JP2004167284A - 空気より得る医療用一酸化窒素 - Google Patents
空気より得る医療用一酸化窒素 Download PDFInfo
- Publication number
- JP2004167284A JP2004167284A JP2004077201A JP2004077201A JP2004167284A JP 2004167284 A JP2004167284 A JP 2004167284A JP 2004077201 A JP2004077201 A JP 2004077201A JP 2004077201 A JP2004077201 A JP 2004077201A JP 2004167284 A JP2004167284 A JP 2004167284A
- Authority
- JP
- Japan
- Prior art keywords
- air
- nitric oxide
- gas
- arc chamber
- arc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
- B01D53/34—Chemical or biological purification of waste gases
- B01D53/46—Removing components of defined structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
- A61M15/0016—Details of inhalators; Constructional features thereof with inhalation check valves located downstream of the dispenser, i.e. traversed by the product
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
- B01D53/34—Chemical or biological purification of waste gases
- B01D53/46—Removing components of defined structure
- B01D53/54—Nitrogen compounds
- B01D53/56—Nitrogen oxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0266—Nitrogen (N)
- A61M2202/0275—Nitric oxide [NO]
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Environmental & Geological Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Anesthesiology (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Respiratory Apparatuses And Protective Means (AREA)
- Treating Waste Gases (AREA)
- Oxygen, Ozone, And Oxides In General (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
Abstract
【解決手段】アークチャンバ(4)は、エアーギャップ(9)で隔てられている電極(5)を有する。電気回路(7)は、電極(5)に高電圧を供給し、電極(5)の間にアーク放電が誘電される。アーク放電により空気と一酸化窒素の混合気体が発生する。一酸化窒素と空気の混合気体は、浄化され、他の気体及び/または肺血管治療薬と混合されて、治療に効果のある混合気体として、特定の付属品を使用して人体の種々の器官に供給される。
【選択図】図1
Description
試験ユニットの性能が図6と図7に示されている。この場合、電極間のギャップは3mmと5mmである。1リットル/分から10リットル/分の範囲で、異なった流量(V)で空気をアークチャンバに導入する。高電圧変圧器の一次コイルの電流を250μA〜1.25mAの範囲で変動させて、高電圧発生回路に供給される電力を増加させる。アークチャンバからの出力は、NOx化学発光ガス分析装置に導入され、異なった濃度の酸化窒素を得る。
気管を切開した30キロの雄のドーセット羊に、7Fr肺血管スワンーガンツーカテーテルと大腿骨動脈ラインを取り付けて、肺血管と全身の動脈の血圧を連続的に監視した。覚醒中の羊に0.6μg/kg/minのU46619(アップジョーン社製)を常時注入した。これは急性の肺血管収縮と高血圧を起こすことができる安定したトロンボキサン(thromboxane)類似体である。U46619注入は、肺動脈血管の圧力(PAP)を平均基準値の19mmHgから79%増加して、33mmHgにした。図4のものと同じアークと回路を使用して、空気と一酸化窒素の混合気体を作った。空気中の一酸化窒素を10ppm吸収後、直ちにPAPが25%減って25mmHgになり、5ミリのエアーギャップ内での高電圧直流スパークによって電気的に発生された一酸化窒素の血管弛緩作用が確認された。図8は、平均PAPの吸入された一酸化窒素の濃度レベル別の依存性を示している。なお、これは化学発光によって測定された。スパーク電流を増加して吸入された一酸化窒素の濃度を15ppmにすると、PAPは23mmHgのレベルに低下した。吸入される一酸化窒素を40ppmにさらに増加させると、PAPはさらに低下して、18mmHgのU46619を注入しなくても基準線のレベルに達した。その後、空気のみが羊の肺に送り込まれ、注入されたU46619の反作用がないため、PAPは34mmHgに達した。この一酸化窒素の吸入試験の間、全身的動脈の圧力(SAP)は94mmHgで一定していた。SAPが一定していたという事実は、吸入された一酸化窒素が肺血管の局部的弛緩剤として作用することを証明するものである。
Claims (11)
- 器官の治療用の空気と一酸化窒素の混合気体を直接供給するために空気と一酸化窒素の混合気体を空気と電源を使って発生する方法であって、
空気取入口から空気を吸入器のアークチャンバへ導入する工程と、
エアーギャップによって隔てられ前記アークチャンバに設けられている一組の電極に、前記エアーギャップ内でアークを誘起させるのに十分なピーク値を有する高電圧電位を供給する工程と、
前記高電圧電位に帯電された電極間でアーク放電を起こして一酸化窒素を発生させる工程と、
前記発生された混合気体を吐出口を介して吐出する工程と、を有することを特徴とする一酸化窒素と空気の混合気体の発生方法。 - 取入口から導入された前記空気を瀘過して、前記アークチャンバへの液滴あるいは個体粒子の侵入を防止する工程をさらに含むことを特徴とする請求項1に記載の方法。
- 前記アークチャンバからの気体を瀘過して、前記アーク放電中に酸化窒素及びオゾンを除去する工程をさらに含むことを特徴とする請求項1に記載の方法。
- 前記アークチャンバからの一酸化窒素と空気の混合気体に、一組の選択可能な開口を有する空気取入アッセンブリを介して導入された空気を混合する工程をさらに含むことを特徴とする請求項1に記載の方法。
- 前記アークチャンバからの気体を浄化して、アーク放電中に二酸化窒素及びオゾンを除去する工程をさらに含むことを特徴とする請求項1に記載の方法。
- 前記混合気体を前記吐出口を介してガスポンプに強制的に送出する工程をさらに含むことを特徴とする請求項1に記載の方法。
- 器官の治療用の空気と一酸化窒素の混合気体を直接供給するために、
空気と一酸化窒素の混合気体を空気と電源を使って発生する方法であって、
空気取入口から空気を吸入器のアークチャンバへ導入する工程と、
エアーギャップによって隔てられ前記アークチャンバに設けられている一組の電極に、前記エアーギャップ内にアークを誘起させるのに十分なピーク値を有する高電圧電位を供給する工程と、
前記高電圧電位に帯電された電極間でアーク放電を起こして一酸化窒素を発生させる工程と、
前記発生された一酸化窒素と空気の混合気体を、特定の器官に供給するための供給装置を介して供給する工程と、を有することを特徴とする空気と一酸化窒素の発生方法。 - 前記一酸化窒素は特定の器官に供給されることを特徴とする請求項7に記載の方法。
- 気体取入マニフォールドを介して選択された気体を導入し、この選択された気体を前記発生された一酸化窒素と空気の混合気体と混合し、前記供給装置を介して混合気体を供給する工程をさらに含むことを特徴とする請求項7に記載の方法。
- 前記供給装置によって供給される混合気体の個々の成分を分析する工程と、
ガス分析装置と前記気体取入マニフォーフルドに接続された調整器を使用して前記供給装置に導入される混合気体の個々の構成要素の濃度を、処方箋に従って調整する工程をさらに含むことを特徴とする請求項9に記載の方法。 - 前記混合気体に追加の気体をさらに添加する工程を含むことを特徴とする請求項1に記載の方法。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/850,383 US5396882A (en) | 1992-03-11 | 1992-03-11 | Generation of nitric oxide from air for medical uses |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51606693A Division JP3573455B2 (ja) | 1992-03-11 | 1993-03-08 | 空気より得る医療用一酸化窒素 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2004167284A true JP2004167284A (ja) | 2004-06-17 |
JP3792701B2 JP3792701B2 (ja) | 2006-07-05 |
Family
ID=25307968
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51606693A Expired - Fee Related JP3573455B2 (ja) | 1992-03-11 | 1993-03-08 | 空気より得る医療用一酸化窒素 |
JP2004077201A Expired - Fee Related JP3792701B2 (ja) | 1992-03-11 | 2004-03-17 | 一酸化窒素と空気の混合気体の発生方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51606693A Expired - Fee Related JP3573455B2 (ja) | 1992-03-11 | 1993-03-08 | 空気より得る医療用一酸化窒素 |
Country Status (16)
Country | Link |
---|---|
US (1) | US5396882A (ja) |
EP (1) | EP0630270B1 (ja) |
JP (2) | JP3573455B2 (ja) |
AT (1) | ATE242022T1 (ja) |
AU (1) | AU3925093A (ja) |
BR (1) | BR9306060A (ja) |
CA (1) | CA2117691C (ja) |
DE (1) | DE69333015T2 (ja) |
DK (1) | DK0630270T3 (ja) |
ES (1) | ES2196006T3 (ja) |
FI (1) | FI110922B (ja) |
MX (1) | MX9301357A (ja) |
NO (1) | NO310961B1 (ja) |
PT (1) | PT630270E (ja) |
TW (1) | TW242117B (ja) |
WO (1) | WO1993017741A1 (ja) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006273677A (ja) * | 2005-03-30 | 2006-10-12 | Kumamoto Univ | No発生装置 |
JP2015110642A (ja) * | 2006-11-07 | 2015-06-18 | ザ ジェネラル ホスピタル コーポレイション | 血管作動性酸素運搬体に誘導される血管収縮の減弱 |
KR20150127279A (ko) * | 2013-03-15 | 2015-11-16 | 더 제너럴 하스피탈 코포레이션 | 흡입용 산화질소의 합성 |
KR20150133775A (ko) * | 2013-03-15 | 2015-11-30 | 더 제너럴 하스피탈 코포레이션 | 산화질소의 흡기 합성 |
JP2016516480A (ja) * | 2013-03-13 | 2016-06-09 | イノ セラピューティックス エルエルシー | 一酸化窒素の送達による治療の最中に酸素化を監視する装置および方法 |
US10426913B2 (en) | 2011-11-07 | 2019-10-01 | Mallinckrodt Hospital Products IP Limited | Apparatus and method for monitoring nitric oxide delivery |
WO2020084994A1 (ja) | 2018-10-25 | 2020-04-30 | 帝人ファーマ株式会社 | 一酸化窒素投与装置 |
WO2020084992A1 (ja) | 2018-10-25 | 2020-04-30 | 帝人ファーマ株式会社 | 一酸化窒素投与装置 |
WO2020084993A1 (ja) | 2018-10-25 | 2020-04-30 | 帝人ファーマ株式会社 | 一酸化窒素投与装置 |
WO2020084995A1 (ja) | 2018-10-25 | 2020-04-30 | 帝人ファーマ株式会社 | 中継投与装置及び一酸化窒素投与システム |
US10773046B2 (en) | 2011-11-07 | 2020-09-15 | Mallinckrodt Hospital Products IP Limited | Apparatus and method for monitoring nitric oxide delivery |
KR102227464B1 (ko) * | 2020-08-03 | 2021-03-12 | 한국핵융합에너지연구원 | 질소산화물을 제어하는 방법 및 장치, 그리고 질소산화물 함유 수 제조 방법 |
JP2022502172A (ja) * | 2018-09-27 | 2022-01-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | ガス送達デバイス |
JP2022169537A (ja) * | 2017-02-27 | 2022-11-09 | サード ポール,インコーポレイテッド | 酸化窒素の移動式生成システムおよび方法 |
JP2023059931A (ja) * | 2014-10-20 | 2023-04-27 | ザ ジェネラル ホスピタル コーポレイション | 一酸化窒素の合成のためのシステム及び方法 |
WO2023096321A1 (ko) * | 2021-11-23 | 2023-06-01 | 한국핵융합에너지연구원 | 플라즈마를 이용한 고순도 no2 가스 발생장치 및 플라즈마 이용 질산태 기반의 고농도 활성수 및 비료수 제조장치 |
Families Citing this family (121)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5570683A (en) * | 1990-12-05 | 1996-11-05 | The General Hospital Corporation | Methods and devices for treating pulmonary vasoconstriction and asthma |
DE122008000012I2 (de) * | 1990-12-05 | 2012-04-12 | Gen Hospital Corp | Vorrichtung zum Behandeln einen Lungengefassverengung und von Asthma. |
US5536241A (en) * | 1990-12-05 | 1996-07-16 | The General Hospital Corporation | Methods and devices for relaxing smooth muscle contractions |
US5814666A (en) * | 1992-04-13 | 1998-09-29 | The United States As Represented By The Department Of Health And Human Services | Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents |
FR2695831B1 (fr) * | 1992-09-24 | 1994-11-10 | Air Liquide | Installation et procédé de fourniture d'un mélange gazeux aux voies respiratoires d'un utilisateur. |
US6880554B1 (en) * | 1992-12-22 | 2005-04-19 | Battelle Memorial Institute | Dispensing device |
DE59409834D1 (de) * | 1993-04-17 | 2001-09-27 | Messer Griesheim Austria Ges M | Gerät zur kontrollierten Zudosierung von NO zur Atemluft von Patienten |
DE69423905T2 (de) * | 1993-07-06 | 2000-10-05 | Aerocrine Ab, Danderyd | System zur feststellung von no-pegeln in ausgeatmeter luft und diagnostische verfahren für zu abnormalen no-pegeln in beziehung stehenden abweichungen |
GB9320978D0 (en) * | 1993-10-12 | 1993-12-01 | Higenbottam Timohy W | Nitric oxide treatment |
US6063407A (en) * | 1995-02-16 | 2000-05-16 | The General Hospital Corporation | Treatment of vascular thrombosis and restenosis with inhaled nitric oxide |
US5823180A (en) * | 1995-04-03 | 1998-10-20 | The General Hospital Corporation | Methods for treating pulmonary vasoconstriction and asthma |
DE29512163U1 (de) * | 1995-07-28 | 1995-10-19 | VHG Versandhandelsgesellschaft mbH, 56581 Ehlscheid | Einrichtung zum Ionisieren von Gasen |
EP0768095B1 (en) * | 1995-10-13 | 2001-12-19 | Siemens-Elema AB | Tracheal tube and device for ventilator systems |
US5873523A (en) * | 1996-02-29 | 1999-02-23 | Yale University | Electrospray employing corona-assisted cone-jet mode |
US5699790A (en) * | 1996-03-21 | 1997-12-23 | Ohmeda Inc. | System for predicting NO2 concentrations |
US5692495A (en) * | 1996-04-02 | 1997-12-02 | The Boc Group, Inc. | Method and apparatus for the production of nitric oxide gas mixture |
US5765548A (en) * | 1996-05-07 | 1998-06-16 | Perry; Bryan J. | Use of nitric oxide in the treatment of exercised induced pulmonary hemorrhaging in equine |
PT973443E (pt) | 1997-01-17 | 2006-08-31 | Ino Therapeutics Gmbh | Sistema comandado de fornecimento de gas |
CA2225013C (en) | 1997-04-04 | 2006-06-06 | Institut Du N.O. Inc. | Injection system for delivery of a gaseous substance |
US5827420A (en) * | 1997-07-29 | 1998-10-27 | World Precision Instruments, Inc. | Method and apparatus for the generation of nitric oxide |
US6656452B1 (en) | 1997-10-21 | 2003-12-02 | The General Hospital Corporation | Use of inhaled NO as anti-inflammatory agent |
US6109260A (en) * | 1998-02-18 | 2000-08-29 | Datex-Ohmeda, Inc. | Nitric oxide administration device with timed pulse |
DE19823748C2 (de) * | 1998-05-27 | 2000-05-18 | Siemens Ag | Verfahren und Vorrichtung zur plasmachemischen Erzeugung von Stickstoffmonoxid |
US20070086954A1 (en) * | 1998-11-23 | 2007-04-19 | Miller Christopher C | Method and apparatus for treatment of respiratory infections by nitric oxide inhalation |
CA2254645A1 (en) * | 1998-11-23 | 2000-05-23 | Pulmonox Medical Corporation | Method and apparatus for treatment of respiratory infections by nitric oxide inhalation |
DE29907307U1 (de) * | 1999-04-24 | 1999-07-29 | Büttner, Klaus, 25336 Klein Nordende | Vorrichtung zur Erzeugung eines Aerosols für therapeutische Zwecke |
US6694969B1 (en) * | 1999-09-22 | 2004-02-24 | Instrumentarium Corp. | Method to improve oxygenation in subjects suffering impaired oxygenation |
US7516742B2 (en) * | 1999-11-24 | 2009-04-14 | Cardinal Health 207, Inc. | Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing |
US6758214B2 (en) | 2000-01-28 | 2004-07-06 | Cyterra Corporation | Simple nitric oxide generator for ambulatory and/or bedside inhaled no treatment |
US6601580B1 (en) | 2000-06-28 | 2003-08-05 | The General Hospital Corporation | Enhancing therapeutic effectiveness of nitric oxide inhalation |
BRPI0113085B1 (pt) * | 2000-08-11 | 2017-09-19 | R. Whitlock David | Preparation to be applied to a surface of an individual understanding ammonia oxidizing bacteria that metabolize transparation, and clothing article |
US7335181B2 (en) * | 2000-12-26 | 2008-02-26 | Pulmonox Technologies Corporation | Nitric oxide decontamination of the upper respiratory tract |
US7122018B2 (en) * | 2000-12-26 | 2006-10-17 | Sensormedics Corporation | Device and method for treatment of wounds with nitric oxide |
US6432077B1 (en) | 2000-12-26 | 2002-08-13 | Sensormedics Corporation | Device and method for treatment of surface infections with nitric oxide |
RU2183474C1 (ru) * | 2001-02-09 | 2002-06-20 | Пекшев Александр Валерьевич | Способ и устройство для формирования no-содержащего газового потока для воздействия на биологический объект |
EP1395241B9 (en) * | 2001-05-25 | 2005-06-15 | Medtronic, Inc. | Implantable medical device with controllable gaseous agent release system |
WO2003000114A2 (en) | 2001-06-21 | 2003-01-03 | Beth Israel Deaconess Medical Center | Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis |
US7040313B2 (en) * | 2001-09-05 | 2006-05-09 | Cyterra Corporation | Method and apparatus for nitric oxide generation |
GB0125222D0 (en) * | 2001-10-19 | 2001-12-12 | Barts & London Nhs Trust | Composition for the treatment of microbial infections |
AU2003222569A1 (en) * | 2002-01-11 | 2003-07-24 | Whitlock, David R. | Compositions including ammonia oxidizing bacteria and methods of using same |
US7531133B2 (en) * | 2002-09-10 | 2009-05-12 | Pulmonox Technologies Corporation | Use of nitric oxide gas in an extracorporeal circuitry to treat blood plasma |
US20100170505A1 (en) * | 2002-11-15 | 2010-07-08 | Speight Bryan Barker | Device for enhancing well-being |
WO2005007173A1 (en) * | 2003-07-09 | 2005-01-27 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health | Use of nitrite salts for the treatment of cardiovascular conditions |
WO2005077005A2 (en) * | 2004-02-04 | 2005-08-25 | The General Hospital Corporation | Enhancing the effectiveness of an inhaled therapeutic gas |
MXPA06013111A (es) * | 2004-05-11 | 2007-05-23 | Sensormedics Corp | Dosificacion intermitente de gas de oxido nitrico. |
US8518457B2 (en) * | 2004-05-11 | 2013-08-27 | Pulmonox Technologies Corporation | Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant |
US7362274B1 (en) * | 2004-07-09 | 2008-04-22 | Huan-Cheng Lien | Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna |
CA2576957C (en) | 2004-08-18 | 2013-04-02 | Geno Llc | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
US7618594B2 (en) | 2004-08-18 | 2009-11-17 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
US20070154570A1 (en) * | 2004-09-29 | 2007-07-05 | Miller Christopher C | Use of nitric oxide in the treatment and disinfection of biofilms |
US8557300B2 (en) * | 2005-05-19 | 2013-10-15 | University Of Cincinnati | Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite |
SE529058C2 (sv) * | 2005-07-08 | 2007-04-17 | Plasma Surgical Invest Ltd | Plasmaalstrande anordning, plasmakirurgisk anordning, användning av en plasmakirurgisk anordning och förfarande för att bilda ett plasma |
SE529053C2 (sv) * | 2005-07-08 | 2007-04-17 | Plasma Surgical Invest Ltd | Plasmaalstrande anordning, plasmakirurgisk anordning och användning av en plasmakirurgisk anordning |
SE529056C2 (sv) | 2005-07-08 | 2007-04-17 | Plasma Surgical Invest Ltd | Plasmaalstrande anordning, plasmakirurgisk anordning och användning av en plasmakirurgisk anordning |
US20070116785A1 (en) * | 2005-11-18 | 2007-05-24 | Miller Christopher C | Nitric oxide as an anti-viral agent, vaccine and vaccine adjuvant |
US8790715B2 (en) | 2006-02-16 | 2014-07-29 | Ino Therapeutics Llc | Method and apparatus for generating nitric oxide for medical use |
GB0607402D0 (en) * | 2006-04-12 | 2006-05-24 | Barts & London Nhs Trust | Therapeutic composition and use |
EP1903003B1 (de) | 2006-07-05 | 2017-07-05 | BSN medical GmbH | Verfahren zur photolytischen Erzeugung von Stickstoffmonoxid |
WO2008012845A1 (en) * | 2006-07-26 | 2008-01-31 | Stmicroelectronics S.R.L. | Use of nitroaniline derivatives for the production of nitric oxide |
US8079998B2 (en) * | 2006-10-20 | 2011-12-20 | Pulmonox Technologies Corporation | Methods and devices for the delivery of therapeutic gases including nitric oxide |
US7928338B2 (en) * | 2007-02-02 | 2011-04-19 | Plasma Surgical Investments Ltd. | Plasma spraying device and method |
US20080193566A1 (en) * | 2007-02-09 | 2008-08-14 | Miller Christopher C | Use of high dose concentrations of gaseous nitric oxide |
JP5575489B2 (ja) | 2007-03-23 | 2014-08-20 | ゲノ エルエルシー | 二酸化窒素(no2)から酸化窒素(no)への変換 |
US10207927B2 (en) * | 2007-04-26 | 2019-02-19 | Ludlum Measurements, Inc. | Method to produce a calibration, reagent or therapeutic gas by exposing a precursor gas to ultraviolet light |
EP3062589B1 (en) | 2007-08-06 | 2024-08-28 | Plasma Surgical, Inc. | Method of generating a pulsed plasma |
US8735766B2 (en) * | 2007-08-06 | 2014-05-27 | Plasma Surgical Investments Limited | Cathode assembly and method for pulsed plasma generation |
US7589473B2 (en) * | 2007-08-06 | 2009-09-15 | Plasma Surgical Investments, Ltd. | Pulsed plasma device and method for generating pulsed plasma |
EP2237788A4 (en) * | 2007-12-27 | 2013-06-05 | Aires Pharmaceuticals Inc | COMPOUNDS FOR OBTAINING AEROSOLIZED NITRITE AND NITRIC OXIDE AND USES THEREOF |
WO2009093169A1 (en) * | 2008-01-22 | 2009-07-30 | Koninklijke Philips Electronics N.V. | Device for the topical delivery of nitric oxide to a skin surface |
CA2713049C (en) * | 2008-01-28 | 2017-02-28 | Geno Llc | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
US8607785B2 (en) | 2008-08-21 | 2013-12-17 | Geno Llc | Systems and devices for generating nitric oxide |
US10780241B2 (en) | 2008-08-21 | 2020-09-22 | Vero Biotech LLC | Devices and methods for minimizing and treating high-altitude sickness |
DE102009013396B3 (de) * | 2009-03-16 | 2010-08-05 | Dräger Medical AG & Co. KG | Vorrichtung und Verfahren zur Steuerung der Sauerstoffdosierung eines Beatmungsgerätes |
WO2010107744A1 (en) | 2009-03-16 | 2010-09-23 | Drexel University | Apparatus for atmospheric pressure pin-to-hole spark discharge and uses thereof |
JP5878866B2 (ja) | 2009-06-22 | 2016-03-08 | ゲノ エルエルシー | 一酸化窒素治療 |
WO2011063335A1 (en) * | 2009-11-20 | 2011-05-26 | Geno Llc | Nitric oxide delivery system |
EP2516329B1 (en) | 2009-12-23 | 2015-07-29 | Koninklijke Philips N.V. | Method for generating nitric oxide |
US8613742B2 (en) * | 2010-01-29 | 2013-12-24 | Plasma Surgical Investments Limited | Methods of sealing vessels using plasma |
WO2011094684A1 (en) * | 2010-02-01 | 2011-08-04 | Geno Llc | Nitric oxide delivery system |
JP5581500B2 (ja) * | 2010-03-10 | 2014-09-03 | 学校法人北里研究所 | 虚血再灌流障害軽減用治療剤および治療装置 |
AU2011245476B2 (en) | 2010-04-26 | 2016-05-12 | VERO Biotech LLC. | Delivery of ultra pure nitric oxide (NO) |
US9089319B2 (en) | 2010-07-22 | 2015-07-28 | Plasma Surgical Investments Limited | Volumetrically oscillating plasma flows |
CN103140438B (zh) | 2010-09-22 | 2016-06-29 | 皇家飞利浦电子股份有限公司 | 产生一氧化氮的方法 |
GB201116271D0 (en) * | 2011-09-21 | 2011-11-02 | Univ Cardiff | Dispersion anaesthetic device |
ES2768250T5 (es) | 2011-10-03 | 2023-12-21 | Nitricgen Inc | Aparato y método para generar óxido nítrico en cantidades controladas y precisas |
WO2013070592A1 (en) | 2011-11-07 | 2013-05-16 | The General Hospital Corporation | Treatment of red blood cells |
CN104394923B (zh) | 2012-03-30 | 2017-07-14 | 密执安大学评议会 | 一氧化氮递送装置 |
US10449321B2 (en) | 2012-03-30 | 2019-10-22 | The Regents Of The University Of Michigan | Gas delivery devices |
US9480785B2 (en) | 2012-03-30 | 2016-11-01 | The Regents Of The University Of Michigan | Nitric oxide delivery devices |
EP2861284A4 (en) * | 2012-05-30 | 2016-03-09 | David Bruce Crosbie | STICK OXIDE GENERATOR AND INHALER |
KR101308788B1 (ko) * | 2012-12-13 | 2013-09-16 | 운해이엔씨(주) | 무균 및 무취의 산화질소 발생장치 |
AU2014203438B2 (en) | 2013-06-25 | 2019-06-20 | Mallinckrodt Hospital Products IP Limited | Methods of reducing the risk of mortality associated with a medical treatment |
WO2015059273A1 (de) | 2013-10-24 | 2015-04-30 | Bsn Medical Gmbh | Eintauchvorrichtung |
US20160193336A1 (en) * | 2013-10-31 | 2016-07-07 | Origin, Inc. | Methods for using nitric oxide in a plasma state to treat medical conditions and diseases |
MX351120B (es) | 2013-11-07 | 2017-10-03 | Bsn Medical Gmbh | Apósito médico. |
RU2553290C1 (ru) * | 2014-01-23 | 2015-06-10 | Российская Федерация, от имени которой выступает Государственная корпорация по атомной энергии "Росатом" | Устройство для получения окиси азота |
US11225640B2 (en) | 2014-04-15 | 2022-01-18 | Aobiome Llc | Ammonia oxidizing bacteria for treatment of psoriasis |
EP4219679A3 (en) | 2014-04-15 | 2023-08-09 | Aobiome LLC | Ammonia-oxidizing nitrosomonas eutropha strain d23 |
EP3427760A1 (en) * | 2014-06-13 | 2019-01-16 | Origin, Inc. | A method for disinfecting clothes, shoes or equipment using nitric oxide |
RU2017102681A (ru) | 2014-06-30 | 2018-07-30 | Ориджин, Инк. | Аппарат для применения оксида азота в месте лечения |
EP3020438A1 (en) | 2014-11-13 | 2016-05-18 | Linde AG | Device for ventilating a patient and method for operating a device for ventilating a patient |
RU2593297C2 (ru) * | 2014-12-29 | 2016-08-10 | Российская Федерация, от имени которой выступает Государственная корпорация по атомной энергии "Росатом" | Способ получения газовой смеси, содержащей окись азота |
GB201500512D0 (en) * | 2015-01-13 | 2015-02-25 | Soe Health Ltd | Therapeutic treatment methods, and apparatus for use therein |
EP3053587A1 (en) | 2015-02-05 | 2016-08-10 | Linde AG | Combination of nitric oxide, helium and antibiotic to treat bacterial lung infections |
EP3108920A1 (en) | 2015-06-22 | 2016-12-28 | Linde AG | Device for delivering nitric oxide and oxygen to a patient |
FI3970730T3 (fi) | 2016-02-12 | 2024-05-28 | Mallinckrodt Pharmaceuticals Ireland Ltd | Järjestelmä inhaloidun typpioksidin käyttöä ja valvontaa varten vasemman kammion apulaitteiden kera |
CN109310842B (zh) * | 2016-03-25 | 2022-08-19 | 通用医疗公司 | 用于电等离子体合成一氧化氮的输送系统和方法 |
CA3046359A1 (en) * | 2016-12-09 | 2018-06-14 | Microdose Therapeutx, Inc. | Inhaler |
EP4234018A3 (en) | 2016-12-14 | 2023-11-01 | Origin, Inc. | A device and method for producing high-concentration, low-temperature nitric oxide |
MX2020010523A (es) * | 2017-02-27 | 2021-02-09 | Third Pole Inc | Sistemas y metodos para generar oxido nitrico. |
JP6704094B2 (ja) * | 2017-02-27 | 2020-06-03 | サード ポール, インコーポレイテッドThird Pole, Inc. | 酸化窒素を生成するためのシステムおよび方法 |
MX2019011432A (es) | 2017-03-31 | 2020-01-20 | Massachusetts Gen Hospital | Sistemas y metodos para un generador de oxido nitrico enfriado. |
JP2022533628A (ja) | 2019-05-15 | 2022-07-25 | サード ポール,インコーポレイテッド | 一酸化窒素生成用電極 |
JP2022532654A (ja) | 2019-05-15 | 2022-07-15 | サード ポール,インコーポレイテッド | 一酸化窒素を生成するシステム及び方法 |
WO2021142472A1 (en) | 2020-01-11 | 2021-07-15 | Third Pole, Inc. | Systems and methods for nitric oxide generation with humidity control |
WO2021248142A2 (en) * | 2020-06-05 | 2021-12-09 | The General Hospital Corporation | Systems and methods for nitric oxide generation and treatment |
WO2021258025A1 (en) | 2020-06-18 | 2021-12-23 | Third Pole, Inc. | Systems and methods for preventing and treating infections with nitric oxide |
US20240277757A1 (en) * | 2021-06-17 | 2024-08-22 | Origin Life Sciences, Inc. | Methods of using a plasma-generated stream of no-containing gas for treatment of a spectrum of medical conditions |
EP4405019A1 (en) * | 2021-09-23 | 2024-07-31 | Third Pole, Inc. | Systems and methods for delivering nitric oxide |
MX2024005111A (es) * | 2021-10-27 | 2024-05-14 | Federalnoye Gosudarstvennoye Unitarnoye Predpriyatiye Rossiyskiy Federalniy Yaderniy Tsentr Vserossi | Dispositivo para producir oxido nitrico. |
CN114348979A (zh) * | 2021-12-31 | 2022-04-15 | 陕西聚能新创煤化科技有限公司 | 基于等离子电离加热装置的no气体生产系统及生产方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3785377A (en) * | 1970-11-12 | 1974-01-15 | S Jorgensen | Plant, preferably for anaesthesia |
US4010897A (en) * | 1976-03-31 | 1977-03-08 | Charles F. Kettering Foundation | Method and apparatus for home production and application of nitrogen fertilizer |
IL57239A (en) * | 1979-05-08 | 1982-04-30 | Alamaro Moshe | Production of nitric oxides |
US4297123A (en) * | 1980-02-07 | 1981-10-27 | Wyse Harold G | Method and apparatus for producing a nitrate fertilizer |
US4336798A (en) * | 1980-10-06 | 1982-06-29 | Anthony V. Beran | Medical corrugated respiratory tube |
US4877589A (en) * | 1988-09-19 | 1989-10-31 | Hare Louis R O | Nitrogen fixation by electric arc and catalyst |
US4915915A (en) * | 1988-10-11 | 1990-04-10 | Treharne Richard W | Water-powdered piezoelectric unit for producing nitrogen fertilizer |
-
1992
- 1992-03-11 US US07/850,383 patent/US5396882A/en not_active Expired - Lifetime
-
1993
- 1993-03-08 AT AT93908422T patent/ATE242022T1/de active
- 1993-03-08 ES ES93908422T patent/ES2196006T3/es not_active Expired - Lifetime
- 1993-03-08 BR BR9306060A patent/BR9306060A/pt not_active IP Right Cessation
- 1993-03-08 DE DE69333015T patent/DE69333015T2/de not_active Expired - Lifetime
- 1993-03-08 EP EP93908422A patent/EP0630270B1/en not_active Expired - Lifetime
- 1993-03-08 CA CA002117691A patent/CA2117691C/en not_active Expired - Fee Related
- 1993-03-08 DK DK93908422T patent/DK0630270T3/da active
- 1993-03-08 PT PT93908422T patent/PT630270E/pt unknown
- 1993-03-08 WO PCT/US1993/002518 patent/WO1993017741A1/en active IP Right Grant
- 1993-03-08 AU AU39250/93A patent/AU3925093A/en not_active Abandoned
- 1993-03-08 JP JP51606693A patent/JP3573455B2/ja not_active Expired - Fee Related
- 1993-03-11 MX MX9301357A patent/MX9301357A/es unknown
- 1993-09-09 TW TW082107415A patent/TW242117B/zh active
-
1994
- 1994-09-09 NO NO19943349A patent/NO310961B1/no not_active IP Right Cessation
- 1994-09-09 FI FI944170A patent/FI110922B/fi not_active IP Right Cessation
-
2004
- 2004-03-17 JP JP2004077201A patent/JP3792701B2/ja not_active Expired - Fee Related
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006273677A (ja) * | 2005-03-30 | 2006-10-12 | Kumamoto Univ | No発生装置 |
JP2015110642A (ja) * | 2006-11-07 | 2015-06-18 | ザ ジェネラル ホスピタル コーポレイション | 血管作動性酸素運搬体に誘導される血管収縮の減弱 |
US10773046B2 (en) | 2011-11-07 | 2020-09-15 | Mallinckrodt Hospital Products IP Limited | Apparatus and method for monitoring nitric oxide delivery |
US10426913B2 (en) | 2011-11-07 | 2019-10-01 | Mallinckrodt Hospital Products IP Limited | Apparatus and method for monitoring nitric oxide delivery |
JP2016516480A (ja) * | 2013-03-13 | 2016-06-09 | イノ セラピューティックス エルエルシー | 一酸化窒素の送達による治療の最中に酸素化を監視する装置および方法 |
KR102447456B1 (ko) * | 2013-03-15 | 2022-09-23 | 더 제너럴 하스피탈 코포레이션 | 흡입용 산화질소의 합성 |
KR20150133775A (ko) * | 2013-03-15 | 2015-11-30 | 더 제너럴 하스피탈 코포레이션 | 산화질소의 흡기 합성 |
KR20150127279A (ko) * | 2013-03-15 | 2015-11-16 | 더 제너럴 하스피탈 코포레이션 | 흡입용 산화질소의 합성 |
KR102317818B1 (ko) * | 2013-03-15 | 2021-10-26 | 더 제너럴 하스피탈 코포레이션 | 산화질소의 흡기 합성 |
JP2023059931A (ja) * | 2014-10-20 | 2023-04-27 | ザ ジェネラル ホスピタル コーポレイション | 一酸化窒素の合成のためのシステム及び方法 |
JP2022169537A (ja) * | 2017-02-27 | 2022-11-09 | サード ポール,インコーポレイテッド | 酸化窒素の移動式生成システムおよび方法 |
JP7548631B2 (ja) | 2018-09-27 | 2024-09-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | ガス送達デバイス |
JP7442207B2 (ja) | 2018-09-27 | 2024-03-04 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | ガス送達デバイス |
JP2022502172A (ja) * | 2018-09-27 | 2022-01-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | ガス送達デバイス |
WO2020084992A1 (ja) | 2018-10-25 | 2020-04-30 | 帝人ファーマ株式会社 | 一酸化窒素投与装置 |
WO2020084995A1 (ja) | 2018-10-25 | 2020-04-30 | 帝人ファーマ株式会社 | 中継投与装置及び一酸化窒素投与システム |
WO2020084993A1 (ja) | 2018-10-25 | 2020-04-30 | 帝人ファーマ株式会社 | 一酸化窒素投与装置 |
WO2020084994A1 (ja) | 2018-10-25 | 2020-04-30 | 帝人ファーマ株式会社 | 一酸化窒素投与装置 |
WO2022030812A1 (ko) * | 2020-08-03 | 2022-02-10 | 한국핵융합에너지연구원 | 질소산화물을 제어하는 방법 및 장치, 그리고 질소산화물 함유 수 제조 방법 |
KR102227464B1 (ko) * | 2020-08-03 | 2021-03-12 | 한국핵융합에너지연구원 | 질소산화물을 제어하는 방법 및 장치, 그리고 질소산화물 함유 수 제조 방법 |
CN116157197A (zh) * | 2020-08-03 | 2023-05-23 | 韩国核融合能源研究院 | 控制氮氧化物的方法和装置和制备含氮氧化物的水的方法 |
WO2023096321A1 (ko) * | 2021-11-23 | 2023-06-01 | 한국핵융합에너지연구원 | 플라즈마를 이용한 고순도 no2 가스 발생장치 및 플라즈마 이용 질산태 기반의 고농도 활성수 및 비료수 제조장치 |
Also Published As
Publication number | Publication date |
---|---|
WO1993017741A1 (en) | 1993-09-16 |
JP3792701B2 (ja) | 2006-07-05 |
FI944170A0 (fi) | 1994-09-09 |
ES2196006T3 (es) | 2003-12-16 |
NO310961B1 (no) | 2001-09-24 |
EP0630270A1 (en) | 1994-12-28 |
BR9306060A (pt) | 1997-11-18 |
DK0630270T3 (da) | 2003-06-23 |
CA2117691A1 (en) | 1993-09-16 |
AU3925093A (en) | 1993-10-05 |
EP0630270B1 (en) | 2003-06-04 |
NO943349L (no) | 1994-11-10 |
JPH07505073A (ja) | 1995-06-08 |
JP3573455B2 (ja) | 2004-10-06 |
CA2117691C (en) | 2006-05-09 |
PT630270E (pt) | 2003-09-30 |
FI110922B (fi) | 2003-04-30 |
DE69333015D1 (de) | 2003-07-10 |
US5396882A (en) | 1995-03-14 |
TW242117B (ja) | 1995-03-01 |
DE69333015T2 (de) | 2004-04-01 |
FI944170A (fi) | 1994-09-09 |
NO943349D0 (no) | 1994-09-09 |
MX9301357A (es) | 1994-04-29 |
ATE242022T1 (de) | 2003-06-15 |
EP0630270A4 (en) | 1995-04-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP3573455B2 (ja) | 空気より得る医療用一酸化窒素 | |
AU2020256426B2 (en) | Systems and methods for the synthesis of nitric oxide | |
JP6968192B2 (ja) | 冷却される一酸化窒素生成器用のシステム及び方法 | |
Yu et al. | Producing nitric oxide by pulsed electrical discharge in air for portable inhalation therapy | |
KR100414699B1 (ko) | 폐병치료에유용한디뉴클레오티드 | |
EP1365778B1 (en) | Treating pulmonary disorders with gaseous agent causing repletion of gsno | |
CN1099997A (zh) | 从空气中生产医用氧化氮 | |
GB2320900A (en) | Inhalers |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20040317 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20040329 |
|
A072 | Dismissal of procedure [no reply to invitation to correct request for examination] |
Free format text: JAPANESE INTERMEDIATE CODE: A072 Effective date: 20040608 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20040706 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20041006 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20050510 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050804 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20051021 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20060307 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20060405 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
LAPS | Cancellation because of no payment of annual fees |