JP2004500074A - Ｉｒａｋ−４：組成物および使用方法 - Google Patents

Ｉｒａｋ−４：組成物および使用方法 Download PDF

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JP2004500074A
JP2004500074A JP2001551215A JP2001551215A JP2004500074A JP 2004500074 A JP2004500074 A JP 2004500074A JP 2001551215 A JP2001551215 A JP 2001551215A JP 2001551215 A JP2001551215 A JP 2001551215A JP 2004500074 A JP2004500074 A JP 2004500074A
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irak
polypeptide
seq
nucleic acid
amino acid
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JP2004500074A5 (enExample
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ウェスケ，　ホルガー
リ，　シュン
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トゥラリック　インコーポレイテッド
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0368—Animal model for inflammation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Biochemistry (AREA)
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  • Diabetes (AREA)
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  • Plant Pathology (AREA)
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  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
JP2001551215A 2000-01-13 2001-01-12 Ｉｒａｋ−４：組成物および使用方法 Pending JP2004500074A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17639500P 2000-01-13 2000-01-13
PCT/US2001/001171 WO2001051641A1 (en) 2000-01-13 2001-01-12 Irak-4: compositions and methods of use

Publications (2)

Publication Number Publication Date
JP2004500074A true JP2004500074A (ja) 2004-01-08
JP2004500074A5 JP2004500074A5 (enExample) 2008-02-07

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ID=22644182

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JP2001551215A Pending JP2004500074A (ja) 2000-01-13 2001-01-12 Ｉｒａｋ−４：組成物および使用方法

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US (2) US6818419B2 (enExample)
EP (1) EP1248847B8 (enExample)
JP (1) JP2004500074A (enExample)
AT (1) ATE390485T1 (enExample)
AU (1) AU783742B2 (enExample)
CA (1) CA2397481A1 (enExample)
DE (1) DE60133366T2 (enExample)
WO (1) WO2001051641A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6692959B2 (en) * 1998-11-25 2004-02-17 Isis Pharmaceuticals, Inc. Antisense modulation of IL-1 receptor-associated kinase-4 expression
WO2002040680A2 (en) * 2000-11-17 2002-05-23 The Burnham Institute Death domain proteins
US6965023B2 (en) 2000-11-17 2005-11-15 The Burnham Institute Death domain proteins
EP1434579B1 (en) 2001-10-09 2011-06-08 Amgen Inc. Imidazole derivatives as antiinflammatory agents
EP2769715A3 (en) 2001-11-26 2014-09-17 Trustees Of Tufts College Methods for treating autoimmune disorders, and reagents related thereto
WO2005052132A2 (en) * 2003-11-24 2005-06-09 Exelixis, Inc Mbms as modifiers of branching morphogenesis and methods of use
US20100279316A1 (en) * 2007-01-19 2010-11-04 Leonid Gorelik Antibodies to Phosphorylated IRAK4
EP2243481A1 (en) * 2009-04-24 2010-10-27 PamGene B.V. Irak kinase family as novel drug target for Alzheimer
DE102009033208A1 (de) 2009-07-15 2011-01-20 Merck Patent Gmbh Aminopyridinderivate
US10155765B2 (en) 2015-03-12 2018-12-18 Merck Sharp & Dohme Corp. Carboxamide inhibitors of IRAK4 activity
US10040802B2 (en) 2015-03-12 2018-08-07 Merck Sharp & Dohme Corp. Thienopyrazine inhibitors of IRAK4 activity
US10329294B2 (en) 2015-03-12 2019-06-25 Merck Sharp & Dohme Corp. Pyrazolopyrimidine inhibitors of IRAK4 activity
WO2017205769A1 (en) 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
WO2017205766A1 (en) 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
WO2017205762A1 (en) 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
CN119630802A (zh) 2022-04-12 2025-03-14 建新公司 Irak4调节剂用于基因疗法的用途
CA3251930A1 (en) * 2022-05-11 2023-11-16 Curis, Inc. TREATMENT OF DISEASES AND DISORDERS WITH MIRACLES MODIFYING COMPOUNDS 4
CN118909142A (zh) * 2024-08-07 2024-11-08 北京爱思益普生物科技股份有限公司 Irak4蛋白的制备方法及其所采用的融合蛋白

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998044113A1 (en) * 1997-03-28 1998-10-08 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO1999027112A1 (en) * 1997-11-26 1999-06-03 Human Genome Sciences, Inc. Human irak-2, a human interleukin-1 receptor associated kinase-2
WO1999060100A1 (en) * 1998-05-15 1999-11-25 Ortho-Mcneil Pharmaceutical, Inc. Irak modified transgenic animals

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6440663B1 (en) * 1998-10-05 2002-08-27 Ludwig Institute For Cancer Research Renal cancer associated antigens and uses therefor
CN1367830A (zh) 1998-10-05 2002-09-04 路德维哥癌症研究院 癌症相关抗原及其应用
WO2000073801A2 (en) 1999-05-28 2000-12-07 Ludwig Institute For Cancer Research Breast, gastric and prostate cancer associated antigens and uses therefor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998044113A1 (en) * 1997-03-28 1998-10-08 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO1999027112A1 (en) * 1997-11-26 1999-06-03 Human Genome Sciences, Inc. Human irak-2, a human interleukin-1 receptor associated kinase-2
WO1999060100A1 (en) * 1998-05-15 1999-11-25 Ortho-Mcneil Pharmaceutical, Inc. Irak modified transgenic animals

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US20030059916A1 (en) 2003-03-27
AU783742B2 (en) 2005-12-01
US20050255549A1 (en) 2005-11-17
WO2001051641A9 (en) 2002-08-08
CA2397481A1 (en) 2001-07-19
EP1248847A1 (en) 2002-10-16
WO2001051641A1 (en) 2001-07-19
US6818419B2 (en) 2004-11-16
DE60133366D1 (de) 2008-05-08
DE60133366T2 (de) 2008-10-02
ATE390485T1 (de) 2008-04-15
EP1248847B1 (en) 2008-03-26
EP1248847B8 (en) 2008-05-28
AU3092601A (en) 2001-07-24
US7235635B2 (en) 2007-06-26

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