JP2004262922A - Cycle supplement - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a supplement set for reducing at least one of symptoms out of dysmenorrhea and premenstrual syndrome. <P>SOLUTION: The supplement set is used for reducing at least one of symptoms out of dysmenorrhea and premenstrual and contains at least a supplement for an ovarian follicle term ingested in the ovarian follicle term. Preferably, the supplement set further contains a supplement for a menstrual term ingested in the menstrual term and a supplement for a luteal phase ingested in the luteal phase. Especially, the supplement for the ovarian follicle term contains vitamin A, β-carotene, cystine, vitamin B6, vitamin B12, vitamin C, vitamin E, folic acid and the like. The supplement for the menstrual term further contains hesperidin, raspberry fruit juice, a hawthorn (crataegus oxyacantha) extract, a grape seed extract, CA, Mg and Fe. The supplement for the luteal phase further contains theanine, soybean isoflavone and the like. <P>COPYRIGHT: (C)2004,JPO&NCIPI

Description

  The present invention relates to a supplement set for alleviating premenstrual syndrome (also referred to herein as PMS) or dysmenorrhea. More specifically, the present invention relates to a supplement set aimed at alleviating premenstrual syndrome (PMS) or menstrual discomfort by taking appropriate nutrients each time according to a woman's menstrual cycle.

  Premenstrual syndrome (PMS) is a variety of physical, mental, and social symptoms that plague women that usually appear before menstruation and disappear with the onset of menstruation, such as “irritability” that occurs before menstruation. Symptoms defined as PMS includes lower abdominal pain, lower back pain, headache, stiff shoulders, irritated, depressed, lethargic, angry, restless, appetite abnormalities, nausea, constipation, swelling, weight gain, decreased urine volume, breast pain, Various symptoms have been reported, such as skin irritation, fatigue, palpitation, and sleepiness. These symptoms are said to occur in the so-called luteal phase, where a lot of progesterone is secreted. For women with a 28-day cycle, the luteal phase generally lasts about 2 weeks.

Methods for alleviating PMS include dehydration therapy, medical therapy includes administration of luteinizing hormones such as progesterone, ovulation suppression therapy, and pharmacological ovariectomy therapy. Health supplements called supplements to relieve PMS include ingredients that relax the mood such as theanine, rosemary and chamomile, female hormone-like ingredients such as soy isoflavones and black cohosh, and substances that cause pain prostaglandin (mainly composed of γ- linolenic acid) evening primrose oil or borage oil is said to reduce the generation of, a combination of several types such as vitamin B ₆ which is said to often missing in people complaining of PMS symptoms Things are commercially available.

  Dysmenorrhea is generally defined as something that causes abnormally strong pain or general disability to menstruation, and that makes it impossible to bed or work. Symptoms of dysmenorrhea such as lower abdominal pain, back pain, nausea, vomiting, diarrhea, and headache have been reported. In this specification, it means dysmenorrhea in a broad sense, including menstrual pain that does not reach the level of dysmenorrhea but shows similar symptoms and complains of any complaints during menstruation. The menstrual period is usually about one week for women with a 28-day cycle.

  As a method for alleviating dysmenorrhea, medical treatment includes mefenamic acid, indomethacin, ibuprofen, diclofenac sodium, loxobrufen sodium and other antiprostaglandin preparations, general analgesics, muscle relaxants, There are methods using tranquilizers, herbal medicines and the like. As a supplement, a combination of materials such as iron preparation, soybean isoflavone and raspberry is commercially available.

  Patients with dysmenorrhea (also referred to herein as dysmenorrhea) may use drugs or supplements during the menstrual period if the symptoms of dysmenorrhea are severe. Many. However, it is customary not to use drugs or supplements that relieve menstrual pain during other periods. Alternatively, the same drug or supplement may be taken daily, regardless of when in the menstrual cycle. For example, Patent Document 1 (Japanese Patent Laid-Open No. 05-155774) discloses concentrated skim milk, whey protein concentrate (WPC), dextrin, whey mineral, unsalted butter, casein phosphopeptide, vitamin A, vitamin C, vitamin It is described that when granules containing D and an iron preparation were drunk daily at 8.5 g per day for 2 to 5 months, about 70% of subjects experienced relief from dysmenorrhea. Although Patent Document 1 describes that a palliative agent for dysmenorrhea is taken every day, PMS and dysmenorrhea in the next luteal phase and menstrual phase are alleviated by taking supplements actively in the follicular phase Is not described.

For women with PMS, awareness of PMS itself may not be very high, but most of them are unresponsive even if they are aware of symptoms, or they are relieved by using supplements when PMS appears Is the current situation. For example, Non-Patent Document 1 (Tomoko Ueda et al., Japanese Journal of Women's Psychosomatic Medicine 6 (2), 2001, 234-239) contains 2 tablets each containing 50 mg of L-theanine, twice a day between meals, It is described that symptom of PMS was improved by ingesting over about 2 weeks from the date of ovulation to the start of menstruation. Alternatively, the same drug or supplement may be taken daily, regardless of when in the menstrual cycle. Patent Document 2 (Japanese Patent Application Laid-Open No. 2001-103931) discloses tablets containing Italian carrot, isoflavone, vitamin B ₆ , lactose, cellulose and rapeseed oil powder, one tablet per day from the start of menstruation for two physiological cycles. It is described that the symptoms of PMS have been improved when ingested (the period from the start date of menstruation to the start date of the next menstrual period is one period). Patent Document 2 describes daily intake of a PMS alleviating agent, but regarding the fact that PMS and dysmenorrhea in the next luteal phase and menstrual phase are alleviated by taking supplements actively in the follicular phase. Not listed.

  Women with severe PMS often have severe menstrual pain. Therefore, women with severe PMS may be using some medication or supplement both during the PMS period and during the menstrual period. However, supplements to relieve these symptoms are not used during the follicular phase (usually about a week after menstruation for women with a 28-day cycle) when neither symptoms of PMS nor dysmenorrhea occur This is a general situation.

As described above, the methods and supplements that have been used in the past have been able to alleviate the symptoms at a specific time, but they have only been dealt with on the fly, and have not been measures to improve the symptoms of PMS or dysmenorrhea.
JP 05-155774 A, page 4 (Example 3) JP 2001-103931 A, page 4 (Evaluation Examples 1 and 2) Tomoko Ueda et al., Japanese Journal of Women's Psychosomatic Medicine 6 (2), 2001, 234-239

  The present invention is intended to solve the above problems, and an object thereof is to provide a supplement set for alleviating at least one symptom of dysmenorrhea or premenstrual syndrome. More specifically, it aims to alleviate premenstrual syndrome (PMS) or menstrual discomfort by taking appropriate nutrients each time according to the menstrual cycle of women.

  As a result of intensive studies to solve the above-mentioned problems, the present inventors have not only the time when the symptoms of PMS or the symptoms of dysmenorrhea appear, but also the time when these symptoms are not seen, that is, the follicle It was found that by taking an appropriate supplement during the period, symptoms of PMS or dysmenorrhea are synergistically alleviated, and the present invention was completed based on this.

  The supplement set of the present invention is a supplement set for alleviating at least one symptom of dysmenorrhea and premenstrual syndrome, and the supplement set includes a supplement for follicular phase, a supplement for menstrual phase, and a supplement for luteal phase Thus, the composition of the supplement for the follicular phase, the composition of the supplement for the menstrual phase, and the composition of the supplement for the luteal phase are different from each other.

  In one embodiment, the follicular phase supplement may comprise at least one of vitamin A, β-carotene and cystine.

In one embodiment, the follicular phase supplements may include cystine, vitamin A, beta-carotene, vitamin _{B 6,} vitamin _{B 12,} vitamin C, vitamin E and folic acid.

In one embodiment, the supplement for follicular phase is 5 mg to 100 mg cystine, 100 μg to 1500 μg vitamin A, 600 μg to 9000 μg β-carotene, 0.5 mg to 3 mg in daily intake. 1.0 mg or less of vitamin B ₆ , 0.8 μg or more and 4.8 μg or less of vitamin B ₁₂ , 30 mg or more and 2000 mg or less of vitamin C, 3 mg or more and 100 mg or less of vitamin E, and 70 μg or more and 400 μg or less of folic acid.

  In one embodiment, the menstrual supplement may comprise at least one of hesperidin, raspberry juice, hawthorn extract and grape seed extract.

In one embodiment, the menstrual supplement may include hesperidin, raspberry juice, hawthorn extract, grape seed extract, calcium, magnesium, iron, vitamin B ₆ , vitamin B ₁₂ , vitamin C and folic acid.

In one embodiment, the menstrual supplement contains 100 mg or more and 3000 mg or less hesperidin, 20 mg or more and 200 mg or less raspberry juice, 2 mg or more and 50 mg or less hawthorn extract, 1 mg or more and 1000 mg or less in daily intake. Grape seed extract, 100 mg to 1000 mg calcium, 50 mg to 300 mg magnesium, 2 mg to 12 mg iron, 0.5 mg to 3.0 mg vitamin B ₆ , 0.8 μg to 4.8 μg vitamin B ₁₂ , 30 mg or more and 2000 mg or less of vitamin C, and 70 μg or more and 400 μg or less of folic acid.

  In one embodiment, the luteal supplement may comprise theanine.

In one embodiment, the luteal phase supplement may comprise theanine, soy isoflavone, calcium, vitamin B ₆ , vitamin B ₁₂ , vitamin C and folic acid.

In one embodiment, the luteal phase supplement comprises 70 mg to 400 mg of theanine, 7 mg to 30 mg of soy isoflavone, 100 mg to 1000 mg of calcium, 0.5 mg to 3.0 mg of daily intake. The following vitamin B ₆ , 0.8 μg to 4.8 μg vitamin B ₁₂ , 30 mg to 2000 mg vitamin C, and 70 μg to 400 μg folic acid may be included.

  The supplement for the follicular phase of the present invention is a supplement for alleviating at least one symptom of dysmenorrhea and premenstrual syndrome, and the supplement is taken only during the follicular phase.

  The present invention provides a supplement that can relieve at least one symptom of dysmenorrhea or premenstrual syndrome. By taking appropriate supplements during the follicular phase, subsequent symptoms of premenstrual syndrome and dysmenorrhea can be dramatically relieved. In addition, by taking the supplement set of the present invention over a long period of two or more cycles, the symptoms of premenstrual syndrome and dysmenorrhea can be alleviated more dramatically as the cycle becomes later.

  Hereinafter, the present invention will be described in detail.

(Definition of terms)
As used herein, “dysmenorrhea” refers to an unpleasant symptom that is felt during the menstrual period but not when the menstrual period ends. As used herein, “dysmenorrhea” is used in the broadest sense. That is, it includes not only dysmenorrhea in a narrow sense but also symptoms that are similar to dysmenorrhea but mild in degree (also called menstrual pain). In the narrow sense, dysmenorrhea refers to those who become bedridden or unable to work due to abnormally strong pain or systemic disorder associated with menstruation. Examples of symptoms of dysmenorrhea include lower abdominal pain, back pain, nausea, vomiting, diarrhea and headache.

  As used herein, “premenstrual syndrome” refers to physical, mental or social symptoms that appear in the luteal phase of the menstrual cycle and disappear with the onset of menstruation. The premenstrual syndrome is described in detail in the supervision of Seiichi Matsumoto, “Research of PMS”, Bunkodo, 1995, pages 1-19.

  Examples of physical symptoms of premenstrual syndrome include pain, breast symptoms, gastrointestinal symptoms, neurological symptoms, allergic symptoms and mucocutaneous symptoms, and water retention symptoms. Examples of pain include lower abdominal pain and back pain. Examples of breast symptoms include breast pain, breast fullness and nipple sensitivity. Examples of gastrointestinal symptoms include abdominal bloating, constipation, abnormal appetite (eg, increased appetite) and nausea. Examples of neurological symptoms include headache, stiff shoulders and dizziness. Examples of allergic symptoms and mucocutaneous symptoms include skin irritation, exacerbations such as asthma, conjunctivitis, rash, acne and urticaria. Examples of water retention symptoms include weight gain, facial limb edema (so-called swelling), and decreased urine output.

  Examples of mental symptoms of premenstrual syndrome include annoyed, depressed, lethargic, angry, restless, palpitation, anxiety, easy to get tired, fatigue, insomnia, sleepiness and somnolence.

  Examples of social symptoms of premenstrual syndrome are: you can't work as usual, you want to be organized, you can't manage your health, things are troublesome, you don't want to be a woman, you don't like menstruation Arguing with others, withdrawing to the house, thinking that no one understands or supports, wanting to be alone, ranting to family and friends, and socializing.

Whether a woman has premenstrual syndrome can be determined according to methods known in the art. For example, it can be determined according to the following diagnostic criteria:
1. Symptoms appear periodically;
2. 2. Symptoms occur in the luteal phase of the menstrual cycle; Symptoms are severe enough to affect daily life to some extent.

  In the present specification, the “follicular phase” means from the day after the end of menstruation to the day before the day when the PMS expression phase starts. More precisely medically, the follicular phase can be from the day after the end of menstruation until the day of ovulation. The day of ovulation is the day before the basal body temperature reaches the high temperature period after the end of menstruation when the basal body temperature is measured, and it is often the day when the basal body temperature has fallen the most. In fact, the date of ovulation is confirmed by a temporary decrease in basal body temperature after menstruation and an increase in the luteal phase. Although the method of measuring basal body temperature is precise, it is necessary to measure every day and is complicated, so if the number of days in the menstrual cycle does not vary so much from cycle to cycle, the determination of the follicular phase is Can be estimated from the days of the past menstrual cycle. For example, for a woman with a menstrual cycle of 28 days, the menstrual period is typically 7 ± 3 days, the luteal phase is 14 ± 2 days (eg, 14 days), and the follicular phase is between the menstrual phase and the luteal phase Is the period. In a woman whose menstrual cycle is 28 days, when menstruation is 7 days, the first day to 7th day is the menstrual period from the first day of menstruation, and the next estimated menstruation date is the 29th day As such, the luteal phase is estimated to be 14 ± 2 days prior to day 28 (eg, 14 days), ie, day 15 (± 2 days) to day 28. It is estimated that the remaining period, that is, the 8th to 14th days is the follicular phase. For example, in the case of a woman whose menstrual cycle is 20 days and menstruation is 4 days, the menstrual period is from the first day to the fourth day with the first day of menstruation as the first day, and the next estimated menstrual day is the 21st day. As such, the luteal phase is 14 ± 2 days prior to day 20 (eg, 14 days), ie, from day 7 (± 2 days) to day 20, and the remaining period, ie, days 5-6. The day is estimated to be in the follicular phase. Similarly, in the case of a woman whose menstrual cycle is 32 days and menstruation is 7 days, the menstrual period is from the first day to the seventh day, and the luteal period is from the 19th day (± 2 days) to the 32nd day, And it is estimated that the follicular stage is the 8th day-the 18th day. Similar estimates can be made for women of other lengths of the menstrual cycle.

  In this specification, “menstrual period” means from the start date of menstruation to the end date of menstruation. The menstrual start date is the day when bleeding starts, and the menstrual end date is the last day when bleeding was confirmed in the same menstrual cycle as this menstrual start date.

  In the present specification, the “luteal phase” refers to 14 ± 2 days (for example, 14 days) from the estimated menstrual start date of the next menstrual cycle. Medically more precisely, the luteal phase can be from the date of ovulation to the day before the start of the next menstrual cycle.

  As used herein, “supplements” refers to foods taken to assist in nutrition. Supplements include special health foods, functional nutritional foods, and other dietary supplements. The supplement can be of any shape. Examples of supplement shapes include tablets, sustained release tablets, capsules, powders, solutions, emulsions, suspensions, soft gels, gel capsules, cookies, biscuits, gum, chocolate, candy, powdered beverages, gummi, jelly And tea bags.

(1. Supplement set)
The supplement set of the present invention is a supplement set for alleviating at least one symptom of dysmenorrhea and premenstrual syndrome. The supplement set of the present invention comprises a follicular phase supplement, a menstrual phase supplement, and a luteal phase supplement. In the supplement set of the present invention, the composition of the follicular phase supplement, the composition of the menstrual phase supplement, and the composition of the luteal phase supplement are different from each other.

(1.1 Supplement for follicular phase)
The supplement for the follicular phase is a supplement for intake only in the follicular phase in principle. The follicular phase supplement includes components that are not included in the menstrual phase supplement or the luteal phase supplement. Examples of such components include vitamin A, β-carotene and cystine. The follicular supplement preferably comprises at least one of vitamin A, β-carotene and cystine, more preferably comprises at least two of vitamin A, β-carotene and cystine, and most preferably Contains all of vitamin A, β-carotene and cystine.

  Vitamin A has an antioxidant ability and is important for maintaining the functions of the retina, epithelial cells, cartilage and biological membranes. It functions to condition the skin. When deficient, it becomes night blindness.

  β-carotene is metabolized in the animal body to form vitamin A, and exhibits the same function as vitamin A.

  Cystine is reduced in the body to cysteine, which is involved in the production of skin, hair, and nails, and functions to arrange these textures.

  The amount of these components in the follicular phase supplement can be appropriately set by those skilled in the art. Examples of preferred amounts of these components in follicular supplements include, for example, daily intake of 5 mg to 100 mg of cystine, 100 μg to 1500 μg of vitamin A, and β- Carotene is 600 μg or more and 9000 μg or less.

The follicular supplement may include one or more other ingredients in addition to at least one of vitamin A, β-carotene and cystine. Examples of such ingredients include vitamin B ₆ , vitamin B ₁₂ , folic acid, vitamin C, vitamin E, proline, hydroxyproline, tryptophan, lysine, alanine, tea extract, iron, soy isoflavone, garcinia, collagen, ceramide And rose hips. The supplement for follicular phase may preferably contain one or more of these other components, more preferably 2 or more, still more preferably 3 or more, particularly preferably 4 or more, and most preferably 5 or more. . The follicular supplement preferably comprises cystine, vitamin A, β-carotene, vitamin B ₆ , vitamin B ₁₂ , vitamin C, vitamin E and folic acid.

Since vitamin B ₆ , vitamin B ₁₂ and folic acid have a hematopoietic function, they have an anti-anemic effect.

  Vitamin C has an anti-scurvy effect because it is involved in collagen formation and, when deficient, causes bleeding.

  Vitamin E has effects such as stabilization of membranes, promotion of peripheral circulation, and suppression of lipid peroxide production due to non-specific antioxidant action.

  Proline is the main component of collagen protein and has the effect of adjusting the texture of the skin.

  Similar to proline, hydroxyproline has the effect of adjusting the texture of the skin.

  Tryptophan works in calming the mind and has an antidepressant action.

  Lysine is effective in preventing osteoporosis and in the body as a raw material for carnitine and tightens the skin.

  Alanine is an amino acid synthesized in vivo by hydroxyproline which is an amino acid constituting collagen.

  The tea extract has an antioxidant ability, has an effect of preventing aging and protecting skin texture.

  Iron has an anti-anemic effect.

  Soy isoflavone has a female hormone-like action, and has an action of adjusting the balance of female hormones.

  Garcinia works by burning body fat and tightening the skin.

  Collagen has the effect of adjusting the texture of the skin.

  Ceramide is a water retention component of the skin and has an effect of giving elasticity and moisture to the skin.

  Rosehip is a plant containing a large amount of vitamin C, and vitamin C has an action of promoting the regeneration of collagen.

The amount of each component in the follicular phase supplement can be appropriately set by those skilled in the art. Examples of preferable amounts of each component in the supplement for follicular phase include, for example, as a daily intake, vitamin B ₆ is 0.5 mg to 3.0 mg, and vitamin B ₁₂ is 0.8 μg or more. 4.8 μg or less, folic acid is 70 μg to 400 μg, vitamin C is 30 mg to 2000 mg, vitamin E is 3 mg to 100 mg, and cystine is 5 mg to 100 mg. Therefore, in a preferred embodiment, the supplement for follicular phase is 5 mg to 100 mg cystine, 100 μg to 1500 μg vitamin A, 600 μg to 9000 μg β-carotene, 0.5 mg or more per day. It may contain 3.0 mg or less of vitamin B ₆ , 0.8 μg or more and 4.8 μg or less of vitamin B ₁₂ , 30 mg or more and 2000 mg or less of vitamin C, 3 mg or more and 100 mg or less of vitamin E, and 70 μg or more and 400 μg or less of folic acid.

  Each component that can be included in a follicular supplement is known in the art and can be readily obtained.

For example, vitamin A is a fat-soluble vitamin and exists in the animal kingdom. Vitamin A is divided into vitamin A ₁ and vitamin A ₂ having similar chemical structures. Vitamin A ₂ has approximately 40% bioactivity of vitamin A ₁ . Vitamin A may be extracted from an animal containing vitamin A or chemically synthesized. Vitamin A is sold, for example, from Roche Vitamin Japan and BASF Takeda Vitamin. Vitamin A may be formulated as a purified product or an extract containing other components.

  β-carotene is a vitamin A provitamin that is metabolized in the animal body to form vitamin A. β-carotene is present in carrot roots, capsicum fruits, various green leaves, and the like. β-carotene may be extracted from a plant containing β-carotene or chemically synthesized. β-carotene is sold by, for example, Sankyo, Sumitomo Pharmaceutical, Tanabe Seiyaku and the like. β-carotene may be formulated as a purified product or an extract containing other components.

  Cystine is a sulfur-containing amino acid. When reduced in the body, it becomes cysteine. Cystine may be in pure form or in the form of a salt (eg, hydrochloride). Cystine may be formulated as a purified product, as an extract containing other components, or as a mixture containing cystine such as eggshell membrane powder. Cysteine may be used in place of cystine. Cysteine may be in pure form or may be in the form of a salt (eg, hydrochloride). Cysteine is generally chemically synthesized. Cysteine hydrochloride is sold, for example, from Ajinomoto, Tanabe Seiyaku, Nippon Rikagaku, Kyowa Hakko. Cysteine may be formulated as a purified product or an extract containing other components.

Vitamin B _6, in nature, there pyridoxine, pyridoxol, as pyridoxal or pyridoxamine. These are converted into each other in vivo. Vitamin B ₆ is a natural, mostly present as phosphate esters. Vitamin B ₆ may be in pure form or in the form of a salt (eg, hydrochloride). Vitamin B ₆ may be extracted from animals and plants containing vitamin B ₆ (for example, vegetable oils, grains, vegetables, yeast, liver, fish, etc.), or may be chemically synthesized. Vitamin B ₆ is, for example, is available from such Daiichi Fine Chemical. Vitamin B ₆ may be formulated as a purified product or an extract containing other components.

Vitamin B ₁₂ is closely related to vitamin and hematopoietic function. Vitamin B ₁₂ may be extracted from animals, including vitamin B _12, it may be obtained by fermentation, or may be chemically synthesized. Vitamin _{B 12} is, for example, is available from such Yamanouchi. Vitamin B ₁₂ may be formulated as a purified product or an extract containing other components.

  Folic acid is one of the vitamin B complexes and is an anti-anemic factor. Folic acid may be extracted from animals and plants and microorganisms (eg, liver, yeast, green leaves) containing folic acid, or may be chemically synthesized. Folic acid is sold, for example, from BASF Takeda Vitamin, Kongo Pharmaceutical, Roche Vitamin Japan, and the like. Folic acid may be formulated as a purified product or an extract containing other components.

  Vitamin C is a water-soluble vitamin, also called L-ascorbic acid. Vitamin C may be extracted from animals and plants containing vitamin C, or may be chemically synthesized. Generally, it is synthesized using glucose as a raw material. Vitamin C is sold, for example, from BASF Takeda Vitamin, Daiichi Fine Chemical, Roche Vitamin Japan, and the like. Vitamin C may be formulated as a purified product or an extract containing other components.

  Vitamin E is also called tocopherol. Vitamins may be extracted from animals containing vitamin E or chemically synthesized. In general, it can be synthesized by condensing trimethylhydroquinone and phytyl bromide or isophytol in the presence of a catalyst. Vitamin E is sold, for example, from Eisai, Nisshin Flour Milling, Roche Vitamin Japan, and the like. Vitamin E may be formulated as a purified product or an extract containing other components.

  Proline is a non-essential amino acid. Proline may be extracted from animals and plants containing proline, may be obtained by protein hydrolysis, may be obtained by fermentation, or may be chemically synthesized. Proline is sold, for example, from Ajinomoto, Kyowa Hakko, Tanabe Seiyaku, Nippon Kayaku. Proline may be formulated as a purified product or an extract containing other components.

  Hydroxyproline is also called L-oxyproline. Hydroxyproline is an oxide of proline. Hydroxyproline may be extracted from animals and plants containing hydroxyproline, or may be chemically synthesized. Hydroxyproline is sold, for example, from Tanabe Seiyaku, Nippon Rikagaku, Kyowa Hakko. Hydroxyproline may be formulated as a purified product or an extract containing other components.

  Tryptophan is an essential amino acid. Tryptophan may be extracted from animals or plants containing tryptophan or may be chemically synthesized. Tryptophan is sold from Ajinomoto, Kyowa Hakko, Tanabe Seiyaku, etc., for example. Tryptophan may be formulated as a purified product or an extract containing other components.

  Lysine is a water-soluble essential amino acid. Lysine may be extracted from animals and plants containing lysine, may be obtained by protein hydrolysis, may be obtained by fermentation, or may be chemically synthesized. Lysine may be in pure form or may be in the form of a salt (eg, hydrochloride). Lysine is sold, for example, from Ajinomoto Co., Kyowa Hakko. Lysine may be formulated as a purified product or an extract containing other components.

  Alanine is a water-soluble amino acid. Alanine may be extracted from animals and plants containing alanine, may be obtained by protein hydrolysis, or may be chemically synthesized. Alanine is sold from Showa Denko, Kyowa Hakko, Tanabe Seiyaku, Takeda Pharmaceutical, and others. Alanine may be formulated as a purified product or an extract containing other components.

  The tea extract refers to a catechin derived from tea leaves. The tea extract is usually from tea made from leaves of Camellia sinensis O.KZE, at room temperature, warm or hot, water, acidic aqueous solution, hydrous ethanol, ethanol, hydrous methanol, methanol, Obtained from one extracted with acetone, ethyl acetate or glycerin aqueous solution. Contains catechins as ingredients. The tea extract includes not only what is obtained from so-called green tea but also what is called oolongcha extract depending on the tea leaf processing method. Tea extract is sold from Taiyo Kagaku, Mitsui Norin, etc., for example. The tea extract may be formulated as a purified product or an extract containing other components.

  Iron is usually used in the form of a salt. Examples of iron salts include ferric chloride, sodium ferrous citrate, iron citrate, ammonium iron citrate, ferrous gluconate, iron sesquioxide, iron chlorophyllin sodium, iron lactate, ferric pyrophosphate Is mentioned. These iron salts are sold by various companies.

  Soy isoflavone is an isoflavone present in soybean. Soy isoflavones are usually extracted from soybean seeds. Soy isoflavones are sold from, for example, Fujicco and Hornen. Soy isoflavone may be formulated as a purified product or an extract containing other components.

  Garcinia, also called tamarind, is the fruit of an evergreen tree of the Hypericaceae family that grows naturally in South Asia. Garcinia may be included as a pulverized fruit (eg, dry powder, juice, paste, etc.), or as an extract (eg, extract, dry powder of extract, etc.) when formulated in a supplement. May be. Preferably, it is an extract. Garcinia is sold, for example, from Nippon Shinyaku, Citrimax, etc.

  Collagen is the major protein in connective tissue cartilage and white bone fibers. Collagen accounts for more than half of mammalian proteins. Collagen may be extracted from animals containing collagen or chemically synthesized. Collagen is sold, for example, from Roche Vitamin Japan and BASF Takeda Vitamin. Collagen may be formulated as a purified product or an extract containing other components.

Ceramide is also called N-acyl sphingosine. Long chain bases of general formula CH ₃ (CH ₂ ) ₁₂ CH═CH—CHOH—CH (CH ₂ OH) —NH—CO—R or N-acyl (fatty acid) derivatives of sphingoids (eg, sphinganine, sphingosine), sphingos It is the genus name of lipids. Here, R is a fatty acid residue, and in this case, it is amide-bonded to 4-sphingenin (sphingosine). Ceramide may be extracted from an animal containing ceramide or may be chemically synthesized. Ceramide is sold from, for example, Japanese fats and oils, Unitika and the like. Ceramide may be formulated as a purified product or an extract containing other components.

  Rose hips are Neubara, especially Rosa canina, R.I. Gallica, R.M. condita, R.A. It refers to fruits or fruits of the Rosaceae family such as Rugosa. Rosehip contains a large amount of vitamin C (ascorbic acid). Rosehips may be included as a pulverized fruit (eg, dry powder, juice, paste, etc.), or as an extract (eg, extract, dry powder, etc.) when formulated in a supplement. May be. Preferably, it is an extract. Rosehip is sold, for example, by Nippon Powder Chemicals Co., Ltd.

  Depending on the dosage form, the follicular phase supplement may be manufactured according to methods well known in the art. For example, when the supplement for follicular phase is a tablet, it can be produced using the techniques and equipment used in conventional tablet production as they are. For example, a method of directly tableting by mixing the main component and additives, a method of tableting after the components are granulated by wet or dry method, and the like can be employed.

  When the supplement for the follicular phase is a liquid preparation, it can be manufactured using the techniques and equipment used in the conventional liquid preparation. For example, it can be produced by using the liquid component as it is or by dissolving the component in a solvent.

  When the supplement for follicular phase is a capsule, it can be produced by filling the capsule in the form of liquid, suspension, paste, powder or granule, or encapsulating with a capsule base material. . The capsule may be a hard capsule or a soft capsule.

  When the follicular phase supplement is a powder, it is manufactured by adding the ingredients as they are, or by adding excipients, binders, disintegrants or other suitable additives to the ingredients, and powdering or granulating them in an appropriate manner. obtain.

  When the follicular phase supplement is an emulsion, it is manufactured by adding a suspending agent or other suitable additive and purified water or oil to the solid ingredients and suspending in an appropriate manner to equalize the whole quality. obtain.

  When the supplement for follicular phase is a suspension, it can be produced by adding an emulsifier and purified water to a liquid component, emulsifying by an appropriate method, and uniforming the whole quality.

  Even if the supplement for follicular phase is in other forms, those skilled in the art can produce supplements in an appropriate form according to a method known in the art.

  Supplements for the follicular phase may be individually packaged for each intake per time, individually packaged for each daily intake, or packaged for several days. Good.

(1.2 Menstrual supplements)
Menstrual supplements are supplements for intake only during menstrual periods in principle. The menstrual supplement can be a menstrual supplement that has been commonly used in the art. Menstrual supplements contain ingredients that are not included in follicular or luteal supplements. Examples of such components include hesperidin, raspberry juice, hawthorn extract and grape seed extract. The menstrual supplement preferably comprises at least one of hesperidin, raspberry juice, hawthorn extract and grape seed extract, more preferably of hesperidin, raspberry juice, hawthorn extract and grape seed extract. Including at least two of hesperidin, raspberry juice, hawthorn extract and grape seed extract, and most preferably all of hesperidin, raspberry juice, hawthorn extract and grape seed extract including.

  Hesperidin has an effect of improving blood flow.

  Raspberry juice contains flavonoids as components, and has an astringent action and a blood flow promoting action.

  The hawthorn extract contains flavonoids, saponins and proanthocyanidins as components, and has an astringent action and a blood flow promoting action.

  Grape seed extract contains proanthocyanidins as components, and has an antioxidant effect and a peripheral vasodilatory effect.

  The amount of these components in the menstrual supplement can be set appropriately by those skilled in the art. Examples of preferred amounts of these components in menstrual supplements include, for example, daily intake of hesperidin from 100 mg to 3000 mg, raspberry juice from 20 mg to 200 mg, hawthorn extract Is 2 mg to 50 mg, and the grape seed extract is 1 mg to 1000 mg.

Menstrual supplements may include one or more other ingredients in addition to at least one of hesperidin, raspberry juice, hawthorn extract and grape seed extract. Examples of such ingredients include calcium, iron, magnesium, vitamin B ₆ , vitamin B ₁₂ , folic acid, vitamin C, vitamin E, soy isoflavone, capsaicin, ginkgo biloba, red clover, chest tree, cat's claw, St. John's wort , Proanthocyanidins, angelica, pomegranates, rosehips, γ-linolenic acid, icosapentaenoic acid, docosahexaenoic acid and the like. Menstrual supplements may preferably contain one or more of these other components, more preferably 2 or more, even more preferably 3 or more, particularly preferably 4 or more, and most preferably 5 or more. . The menstrual supplement preferably comprises hesperidin, raspberry juice, hawthorn extract, grape seed extract, calcium, magnesium, iron, vitamin B ₆ , vitamin B ₁₂ , vitamin C and folic acid.

  Among these other ingredients, ingredients that can be included only in menstrual supplements are capsaicin, ginkgo biloba, red clover and St. John's wort.

  Capsaicin has a gastric action, a bactericidal action, a body warming action, and the like.

  Ginkgo biloba has actions such as promoting female hormone secretion, vasodilatory action, improving coldness, and reducing headache.

  Red clover contains isoflavones, has a female hormone-like action, and has a function of balancing female hormones.

  St. John's wort has a sedative action, a depressive action, an irritating action, a bactericidal action and the like.

  The chest tree has the action of alleviating lower abdominal pain, breast pain, irritability, depression, stiff shoulders, coldness, and the like.

  Cat's claw has analgesic action, low back pain relief, stiff shoulder relief, immune enhancement, diuretic action and the like.

  Proanthocyanidins are antioxidative, restore vascular elasticity, increase capillary permeability, strengthen collagen, promote the production of benign fatty acids, assist in repairing inflammatory cell tissues, nutritional support for vision and retina, premenstrual syndrome Has nutritional support for symptoms related to

  Angelica has actions such as elimination of indigestion, anti-anemic action, anti-abdominal pain action, anti-bacterial action, anti-fungal action, sweating action, and relief of menstrual pain.

  Pomegranate contains a substance having a female hormone-like action, and this substance has a function of balancing female hormones.

  γ-Linolenic acid has a diuretic action and has an action of preventing swelling by promoting the excretion of sodium.

  Eicosapentaenoic acid has the effect of promoting blood flow.

  Docosahexaenoic acid has the effect of promoting blood flow.

The amount of each component in the menstrual supplement can be appropriately set by those skilled in the art. Examples of preferable amounts of each component in the supplement for menstrual periods include, for example, as intake per day, hesperidin is 100 mg to 3000 mg, hawthorn extract is 2 mg to 50 mg, and calcium is 100 mg. 1000 mg or less, iron is 2 mg or more and 12 mg or less, magnesium is 50 mg or more and 300 mg or less, vitamin B ₆ is 0.5 mg or more and 3.0 mg or less, and vitamin B ₁₂ is 0.8 μg or more and 4.8 μg. Folic acid is 70 to 400 μg, vitamin C is 30 to 2000 mg, vitamin E is 3 to 100 mg, and soy isoflavone is 7 to 30 mg. Therefore, in a preferred embodiment, the menstrual supplement comprises 100 mg or more and 3000 mg or less hesperidin, 20 mg or more and 2000 mg or less raspberry juice, 2 mg or more and 50 mg or less hawthorn extract, 1 mg or more and 1000 mg or less in daily intake. Grape seed extract, 100 mg to 1000 mg calcium, 50 mg to 300 mg magnesium, 2 mg to 12 mg iron, 0.5 mg to 3.0 mg vitamin B ₆ , 0.8 μg to 4.8 μg vitamin B ₁₂ , 30 mg to 2000 mg vitamin C, and 70 μg to 400 μg folic acid may be included.

  Each component that can be included in the menstrual supplement is known in the art and can be readily obtained.

  Hesperidin is a substance also called vitamin P. What is generally sold as hesperidin is obtained by extraction from citrus peel, fruit juice or seed with an alkaline aqueous solution at room temperature. The component of this extract is hesperidin. Hesperidin is sold, for example, from Hayashibara and Toyo Sugar. Hesperidin may be formulated as a purified product or an extract containing other components.

  Raspberry juice is a juice of raspberry fruits of the Rosaceae family. The raspberry juice may be liquid or solid (dried fruit juice) when blended in a supplement. Preferably, it is a solid. Raspberry juice is sold by, for example, Matsuura Pharmaceutical, Japan Powdered Drugs, and others. Raspberry juice may be formulated as a purified product or an extract containing other components.

  The hawthorn extract is an extract of flowers, leaves or fruits of the Rosaceae hawthorn. The hawthorn extract is sold by, for example, Matsuura Pharmaceutical Co., Ltd., Japan Powdered Drugs, etc. The hawthorn extract may be formulated as a purified product or an extract containing other components.

  The grape seed extract refers to a product mainly composed of proanthocyanidins obtained from American grapes or grape seeds. Grape seed extract can be obtained, for example, by extracting from seeds of American grapevine (Vitis lavrusca LINEN) or grapevine (Vitis vinifera LINENE) with hot water, hot ethanol or room temperature acetone. Or this extract may be obtained from what was fermented using yeast, or may be obtained from what was hydrolyzed with tannase. The main component is proanthocyanidins. Grape seed extract is sold, for example, from INDENA, Kikkoman and the like. The grape seed extract may be formulated as a purified product or an extract containing other components.

  Calcium is usually used in the form of calcium salt or as a substance containing a large amount of calcium salt. Examples of calcium salts include uncalcined calcium and bone uncalcined calcium. Examples of uncalcined calcium include shell uncalcined calcium, coral uncalcined calcium, nacreous uncalcined calcium, eggshell uncalcined calcium, and milk calcium. Calcium is, for example, N.I. Sold by C Corporation, Taiyo Kagaku and others. Calcium may be formulated as a purified product or an extract containing other components.

  Magnesium is usually used in the form of a salt. Examples of magnesium salts include magnesium chloride, magnesium L-glutamate, magnesium oxide, magnesium carbonate, and magnesium sulfate. These magnesium salts are sold by various companies.

  Capsaicin is a pungent component mainly contained in red pepper. Also called trans-8-methyl-N-vanillyl-6-nonenamide. It is the alkaloid component of the fruit of many species of Capsicum. Capsaicin may be extracted from pepper fruit or may be chemically synthesized. Capsaicin is sold, for example, from Nippon Shinyaku and bee foods. Capsaicin may be formulated as a purified product or an extract containing other components.

  Ginkgo biloba is a ginkgo biloba leaf. The ginkgo biloba leaves are preferably collected at the time of green leaves. Ginkgo biloba leaves may be included as pulverized leaves (eg, dry powder, juice, paste, etc.), or as extracts (eg, extract, dry extract powder, etc.) when blended in supplements May be. Preferably, it is an extract. Ginkgo biloba extract is sold, for example, from Nippon Shinyaku, INDEA, etc. The ginkgo biloba extract may be formulated as a purified product or an extract containing other components.

  Red clover, also called red clover, is a plant belonging to the genus Syxomyx that is native to Europe. Red clover mainly uses flowers. Red clover is mainly contained as an extract (for example, an extract, a dry powder of an extract, etc.) when blended in a supplement. The red clover extract is sold, for example, from Nippon Powdered Chemicals, Matsuura Pharmaceutical. The red clover extract may be formulated as a purified product or an extract containing other components.

  The chest tree is a plant belonging to the family Violidae, also called Italian carrots and carrots. Usually fruits are used. When added to a supplement, the chest tree may be included as a pulverized fruit (eg, dry powder, juice, paste, etc.) or as an extract (eg, extract, dry extract powder, etc.). May be. Preferably, it is an extract. Chest tree extracts are sold, for example, from Nippon Powdered Chemicals, Matsuura Pharmaceutical. Chest tree extract may be formulated as a purified product or an extract containing other components.

  Cat's Claw is a vine plant belonging to the genus Rubiaceae that grows naturally in the Amazon outback of Peru in South America at an altitude of 400m to 800m. Cats claw is mainly used for roots. Cats claw may be included as a root grind (eg, dry powder, juice, paste, etc.) or as an extract (eg, extract, dry powder, etc.) when formulated in a supplement. May be. Preferably, it is an extract. Cat's claw extract is sold, for example, by Nippon Powder Chemicals, Matsuura Pharmaceutical. The cat's claw extract may be formulated as a purified product or an extract containing other components.

  St. John's wort is Hypericum perforatum. Usually, the ground part is used. St. John's wort may be included as an aboveground pulverized product (eg, dry powder, juice, paste, etc.) when incorporated into a supplement, or as an extract (eg, extract, dry powder of extract, etc.) May be included. Preferably, it is an extract. St. John's wort extract is sold, for example, from Nippon Powdered Chemicals, Matsuura Pharmaceutical. St. John's wort extract may be formulated as a purified product or an extract containing other components.

  Proanthocyanidins are polyphenols contained in grape seed extract. In addition to grape seeds, proanthocyanidins are also contained in hawthorn, black soybeans, blueberries and the like. Proanthocyanidins are usually extracted from plants containing proanthocyanidins. Proanthocyanidins are sold by, for example, Kikkoman, INDena and the like. Proanthocyanidins may be formulated as a purified product or an extract containing other components.

  Angelica is a plant of the celery family that is also called European crested ibis. Usually roots, stems, seeds, flowers, etc. are used. Angelica may be included as a pulverized product of these parts (eg, dry powder, juice, paste, etc.), or as an extract (eg, extract, dry powder of extract, etc.) when formulated in a supplement. May be included. Preferably, it is an extract. Angelica extract is sold by, for example, Japanese powder medicine, Tokiwa Phytochemical Research Institute. Angelica extract may be formulated as a purified product or an extract containing other components.

  Pomegranate is a fruit of the pomegranate family Punica granatum. Pomegranate may be included as a pulverized fruit or pulp (eg, dry powder, juice, paste, etc.) when blended into a supplement, or as an extract (eg, extract, dry powder of extract, etc.) May be included. Preferably, it is a dried product or an extract of juice. The pomegranate extract is sold by, for example, Japanese powder medicine, Tokiwa Plant Chemistry Laboratory. The pomegranate extract may be formulated as a purified product or an extract containing other components.

γ-Linolenic acid is a fatty acid essential as an animal nutrient represented by CH ₃ (CH ₂ CH═CH) ₃ (CH ₂ ) ₇ COOH. γ-linolenic acid may be extracted from a plant containing γ-linolenic acid or may be chemically synthesized. γ-Linolenic acid is sold, for example, from Hornen. γ-Linolenic acid may be formulated as a purified product or an extract containing other components.

  Eicosapentaenoic acid is a generic name for unsaturated fatty acids having 20 carbon atoms and 5 double bonds, also called eicosapentaenoic acid. As natural products, there are linear cis-unsaturated n-3 fatty acids which are all cis-type with double bond positions of 5, 8, 11, 14, and 17. Eicosapentaenoic acid is contained in fish fats called “blue ones” such as sardines and mackerel. Eicosapentaenoic acid may be extracted from fish containing icosapentaenoic acid or may be chemically synthesized. Eicosapentaenoic acid is sold, for example, from Nissui, Maruha, etc. Eicosapentaenoic acid may be formulated as a purified product or an extract containing other components.

  Docosahexaenoic acid is an n-3 linear unsaturated fatty acid having 22 carbon atoms and having a cis double bond at positions 4, 7, 10, 13, 16, and 19. Docosahexaenoic acid is abundant in sardines, horse mackerel, mackerel, salmon, and herring. Docosahexaenoic acid may be extracted from fish containing docosahexaenoic acid or may be chemically synthesized. Docosahexaenoic acid is sold, for example, from Nissui, Maruha, etc. Docosahexaenoic acid may be formulated as a purified product or an extract containing other components.

Vitamin B ₆ , vitamin B ₁₂ , folic acid, vitamin C, vitamin E, iron, soybean isoflavone, and rosehip are as described in 1.1 above. Iron is preferably included only in menstrual supplements.

  Menstrual supplements may be manufactured according to methods well known in the art, depending on the dosage form. The example of the manufacturing method according to the dosage form is as described in 1.1 above.

  Menstrual supplements may be individually packaged for each intake, may be individually packaged for each daily intake, or may be packaged together for several days Good.

(1.3 Supplement for luteal phase)
The luteal phase supplement is a supplement for intake only during the luteal phase. The luteal phase supplement can be a luteal phase supplement that has been commonly used in the art. The luteal phase supplement includes ingredients that are not included in either the follicular phase supplement or the menstrual phase supplement. An example of such a component is theanine. The luteal phase supplement preferably comprises theanine. Theanine has the action of drawing out alpha waves in the brain and eliminating irritation.

  The amount of theanine in the luteal phase supplement can be appropriately set by those skilled in the art. If the example of the preferable quantity of theanine in the supplement for luteal phases is given, for example, the intake per day is 70 mg or more and 400 mg or less.

The luteal phase supplement may contain one or more other ingredients in addition to theanine. Examples of such ingredients include iron, soy isoflavone, potassium, calcium, magnesium, vitamin B ₆ , vitamin B ₁₂ , folic acid, vitamin C, black cohosh, cat's claw, devil's claw, passion flower, chest tree, borage oil, Evening primrose, proanthocyanidins, dietary fiber, angelica, pomegranate, merryrot, gotsukola, γ-linolenic acid, icosapentaenoic acid, docosahexaenoic acid and the like. The luteal phase supplement may preferably contain one or more of these other components, more preferably 2 or more, even more preferably 3 or more, particularly preferably 4 or more, and most preferably 5 or more. . The luteal phase supplement preferably comprises theanine, soy isoflavone, calcium, vitamin B ₆ , vitamin B ₁₂ , vitamin C and folic acid.

  Among these other ingredients, the ingredients that can be included only in the luteal supplement are potassium, black cohosh, devil's claw, passion flower, borage oil, evening primrose, dietary fiber, merilot and gotsukola.

  Components that can be included in luteal and menstrual supplements but not in follicular supplements include calcium, magnesium, chesttree, cat's claw, angelica, proanthocyanidins, pomegranate, γ-linolenic acid, icosapentaene Acid, docosahexaenoic acid.

  There are no ingredients that can be included in the luteal phase supplement and the follicular phase supplement but not in the menstrual phase supplement.

  Ingredients that are not included in the luteal phase supplement but may be included in the menstrual and follicular supplements are vitamin E and rosehip.

Ingredients that can be included in all three supplements are vitamin B ₆ , vitamin B ₁₂ , folic acid, vitamin C, iron and soy isoflavone.

  Potassium has a diuretic effect and has the action of excreting sodium and removing swelling.

  Black cohosh has a female hormone-like action and has an action to balance female hormones.

  Devil's claw has anti-inflammatory effects and relieves symptoms such as menstrual pain.

  Passion flower has actions such as sedation, hypnosis, mental stability, relaxation, spasm, and analgesia.

  Borage oil has the effect of suppressing the generation of prostaglandins that cause pain.

  Evening Primrose has an effect of improving blood flow and adjusting the balance of prostaglandins.

  Dietary fiber has an intestinal regulating action.

  Merirot has effects such as eliminating swelling and promoting blood circulation.

  Gotsukora has effects such as the synthesis of collagen or hyaluronic acid, the promotion of growth of skin, nails and hair, and eliminates swelling. .

The amount of each component in the luteal phase supplement can be appropriately set by those skilled in the art. Examples of preferable amounts of each component in the supplement for the luteal phase include, for example, as daily intake, theanine is 70 mg to 400 mg, calcium is 100 mg to 1000 mg, and vitamin B ₆ is 0 0.5 mg to 3.0 mg, vitamin B ₁₂ is 0.8 μg to 4.8 μg, folic acid is 70 μg to 400 μg, vitamin C is 30 mg to 2000 mg, and soy isoflavone is 7 mg or more 30 mg or less. Therefore, in a preferred embodiment, the luteal phase supplement comprises 70 mg to 400 mg theanine, 7 mg to 30 mg soy isoflavone, 100 mg to 1000 mg calcium, 0.5 mg to 3. It may contain 0 mg or less vitamin B ₆ , 0.8 μg or more and 4.8 μg or less vitamin B ₁₂ , 30 mg or more and 2000 mg or less vitamin C, and 70 μg or more and 400 μg or less folic acid.

  Each component that may be included in the luteal phase supplement is known in the art and can be readily obtained.

  Theanine is a kind of amino acid and is also called L-glutamic acid-γ-monoethylamide. Known as the umami ingredient of Gyokuro. Theanine may be extracted from a plant containing theanine or chemically synthesized. Theanine can be produced, for example, by heating L-glutamic acid under high pressure to produce pyrrolidone carboxylic acid to form a copper salt, and then adding anhydrous monoethylamine thereto and heating under high pressure. Theanine is sold, for example, from Taiyo Kagaku. Theanine may be formulated as a purified product or an extract containing other components.

  Potassium is usually used in the form of a salt. Examples of potassium salts include potassium chloride, monopotassium citrate, tripotassium citrate, potassium gluconate, potassium L-glutamate, potassium bromate, dl-potassium hydrogen tartrate, potassium nitrate, potassium hydroxide, potassium sorbate, carbonate Examples include potassium, tetrapotassium pyrophosphate, potassium polyphosphate, potassium metaphosphate, aluminum potassium sulfate, tripotassium phosphate, dipotassium hydrogen phosphate, and potassium dihydrogen phosphate. These potassium salts are sold by various companies.

  Black cohosh is a plant native to the western part of North America, also called the American Shouma. Mainly roots and rhizomes are used. Black cohosh may be included as a pulverized product of these parts (eg, dry powder, juice, paste, etc.), or as an extract (eg, extract, dry powder of extract, etc.) when formulated in a supplement. May be included. Preferably, it is an extract. Black cohosh extract is sold, for example, from Imperial Chinese medicine, Japanese powder medicine. The black cohosh extract may be formulated as a purified product or an extract containing other components.

  Devil's claw is a plant (Harpophytum procumbens) that grows naturally in grasslands in Africa, the Kalahari Desert, and Namibia. Mainly bulbs are used. Devil's claw may be included as a pulverized bulb (eg, dry powder, juice, paste, etc.) or as an extract (eg, extract, dry powder, etc.) when formulated in a supplement. May be. Preferably, it is an extract. The devil's claw extract is sold by, for example, Kouhan Pharmaceutical, Kenko Tsusho. The devil's claw extract may be formulated as a purified product or an extract containing other components.

  Passion flower is a vine plant of the passiaceae family. Usually, whole plants including leaf parts are used. Passion flour may be included as a whole plant pulverized product (eg, dry powder, juice, paste, etc.) or as an extract (eg, extract, dry extract powder, etc.) when blended into a supplement. May be included. Preferably, it is an extract. Passion flower extract is sold by, for example, Imperial Chinese medicine, Tokiwa plant chemistry laboratory. The passion flower extract may be formulated as a purified product or an extract containing other components.

  Borage oil is oil collected from the seeds of Borage grass (Borago officinalis L.), a kind of herb native to the Mediterranean Sea. Borage oil is rich in γ-linolenic acid. Borage oil is sold, for example, from Japanese fats and oils, Soho Tsusho. Borage oil may be formulated as a refined product or an extract containing other components.

  Evening Primrose is native to Chile, South America, and is also called evening primrose or evening primrose. Evening Primrose mainly uses seeds. Oil collected from evening primrose seeds is also called evening primrose oil and is rich in γ-linolenic acid. Evening primrose may be included as a seed pulverized product (eg, dry powder, juice, paste, etc.) when incorporated into a supplement, and an extract (eg, oil, extract, dry powder of extract, etc.) ) May be included. Preferably, it is an extract. Evening Primrose extract is sold, for example, by Tokiwa Phytochemical Laboratories, Imperial Chinese Medicine and the like. The evening primrose extract may be formulated as a purified product, an extract containing other components, or may be formulated as evening primrose oil.

  Dietary fiber refers to a fiber that is not digested by animal or human digestive enzymes and is composed of polysaccharides or lignin that are structural substances of plant cell walls contained in food or food ingredients. Dietary fiber is contained in various plants. Dietary fiber may be included as a pulverized plant (eg, dry powder, juice, paste, etc.), or as an extract (eg, extract, dry powder, etc.) when blended into a supplement May be. Preferably, it is an extract. Dietary fiber is sold from Taiyo Kagaku, Matsutani Kagaku, etc., for example. Dietary fiber may be formulated as a purified product or an extract containing other components.

  Merirot is a leguminous plant, also called sweet clover, shrimp swordfish, shinagawa swordfish. Usually flowers, stems and leaves are used. Merrirot may be included as a pulverized product of these parts (eg, dry powder, juice, paste, etc.) when incorporated into a supplement, or as an extract (eg, extract, dry powder of extract, etc.) May be included. Preferably, it is an extract. Merirot extract is sold, for example, by Tokiwa Phytochemical Laboratories, Nippon Powder Chemicals. Merirot extract may be formulated as a purified product or an extract containing other components.

  Gotsukora is a celery family plant distributed over a wide area from Africa and India to Southeast Asia. As for the gotsukora, the above-ground part, preferably a leaf is used. Gotsukora may be included as a pulverized leaf (eg, dry powder, juice, paste, etc.), or as an extract (eg, extract, dry extract powder, etc.) when formulated in a supplement. May be. Preferably, it is an extract. More preferred is an extract in an aqueous ethanol solution. Gotsukola extract is sold, for example, from Nippon Shinyaku. The Gotsukola extract may be formulated as a purified product or an extract containing other components.

Iron, soybean isoflavone, vitamin B ₆ , vitamin B ₁₂ , folic acid, vitamin C, vitamin E and rosehip are as described in 1.1 above.

  Calcium, magnesium, cats claw, chest tree, proanthocyanidins, angelica, pomegranate, chest tree, γ-linolenic acid, icosapentaenoic acid and docosahexaenoic acid are as described in 1.2 above.

  The luteal phase supplement may be manufactured according to methods well known in the art, depending on the dosage form. The example of the manufacturing method according to the dosage form is as described in 1.1 above.

  The luteal phase supplements may be individually packaged for each intake, may be individually packaged for each daily intake, or may be packaged together for several days. Good.

(1.4 Summary of ingredients contained in each period)
A summary of the components contained in the supplements described in 1.1 to 1.3 above is shown in Table 1 below.

１つの実施形態では、各サプリメントは、◎のうちの少なくとも１つの成分を必ず含み、そして○の成分を含んでもよい。通常、×の成分は含まない。

In one embodiment, each supplement necessarily includes at least one component of ◎ and may include a component of ○. Usually, the x component is not included.

(2. Method for producing supplement set of the present invention)
The supplement set of the present invention can be produced by combining a follicular phase supplement, a menstrual phase supplement, and a luteal phase supplement. The supplement set of the present invention can be packaged in a container such as a box, bag, can or bottle. The supplement set of the present invention may be a set for a plurality of units with one period as one unit, but is preferably a set for one period.

  The container containing the supplement set may contain instructions explaining how to use the supplement set of the present invention, or the usage may be described on the surface of the container.

(3. Method of taking supplement set of the present invention)
The supplement set of the present invention may be taken by women with dysmenorrhea or premenstrual syndrome. By taking the supplement set of the present invention, at least one symptom of dysmenorrhea and premenstrual syndrome is alleviated. When ingesting the supplement set of the present invention, a follicular phase supplement may be ingested during the follicular phase, a menstrual phase supplement during the menstrual phase, and a luteal phase supplement during the luteal phase. It is preferable not to take supplements for a period different from that period. That is, it is preferable not to take supplements for the follicular phase during the menstrual period. It is also preferable not to take supplements for two or more different times per day.

  In each period, the length of each period is preferably 1/3 or more, more preferably 1/2 or more, even more preferably 2/3 or more, and most preferably, supplements for each period are taken on all days. It is preferable.

  The upper limit of the number of days for taking supplements for each period is preferably the number of days in each period + 2 days, and more preferably the number of days in each period + 1 day. For example, if the menstrual period is 7 days, it is preferably a maximum of 9 days, more preferably a maximum of 8 days, and most preferably a maximum of 7 days. The same applies to the follicular stage. If the luteal phase is 14 days, it is preferably a maximum of 16 days, more preferably a maximum of 15 days, and most preferably a maximum of 14 days. As described above, the effect of the supplement set according to the present invention can be obtained even when there are one or two days of taking supplements that are not actually appropriate at the boundary between the respective periods.

  For example, for a woman whose menstrual cycle is 28 days, usually about 7 days are menstrual periods. Therefore, it is preferably taken for 2 days or more in the menstrual period, more preferably taken for 3 days or more, more preferably taken for 4 days or more, particularly preferably taken for 5 days or more, 6 Most preferably taken for more than a day. Menstrual supplements are preferably taken over 3 to 10 days of the menstrual period, depending on the length of one cycle of the menstrual cycle, that is, individual differences.

  For women with a menstrual cycle of 28 days, usually about 7 days is the follicular phase. Therefore, it is preferably taken for 2 days or more in the follicular phase, more preferably taken for 3 days or more, more preferably taken for 4 days or more, particularly preferably taken for 5 days or more, 6 Most preferably taken for more than a day. The supplement for the follicular phase varies depending on the length of one cycle of the menstrual cycle, that is, individual differences, but is usually preferably taken over 5 to 20 days in the follicular phase.

  For women with a menstrual cycle of 28 days, typically about 14 days is the luteal phase. Therefore, it is preferably taken for 4 days or more in the luteal phase, more preferably taken for 6 days or more, more preferably taken for 8 days or more, particularly preferably taken for 10 days or more, 12 Most preferably taken for more than a day. The supplement for the luteal phase is preferably taken over 12 to 17 days of the luteal phase, although it varies depending on the length of one cycle of the menstrual cycle, that is, individual differences.

  When taking the supplement of the supplement set of the present invention, the woman who takes it needs to recognize or be aware of the time when she is now and take an appropriate supplement. When you are in can be most accurately determined by measuring basal body temperature. For example, while menstrual blood is present, menstrual periods are taken, so menstrual supplements are taken. When the menstrual period is over, the follicular phase is entered, so supplements for the follicular phase are taken. The boundary between the follicular phase and the luteal phase is determined by an increase in basal body temperature after the date of ovulation. The luteal phase is from the day after ovulation to the next menstrual period.

  As a simpler intake method, the menstrual period is taken during menstrual blood, and the period from the end of menstruation to about 14 ± 2 days before the estimated menstrual period of the next menstrual cycle (for example, 14 days) is the follicular period The luteal phase may be 14 ± 2 days (for example, 14 days) before the estimated menstrual start date of the next menstrual cycle. For women whose menstrual cycle is not stable, the period during menstrual blood is taken as menstrual period, the period from the end of menstruation to the day before the day when premenstrual syndrome occurs is regarded as the follicular stage, and premenstrual syndrome develops The luteal phase may be from the first day to the day before the next menstrual start date. Since the boundary between the follicular phase and the luteal phase is often difficult to understand, the actual boundary and the type of supplement taken over several days (preferably 3 days or less, more preferably 2 days or less, and even more preferably 1 day or less) Even if they are inconsistent with each other, the reduction in the effect of the supplement set according to the present invention is within an allowable range.

  The supplement is preferably taken at a frequency of once or more per day, but may be taken once every two days, once every three days, once every four days, or the like. When ingesting once every two days, you may ingest for two days at a time. When ingested once every 3 days, you may ingest 2 days or 3 days at a time. When ingested once every 4 days, you may ingest 2 days, 3 days, or 4 days at a time. Since the absorption efficiency of vitamins becomes higher, it is more preferable to take it twice or more a day.

  The timing for taking the supplement is not particularly limited. It may be any of before meals, between meals, after meals, after getting up, before going to bed, and taking clothes. “Before a meal” means about 1 hour to about 30 minutes before a meal. The interval between meals is a period between meals. For example, the time between two meals after meals is between meals. “After meal” refers to about 30 minutes to about 1 hour after meal. The supplement of the present invention is preferably taken after meals. An appropriate dosage form can be selected depending on the timing of intake.

(Production Example 1: Manufacture of menstrual supplements)
As a supplement for menstrual periods, 200 mg of Hesperidin (product of Hayashibara; trade name Hesperidin PA-T) per 6 tablets, 82 mg of raspberry juice (made by Matsuura Pharmaceutical; trade name Raspberry juice extract), Hawthorn extract (made by Matsuura Pharmaceutical) Trade name: Hawthorn extract F) 2 mg, grape seed extract (Kikkoman; trade name Gravinol) 2 mg, calcium (Kyowa Hakko; trade name Dolomite) 160 mg, magnesium (Kyowa Hakko; trade name Dolomite) 80 mg, iron (product of Tomita Pharmaceutical; trade name: ferric pyrophosphate) 4 mg, vitamin B ₆ (product of BASF Takeda vitamin; product name vitamin B ₆ ) 1.5 mg, vitamin B ₁₂ (product of BASF Takeda vitamin; product) Name Vitamin B ₁₂ ) 2.4 μg, Vitamin C (BASF Takeda Vita) A tablet containing 100 mg of Min; trade name ascorbic acid) and 200 μg of folic acid (BASF Takeda Vitamin; trade name folic acid) was prepared and used as a daily intake. In the manufacture of tablets, sugar and corn starch were used as additives, granules were prepared using a fluidized bed granulator, and tableting was performed using a rotary tableting machine.

(Production Example 2: Production of supplement for follicular phase)
As supplements for the follicular phase, 13 mg of cystine (made by Kewpie; trade name EM powder 300), 210 μg of vitamin A (product of Sankyo; trade name dry vitamin A), β-carotene (made by Roche vitamin; trade name β-) per 6 tablets Carotene 10% CWS) 1000 μg, vitamin B ₆ (BASF Takeda Vitamin; trade name Vitamin B ₆ ) 1.5 mg, Vitamin B ₁₂ (BASF Takeda Vitamin; trade name Vitamin B ₁₂ ) 2.4 μg, Vitamin C (BASF Takeda Vitamin; trade name ascorbic acid) 200 mg, Vitamin E (Riken Vitamin; trade name powdered tocopherol) 50 mg, and folic acid (BASF Takeda Vitamin; trade name folic acid) 200 μg Daily intake. In the manufacture of tablets, sugar and corn starch were used as additives, granules were prepared using a fluidized bed granulator, and tableting was performed using a rotary tableting machine.

(Production Example 3: Production of supplement for luteal phase)
As a supplement for the luteal phase, 200 mg of theanine (made by Taiyo Kagaku; trade name Santheanine), 6 mg of soybean isoflavone (made by Fujikko; trade name Fujiflavone P10), calcium (made by NC Corporation; trade name) per 6 tablets ) 200 mg, Vitamin B ₆ (BASF Takeda Vitamin; trade name Vitamin B ₆ ) 3.0 mg, Vitamin B ₁₂ (BASF Takeda Vitamin; trade name Vitamin B ₁₂ ) 2.4 μg, Vitamin C (BASF Takeda Vitamin) A tablet containing 200 mg of product name: ascorbic acid (200 mg) and folic acid (BASF Takeda Vitamin; product name: folic acid) was prepared and used as a daily intake. In the manufacture of tablets, sugar and corn starch were used as additives, granules were prepared using a fluidized bed granulator, and tableting was performed using a rotary tableting machine.

(Example 1 and Comparative Example 1: Evaluation 1 of the supplement set of the present invention)
The effect of the supplement set of the present invention was evaluated by allowing the subject having at least one symptom of dysmenorrhea and premenstrual syndrome to take the supplement set of the present invention. For the evaluation, measurement of PMS memory score was used. In this evaluation, not only the luteal phase but also the menstrual and follicular phases were evaluated using the same evaluation items.

  Here, the PMS memory score is a total obtained by adding the scores of each symptom entered by each subject in the PMS memory for each symptom shown in Table 2 below.

  PMS memory was developed by the Menstrual Liaison Council and the Japan Family Planning Association for the diagnosis of PMS. It examines symptoms frequently associated with menstruation in Japanese women and attaches a list of them. It is a booklet created to record the daily symptoms and degree. Specifically, the symptom list includes 25 symptoms as physical symptoms, 15 symptoms as psychiatric symptoms, and 12 symptoms as social symptoms (Table 2), and subjects have 4 levels (0: no symptoms, 1: a little). No impact on daily life, 2: just enough to affect daily life, 3: vigorous). The PMS memory score is obtained by adding the scores of each symptom entered by the subject and totaling them. For example, if a subject complains of three symptoms on a day with a degree of 1, 3, and 3, respectively, the score for that day is 7 in total.

  The PMS memory can be used not only for PMS diagnosis but also for female physical condition recording. It is also used for food effect verification tests, and the effect is judged by comparing PMS memory scores such as intake period and non-intake period.

本評価においては、無処理の期間（月経期、卵胞期および黄体期）のＰＭＳメモリースコアの平均値に差が出ないように、被験者２４名を１２名づつ２群にわけた。これらの被験者は、月経周期の日数が比較的安定している（すなわち、周期ごとのばらつきが少ない）女性であった。

In this evaluation, 24 subjects were divided into 2 groups of 12 subjects so that there was no difference in the average value of PMS memory scores during the non-treatment period (menstrual period, follicular phase and luteal phase). These subjects were women whose menstrual cycle days were relatively stable (ie, less variable from cycle to cycle).

  The subjects in the Example 1 evaluation group included the menstrual supplement produced in Production Example 1 in the menstrual phase, the follicular phase supplement in Production Example 2 in the follicular phase, and the luteal phase supplement in Production Example 3 in the luteal phase. Ingested twice daily for each period.

  In the period corresponding to the follicular phase, the subjects in the Comparative Example 1 evaluation group received supplements once daily during each period in the same manner as in the Example 1 evaluation group, except that no supplements were taken.

  Through each menstrual cycle, increase / decrease of the value of each PMS memory in the menstrual period, the follicular phase, and the luteal phase during one supplement non-intake period and three supplement intake periods was confirmed.

  When taking supplements, subjects were determined that the bleeding period was menstrual, the follicle period was from the day following the menstrual period to the day of ovulation, and the day after the day of ovulation until the day before the beginning of the next menstrual cycle was determined as the luteal phase. I was asked to. The subjects were asked to adjust their basal body temperature by predicting from the number of days in their menstrual cycle that the next menstrual start date and that the luteal phase would begin about two weeks before that. When basal body temperature is measured while being conscious in this way, changes in physical condition tend to appear sensitively to changes in basal body temperature. Subjects were also asked to record which supplements were consumed at what time.

  As for the score of each period, the menstrual period is 7 days from the start date of menstruation, the follicular phase is 5 days from the start of menstruation to the 8th to 12th days, and the luteal phase is the score of 10 days from the start date of the next menstruation. And the average score for each period was obtained by dividing this total by the number of subjects.

  From the obtained average score, the symptom improvement rate by taking the supplement was calculated. The improvement rate of the symptom was obtained by the following formula (Equation 1) using the non-intake period (0th cycle) as a reference value.

数１に示される数式の利用した例として、次式（数２）をあげる。

The following formula (Formula 2) is given as an example using the formula shown in Formula 1.

これらの結果を以下の表３に示す。

These results are shown in Table 3 below.

この結果、月経期および黄体期のみにサプリメントを摂取すると、月経期および黄体期における月経困難症またはＰＭＳの症状の緩和が得られるが、卵胞期にはかえって症状が悪化する傾向があることがわかった。また、卵胞期にサプリメントを摂取すると、卵胞期の症状は複数の周期を経るほど症状が改善され、しかも、卵胞期のみならず月経期および黄体期の月経困難症またはＰＭＳの症状が飛躍的に改善されることがわかった。このことから、月経困難症またはＰＭＳの症状を感じたときだけでなく、不快症状のほとんどない卵胞期にも適切なサプリメントを摂取することが、これらの症状の緩和のために極めて重要であることがわかる。さらに、１周期だけでなく、２周期、３周期と長期にわたって本発明のサプリメントセットを摂取することによって、累積的に症状の緩和が見られることがわかった。このことから、本発明のサプリメントセットを、長期にわたり継続的に摂取することが好ましいことがわかった。

As a result, taking supplements only during the menstrual period and the luteal phase can relieve symptoms of dysmenorrhea or PMS during the menstrual period and the luteal phase, but it is found that the symptoms tend to worsen in the follicular phase. It was. In addition, when supplements are ingested during the follicular phase, the symptoms of the follicular phase improve as multiple cycles occur, and the symptoms of dysmenorrhea or PMS not only in the follicular phase but also in the menstrual and luteal phases are dramatically increased. I found it improved. From this, it is extremely important for alleviating these symptoms to take appropriate supplements not only when dysmenorrhea or PMS symptoms are felt, but also during the follicular phase when there are few unpleasant symptoms I understand. Furthermore, it was found that symptom relief was cumulatively observed by taking the supplement set of the present invention not only for one period but also for two or three periods. From this, it was found that it is preferable to continuously take the supplement set of the present invention over a long period of time.

  In particular, it is understood that dysmenorrhea and PMS are significantly improved by taking vitamin A, β-carotene and cystine during the follicular phase.

(Comparative Production Example 1: Production of a conventional supplement for preventing dysmenorrhea)
According to Examples 1 and 2 of Patent Document 1, a supplement for preventing dysmenorrhea was produced.

(Comparative Production Example 2: Production of conventional premenstrual syndrome prevention supplement)
According to Example 1 of Patent Document 2, a supplement for preventing premenstrual syndrome was produced.

(Example 2 and Comparative Example 2: Comparative evaluation of the supplement set of the present invention with a conventional supplement for preventing dysmenorrhea and a supplement for preventing premenstrual syndrome)
In order to compare the effect when the supplement set of the present invention was ingested with the effect when the conventional dysmenorrhea prevention supplement and the premenstrual syndrome prevention supplement were continuously ingested in the same manner as in Evaluation 1, And evaluated.

  First, in the same manner as in Example 1 and Comparative Example 1 (Evaluation 1), 13 subjects were selected so that there was no difference in the average PMS memory score during the non-treatment period (menstrual period, follicular phase and luteal phase). Divided into 2 groups of 6 and 7. These subjects were women whose menstrual cycle days were relatively stable (ie, less variable from cycle to cycle).

  Example 2 The subjects (6 subjects) in the evaluation group included the menstrual supplement produced in Production Example 1 in the menstrual phase, the follicular phase supplement in Production Example 2 in the follicular phase, and the luteal phase in Production Example 3. The supplements were taken twice daily during each period during the luteal phase.

  Comparative Example 2 In the evaluation group (7 subjects), 8.5 g of the supplement for dysmenorrhea produced in Comparative Example 1 was passed through the menstrual period, follicular phase, and luteal phase (that is, in Example 3 of Patent Document 1). Once a day each time) and 200 mg of the supplement for improving premenstrual syndrome produced in Comparative Example 2 (that is, the same amount as the amount consumed in Evaluation Example 1 of Patent Document 2) once a day I was ingested.

  Regarding the evaluation methods other than the supplements used, the increase / decrease in the numerical value of the PMS memory was confirmed in the same manner as in Evaluation 1, the score was tabulated, and the improvement rate was calculated.

  The results are shown in Table 4 below.

この結果、従来の月経困難症予防用サプリメントと月経前症候群予防用サプリメントとを併用して連続摂取するよりも、本発明のサプリメントセットを月経期、卵胞期および黄体期に合わせて適切に摂取する方が顕著に優れた改善率が得られることがわかった。特に、従来のサプリメントを併用して連続摂取した場合、長期間摂取しないと症状の改善が余り見られず、摂取１周期目にはほとんど改善されなかった。一方、本発明のサプリメントセットを用いれば、摂取１周期目であっても約３０％を超える改善率が得られ、その上、評価１と同様に、１周期だけでなく、２周期、３周期と長期にわたって本発明のサプリメントセットを摂取することによって、累積的に症状の緩和が見られる（例えば、摂取６周期目では約６０％を超える改善率が得られる）ことがわかった。このことから、本発明のサプリメントセットを、長期にわたり継続的に摂取することが好ましいことがわかった。

As a result, the supplement set of the present invention is appropriately ingested according to the menstrual period, follicular phase, and luteal phase, rather than continuously ingesting a conventional supplement for preventing dysmenorrhea and a supplement for preventing premenstrual syndrome. It was found that the improvement rate was significantly superior. In particular, in the case of continuous ingestion in combination with conventional supplements, symptom was not improved much if not ingested for a long period of time, and it was hardly improved in the first ingestion period. On the other hand, if the supplement set of the present invention is used, an improvement rate exceeding about 30% can be obtained even in the first intake period, and in addition, as in evaluation 1, not only one period but also two periods, three periods. It was found that by taking the supplement set of the present invention over a long period of time, the symptoms alleviated cumulatively (for example, an improvement rate of more than about 60% is obtained in the 6th intake cycle). From this, it was found that it is preferable to continuously take the supplement set of the present invention over a long period of time.

  In addition, when taken in combination with conventional supplements, the follicular phase symptoms worsened or hardly improved, but when the supplement set of the present invention was taken, the follicular phase symptoms were also dramatically improved. It was. From these facts, it was found that the supplement set of the present invention has a remarkably excellent effect even when compared with simply using a conventional supplement for preventing dysmenorrhea and a supplement for preventing premenstrual syndrome. . Therefore, it was found that it is important to take appropriate supplements at each period such as menstrual period, follicular phase and luteal phase.

The present invention provides a supplement set that can alleviate these symptoms for women suffering from at least one of dysmenorrhea and premenstrual syndrome.

Claims (11)

A supplement set for alleviating at least one symptom of dysmenorrhea and premenstrual syndrome, the supplement set comprising a follicular phase supplement, a menstrual phase supplement, and a luteal phase supplement, the supplement for follicular phase A supplement set in which the composition of the menstrual supplement and the composition of the supplement for the luteal phase are different from each other. The supplement set according to claim 1, wherein the supplement for follicular phase comprises at least one of vitamin A, β-carotene and cystine. The supplement set according to claim 1, wherein the follicular stage supplement comprises cystine, vitamin A, β-carotene, vitamin B ₆ , vitamin B ₁₂ , vitamin C, vitamin E, and folic acid. The supplement for follicular phase contains 5 mg to 100 mg of cystine, 100 μg to 1500 μg of vitamin A, 600 μg to 9000 μg of β-carotene, 0.5 mg to 3.0 mg of vitamin B in the daily intake. _6. The supplement set according to claim 1, comprising 0.8 to 4.8 μg of vitamin B ₁₂ , 30 to 2000 mg of vitamin C, 3 to 100 mg of vitamin E, and 70 to 400 μg of folic acid. The supplement set according to claim 1, wherein the menstrual supplement includes at least one of hesperidin, raspberry juice, hawthorn extract and grape seed extract. Supplements for the menstrual period includes hesperidin, raspberry juice, hawthorn extract, grape seed extract, calcium, magnesium, iron, vitamin B _6, vitamin B _12, vitamin C and folic acid supplements set according to claim 1 . The menstrual supplement contains 100 mg or more and 3000 mg or less hesperidin, 20 mg or more and 200 mg or less raspberry juice, 2 mg or more and 50 mg or less hawthorn extract, 1 mg or more and 1000 mg or less grape seed extract, 100 mg per day. 1000 mg or less calcium, 50 mg or more and 300 mg or less magnesium, 2 mg or more and 12 mg or less iron, 0.5 mg or more and 3.0 mg or less vitamin B ₆ , 0.8 μg or more and 4.8 μg or less vitamin B ₁₂ , 30 mg or more and 2000 mg or less The supplement set according to claim 1, comprising vitamin C, and 70 μg or more and 400 μg or less of folic acid. The supplement set according to claim 1, wherein the luteal phase supplement comprises theanine. The supplement set according to claim 1, wherein the luteal phase supplement comprises theanine, soy isoflavone, calcium, vitamin B ₆ , vitamin B ₁₂ , vitamin C and folic acid. The luteal phase supplement contains 70 mg or more and 400 mg or less of theanine, 7 mg or more and 30 mg or less of soy isoflavone, 100 mg or more and 1000 mg or less of calcium, 0.5 mg or more and 3.0 mg or less of vitamin B ₆ in the daily intake. The supplement set according to claim 10, comprising 0.8 μg or more and 4.8 μg or less of vitamin B ₁₂ , 30 mg or more and 2000 mg or less of vitamin C, and 70 μg or more and 400 μg or less of folic acid. A supplement for follicular phase for alleviating at least one symptom of dysmenorrhea and premenstrual syndrome, wherein the supplement is taken only in the follicular phase.