JP2004503519A - サルメテロールの新規な調製方法 - Google Patents

サルメテロールの新規な調製方法 Download PDF

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Publication number
JP2004503519A
JP2004503519A JP2002510422A JP2002510422A JP2004503519A JP 2004503519 A JP2004503519 A JP 2004503519A JP 2002510422 A JP2002510422 A JP 2002510422A JP 2002510422 A JP2002510422 A JP 2002510422A JP 2004503519 A JP2004503519 A JP 2004503519A
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JP
Japan
Prior art keywords
formula
salt
solvate
compound
single enantiomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002510422A
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English (en)
Japanese (ja)
Other versions
JP2004503519A5 (enExample
Inventor
プロコピュウ，パナイオティス，アレクサンドル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of JP2004503519A publication Critical patent/JP2004503519A/ja
Publication of JP2004503519A5 publication Critical patent/JP2004503519A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/34—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton and at least one hydroxy group bound to another carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
JP2002510422A 2000-06-14 2001-06-13 サルメテロールの新規な調製方法 Pending JP2004503519A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0014546.6A GB0014546D0 (en) 2000-06-14 2000-06-14 A novel process
PCT/GB2001/002624 WO2001096278A2 (en) 2000-06-14 2001-06-13 A novel process for preparing salmeterol

Publications (2)

Publication Number Publication Date
JP2004503519A true JP2004503519A (ja) 2004-02-05
JP2004503519A5 JP2004503519A5 (enExample) 2008-03-27

Family

ID=9893647

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002510422A Pending JP2004503519A (ja) 2000-06-14 2001-06-13 サルメテロールの新規な調製方法

Country Status (6)

Country Link
US (2) US6911560B2 (enExample)
EP (1) EP1289926A2 (enExample)
JP (1) JP2004503519A (enExample)
AU (1) AU2001264119A1 (enExample)
GB (1) GB0014546D0 (enExample)
WO (1) WO2001096278A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60320007T2 (de) 2002-10-28 2009-06-18 Glaxo Group Ltd., Greenford Phenthanolamin-Derivate zur Behandlung von Atemwegserkrankungen
PL1937626T3 (pl) 2005-10-17 2016-08-31 Generics Uk Ltd Sposób i związki do otrzymywania salmeterolu
CN102584608B (zh) * 2011-01-06 2014-11-19 上海医药工业研究院 α-(氨甲基)-4-羟基-1,3-苯二甲醇的制备方法及其中间体
US9447067B2 (en) * 2014-10-03 2016-09-20 Amphastar Pahmaceuticals, Inc. Method of preparing intermediate of salmeterol
CN105884625B (zh) * 2016-05-10 2018-11-13 浙江工业大学 一种r-沙美特罗的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63264443A (ja) * 1983-04-18 1988-11-01 グラクソ、グループ、リミテッド フェネタノールアミン誘導体
JPH03133946A (ja) * 1989-10-10 1991-06-07 Glaxo Group Ltd フェンエタノールアミン化合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4118293A1 (de) 1990-06-05 1991-12-12 Glaxo Group Ltd Dichloranilinverbindung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63264443A (ja) * 1983-04-18 1988-11-01 グラクソ、グループ、リミテッド フェネタノールアミン誘導体
JPH03133946A (ja) * 1989-10-10 1991-06-07 Glaxo Group Ltd フェンエタノールアミン化合物

Also Published As

Publication number Publication date
US20030162840A1 (en) 2003-08-28
WO2001096278A3 (en) 2002-03-21
US6911560B2 (en) 2005-06-28
EP1289926A2 (en) 2003-03-12
US7294725B1 (en) 2007-11-13
AU2001264119A1 (en) 2001-12-24
GB0014546D0 (en) 2000-08-09
WO2001096278A2 (en) 2001-12-20

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