素を第二の要素に形成された凹部内に挿入することにより拡張される、モジュラー式接続具。
- 請求項12によるモジュラー式接続具において、開口が第一の要素を完全に貫通して伸びる、モジュラー式接続具。
- 請求項12によるモジュラー式接続具において、開口が第一の要素に形成された盲穴を備える、モジュラー式接続具。
- 請求項12によるモジュラー式接続具において、開口が一対の平行な開口部を備える、モジュラー式接続具。
- 請求項12によるモジュラー式接続具において、前記テーパー付き接続具及び前記係合嵌め式接続具が互いに軸方向に重なり合う、モジュラー式接続具。
- 請求項4によるモジュラー式接続具において、前記第一の同心状壁が、前記第二の同心状壁に対して圧力係止されるように収縮される、モジュラー式接続具。
- 第一の要素と、第二の要素とを備え、第一の要素及び第二の要素が、モジュラー式接続具により互いに固着された整形外科的構成要素において、前記モジュラー式接続具が、テーパー付き接続具と、係合嵌め式接続具とを組み合わせて備える、整形外科的構成要素。
- 請求項18による整形外科的構成要素において、前記テーパー付き接続具が、第一のテーパー付き部分が第二のテーパー付き部分と相互作用することにより形成される、整形外科的構成要素。
- 請求項19による整形外科的構成要素において、前記第二のテーパー付き部分が、前記第一の要素に開口を画成する側壁の一部分に沿って形成され、前記第一のテーパー付き部分が前記第二の要素の突起上に形成される、整形外科的構成要素。
- 請求項18による整形外科的構成要素において、前記係合嵌め式接続具が、第一の同心状壁が第二の同心状壁と相互作用することにより形成される、整形外科的構成要素。
- 請求項21による整形外科的構成要素において、前記第二の同心状壁が、前記第一の要素内を伸びる開口を画成する側壁の一部分に沿って形成され、前記第一の同心状壁が前記第二の要素の突起上に形成される、整形外科的構成要素。
- 請求項18による整形外科的構成要素において、
前記テーパー付き接続具が、第一のテーパー付き部分が第二のテーパー付き部分と相互作用することにより形成され、前記第二のテーパー付き部分が前記第一の要素に開口を画成する側壁の一部分に沿って形成され、前記第一のテーパー付き部分が前記第二の要素の突起上に形成され、
前記係合嵌め式接続具が、第一の同心状壁が第二の同心状壁と相互作用することにより形成され、前記第二の同心状壁が前記第一の要素に開口を画成する側壁の一部分に沿って形成され、前記第一の同心状壁が前記第二の要素の突起上に形成される、整形外科的構成要素。 - 請求項23による整形外科的構成要素において、前記第一の同心状壁が、前記第一のテーパー付き部分と同軸状に且つ該第一のテーパー付き部分の末端側にて第二の要素の突起上に配置される、整形外科的構成要素。
- 請求項24による整形外科的構成要素において、前記第二の同心状壁が、前記第二のテーパー付き部分と同軸状に且つ該第二のテーパー付き部分の末端側にて第一の要素上に配置される、整形外科的構成要素。
- 請求項21による整形外科的構成要素において、前記第一の同心状壁が前記第二の同心状壁の内側に配置される、整形外科的構成要素。
- 請求項26による整形外科的構成要素において、前記第一の同心状壁が、前記第二の同心状壁に対して圧力係止されるように変形される、整形外科的構成要素。
- 請求項27による整形外科的構成要素において、前記第一の同心状壁が、前記第二の同心状壁に対して圧力係止されるように半径方向に拡張される、整形外科的構成要素。
- 請求項28による整形外科的構成要素において、前記第二の同心状壁が、前記第一の要素に開口を画成する側壁の一部分に沿って形成され、前記第一の同心状壁が前記第二の要素の突起上に形成され、前記第一の同心状壁が、第三の要素を前記第二の要素に形成された凹部内に挿入することにより拡張される、整形外科的構成要素。
- 請求項29による整形外科的構成要素において、開口が第一の要素を完全に貫通して伸びる、整形外科的構成要素。
- 請求項29による整形外科的構成要素において、開口が第一の要素に形成された盲穴を備える、整形外科的構成要素。
- 請求項29による整形外科的構成要素において、開口が一対の平行な開口部を備える、整形外科的構成要素。
- 請求項29による整形外科的構成要素において、前記テーパー付き接続具及び前記係合嵌め式接続具が互いに軸方向に重なり合う、整形外科的構成要素。
- 請求項21による整形外科的構成要素において、前記第一の同心状壁が、前記第二の同心状壁に対して圧力係止されるように収縮される、整形外科的構成要素。
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- 2001-07-20 DE DE60137050T patent/DE60137050D1/de not_active Expired - Lifetime
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- 2001-07-20 WO PCT/US2001/022999 patent/WO2002007653A1/en active IP Right Grant
- 2001-07-20 EP EP01959079A patent/EP1309295B1/en not_active Expired - Lifetime
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- 2001-07-20 AU AU77949/01A patent/AU782023B2/en not_active Expired
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- 2001-07-20 US US09/909,929 patent/US6669728B2/en not_active Expired - Lifetime
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2004
- 2004-01-26 US US10/764,831 patent/US7097664B2/en not_active Expired - Lifetime
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2006
- 2006-08-15 US US11/504,544 patent/US8303668B2/en active Active
- 2006-10-24 US US11/585,667 patent/US7537408B2/en not_active Expired - Lifetime
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2012
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS5342010A (en) * | 1976-09-28 | 1978-04-17 | Matsushita Electric Ind Co Ltd | Preparation of magnetic recording medium |
JPS5481061A (en) * | 1977-12-12 | 1979-06-28 | Meidensha Electric Mfg Co Ltd | Semiconductor controller |
JPS5865415A (ja) * | 1981-09-28 | 1983-04-19 | Nec Corp | 磁気光学素子 |
JPH10277069A (ja) * | 1996-07-23 | 1998-10-20 | Johnson & Johnson Professional Inc | 医療締結装置 |
Also Published As
Publication number | Publication date |
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DE60137050D1 (de) | 2009-01-29 |
US20050089365A1 (en) | 2005-04-28 |
EP1309295B1 (en) | 2008-12-17 |
US20070134060A1 (en) | 2007-06-14 |
JP2004504101A (ja) | 2004-02-12 |
US6669728B2 (en) | 2003-12-30 |
WO2002007653A1 (en) | 2002-01-31 |
JP4949593B2 (ja) | 2012-06-13 |
EP1309295A4 (en) | 2006-11-15 |
AU782023B2 (en) | 2005-06-30 |
US7537408B2 (en) | 2009-05-26 |
AU7794901A (en) | 2002-02-05 |
EP1309295A2 (en) | 2003-05-14 |
ATE421305T1 (de) | 2009-02-15 |
EP1301147B1 (en) | 2009-01-21 |
AU780571B2 (en) | 2005-04-07 |
US7097664B2 (en) | 2006-08-29 |
AU8067001A (en) | 2002-02-05 |
US6682568B2 (en) | 2004-01-27 |
US20070093908A1 (en) | 2007-04-26 |
JP4223802B2 (ja) | 2009-02-12 |
US20020072799A1 (en) | 2002-06-13 |
DE60137504D1 (de) | 2009-03-12 |
EP1301147A1 (en) | 2003-04-16 |
US8303668B2 (en) | 2012-11-06 |
EP1301147A4 (en) | 2006-11-15 |
US20020040244A1 (en) | 2002-04-04 |
US20130253658A1 (en) | 2013-09-26 |
US20040243248A1 (en) | 2004-12-02 |
ATE417574T1 (de) | 2009-01-15 |
US7125193B2 (en) | 2006-10-24 |
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