JP2004010511A5 - - Google Patents

Info

Publication number

JP2004010511A5

JP2004010511A5 JP2002163839A JP2002163839A JP2004010511A5 JP 2004010511 A5 JP2004010511 A5 JP 2004010511A5 JP 2002163839 A JP2002163839 A JP 2002163839A JP 2002163839 A JP2002163839 A JP 2002163839A JP 2004010511 A5 JP2004010511 A5 JP 2004010511A5

Authority

JP

Japan

Prior art keywords

pth

aqueous solution

solution injection

human

methionine

Prior art date

2002-06-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000007864 aqueous solution Substances 0.000 claims 16
• 108090000445 Parathyroid hormone Proteins 0.000 claims 14
• 238000002347 injection Methods 0.000 claims 11
• 239000007924 injection Substances 0.000 claims 11
• 229930182817 methionine Natural products 0.000 claims 7
• OGBMKVWORPGQRR-UMXFMPSGSA-N teriparatide Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CNC=N1 OGBMKVWORPGQRR-UMXFMPSGSA-N 0.000 claims 7
• 238000000034 method Methods 0.000 claims 6
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 5
• TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 5
• HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 5
• 239000003381 stabilizer Substances 0.000 claims 5
• 230000000087 stabilizing effect Effects 0.000 claims 5
• 239000000811 xylitol Substances 0.000 claims 5
• HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 5
• 229960002675 xylitol Drugs 0.000 claims 5
• 235000010447 xylitol Nutrition 0.000 claims 5
• 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 2
• 229940071643 prefilled syringe Drugs 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 1