JP2003531587A5 - - Google Patents

Info

Publication number

JP2003531587A5

JP2003531587A5 JP2001572867A JP2001572867A JP2003531587A5 JP 2003531587 A5 JP2003531587 A5 JP 2003531587A5 JP 2001572867 A JP2001572867 A JP 2001572867A JP 2001572867 A JP2001572867 A JP 2001572867A JP 2003531587 A5 JP2003531587 A5 JP 2003531587A5

Authority

JP

Japan

Prior art keywords

seq

nos

compound

expression

schizophrenia

Prior art date

2001-04-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 150000001875 compounds Chemical class 0.000 description 4
• 238000000034 method Methods 0.000 description 4
• 108090000623 proteins and genes Proteins 0.000 description 3
• 201000000980 schizophrenia Diseases 0.000 description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
• 101150052590 Cirl gene Proteins 0.000 description 2
• 102000005951 Netrin Receptors Human genes 0.000 description 2
• 108010030865 Netrin Receptors Proteins 0.000 description 2
• 101100434522 Rattus norvegicus Adgrl1 gene Proteins 0.000 description 2
• 108050009621 Synapsin Proteins 0.000 description 2
• 102000001435 Synapsin Human genes 0.000 description 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
• 101100532553 Escherichia coli (strain K12) sapD gene Proteins 0.000 description 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
• 238000010171 animal model Methods 0.000 description 1
• 230000002932 anti-schizophrenic effect Effects 0.000 description 1
• 210000004556 brain Anatomy 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• 230000006698 induction Effects 0.000 description 1
• 238000012216 screening Methods 0.000 description 1