JP2004089849A - Suction and discharging apparatus for minute amount of liquid - Google Patents

Suction and discharging apparatus for minute amount of liquid Download PDF

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JP2004089849A
JP2004089849A JP2002254377A JP2002254377A JP2004089849A JP 2004089849 A JP2004089849 A JP 2004089849A JP 2002254377 A JP2002254377 A JP 2002254377A JP 2002254377 A JP2002254377 A JP 2002254377A JP 2004089849 A JP2004089849 A JP 2004089849A
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solenoid valve
flow path
liquid
positive pressure
negative pressure
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JP3599726B2 (en
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Yasukatsu Inouchi
井野内　康克
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Abstract

<P>PROBLEM TO BE SOLVED: To provide a suction and discharging apparatus for minute amount of liquid enabling automatic suction and discharging of the minute amount of the liquid and exact handling of desired amount thereof and further blowing the sucked liquid securely. <P>SOLUTION: The suction and discharging apparatus comprises a common flow path (10), a solenoid valve (1) connected to a tip of the common flow path (10) with a supply port (20), an electrically controlling part(2) to control opening/closing of the solenoid valve (1) with time, a positive pressure generating means (3) and a negative pressure generating means (4) which are arranged at a base end of the common flow path (10), and a switching means (5) for switching between positive pressure/negative pressure of the supply port (20) of the solenoid valve (1). The suction and discharging apparatus is constituted to suck the liquid from the tip of the solenoid valve (1) in a negative pressure open state of the solenoid valve (1) and to discharge the liquid sucked from the tip of the solenoid valve (1) in a positive pressure open state of the solenoid valve (1). <P>COPYRIGHT: (C)2004,JPO

Description

【０００１】
【発明の属する技術分野】
本発明は、微量液体吸入吐出装置に関する。
【０００２】
【従来の技術】
従来、理科学において、（例えば、バイオ薬品に用いられる水溶液や溶媒などの）液体を微量取り扱うのにマイクロシリンジが用いられていた。具体的には、手動でマイクロシリンジを操作して、微量の液体を吸入し、吐出していた。
【０００３】
【発明が解決しようとする課題】
しかしながら、従来のようにマイクロシリンジを用いると、手動で操作するため、所望の量を正確に取り扱うことが難しく、さらに、吐出の際に、吸入した液体を勢いよく飛ばすことができなかった。
【０００４】
そこで、本発明は、微量の液体の吸入吐出を自動で行うことができ、かつ、所望の量を正確に取り扱うことができ、さらに、吸入した液体を確実に飛ばすことができる微量液体吸入吐出装置を提供することを目的とする。
【０００５】
【課題を解決するための手段】
上述の目的を達成するために、本発明に係る微量液体吸入吐出装置は、共用流路と、該共用流路の先端に供給ポートにて接続された電磁弁と、該電磁弁の開閉を時間にて制御する電気的制御部と、上記共用流路の基端に配設された正圧発生手段及び負圧発生手段と、上記電磁弁の供給ポートを正圧・負圧に切り換える切換手段と、を備え、上記電磁弁の負圧開状態で、上記電磁弁の先端側から液体を吸入し、上記電磁弁の正圧開状態で、上記電磁弁の先端側から吸入した液体を吐出するように構成したものである。
【０００６】
また、共用流路と、該共用流路の先端に供給ポートにて接続された電磁弁と、該電磁弁の開閉を時間にて制御する電気的制御部と、上記共用流路の基端側で分岐される第１流路及び第２流路と、該第１流路及び第２流路の基端に配設されてエアを供給するコンプレッサと、該コンプレッサからのエアを第１流路・第２流路に切り換える切換弁と、上記第１流路に介在されて上記コンプレッサからのエアにて上記共用流路を真空引きするエジェクタと、を備え、上記コンプレッサからのエアを上記第１流路に切り換えて上記電磁弁の供給ポートを負圧にすると共に上記コンプレッサからのエアを上記第２流路に切り換えて上記電磁弁の供給ポートを正圧にするように構成し、さらに、上記電磁弁の負圧開状態で、上記電磁弁の先端側から液体を吸入し、上記電磁弁の正圧開状態で、上記電磁弁の先端側から吸入した液体を吐出するように構成したものである。
【０００７】
また、電気的制御部が、電磁弁の負圧開状態の時間と電磁弁の正圧開状態の時間とを独立して制御するように構成されている。また、電磁弁が、吸入した液体を保留する極細管を先端に突出している。
【０００８】
【発明の実施の形態】
以下、実施の形態を示す図面に基づき、本発明を詳説する。
【０００９】
図１と図２の全体簡略構成説明図に示すように、本発明の微量液体吸入吐出装置は、共用流路１０と、共用流路１０の先端に供給ポート２０にて接続された電磁弁１と、電磁弁１の開閉を時間にて制御する電気的制御部２と、共用流路１０の基端に配設された正圧発生手段３及び負圧発生手段４と、電磁弁１の供給ポート２０を正圧・負圧に切り換える切換手段５と、を備えている。
【００１０】
そして、（図１に示す）電磁弁１の負圧開状態で、電磁弁１の先端側から液体を吸入し、（図２に示す）電磁弁１の正圧開状態で、電磁弁１の先端側から液体を吐出するように構成している。ここで、電磁弁１の負圧開状態とは、供給ポート２０が負圧状態にある電磁弁１を開状態にしていることをいい、電磁弁１の正圧開状態とは、供給ポート２０が正圧状態にある電磁弁１を開状態にしていることをいう。
【００１１】
本装置は、理科学において、（例えば、バイオ薬品に用いられる水溶液や溶媒などの）液体を微量取り扱うのに用いられ、例えば、図９に示すように、一の容器１３から液体を所望量ずつ取り出して、他の容器１４の複数の窪部１４ａの夫々に注入していく。また、本装置は、液晶の注入や、試薬品の分注や、（水溶液・溶媒・アルコール溶液・溶剤（有機溶剤）・インク・オイル等の）微量液体を飛ばすことに用いられる。
【００１２】
具体的に述べると、本装置は、共用流路１０の基端側で分岐される第１流路１１及び第２流路１２と、第１流路１１及び第２流路１２の基端に配設されてエアを供給するコンプレッサ６と、コンプレッサ６からのエアを第１流路１１・第２流路１２に切り換える切換弁７と、第１流路１１に介在されてコンプレッサ６からのエアにて共用流路１０を真空引きするエジェクタ８と、を備えている。要するに、第１流路１１及び第２流路１２の基端と切換弁７とが連結され、第１流路１１及び第２流路１２の先端と共用流路１０の基端とが連結されている。
【００１３】
即ち、正圧発生手段３は、コンプレッサ６、第２流路１２等からなり、負圧発生手段４は、コンプレッサ６、第１流路１１、エジェクタ８等からなり、切換手段５は、切換弁７等からなる。
【００１４】
共用流路１０、第１流路１１、及び、第２流路１２は、例えば、可撓性を有する細径のホースからなる。
【００１５】
切換弁７は、（図１に示す）非通電状態で、コンプレッサ６からのエアを第１流路１１に供給するように構成され、（図２に示す）通電状態で、コンプレッサ６からのエアを第２流路１２に供給するように構成されている。
【００１６】
エジェクタ８は、第１流路１１の途中に配設され、図１に示すように、エジェクタ８内部のノズルで、コンプレッサ６からのエアを高速で噴出して、エジェクタ８よりも先端側の第１流路１１及び共用流路１０からエアを負圧吸引するように構成されている。
【００１７】
このように、本装置は、コンプレッサ６からのエアを第１流路１１に切り換えて電磁弁１の供給ポート２０を負圧にし（図１参照）、他方、コンプレッサ６からのエアを第２流路１２に切り換えて電磁弁１の供給ポート２０を正圧にする（図２参照）ように構成されている。なお、正圧のゲージ圧力は、　０．００１〜　０．１ＭＰａに設定される。
【００１８】
電磁弁１は、図３に示すように、ブロック状の本体部２２と、本体部２２の内部空間に配設される弁部（プランジャ）２３と、弁部２３の周囲に配設されるように本体部２２に巻設されるコイル２４と、本体部２２の先端に突出状に内部空間に連結される極細管２１と、を備えている。
【００１９】
具体的に述べると、本体部２２の内部空間は、（ホースなどの）共用流路１０が連結される基端側空間２５と、極細管２１が連結される先端側空間２６と、基端側空間２５と先端側空間２６とを連結する円筒状の連通孔２７と、からなる。ここで、共用流路１０が差し込まれる本体部２２の開口部を、供給ポート２０といい、極細管２１が差し込まれる本体部２２の開口部を、排気ポート１９という。
【００２０】
弁部２３は、連通孔２７に摺動自在に密嵌されつつ、極細管２１の基端開口を施蓋・開蓋するように構成されている。具体的には、弁部２３は、極細管２１の基端開口を施蓋するように圧縮スプリング２９にて常時弾発付勢されており、コイル２４に通電することで、図４に示すように、圧縮スプリング２９に抗して引き上げられて、極細管２１の基端開口を開蓋するように構成されている。即ち、電磁弁１への通電のＯＮ−ＯＦＦ切換えにより、弁部２３の開閉切換えとなる。
【００２１】
このとき、弁部２３が必要以上に引き上がらないように（電磁弁１の開閉のタイムロスを防ぐために）、弁部２３の基端面に当接する当り棒２８を、連通孔２７に固定状に密嵌している。
【００２２】
ここで、図３、図４、図５に示すように、弁部２３は、連通孔２７に密嵌されている部位の外周面に、軸心方向に沿って複数の溝部２３ａを有し、溝部２３ａと先端側空間２６とが常時連通した状態にある。
【００２３】
また、図３、図４、図６に示すように、当り棒２８は、連通孔２７に密嵌されている部位の外周面に、軸心方向に沿って複数の溝部２８ａを有し、溝部２８ａと基端側空間２５とが常時連通した状態にある。
【００２４】
即ち、基端側空間２５と先端側空間２６とが、当り棒２８の溝部２８ａと弁部２３の溝部２３ａとを介して、常時連通した状態にあり、供給ポート２０を負圧にすると、先端側空間２６も負圧となり、供給ポート２０を正圧にすると、先端側空間２６も正圧となる。
【００２５】
電気的制御部２は、図３と図４に示すように、コイル２４に電気的に接続され、一定時間の間、コイル２４に通電して電磁弁１を開状態とするように構成されている。即ち、負圧状態の電磁弁１を開状態に保持する時間の長さにより、極細管２１から液体を吸入する量が決定され、他方、正圧状態の電磁弁１を開状態に保持する時間の長さにより、極細管２１から液体を吐出する量が決定される。
なお、一定時間としては、　０．１ｍｓｅｃ〜　９．９ｍｓｅｃに設定される。
【００２６】
このとき、電気的制御部２を、電磁弁１の負圧開状態の時間と電磁弁１の正圧開状態の時間とを独立して制御するように構成してもよい。例えば、粘性を有する（一定量の）液体を取り扱う場合、極細管２１にて液体を吸入する時間は、極細管２１から液体を吐出する時間よりも短くなるため、電磁弁１の負圧開状態の時間を、電磁弁１の正圧開状態の時間よりも短くすることで、同量の液体の吸入・吐出を行うことができる。
【００２７】
なお、電気的制御部２は、（図１の）切換弁７と共に、図示省略の（タイマーなどの）中央制御部に電気的に接続されており、この中央制御部は、電気的制御部２と切換弁７とを独立してＯＮ−ＯＦＦ状態に切り換えるように構成されている。即ち、切換弁７を所定時間ＯＦＦとした（図１参照）後で、電気的制御部２（電磁弁１）をＯＮとし（図４参照）、切換弁７を所定時間ＯＮとした（図２参照）後で、電気的制御部２（電磁弁１）をＯＮとする（図４参照）。
【００２８】
ここで、電磁弁１の負圧開状態で吸入された液体は、極細管２１にのみ（一時的に）保留され、このときの液量は、１０ｎｌ（１／１０５　ｃｃ）〜１０００ｎｌ（１／１０３　ｃｃ）に設定される。
【００２９】
次に、本装置の作用（機能）及び使用方法を説明すると、図７（イ）に示すように、電磁弁１の閉状態にて、電磁弁１の内部空間のエアを吸引して負圧状態にし、図７（ロ）に示すように、一の容器１３の液体に極細管２１の先端を漬けてから、電磁弁１を開けて、極細管２１から液体を吸引する。このとき、電気的制御部２にて、一定時間の間、電磁弁１を開状態とすることで、図７（ハ）に示すように、所望の量の液体を吸入することができる。
【００３０】
その後、図８（イ）に示すように、電磁弁１の閉状態にて、電磁弁１の内部空間にエアを送り込んで正圧状態にし、予圧を付与しておく。そして、図８（ロ）に示すように、他の容器１４の内部に極細管２１の先端を向けてから、電磁弁１を開けて、極細管２１から液体を勢いよく飛ばしながら吐出する。このとき、電気的制御部２にて、一定時間の間、電磁弁１を開状態とすることで、所望の量の液体を吐出することができる。
なお、本発明では、一回で吸入した液体の全量を吐出するようにしている。
【００３１】
次に、図９に、本装置の使用状態の一例を示し、一の容器１３と他の容器１４とが離間して配設されており、電磁弁１にて一の容器１３から液体を所望量（一回分）だけ取り出して、電磁弁１を一の容器１３から他の容器１４側（矢印Ａ方向）に移動させて、他の容器１４の複数の窪部１４ａの内の一つの窪部１４ａに一回分の全量を注入する。そして、電磁弁１を他の容器１４から一の容器１３側（矢印Ｂ方向）に戻して、再度、電磁弁１にて一の容器１３から液体を所望量（一回分）だけ取り出して、注入を繰り返す。
【００３２】
このとき、電磁弁１の矢印Ａ方向及び矢印Ｂ方向への移動速度を制御する（図示省略の）インターバルタイマーを設け、電磁弁１の矢印Ａ方向への移動速度を、電磁弁１を矢印Ａ方向に移動させている間に正圧状態とできる速度とし、かつ、電磁弁１の矢印Ｂ方向への移動速度を、電磁弁１を矢印Ｂ方向に移動させている間に負圧状態とできる速度としている。
【００３３】
次に、図１０に、本発明の他の実施の形態を示し、共用流路１０の基端にコンプレッサ６及び真空ポンプ９を配設し、切換弁７にて、共用流路１０を、コンプレッサ６の流路又は真空ポンプ９の流路に連結切り換えるように構成している。即ち、図１０に示すように、切換弁７のＯＦＦ状態で、共用流路１０を真空ポンプ９の流路に連結し、電磁弁１の供給ポート２０を負圧にして、極細管２１から液体を吸入する。他方、図１１に示すように、切換弁７のＯＮ状態で、共用流路１０をコンプレッサ６の流路に連結し、電磁弁１の供給ポート２０を正圧にして、極細管２１から液体を吐出する。
【００３４】
なお、本発明は上述の実施の形態に限定されず、本発明の要旨を逸脱しない範囲で設計変更可能である。例えば、電磁弁１の負圧開状態の時間と電磁弁１の正圧開状態の時間とを共通に制御するようにしてもよく、また、（一回で）吸入した液体を、複数回に分けて吐出するようにしてもよい。
【００３５】
【発明の効果】
本発明は上述の如く構成されるので、次に記載する効果を奏する。
【００３６】
（請求項１によれば、）微量の液体の吸入・吐出を自動で行うことができるため、正確な量の液体を吸入・吐出することができて、精度の優れたものとなる。
また、吸入した液体を勢いよく飛ばしながら吐出することができ、用途のひろいものとなる。
【００３７】
（請求項２によれば、）微量の液体の吸入・吐出を自動で行うことができるため、正確な量の液体を吸入・吐出することができて、精度の優れたものとなる。
また、吸入した液体を勢いよく飛ばしながら吐出することができ、用途のひろいものとなる。さらに、一台のコンプレッサ６で電磁弁１を負圧・正圧とできるため、装置の小型化を図ることができる。
【００３８】
（請求項３によれば、）液体の性質（例えば、粘度の大小）に応じて、電磁弁１の負圧開状態の時間と電磁弁１の正圧開状態の時間とを調節して、正確に所望の量の液体の吸入・吐出を行うことができる。例えば、吸入量と吐出量とを同一にすることができる。
（請求項４によれば、）極細管２１内で液体を保留しているため、吐出量を高精度なものとでき、かつ、液体の吐出の反応性に優れたものとなる。
【図面の簡単な説明】
【図１】本発明の実施の一形態を示す負圧状態の全体簡略構成説明図である。
【図２】正圧状態を示す全体簡略構成説明図である。
【図３】電磁弁の閉状態を示す縦断面図である。
【図４】電磁弁の開状態を示す縦断面図である。
【図５】電磁弁の要部横断面図である。
【図６】電磁弁の要部横断面図である。
【図７】要部作用説明図である。
【図８】要部作用説明図である。
【図９】使用状態を示す斜視図である。
【図１０】本発明の他の実施の形態を示す負圧状態の全体簡略構成説明図である。
【図１１】正圧状態の全体簡略構成説明図である。
【符号の説明】
１　電磁弁
２　電気的制御部
３　正圧発生手段
４　負圧発生手段
５　切換手段
６　コンプレッサ
７　切換弁
８　エジェクタ
１０　共用流路
１１　第１流路
１２　第２流路
２０　供給ポート
２１　極細管[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a device for suctioning and discharging a trace amount of liquid.
[0002]
[Prior art]
Conventionally, in science and technology, micro syringes have been used to handle small amounts of liquids (eg, aqueous solutions and solvents used for biopharmaceuticals). Specifically, a micro syringe was manually operated to inhale and discharge a small amount of liquid.
[0003]
[Problems to be solved by the invention]
However, when a microsyringe is used as in the prior art, it is difficult to handle a desired amount accurately because it is manually operated, and it is not possible to fly the sucked liquid vigorously during ejection.
[0004]
Therefore, the present invention provides a small-volume liquid suction and discharge device that can automatically perform the suction and discharge of a small amount of liquid, can accurately handle a desired amount, and can surely blow off the sucked liquid. The purpose is to provide.
[0005]
[Means for Solving the Problems]
In order to achieve the above object, a trace liquid suction / discharge device according to the present invention includes a common flow path, an electromagnetic valve connected to a distal end of the common flow path at a supply port, and opening and closing of the electromagnetic valve. An electrical control unit controlled by the control unit, positive pressure generating means and negative pressure generating means disposed at the base end of the common flow path, and switching means for switching the supply port of the solenoid valve to positive pressure / negative pressure. In the negative pressure open state of the solenoid valve, liquid is sucked from the tip side of the solenoid valve, and in the positive pressure open state of the solenoid valve, the liquid sucked from the tip side of the solenoid valve is discharged. It is what was constituted.
[0006]
A common flow path, a solenoid valve connected to a distal end of the common flow path by a supply port, an electric control unit that controls opening and closing of the solenoid valve with time, and a base end side of the common flow path. A first flow path and a second flow path branched by the first flow path, a compressor disposed at a base end of the first flow path and the second flow path to supply air, and a flow path of air from the compressor to the first flow path A switching valve for switching to the second flow path, and an ejector interposed in the first flow path to evacuate the common flow path with air from the compressor, and to supply air from the compressor to the first flow path. The supply port of the solenoid valve is switched to a flow path to make the supply port of the solenoid valve a negative pressure, and the air from the compressor is switched to the second flow path to make the supply port of the solenoid valve a positive pressure; When the negative pressure of the solenoid valve is open, liquid is Type, the positive pressure-opening state of the solenoid valve, which is constituted to discharge liquid sucked from the tip side of the solenoid valve.
[0007]
Further, the electric control unit is configured to independently control the time when the solenoid valve is in the negative pressure open state and the time when the solenoid valve is in the positive pressure open state. In addition, an electromagnetic valve protrudes from the tip of an ultrafine tube that holds the sucked liquid.
[0008]
BEST MODE FOR CARRYING OUT THE INVENTION
Hereinafter, the present invention will be described in detail with reference to the drawings showing the embodiments.
[0009]
As shown in FIGS. 1 and 2, a small amount liquid suction / discharge device according to the present invention includes a common flow path 10 and an electromagnetic valve 1 connected to a distal end of the common flow path 10 by a supply port 20. An electric control unit 2 that controls the opening and closing of the electromagnetic valve 1 with time, a positive pressure generating unit 3 and a negative pressure generating unit 4 disposed at the base end of the shared flow path 10, and a supply of the electromagnetic valve 1. Switching means 5 for switching the port 20 between positive pressure and negative pressure.
[0010]
When the solenoid valve 1 (shown in FIG. 1) is in the negative pressure open state, liquid is sucked from the tip side of the solenoid valve 1, and when the solenoid valve 1 (shown in FIG. 2) is in the positive pressure open state, the solenoid valve 1 is opened. The liquid is ejected from the front end side. Here, the negative pressure open state of the solenoid valve 1 means that the solenoid valve 1 in which the supply port 20 is in the negative pressure state is open, and the positive pressure open state of the solenoid valve 1 refers to the supply port 20. Indicates that the solenoid valve 1 in the positive pressure state is in the open state.
[0011]
This device is used in science and technology to handle a small amount of liquid (for example, an aqueous solution or a solvent used for biopharmaceuticals). For example, as shown in FIG. It is taken out and poured into each of the plurality of recesses 14a of the other container 14. Further, the present apparatus is used for injecting liquid crystal, dispensing reagents, and flying a small amount of liquid (aqueous solution, solvent, alcohol solution, solvent (organic solvent), ink, oil, etc.).
[0012]
More specifically, the present apparatus includes a first flow path 11 and a second flow path 12 that are branched on the base end side of the shared flow path 10, and a base end of the first flow path 11 and the second flow path 12. A compressor 6 disposed to supply air, a switching valve 7 for switching air from the compressor 6 to a first flow path 11 and a second flow path 12, and air from the compressor 6 interposed in the first flow path 11. And an ejector 8 for evacuating the common flow path 10. In short, the base ends of the first flow path 11 and the second flow path 12 are connected to the switching valve 7, and the distal ends of the first flow path 11 and the second flow path 12 are connected to the base end of the common flow path 10. ing.
[0013]
That is, the positive pressure generating means 3 includes the compressor 6, the second flow path 12, etc., the negative pressure generating means 4 includes the compressor 6, the first flow path 11, the ejector 8, etc., and the switching means 5 includes the switching valve. Consists of 7 mag.
[0014]
The common flow path 10, the first flow path 11, and the second flow path 12 are made of, for example, flexible small-diameter hoses.
[0015]
The switching valve 7 is configured to supply air from the compressor 6 to the first flow path 11 in a non-energized state (shown in FIG. 1), and to supply air from the compressor 6 in an energized state (shown in FIG. 2). Is supplied to the second flow path 12.
[0016]
The ejector 8 is disposed in the middle of the first flow path 11 and, as shown in FIG. The air is suctioned from the one flow path 11 and the common flow path 10 under a negative pressure.
[0017]
As described above, the present apparatus switches the air from the compressor 6 to the first flow path 11 to make the supply port 20 of the solenoid valve 1 a negative pressure (see FIG. 1), while the air from the compressor 6 is changed to the second flow. The supply port 20 of the solenoid valve 1 is switched to the path 12 so as to have a positive pressure (see FIG. 2). The gauge pressure of the positive pressure is set to 0.001 to 0.1 MPa.
[0018]
As shown in FIG. 3, the solenoid valve 1 is arranged around a block-shaped main body 22, a valve section (plunger) 23 disposed in an internal space of the main body section 22, and the valve section 23. A coil 24 wound around the main body 22 and an ultrafine tube 21 protruding from the tip of the main body 22 and connected to the internal space.
[0019]
More specifically, the internal space of the main body 22 includes a proximal space 25 to which the common flow path 10 (such as a hose) is connected, a distal space 26 to which the microfine tube 21 is connected, and a proximal space. And a cylindrical communication hole 27 connecting the space 25 and the front end side space 26. Here, the opening of the main body 22 into which the common flow channel 10 is inserted is referred to as a supply port 20, and the opening of the main body 22 into which the ultrafine tube 21 is inserted is referred to as an exhaust port 19.
[0020]
The valve portion 23 is configured to cover and open the base end opening of the microfine tube 21 while being slidably fitted tightly into the communication hole 27. More specifically, the valve portion 23 is constantly resiliently urged by a compression spring 29 so as to cover the base end opening of the microfine tube 21, and by energizing the coil 24, as shown in FIG. The micro-tube 21 is lifted up against the compression spring 29 to open the base opening of the microfine tube 21. That is, the ON / OFF switching of the energization to the solenoid valve 1 causes the opening and closing of the valve portion 23 to be switched.
[0021]
At this time, the contact rod 28 abutting the base end face of the valve portion 23 is fixedly and tightly fitted to the communication hole 27 so that the valve portion 23 does not pull up more than necessary (to prevent a time loss of opening and closing the solenoid valve 1). It is fitting.
[0022]
Here, as shown in FIGS. 3, 4, and 5, the valve portion 23 has a plurality of grooves 23 a along an axial direction on an outer peripheral surface of a portion closely fitted to the communication hole 27. The groove 23a and the front end space 26 are always in communication.
[0023]
As shown in FIGS. 3, 4, and 6, the contact rod 28 has a plurality of groove portions 28a along the axial direction on an outer peripheral surface of a portion closely fitted to the communication hole 27, and 28a and the base end space 25 are always in communication.
[0024]
That is, the proximal end space 25 and the distal end space 26 are always in communication with each other via the groove 28a of the contact rod 28 and the groove 23a of the valve portion 23. When the side space 26 also has a negative pressure and the supply port 20 has a positive pressure, the front end side space 26 also has a positive pressure.
[0025]
The electric control unit 2 is electrically connected to the coil 24, and is configured to energize the coil 24 for a certain period of time to open the solenoid valve 1 as shown in FIGS. I have. That is, the amount of liquid to be sucked from the ultrafine tube 21 is determined by the length of time for which the solenoid valve 1 in the negative pressure state is kept open, and the time for keeping the solenoid valve 1 in the positive pressure state open. The amount of liquid to be ejected from the ultrafine tube 21 is determined by the length of the liquid.
The fixed time is set to 0.1 msec to 9.9 msec.
[0026]
At this time, the electric control unit 2 may be configured to independently control the time in which the solenoid valve 1 is in the negative pressure open state and the time in which the solenoid valve 1 is in the positive pressure open state. For example, when handling a viscous (a fixed amount of) liquid, the time for sucking the liquid in the microfine tube 21 is shorter than the time for discharging the liquid from the microfine tube 21. Is shorter than the time when the solenoid valve 1 is in the positive pressure open state, the same amount of liquid can be sucked and discharged.
[0027]
The electric control unit 2 is electrically connected to a central control unit (such as a timer) (not shown) together with the switching valve 7 (of FIG. 1). And the switching valve 7 are independently switched to the ON-OFF state. That is, after the switching valve 7 is turned off for a predetermined time (see FIG. 1), the electric control unit 2 (the solenoid valve 1) is turned on (see FIG. 4), and the switching valve 7 is turned on for a predetermined time (see FIG. 2). After that, the electric control unit 2 (the solenoid valve 1) is turned ON (see FIG. 4).
[0028]
Here, the liquid sucked in the negative pressure open state of the solenoid valve 1 is retained (temporarily) only in the ultrafine tube 21, and the liquid amount at this time is 10 nl (1/10 5 cc) to 1000 nl (1). / 10 3 cc).
[0029]
Next, the operation (function) and method of use of the present device will be described. As shown in FIG. 7 (a), when the solenoid valve 1 is closed, air in the internal space of the solenoid valve 1 is sucked and a negative pressure is applied. In this state, as shown in FIG. 7B, the tip of the ultrafine tube 21 is immersed in the liquid in one container 13, and then the solenoid valve 1 is opened to suck the liquid from the ultrafine tube 21. At this time, the electric control unit 2 keeps the solenoid valve 1 open for a certain period of time, so that a desired amount of liquid can be sucked as shown in FIG.
[0030]
Thereafter, as shown in FIG. 8A, in the closed state of the solenoid valve 1, air is fed into the internal space of the solenoid valve 1 to be in a positive pressure state, and a preload is applied. Then, as shown in FIG. 8 (b), after the tip of the microfine tube 21 is directed inside the other container 14, the solenoid valve 1 is opened, and the liquid is discharged from the microfine tube 21 while vigorously flying. At this time, a desired amount of liquid can be discharged by opening the electromagnetic valve 1 for a predetermined time in the electric control unit 2.
In the present invention, the entire amount of the liquid sucked in at one time is discharged.
[0031]
Next, FIG. 9 shows an example of a use state of the present apparatus, in which one container 13 and another container 14 are disposed apart from each other, and a desired liquid is supplied from one container 13 by the solenoid valve 1. The solenoid valve 1 is moved from one container 13 to the other container 14 side (in the direction of the arrow A), and one of the plurality of concave portions 14a of the other container 14 is taken out. Inject the entire amount of one dose into 14a. Then, the electromagnetic valve 1 is returned from the other container 14 to the one container 13 side (the direction of the arrow B), and a desired amount (one time) of the liquid is taken out of the one container 13 by the electromagnetic valve 1 again and injected. repeat.
[0032]
At this time, an interval timer (not shown) for controlling the moving speed of the solenoid valve 1 in the directions of arrow A and arrow B is provided, and the moving speed of the solenoid valve 1 in the direction of arrow A is controlled by the arrow A. And the moving speed of the solenoid valve 1 in the direction of arrow B can be made negative while moving the solenoid valve 1 in the direction of arrow B. Speed.
[0033]
Next, FIG. 10 shows another embodiment of the present invention, in which a compressor 6 and a vacuum pump 9 are provided at the base end of a common flow path 10, and the common flow path 10 is The connection is switched to the passage 6 or the passage of the vacuum pump 9. That is, as shown in FIG. 10, when the switching valve 7 is in the OFF state, the common flow path 10 is connected to the flow path of the vacuum pump 9, the supply port 20 of the solenoid valve 1 is set to a negative pressure, Inhalation. On the other hand, as shown in FIG. 11, when the switching valve 7 is in the ON state, the common flow path 10 is connected to the flow path of the compressor 6, the supply port 20 of the solenoid valve 1 is set to a positive pressure, and liquid is Discharge.
[0034]
It should be noted that the present invention is not limited to the above-described embodiment, and design changes can be made without departing from the spirit of the present invention. For example, the time in which the solenoid valve 1 is in the negative pressure open state and the time in which the solenoid valve 1 is in the positive pressure open state may be controlled in common. You may make it discharge separately.
[0035]
【The invention's effect】
Since the present invention is configured as described above, the following effects can be obtained.
[0036]
(According to claim 1) Since a small amount of liquid can be automatically sucked and discharged, an accurate amount of liquid can be sucked and discharged, and the accuracy is excellent.
In addition, the inhaled liquid can be ejected while being vigorously blown off, which is a wide variety of applications.
[0037]
(According to claim 2) Since a small amount of liquid can be sucked and discharged automatically, a precise amount of liquid can be sucked and discharged, and the accuracy is excellent.
In addition, the inhaled liquid can be ejected while being vigorously blown off, which is a wide variety of applications. Further, since the solenoid valve 1 can be set to the negative pressure and the positive pressure by one compressor 6, the size of the device can be reduced.
[0038]
(According to claim 3), the time in which the solenoid valve 1 is in the negative pressure open state and the time in which the solenoid valve 1 is in the positive pressure open state are adjusted according to the properties of the liquid (for example, the magnitude of the viscosity). It is possible to accurately suck and discharge a desired amount of liquid. For example, the suction amount and the discharge amount can be made the same.
(According to claim 4) Since the liquid is held in the ultrafine tube 21, the discharge amount can be made high-accuracy and the reactivity of the liquid discharge is excellent.
[Brief description of the drawings]
FIG. 1 is an explanatory diagram of the entire simplified configuration of a negative pressure state according to an embodiment of the present invention.
FIG. 2 is an explanatory diagram of the entire simplified configuration showing a positive pressure state.
FIG. 3 is a longitudinal sectional view showing a closed state of a solenoid valve.
FIG. 4 is a longitudinal sectional view showing an open state of a solenoid valve.
FIG. 5 is a cross-sectional view of a main part of the solenoid valve.
FIG. 6 is a cross-sectional view of a main part of the solenoid valve.
FIG. 7 is an explanatory diagram of an operation of a main part.
FIG. 8 is an explanatory diagram of an operation of a main part.
FIG. 9 is a perspective view showing a use state.
FIG. 10 is an explanatory diagram of the entire simplified configuration of a negative pressure state according to another embodiment of the present invention.
FIG. 11 is an explanatory diagram of the entire simplified configuration in a positive pressure state.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Solenoid valve 2 Electric control part 3 Positive pressure generating means 4 Negative pressure generating means 5 Switching means 6 Compressor 7 Switching valve 8 Ejector 10 Shared flow path 11 First flow path 12 Second flow path 20 Supply port 21 Extra-fine tube

Claims (4)

共用流路（１０）と、該共用流路（１０）の先端に供給ポート（２０）にて接続された電磁弁（１）と、該電磁弁（１）の開閉を時間にて制御する電気的制御部（２）と、上記共用流路（１０）の基端に配設された正圧発生手段（３）及び負圧発生手段（４）と、上記電磁弁（１）の供給ポート（２０）を正圧・負圧に切り換える切換手段（５）と、を備え、上記電磁弁（１）の負圧開状態で、上記電磁弁（１）の先端側から液体を吸入し、上記電磁弁（１）の正圧開状態で、上記電磁弁（１）の先端側から吸入した液体を吐出するように構成したことを特徴とする微量液体吸入吐出装置。A common flow path (10), a solenoid valve (1) connected to a distal end of the common flow path (10) at a supply port (20), and electricity for controlling opening and closing of the solenoid valve (1) with time. Control unit (2), positive pressure generating means (3) and negative pressure generating means (4) disposed at the base end of the shared flow path (10), and a supply port ( A switching means (5) for switching the pressure of the solenoid valve (20) to a positive pressure or a negative pressure; A small amount liquid suction / discharge device configured to discharge liquid sucked from the front end side of the electromagnetic valve (1) when the valve (1) is in a positive pressure open state. 共用流路（１０）と、該共用流路（１０）の先端に供給ポート（２０）にて接続された電磁弁（１）と、該電磁弁（１）の開閉を時間にて制御する電気的制御部（２）と、上記共用流路（１０）の基端側で分岐される第１流路（１１）及び第２流路（１２）と、該第１流路（１１）及び第２流路（１２）の基端に配設されてエアを供給するコンプレッサ（６）と、該コンプレッサ（６）からのエアを第１流路（１１）・第２流路（１２）に切り換える切換弁（７）と、上記第１流路（１１）に介在されて上記コンプレッサ（６）からのエアにて上記共用流路（１０）を真空引きするエジェクタ（８）と、を備え、上記コンプレッサ（６）からのエアを上記第１流路（１１）に切り換えて上記電磁弁（１）の供給ポート（２０）を負圧にすると共に上記コンプレッサ（６）からのエアを上記第２流路（１２）に切り換えて上記電磁弁（１）の供給ポート（２０）を正圧にするように構成し、さらに、上記電磁弁（１）の負圧開状態で、上記電磁弁（１）の先端側から液体を吸入し、上記電磁弁（１）の正圧開状態で、上記電磁弁（１）の先端側から吸入した液体を吐出するように構成したことを特徴とする微量液体吸入吐出装置。A common flow path (10), a solenoid valve (1) connected to a distal end of the common flow path (10) at a supply port (20), and electricity for controlling opening and closing of the solenoid valve (1) with time. Control section (2), a first flow path (11) and a second flow path (12) branched on the base end side of the common flow path (10), and the first flow path (11) and a second flow path (12). A compressor (6) disposed at the base end of the two flow paths (12) and supplying air, and switching air from the compressor (6) to a first flow path (11) and a second flow path (12). A switching valve (7); and an ejector (8) interposed in the first flow path (11) and evacuating the common flow path (10) with air from the compressor (6). When the air from the compressor (6) is switched to the first flow path (11) to make the supply port (20) of the solenoid valve (1) negative pressure Then, the air from the compressor (6) is switched to the second flow path (12) so that the supply port (20) of the solenoid valve (1) is set to a positive pressure. In the negative pressure open state, liquid is sucked from the front end of the solenoid valve (1), and in the positive pressure open state of the solenoid valve (1), the liquid sucked from the front end of the solenoid valve (1) is sucked. A small amount liquid suction / discharge device configured to discharge. 電気的制御部（２）が、電磁弁（１）の負圧開状態の時間と電磁弁（１）の正圧開状態の時間とを独立して制御するように構成されている請求項１又は２記載の微量液体吸入吐出装置。The electric control unit (2) is configured to independently control a time in which the solenoid valve (1) is in the negative pressure open state and a time in which the solenoid valve (1) is in the positive pressure open state. Or a microfluidic liquid suction and discharge device according to 2. 電磁弁（１）が、吸入した液体を保留する極細管（２１）を先端に突出している請求項１、２又は３記載の微量液体吸入吐出装置。4. A device for suctioning and discharging a small amount of liquid according to claim 1, wherein the solenoid valve (1) protrudes from a tip of an ultrafine tube (21) for holding the sucked liquid.
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JP2008518216A (en) * 2004-10-28 2008-05-29 北京博奥生物芯片有限▲責▼任公司 Micro capacity liquid injection system
US8900530B2 (en) 2004-10-28 2014-12-02 Capitalbio Corporation Micro-volume liquid ejection system
JP2009519439A (en) * 2005-12-12 2009-05-14 サイテック コーポレイション Method and apparatus for obtaining an aliquot from a liquid cell sample
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CN104994773A (en) * 2013-02-20 2015-10-21 艺康美国股份有限公司 Thermal valve
CN106967584A (en) * 2017-05-04 2017-07-21 南昌大学 A kind of automated cell suspension blows and beats evenly mixing device
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