JP2004250354A5 - - Google Patents
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- Publication number
- JP2004250354A5 JP2004250354A5 JP2003040593A JP2003040593A JP2004250354A5 JP 2004250354 A5 JP2004250354 A5 JP 2004250354A5 JP 2003040593 A JP2003040593 A JP 2003040593A JP 2003040593 A JP2003040593 A JP 2003040593A JP 2004250354 A5 JP2004250354 A5 JP 2004250354A5
- Authority
- JP
- Japan
- Prior art keywords
- achillea
- weight
- extract
- yarrow
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000722941 Achillea Species 0.000 description 17
- 240000000073 Achillea millefolium Species 0.000 description 17
- 239000003112 inhibitor Substances 0.000 description 16
- 210000002752 melanocyte Anatomy 0.000 description 16
- 210000001787 dendrite Anatomy 0.000 description 13
- 239000002537 cosmetic Substances 0.000 description 12
- 235000007754 Achillea millefolium Nutrition 0.000 description 11
- 241000196324 Embryophyta Species 0.000 description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 6
- 102000003425 Tyrosinase Human genes 0.000 description 5
- 108060008724 Tyrosinase Proteins 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- 244000178848 Achillea moschata Species 0.000 description 3
- 235000015235 Achillea moschata Nutrition 0.000 description 3
- 244000013628 Achillea ptarmica Species 0.000 description 3
- 241000783415 Achillea salicifolia Species 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 208000012641 Pigmentation disease Diseases 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 101710147108 Tyrosinase inhibitor Proteins 0.000 description 3
- 230000008099 melanin synthesis Effects 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 241000544602 Ageratum Species 0.000 description 2
- 241000208838 Asteraceae Species 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- -1 for example Substances 0.000 description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- TZIHFWKZFHZASV-UHFFFAOYSA-N methyl formate Chemical compound COC=O TZIHFWKZFHZASV-UHFFFAOYSA-N 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 241000894007 species Species 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- PAFJZWHXMSQJKV-UQZRNVAESA-N (3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol;octadecanoic acid Chemical compound OC[C@@H](O)C1OC[C@H](O)[C@H]1O.OC[C@@H](O)C1OC[C@H](O)[C@H]1O.OC[C@@H](O)C1OC[C@H](O)[C@H]1O.CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O PAFJZWHXMSQJKV-UQZRNVAESA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 241000402754 Erythranthe moschata Species 0.000 description 1
- 241001539176 Hime Species 0.000 description 1
- 241000409208 Packera millefolia Species 0.000 description 1
- 241000207929 Scutellaria Species 0.000 description 1
- 206010040829 Skin discolouration Diseases 0.000 description 1
- 244000062793 Sorghum vulgare Species 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229960000271 arbutin Drugs 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229940067596 butylparaben Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 235000019713 millet Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003040593A JP4262494B2 (ja) | 2003-02-19 | 2003-02-19 | メラノサイトのデンドライト伸長抑制剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003040593A JP4262494B2 (ja) | 2003-02-19 | 2003-02-19 | メラノサイトのデンドライト伸長抑制剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008259152A Division JP2009046503A (ja) | 2008-10-06 | 2008-10-06 | メラノサイトのデンドライトの伸長抑制剤の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004250354A JP2004250354A (ja) | 2004-09-09 |
| JP2004250354A5 true JP2004250354A5 (https=) | 2006-03-16 |
| JP4262494B2 JP4262494B2 (ja) | 2009-05-13 |
Family
ID=33024414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003040593A Expired - Lifetime JP4262494B2 (ja) | 2003-02-19 | 2003-02-19 | メラノサイトのデンドライト伸長抑制剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4262494B2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4499543B2 (ja) * | 2003-12-15 | 2010-07-07 | 株式会社クラレ | 皮膚外用剤 |
| US7795300B2 (en) | 2003-12-15 | 2010-09-14 | Kuraray Co., Ltd. | External preparation for skin |
| JP2008520588A (ja) * | 2004-11-18 | 2008-06-19 | ビオファーマコペ デジン アンテルナショナル インク． | 植物抽出物およびその皮膚科使用法 |
| KR100823078B1 (ko) * | 2006-12-12 | 2008-04-18 | (주)아모레퍼시픽 | 파그라에아 추출물을 함유한 화장료 조성물 |
| EP2165694B8 (en) | 2007-05-29 | 2017-11-08 | Pola Chemical Industries Inc. | Vesicle useful for external preparation for skin, and external preparation for skin comprising the vesicle |
| JP6242575B2 (ja) * | 2013-01-09 | 2017-12-06 | 御木本製薬株式会社 | デンドライト伸長抑制剤 |
| JP6144962B2 (ja) * | 2013-05-10 | 2017-06-07 | 富士産業株式会社 | 頭皮用育毛剤 |
| JP6454097B2 (ja) * | 2013-07-05 | 2019-01-16 | 御木本製薬株式会社 | デンドライト伸長抑制剤及び美白用化粧料 |
| EP3615147B1 (de) | 2017-04-28 | 2024-09-11 | Symrise AG | Schafgarbe frischpflanzenpresssaft konzentrat, herstellung und verwendung |
| FR3158236A1 (fr) * | 2024-01-11 | 2025-07-18 | Mavilef Holdings Pte Ltd | Composition cosmétique pour éclaircir ou blanchir la peau |
-
2003
- 2003-02-19 JP JP2003040593A patent/JP4262494B2/ja not_active Expired - Lifetime
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