JP2003530346A5 - - Google Patents
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- Publication number
- JP2003530346A5 JP2003530346A5 JP2001574102A JP2001574102A JP2003530346A5 JP 2003530346 A5 JP2003530346 A5 JP 2003530346A5 JP 2001574102 A JP2001574102 A JP 2001574102A JP 2001574102 A JP2001574102 A JP 2001574102A JP 2003530346 A5 JP2003530346 A5 JP 2003530346A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- acid
- bis
- composition
- chlorobenzamidophenoxyisobutyryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 12
- -1 4-chlorobenzamidophenoxyisobutyryl Chemical group 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- KGRVJHAUYBGFFP-UHFFFAOYSA-N 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) Chemical compound CC(C)(C)C1=CC(C)=CC(CC=2C(=C(C=C(C)C=2)C(C)(C)C)O)=C1O KGRVJHAUYBGFFP-UHFFFAOYSA-N 0.000 description 4
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 description 4
- 229960003067 cystine Drugs 0.000 description 4
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 description 4
- 229960004963 mesalazine Drugs 0.000 description 4
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000007795 chemical reaction product Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 230000036252 glycation Effects 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 208000037157 Azotemia Diseases 0.000 description 1
- 206010029350 Neurotoxicity Diseases 0.000 description 1
- 206010044221 Toxic encephalopathy Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000007135 neurotoxicity Effects 0.000 description 1
- 231100000228 neurotoxicity Toxicity 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 208000009852 uremia Diseases 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/543,703 US6337350B1 (en) | 1999-04-05 | 2000-04-05 | Inhibitors of formation of advanced glycation endproducts (AGEs) |
| US09/543,703 | 2000-04-05 | ||
| US55991300A | 2000-04-28 | 2000-04-28 | |
| US09/559,913 | 2000-04-28 | ||
| US09/626,859 US6589944B1 (en) | 1999-04-05 | 2000-07-27 | Breakers of advanced glycation endproducts |
| US09/626,859 | 2000-07-27 | ||
| PCT/US2001/009645 WO2001076584A2 (en) | 2000-04-05 | 2001-03-27 | Use of breakers of advanced glycation endproducts for treating deleterious effects of aging and debilitating diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003530346A JP2003530346A (ja) | 2003-10-14 |
| JP2003530346A5 true JP2003530346A5 (https=) | 2008-04-24 |
Family
ID=27415415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001574102A Pending JP2003530346A (ja) | 2000-04-05 | 2001-03-27 | 後期糖化最終生成物の新規破壊剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6589944B1 (https=) |
| EP (1) | EP1272172A2 (https=) |
| JP (1) | JP2003530346A (https=) |
| AU (2) | AU5519501A (https=) |
| CA (1) | CA2405411A1 (https=) |
| WO (1) | WO2001076584A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7030133B2 (en) * | 1999-04-05 | 2006-04-18 | City Of Hope | Inhibitors of formation of advanced glycation endproducts (AGEs) |
| WO2002018324A2 (en) | 2000-08-29 | 2002-03-07 | Nobex Corporation | Immunoregulatory compounds, derivatives thereof and their use |
| US8048924B2 (en) | 2001-08-29 | 2011-11-01 | Biocon Limited | Methods and compositions employing 4-aminophenylacetic acid compounds |
| DE10158076B4 (de) * | 2001-11-27 | 2005-09-01 | Beiersdorf Ag | Kosmetische und/oder dermatologische Zubereitungen mit einem Gehalt an Aryl-Ureido-Verbindungen und ihre Verwendung |
| JP4976851B2 (ja) * | 2003-10-27 | 2012-07-18 | シティ・オブ・ホープ | 脂質レベルを哺乳動物において低下させる方法 |
| DK1773767T3 (en) | 2004-07-07 | 2016-03-21 | Biocon Ltd | Synthesis of azo bound in immune regulatory relations |
| JP5188804B2 (ja) | 2004-08-03 | 2013-04-24 | トランステック ファーマ，インコーポレイティド | Ｒａｇｅ融合タンパク質及びその使用方法 |
| FR2883873B1 (fr) | 2005-03-31 | 2009-07-10 | Pharmamens Sarl | Inhibiteurs d'age |
| WO2007044309A2 (en) * | 2005-10-05 | 2007-04-19 | Vasix Corporation | Device and method for inhibiting age complex formation |
| US8580854B2 (en) * | 2005-11-09 | 2013-11-12 | City Of Hope | Methods of suppression of rage gene expression and rage triggered inflammatory genes by selected age-inhibitors |
| AU2007248784B2 (en) | 2006-05-05 | 2013-11-21 | Vtv Therapeutics Llc | RAGE fusion proteins, formulations, and methods of use thereof |
| WO2008033125A1 (en) * | 2006-09-13 | 2008-03-20 | The Procter & Gamble Company | Methods of treatment for ulcerative colitis using aminosalicylate |
| AU2006348180A1 (en) * | 2006-09-13 | 2008-03-20 | Warner Chilcott Company, Llc | Methods of treatment for ulcerative colitis |
| CA2675638C (en) * | 2007-01-16 | 2015-11-24 | Ipintl, Llc | Composition comprising serotonin for treating metabolic syndrome |
| DE102007041232A1 (de) | 2007-08-30 | 2009-03-05 | Henkel Ag & Co. Kgaa | Verwendung von Sulfonylharnstoffen zur Spaltung von AGEs |
| EP2158210B1 (en) | 2007-06-14 | 2015-12-09 | Galactica Pharmaceuticals, Inc. | Rage fusion proteins |
| US8124655B2 (en) * | 2007-06-15 | 2012-02-28 | City Of Hope | Use of LR-90 and LR-102 to overcome insulin resistance |
| FR2918570B1 (fr) * | 2007-07-09 | 2012-10-05 | Engelhard Lyon | DIGLYCATION DES AGEs. |
| DE102007054653A1 (de) | 2007-11-14 | 2009-05-20 | Henkel Ag & Co. Kgaa | Verwendung von Thioharnstoff-Derivaten zur Spaltung von AGEs |
| CA2666036C (en) | 2008-05-16 | 2017-09-12 | Chien-Hung Chen | Novel compositions and methods for treating hyperproliferative diseases |
| US8377947B2 (en) * | 2009-03-16 | 2013-02-19 | Chien-Hung Chen | Treating alzheimer's disease and osteoporosis and reducing aging |
| US9034341B2 (en) | 2009-04-20 | 2015-05-19 | Transtech Pharma, Llc | Control of RAGE fusion protein glycosylation and RAGE fusion protein compositions |
| WO2012103523A2 (en) * | 2011-01-27 | 2012-08-02 | Samuel Rahbar | Novel modulators of development of adipocyte and cancer cells |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57500432A (https=) * | 1980-03-20 | 1982-03-11 | ||
| US5100919A (en) | 1984-03-19 | 1992-03-31 | The Rockefeller University | Biguanides and derivatives thereof as inhibitors of advanced glycosylation of a target protein |
| JP4294120B2 (ja) * | 1998-05-12 | 2009-07-08 | 株式会社フジモト・ブラザーズ | 抗炎症用薬剤組成物 |
| WO2000059875A2 (en) * | 1999-04-05 | 2000-10-12 | City Of Hope | Novel inhibitors of formation of advanced glycation endproducts (age's) |
| WO2000066102A2 (en) | 1999-04-29 | 2000-11-09 | City Of Hope | Pentoxifylline, pioglitazone and metformin are inhibitors of formation of advanced glycation endproducts (age's) |
-
2000
- 2000-07-27 US US09/626,859 patent/US6589944B1/en not_active Expired - Lifetime
-
2001
- 2001-03-27 JP JP2001574102A patent/JP2003530346A/ja active Pending
- 2001-03-27 AU AU5519501A patent/AU5519501A/xx active Pending
- 2001-03-27 AU AU2001255195A patent/AU2001255195B2/en not_active Expired
- 2001-03-27 WO PCT/US2001/009645 patent/WO2001076584A2/en not_active Ceased
- 2001-03-27 EP EP01928322A patent/EP1272172A2/en not_active Withdrawn
- 2001-03-27 CA CA002405411A patent/CA2405411A1/en not_active Abandoned
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