JP2003533188A - 疼痛シグナル伝達分子 - Google Patents

疼痛シグナル伝達分子

Info

Publication number
JP2003533188A
JP2003533188A JP2001580979A JP2001580979A JP2003533188A JP 2003533188 A JP2003533188 A JP 2003533188A JP 2001580979 A JP2001580979 A JP 2001580979A JP 2001580979 A JP2001580979 A JP 2001580979A JP 2003533188 A JP2003533188 A JP 2003533188A
Authority
JP
Japan
Prior art keywords
mrg
polypeptide
antibody
drg
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001580979A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003533188A5 (cg-RX-API-DMAC7.html
Inventor
ジェイ． アンダーソン，デイビッド
ドン，シンジョン
ジルカ，マーク
ハン，サン−キョウ
シモン，メルビン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology
Original Assignee
California Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/704,707 external-priority patent/US7691604B1/en
Application filed by California Institute of Technology filed Critical California Institute of Technology
Publication of JP2003533188A publication Critical patent/JP2003533188A/ja
Publication of JP2003533188A5 publication Critical patent/JP2003533188A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2001580979A 2000-05-04 2001-05-04 疼痛シグナル伝達分子 Pending JP2003533188A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US20202700P 2000-05-04 2000-05-04
US60/202,027 2000-05-04
US22234400P 2000-08-01 2000-08-01
US60/222,344 2000-08-01
US09/704,707 2000-11-03
US09/704,707 US7691604B1 (en) 2000-05-04 2000-11-03 MRG polypeptides and nucleic acids encoding the same
US28549301P 2001-04-19 2001-04-19
US60/285,493 2001-04-19
PCT/US2001/014519 WO2001083555A2 (en) 2000-05-04 2001-05-04 Pain signaling molecules

Publications (2)

Publication Number Publication Date
JP2003533188A true JP2003533188A (ja) 2003-11-11
JP2003533188A5 JP2003533188A5 (cg-RX-API-DMAC7.html) 2006-01-05

Family

ID=27498450

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001580979A Pending JP2003533188A (ja) 2000-05-04 2001-05-04 疼痛シグナル伝達分子

Country Status (7)

Country Link
EP (1) EP1280904B1 (cg-RX-API-DMAC7.html)
JP (1) JP2003533188A (cg-RX-API-DMAC7.html)
AT (1) ATE312919T1 (cg-RX-API-DMAC7.html)
AU (1) AU2001259508A1 (cg-RX-API-DMAC7.html)
CA (1) CA2407219A1 (cg-RX-API-DMAC7.html)
DE (1) DE60115878T2 (cg-RX-API-DMAC7.html)
WO (1) WO2001083555A2 (cg-RX-API-DMAC7.html)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020064822A1 (en) * 2000-03-13 2002-05-30 Ming-Hui Wei Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof
US20030092035A1 (en) 2000-05-04 2003-05-15 Anderson David J. Pain signaling molecules
DE60135773D1 (en) 2000-10-17 2008-10-23 Astrazeneca Ab Assays
US20040076951A1 (en) * 2000-10-25 2004-04-22 Ming-Hui Wei Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof
EP1360294A2 (en) * 2001-02-08 2003-11-12 Bayer Aktiengesellschaft Regulation of human dorsal root receptor-like g protein-coupled receptor
DE10225443A1 (de) 2002-06-08 2003-12-18 Aventis Pharma Gmbh Verfahren zur Identifizierung von Agonisten oder Antagonisten für den G-Protein gekoppelten Rezeptor mas like 1
WO2004039972A1 (ja) * 2002-10-29 2004-05-13 Takeda Pharmaceutical Company Limited Ｈｉ７ｔ２１３遺伝子導入動物および新規なｈｉ７ｔ２１３タンパク質およびそのｄｎａ
US7056685B1 (en) 2002-11-05 2006-06-06 Amgen Inc. Receptor ligands and methods of modulating receptors
DE10310758A1 (de) * 2003-03-11 2004-09-23 Grünenthal GmbH Identifizierung von schmerzrelevanten Genen der SNSR (Sensory Neuron Specific Receptor)-Familie
WO2005003763A2 (en) * 2003-06-18 2005-01-13 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with mas related g-protein coupled receptor 3 (mrgx3)
EP1689401A1 (en) 2003-10-02 2006-08-16 Elan Pharmaceuticals, Inc. Method for reducing pain
WO2005114208A1 (en) * 2004-05-13 2005-12-01 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with mas-related gene mrgd (mrgd)
WO2006005470A2 (en) * 2004-07-15 2006-01-19 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with mas related g-protein coupled receptor e (mrge)
WO2006066599A2 (en) * 2004-12-22 2006-06-29 Rheoscience A/S Mas related g protein coupled receptors as drug targets
CN112266931B (zh) * 2020-10-15 2022-04-29 海湃泰克(北京)生物医药科技有限公司 特异性表达hMRGPRX4的转基因大鼠的构建方法及其应用
CN118956756B (zh) * 2024-09-29 2025-07-25 中国人民解放军空军军医大学 一种痛感受器皮肤类器官芯片及其培养基、构建方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9704836D0 (sv) * 1997-12-22 1997-12-22 Astra Pharma Inc Novel receptor
JP2000023676A (ja) * 1998-07-14 2000-01-25 Asahi Chem Ind Co Ltd ７回膜貫通型受容体蛋白質ｅｒｇ５

Also Published As

Publication number Publication date
DE60115878T2 (de) 2006-08-24
DE60115878D1 (de) 2006-01-19
EP1280904A2 (en) 2003-02-05
WO2001083555A3 (en) 2002-05-02
CA2407219A1 (en) 2001-11-08
ATE312919T1 (de) 2005-12-15
AU2001259508A1 (en) 2001-11-12
EP1280904B1 (en) 2005-12-14
WO2001083555A2 (en) 2001-11-08

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