JP2004073182A5 - - Google Patents

Info

Publication number

JP2004073182A5

JP2004073182A5 JP2003144204A JP2003144204A JP2004073182A5 JP 2004073182 A5 JP2004073182 A5 JP 2004073182A5 JP 2003144204 A JP2003144204 A JP 2003144204A JP 2003144204 A JP2003144204 A JP 2003144204A JP 2004073182 A5 JP2004073182 A5 JP 2004073182A5

Authority

JP

Japan

Prior art keywords

amino acid

acid sequence

same

seq

protein

Prior art date

2003-05-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 125000003275 alpha amino acid group Chemical group 0.000 description 49
• 108090000623 proteins and genes Proteins 0.000 description 26
• 102000004169 proteins and genes Human genes 0.000 description 25
• 108090000765 processed proteins & peptides Proteins 0.000 description 21
• 150000003839 salts Chemical class 0.000 description 19
• 238000012216 screening Methods 0.000 description 12
• 206010020772 Hypertension Diseases 0.000 description 11
• 206010003210 Arteriosclerosis Diseases 0.000 description 10
• 208000008589 Obesity Diseases 0.000 description 10
• 208000011775 arteriosclerosis disease Diseases 0.000 description 10
• 206010012601 diabetes mellitus Diseases 0.000 description 10
• 208000019622 heart disease Diseases 0.000 description 10
• 235000020824 obesity Nutrition 0.000 description 10
• 239000002157 polynucleotide Substances 0.000 description 10
• 102000040430 polynucleotide Human genes 0.000 description 10
• 108091033319 polynucleotide Proteins 0.000 description 10
• 229940122355 Insulin sensitizer Drugs 0.000 description 9
• 238000000034 method Methods 0.000 description 7
• 208000031226 Hyperlipidaemia Diseases 0.000 description 6
• 206010022489 Insulin Resistance Diseases 0.000 description 5
• 239000003795 chemical substances by application Substances 0.000 description 5
• 208000001072 type 2 diabetes mellitus Diseases 0.000 description 5
• 239000000032 diagnostic agent Substances 0.000 description 4
• 229940039227 diagnostic agent Drugs 0.000 description 4
• 239000003814 drug Substances 0.000 description 4
• 229940124597 therapeutic agent Drugs 0.000 description 4
• 208000019838 Blood disease Diseases 0.000 description 3
• 230000000692 anti-sense effect Effects 0.000 description 3
• 150000001875 compounds Chemical class 0.000 description 3
• 208000014951 hematologic disease Diseases 0.000 description 3
• 208000018706 hematopoietic system disease Diseases 0.000 description 3
• 230000003449 preventive effect Effects 0.000 description 3
• 230000000295 complement effect Effects 0.000 description 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
• 239000003446 ligand Substances 0.000 description 2
• 230000002265 prevention Effects 0.000 description 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• 102000004877 Insulin Human genes 0.000 description 1
• 108090001061 Insulin Proteins 0.000 description 1
• 239000005557 antagonist Substances 0.000 description 1
• 230000000694 effects Effects 0.000 description 1
• 229940125396 insulin Drugs 0.000 description 1
• 239000002773 nucleotide Substances 0.000 description 1
• 125000003729 nucleotide group Chemical group 0.000 description 1
• 230000000069 prophylactic effect Effects 0.000 description 1