JP2003532400A - 微小流体装置 - Google Patents

微小流体装置

Info

Publication number
JP2003532400A
JP2003532400A JP2001581990A JP2001581990A JP2003532400A JP 2003532400 A JP2003532400 A JP 2003532400A JP 2001581990 A JP2001581990 A JP 2001581990A JP 2001581990 A JP2001581990 A JP 2001581990A JP 2003532400 A JP2003532400 A JP 2003532400A
Authority
JP
Japan
Prior art keywords
particles
reaction
reaction chamber
beads
filter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2001581990A
Other languages
English (en)
Japanese (ja)
Inventor
アンダーソン、ヘレン
ステム、ゴラン
ヴァン・デル・ウィジンガアート、ウォテル
Original Assignee
パイロシーケンシング・アーベー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by パイロシーケンシング・アーベー filed Critical パイロシーケンシング・アーベー
Publication of JP2003532400A publication Critical patent/JP2003532400A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D71/00Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/02Inorganic material
    • B01D71/0213Silicon
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40Concentrating samples
    • G01N1/4077Concentrating samples by other techniques involving separation of suspended solids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14Ultrafiltration; Microfiltration
    • B01D61/18Apparatus therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D67/00Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0039Inorganic membrane manufacture
    • B01D67/0053Inorganic membrane manufacture by inducing porosity into non porous precursor membranes
    • B01D67/0058Inorganic membrane manufacture by inducing porosity into non porous precursor membranes by selective elimination of components, e.g. by leaching
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D69/00Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D71/00Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/02Inorganic material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/005Beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668Trapping microscopic beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0681Filter
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0825Test strips
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
JP2001581990A 2000-05-12 2001-05-14 微小流体装置 Withdrawn JP2003532400A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0001768-1 2000-05-12
SE0001768A SE0001768D0 (sv) 2000-05-12 2000-05-12 Mikrofluidisk flödescell för manipulering av partiklar
PCT/GB2001/002119 WO2001085341A1 (en) 2000-05-12 2001-05-14 Microfluidic devices

Publications (1)

Publication Number Publication Date
JP2003532400A true JP2003532400A (ja) 2003-11-05

Family

ID=20279654

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001581990A Withdrawn JP2003532400A (ja) 2000-05-12 2001-05-14 微小流体装置

Country Status (5)

Country Link
EP (1) EP1280601A1 (sv)
JP (1) JP2003532400A (sv)
AU (1) AU5499201A (sv)
SE (1) SE0001768D0 (sv)
WO (1) WO2001085341A1 (sv)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004132708A (ja) * 2002-10-08 2004-04-30 Shimadzu Corp ダイアフラムを用いフィルタ機能を有するバルブ
JP2005257597A (ja) * 2004-03-15 2005-09-22 Japan Science & Technology Agency ビーズ担体充填式マイクロチップおよびそれを用いたビーズ担体の配置方法
JP2010227011A (ja) * 2009-03-27 2010-10-14 Seiko Epson Corp 細胞処理デバイス、細胞処理カートリッジおよび体液処理システム
JP2011145276A (ja) * 2009-12-16 2011-07-28 Sony Corp マイクロビーズ検査用のセル及びマイクロビーズの解析方法
WO2016203807A1 (ja) * 2015-06-18 2016-12-22 ソニー株式会社 分析用プローブ
KR20170018166A (ko) * 2015-08-06 2017-02-16 한양대학교 산학협력단 진동자를 구비하는 미세입자 분리소자
JP2018186814A (ja) * 2017-05-10 2018-11-29 上準微流體股▲ふん▼有限公司MiCareo Taiwan Co., Ltd. マイクロ流体チップ、細胞を濃縮する装置及びマイクロ流体チップ内で細胞を濃縮する方法
JP2020196687A (ja) * 2019-06-04 2020-12-10 株式会社日立プラントサービス 固相合成装置

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US20030164335A1 (en) * 1998-10-23 2003-09-04 Grate Jay W. Method for high throughput separations in microfluidic systems using small particles
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
CA2290731A1 (en) 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
US20030150791A1 (en) 2002-02-13 2003-08-14 Cho Steven T. Micro-fluidic anti-microbial filter
EP1499706A4 (en) 2002-04-01 2010-11-03 Fluidigm Corp MICROFLUIDIC PARTICLE ANALYSIS SYSTEMS
EP1359228B1 (en) * 2002-04-23 2013-11-27 Accenture Global Services Limited DNA authentification based on scattered-light detection
US20030217923A1 (en) * 2002-05-24 2003-11-27 Harrison D. Jed Apparatus and method for trapping bead based reagents within microfluidic analysis systems
US7220592B2 (en) 2002-11-15 2007-05-22 Eksigent Technologies, Llc Particulate processing system
US7175810B2 (en) 2002-11-15 2007-02-13 Eksigent Technologies Processing of particles
EP1594694A4 (en) 2002-12-30 2010-01-20 Univ California METHODS AND APPARATUS FOR DETECTION AND ANALYSIS OF PATHOGENIC AGENTS
AU2003900796A0 (en) * 2003-02-24 2003-03-13 Microtechnology Centre Management Limited Microfluidic filter
US7259855B2 (en) 2003-10-14 2007-08-21 3M Innovative Properties Company Porous microsphere resonators
US7444045B2 (en) 2003-10-14 2008-10-28 3M Innovative Properties Company Hybrid sphere-waveguide resonators
US20060046305A1 (en) * 2003-10-15 2006-03-02 National University Of Singapore Method and apparatus for detecting analyte with filter
WO2005060345A2 (en) * 2003-12-22 2005-07-07 Biotage Ab New method for sequencing-by-synthesis
US20050214737A1 (en) * 2004-03-26 2005-09-29 Dejneka Matthew J Transparent filtered capillaries
US7077175B2 (en) 2004-04-09 2006-07-18 Hongfeng Yin Particle packing of microdevice
US7352933B2 (en) 2004-05-27 2008-04-01 3M Innovative Properties Company Dielectric microcavity sensors
US7271379B2 (en) 2004-05-27 2007-09-18 3M Innovative Properties Company Dielectric microcavity fluorosensors excited with a broadband light source
US7799553B2 (en) 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
EP1794581A2 (en) 2004-09-15 2007-06-13 Microchip Biotechnologies, Inc. Microfluidic devices
US7257279B2 (en) * 2004-09-20 2007-08-14 3M Innovative Properties Company Systems and methods for biosensing and microresonator sensors for same
DE102005042884B3 (de) * 2005-09-09 2007-01-18 Gesellschaft zur Förderung der Analytischen Wissenschaften e.V. Verfahren und Vorrichtung zur Herstellung von kugel- oder schlauchförmigen künstlichen Membranen
CA2624634A1 (en) 2005-10-03 2007-04-12 Applera Corporation Compositions, methods, and kits for amplifying nucleic acids
DE102005062723B4 (de) * 2005-12-22 2007-11-22 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Probenaufarbeitungschip, Reaktionskammer und Verwendung des Probenaufarbeitungschips
US7749365B2 (en) 2006-02-01 2010-07-06 IntegenX, Inc. Optimized sample injection structures in microfluidic separations
WO2008030631A2 (en) 2006-02-03 2008-03-13 Microchip Biotechnologies, Inc. Microfluidic devices
US7766033B2 (en) 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
US7532790B2 (en) 2006-03-29 2009-05-12 3M Innovative Properties Company Method of coupling light into microresonators
US7389025B2 (en) 2006-03-29 2008-06-17 3M Innovative Properties Company Coupling light into microresonators
WO2008024070A1 (en) * 2006-08-22 2008-02-28 Agency For Science, Technology And Research Microfluidic filtration unit, device and methods thereof
US8841116B2 (en) 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
US20110039303A1 (en) 2007-02-05 2011-02-17 Stevan Bogdan Jovanovich Microfluidic and nanofluidic devices, systems, and applications
US8454906B2 (en) 2007-07-24 2013-06-04 The Regents Of The University Of California Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions
MX2010005579A (es) 2007-11-29 2010-06-01 Ibm Aparato y metodo para deteccion de un analito en una muestra.
US20090253181A1 (en) 2008-01-22 2009-10-08 Microchip Biotechnologies, Inc. Universal sample preparation system and use in an integrated analysis system
FI20085299A0 (sv) 2008-04-10 2008-04-10 Valtion Teknillinen Mikrofluidiska chip-anordningar och användning av dessa
CN101999075B (zh) * 2008-04-11 2014-10-29 皇家飞利浦电子股份有限公司 探测粒子的探测装置
KR20110111449A (ko) 2008-12-31 2011-10-11 인터젠엑스 인크. 미세유체 칩을 갖는 기구
EP2411539B1 (en) 2009-03-25 2018-10-03 Life Technologies Corporation Discriminatory positive/extraction control dna
CN102459565A (zh) 2009-06-02 2012-05-16 尹特根埃克斯有限公司 具有隔膜阀的流控设备
SG176669A1 (en) 2009-06-05 2012-01-30 Integenx Inc Universal sample preparation system and use in an integrated analysis system
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
US8763642B2 (en) 2010-08-20 2014-07-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves
WO2012024658A2 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Integrated analysis system
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
US9952126B2 (en) 2012-02-29 2018-04-24 Fluidigm Corporation Methods for multiple single-cell capturing and processing using micro fluidics
FR2993281B1 (fr) * 2012-07-13 2014-07-18 Biomerieux Sa Systeme automatise de lyse de microorganismes presents dans un echantillon, d'extraction et de purification des acides nucleiques desdits microorganismes aux fins d'analyse
DE102013203682A1 (de) 2013-03-05 2014-09-11 Robert Bosch Gmbh Vorrichtung zur Durchführung von chemischen und/oder biochemischen Prozessen
US10191071B2 (en) 2013-11-18 2019-01-29 IntegenX, Inc. Cartridges and instruments for sample analysis
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
CN107106983B (zh) 2014-10-22 2021-04-16 尹特根埃克斯有限公司 用于样品制备、处理和分析的系统和方法
US20210245153A1 (en) 2018-07-09 2021-08-12 Hewlett-Packard Development Company, L.P. Analyte capturing devices with fluidic ejection devices
IL311084A (en) 2018-11-30 2024-04-01 Caris Mpi Inc New generation molecular characterization
EP4069865A4 (en) 2019-12-02 2023-12-20 Caris MPI, Inc. PLATINUM RESISTANCE TEST FOR PAN CANCER

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US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
AU745989B2 (en) * 1997-08-13 2002-04-11 Cepheid Microstructures for the manipulation of fluid samples

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004132708A (ja) * 2002-10-08 2004-04-30 Shimadzu Corp ダイアフラムを用いフィルタ機能を有するバルブ
JP2005257597A (ja) * 2004-03-15 2005-09-22 Japan Science & Technology Agency ビーズ担体充填式マイクロチップおよびそれを用いたビーズ担体の配置方法
JP2010227011A (ja) * 2009-03-27 2010-10-14 Seiko Epson Corp 細胞処理デバイス、細胞処理カートリッジおよび体液処理システム
JP2011145276A (ja) * 2009-12-16 2011-07-28 Sony Corp マイクロビーズ検査用のセル及びマイクロビーズの解析方法
WO2016203807A1 (ja) * 2015-06-18 2016-12-22 ソニー株式会社 分析用プローブ
KR20170018166A (ko) * 2015-08-06 2017-02-16 한양대학교 산학협력단 진동자를 구비하는 미세입자 분리소자
KR101726064B1 (ko) 2015-08-06 2017-04-13 한양대학교 산학협력단 진동자를 구비하는 미세입자 분리소자
JP2018186814A (ja) * 2017-05-10 2018-11-29 上準微流體股▲ふん▼有限公司MiCareo Taiwan Co., Ltd. マイクロ流体チップ、細胞を濃縮する装置及びマイクロ流体チップ内で細胞を濃縮する方法
US10730049B2 (en) 2017-05-10 2020-08-04 Micareo Taiwan Co., Ltd. Microfluidic chip, apparatus for enriching cells and method for enriching cells in a microfluidic chip
JP2020196687A (ja) * 2019-06-04 2020-12-10 株式会社日立プラントサービス 固相合成装置
JP7299071B2 (ja) 2019-06-04 2023-06-27 株式会社日立プラントサービス 固相合成装置

Also Published As

Publication number Publication date
WO2001085341A1 (en) 2001-11-15
EP1280601A1 (en) 2003-02-05
SE0001768D0 (sv) 2000-05-12
AU5499201A (en) 2001-11-20

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Effective date: 20080805