JP2003518008A - Preformed gel sheet - Google Patents

Abstract

  (57) [Summary] A preformed sheet-like device comprising: (a) (i) a red algal polysaccharide; (ii) a mannose-containing polysaccharide selected from galactomannan, glucomannan and derivatives or mixtures thereof, and (iii) fermentation. An apparatus comprising less than 10% of a polysaccharide mixture consisting of polysaccharides or derivatives thereof; and (b) about 30% to about 99.5% of water, wherein said apparatus comprises less than 10% of total polysaccharides. ). The preformed sheet-like device of the present invention is suitable for topical application, has a desired amount of syneresis and / or improved mechanical properties such as strength or flexibility, as well as excellent humidification and hydration properties. And cooling properties. Furthermore, the device of the present invention is easy to handle, unobtrusive, and conforms to the contour of the surface of interest when applied.

Description

Detailed Description of the Invention

FIELD OF THE INVENTION The present invention relates to a new, preformed gel sheet device. In particular, a self-adhesive pre-adhesive patch or mask containing from about 30% to about 99.5% water and at least two water-soluble polymer gel formers for delivering beneficial agents to the skin, hair or nails. The present invention relates to a molded gel sheet device. The device is suitable for topical application and exhibits excellent moisturizing and hydrating properties with the desired amount of syneresis and improved mechanical properties such as strength and flexibility. Moreover, the device of the present invention is discreet and, when applied, conforms to the contours of the surface of interest. The desired properties are achieved by selecting with respect to the chemical composition of the preformed gel sheet device, the rheological properties, especially the relationship between the exudate release of the gels that make up the device, the force required to break, and the percent compression at break. It

BACKGROUND OF THE INVENTION Patches or the like containing water-soluble polymer gel formers instead of creams, lotions or the like to cosmetically care for the skin or to promote healing of burns or wounds. The benefits of using other devices are recognized in the art. A variety of cosmetic patches or devices are commercially available or described as useful for delivering skin care actives such as vitamins, anti-acne agents, moisturizers and the like.
Patches and devices have also been described in the literature and have entered the medical field as a useful means for transdermal administration of drugs. However, many of these patches or devices have deficiencies in their physical product form, which causes the consumer or user to notice unpleasant properties during use. For example, some of the patches and devices are too wet or sticky because they do not form a solid gel structure because the gelling agents that make up the patches and devices are difficult to handle and difficult to apply to the skin. There are also patches or devices that are strongly sticky and are awkward and uncomfortable to wear and remove,
And many patches effectively release and impermeable to the beneficial agent. Some patches or devices are too dry or inflexible and therefore do not fit the contours of the surface to which they are applied.

Moreover, such patches or devices require in-situ shaping of the skin, thus making the application cumbersome. For example, US-A-4,291,025 is 5-12%
Agar gel, containing 20-75% diethylene glycol and up to 100% by weight of water, and a method for producing said dressing. The composition may additionally contain gel enhancers and special purpose ingredients such as vitamins, antibiotics. U
According to one feature of the invention of S-A-4,291,025, a solid, high-strength agar-agar gel is produced and then cut into small pellets or pieces. As a further feature, the agar gel is then converted to a sol by heating, where the sol is applied to the targeted skin and cooled in situ to form a removable gel morphology.

Flexibility and strength are important features in gel-like devices. WO97 / 1794
4 is soluble alginate (0.1-5%), agar (0.01-0.5%), pectin (0.01-0.5%), xanthan gum (0.05-1%), A cosmetic formulation consisting of a gel material consisting of a harmonious mixture of polysaccharides containing the balance of water is disclosed. The gel material is optionally enriched with water-soluble or water-dispersible active ingredients. The gel material is easy to handle and can be manufactured to form the structural gels disclosed as being well compatible with the skin surface.

US-A-4,318,746 disperses, dissolves or hydrates in warm water and forms at least 0.5% of a first polymer capable of forming or forming a solid gel upon cooling. A gel that is at least 2% of a second polymer that is insoluble in warm water and that dissolves or hydrates upon cooling and that is compatible with the first polymer, and water. The specification states that the gel is stiff, cohesive and tacky, and is useful, for example, for topical administration of electrodes or drugs. The specification outlines that one of the advantages of the gel is that it is relatively stiff and tacky at temperatures below 60-65 ° C.

WO 90/14110 may take the form of a free-standing slab, pad or wafer of desired size, shape and thickness containing water insoluble alginates and suspending agents such as xanthan gum alone or a combination of xanthan gum and locust bean gum. Discloses medicines. Gellan gum is also disclosed as a more useful suspending agent. Suspending agents in the product may also act as gel formers. The product may optionally include anti-inflammatory or antiseptic agents, iodine. The slab or wafer shaped product may be an exposed or gauze-covered gel, lined with plastic to form an integrated surgical article.

However, many gels may not have sufficient strength to be preformed into a self-supporting sheet-like device, which is why occlusive or non-occlusive backing materials (often referred to as “base”). (Represented as "material"). The substrate is also used to prevent evaporation of the active ingredient, or an adhesive is coated around it as a means for adhering the device to the skin. The substrate may be impregnated, adhered or laminated to the surface of one of the layers that make up the patch or device. EP-B-507,160 is a drug-retaining layer on a support (wherein the drug-retaining layer is lidocaine, and 0.5% to 50% of a water-soluble high molecular weight substance, 20 to 70%).
Of water and an adhesive gel base with 1 to 70% water retention agent) for external application to the skin. Suitable supports are described as flexible materials such as nonwovens. However, the substrate needs to be compatible with the gel. If the gel comes off in a thin layer from the substrate, the substrate is not compatible with the gel. Even if the gel composition possesses the desired flexibility and strength, the combination of substrates with such gel properties and such gels remains a problem. The combination of a flexible substrate and a flexible gel does not necessarily make a flexible patch or device. Aside from thin layer delamination, many flexible substrates often exhibit considerable porosity, which results in the wet gel infiltrating the substrate, forming a strong gel network within the fibers. . It is believed that such reticulated fibers reduce the flexibility of the resulting device. Further, the substrate may not be able to provide a patch or device that has a discreet appearance on the skin, hair, or nails. This often depends on the choice of substrate and its properties.

GB 1,341,999 discloses a gelled medium suitable for the treatment of burns which comprises a liquid phase, a burn healing agent and a substantial amount of gel-forming agent. Gelled media are described as being flexible and plastic to conform to an essentially dry, continuous, non-stick surface and body. The preferred gel former is disclosed as a combination of xanthan and locust bean gum. It also discloses an example of a burn treatment disinfecting pad containing agarose, water and silver nitrate. Here, we consider that a small amount of syneresis in a gel-like medium helps to wet the surface with a burn healing substance, and facilitates removal of the medium from the human body. However, we have found that the gel-like media described in the examples of GB 1,341,999 are
While exhibiting the desired amount of syneresis, it does not have sufficient flexibility needed to fit the contours of the surface of interest well, or they are very elastic and in sheet form due to deformation. I found it difficult to maintain.

All gels undergo some degree of syneresis. That is, the gel contracts with the exudation of the liquid in a state where the gel is stationary. Syneresis provides a mechanism for delivering beneficial agents to the area of interest. The liquid layer of exudate formed on the surface of the gel-like medium diffuses easily and helps to reduce the wearing time of the device. It has been found by the present inventors that a moderate amount of syneresis is a highly desirable property for devices containing gels. Because the liquid that exudes to the surface of the gel-like device facilitates its adhesion to the area of interest, thus requiring the gel body to be overcoated with additional adhesive or the need for either an adhesive-coated substrate. It is to lose it. By comparison, if a gel-like device exhibits too little syneresis, the device is unlikely to provide sufficient adhesion to the area of interest, even if it wets the area, while excessive amounts of syneresis are not effective. It will be an unattractive product.

EP-A-161 681 discloses a gel plate containing an aqueous solution of a polysaccharide and a polyhydric alcohol. A preferred polysaccharide for gel plates is a blend of carrageenan and galactomannan or carrageenan alone. The composition may optionally contain pharmaceutical ingredients such as skin irritants, anti-inflammatory agents, analgesics and antibiotics.
The gel plate is transparent or unobtrusive and is disclosed to have a refreshing feel and sufficient tackiness, as well as sufficient elasticity, stretchability and strength. However, the inventor has discovered that the gel plate described in EP-A-161681 does not exhibit the desired amount of syneresis.

JP-B2-2761936 discloses an aqueous sheet pack containing xanthan gum and locust bean gum in combination with a water-soluble solvent. The sheet-like pack of the invention is disclosed as having excellent shape retention at high temperature, providing a moisturizing feeling, and having a high moisturizing effect on the skin. In the examples it is disclosed that the pack may further contain 0.1% skin cosmetic ingredients.

[0012] JP-A-54 92618 discloses a wet pap containing aqueous calcium ions cross-linked with an alginate gel as a base, anti-inflammatory and analgesic substances and water. In Example 5, locust bean gum, konjac powder, 3%
A wet pap containing a mixture of a sodium alginate solution, a source of calcium phosphate monohydrate and a styrene-butadiene copolymer latex is disclosed. This document shows that the addition of a water-soluble polymer increases the shape retention of the pap, and that addition of locust bean gum and konjak mannan, or carrageenan alone, results in a highly elastic gel. However, the addition of water-soluble polymers such as konjak and locust bean gum, among others, to wet paps has been shown to interfere with water release. In addition, the wet pap gel-containing base of the invention is shown to be less water-releasing.

EP-A-750,905 discloses a water-soluble adhesive sheet, the water-soluble protective layer being laminated on one surface of this sheet and / or one or more release liners (release liners). It is stated that the material may optionally be included. Patches are disclosed as bath agents, which are topically applied to the skin surface and dissolve during bathing to alleviate various cardiovascular, muscle, joint and skin disorders. The patch optionally contains a number of cosmetic and pharmaceutically active substances.

Water-soluble polymers such as polysaccharides are also used as gelling agents or thickeners, but not as patch compositions. For example, US-A-4,661,475
(A) 10 to 90 parts by weight of cassia galactomannan and (b) 90 to 90 parts by weight.
Disclosed are gelling compositions and thickeners containing 10 parts of carrageenan, agar, xanthan gum or mixtures thereof. The composition described in this specification is
For example, it is useful as a thickener for medicinal or cosmetic purposes. JP97020649 discloses a base material composition containing a gellan gum, a base comprising cations and water, and EP-A-803,245 comprises 15-90% water,
A compact solid gel is described which comprises 0.3-4% thermoreversible polysaccharides, 4-40% humectant, and 2-35% powder phase. Example 2 of this specification describes a solid gel containing carrageenan (0.60%) and xanthan gum (1.00%). The object of the invention is defined to provide an aqueous gel which can be applied directly to the skin with a finger or a dedicated applicator. The solid compact gels of that invention are described as being easier to spread and the compact product form makes it easier to control the amount of gel to be removed.

Although the above-mentioned patches or sheets in the cosmetics and medical field have shown progress in reaching the desired physical and use properties, the document discloses that an aqueous solution containing a mixture of at least two water-soluble polymer gel formers, There is no mention of a self-supporting preformed gel sheet device, although this device has not only the desired amount of syneresis but also strength and flexibility. Furthermore, there is no suggestion that all three parameters are essential to reach the desired use properties of the preformed gel sheet device.

Surprisingly, a solid preformed gel-sheet device is self-supporting if it not only has the flexibility to match the contours of the surface of interest but also exhibits a moderate amount of syneresis. It has now become clear that high strength structures can be achieved. The syneresis exhibited by the gel-like devices herein promotes its stickiness to the surface of interest, thus obviating the need for adhesives or adhesive-coated substrates to be overcoated in gel form. The device herein is thin, yet easy to handle and apply. The desired physical and use properties are achieved by selecting the chemical composition and rheological properties of the gel-like device with respect to syneresis, strength and flexibility relationships. The seating device herein is a patch or mask for cosmetic or therapeutic purposes.

SUMMARY OF THE INVENTION The present invention is a preformed gel sheet device, which is a patch or mask for delivering a beneficial agent to the skin, hair or nails, from about 30% to about 99%. % Of water and at least two water-soluble polymer gel formers, and the gel comprising the device released exudates of greater than 0.7 g and less than 1.3 g, the percent at break. The compression is more than 45% and less than 90%, and the damage is 3
It requires more than 0N).

A second aspect of the present invention is to provide a cosmetic care method that includes applying a preformed gel sheet device to the skin, hair or nails. As a third aspect of the present invention, there is provided a preformed gel sheet-like device containing a polysaccharide mixture comprising (i) a red algal polysaccharide and (ii) a mannose-containing polysaccharide. Contains less than 2% of the total polysaccharides, and the ratio of the red algal polysaccharide to the mannose-containing polysaccharide is about 1: 1 to about 10: 1, and the force required for the gel constituting the device to break is Greater than 60N.

The preformed gel sheet device of the present invention exhibits a moderate amount of syneresis and provides excellent use characteristics in terms of unobtrusiveness, compatibility, hydration and humidification upon topical application. In addition, the preformed gel sheet device of the present invention has excellent mechanical properties, forms a flexible, high strength structure, and has fairly high elasticity.

DETAILED DESCRIPTION OF THE INVENTION The preformed gel sheet device of the present invention comprises water and a mixture of at least two water-soluble polymeric gel formers, and various optional ingredients as set forth below.
All concentrations and ratios are by weight of the total composition of the device, unless otherwise indicated. As used herein, the term "preformed" means that the device so described has been manufactured into a product form having a predetermined thickness, shape and size, with the aid of a finger. It means that it may be removed from the package and placed on the surface of interest or covered loosely, without the need for spreading, rubbing or covering in the product area on the area of interest.

As used herein, the term “sheet-like device” means a patch or mask for cosmetic or medical use in which the described device has a planar or non-planar shape, wherein The patch is a continuous one-layer, two-layer, or multi-layer plate-like sheet, has a shape predetermined by the specific area of the skin, hair, or nails to be maintained, and the mask is an eye, A non-continuous, one-, two- or multi-layered plate-like sheet covering a facial area having openings for the nose or mouth.

As used herein, the term “water soluble” means that a polymeric gel former capable of gelling, either at room temperature or by heating to form a continuous phase, can be dissolved in an aqueous solution.

As used herein, the term “syneresis” means the process whereby a gel contracts in the static state with exudation of liquid. Without being bound by theory, the gel composition binds or encapsulates other components in the composition.
It is believed to form a dimensional matrix. Syneresis is believed to be involved in the initial homogeneous separation of the condensable gel phase into the liquid. The exudate is a solution whose composition depends on the composition contained in the original gel. When the device of the present invention is applied to a target area, the device releases the bound components within the gel matrix, such as water or beneficial agent, to the target area, and some of its volume to penetrate the target area. Lose.

As used herein, the term “polysaccharide” means a linear or branched polymer of naturally derived or synthetically produced monosaccharide units, which has a low dry concentration in water. When dispersed, it swells and gels the aqueous phase.

The term “exudate release” as used herein means an indication of the amount of syneresis exhibited by the gel. Said method is described in the section entitled "Methods".

The term “percent compression at break” as used herein is a measure of the flexibility of the gel. Said method is described in the section entitled "Methods".

As used herein, the term “force required to break” is a measure of gel strength. Said method is described in the section entitled "Methods".

The term “brittleness” as used herein means a gel that breaks easily when flexed.

The preformed gel sheet device of the present invention is suitable for topical application to the skin, hair or nails.

Water-Soluble Polymer Gel Forming Agent As an essential component of the preformed gel sheet device described herein,
The device comprises a mixture of at least two water soluble polymer gel formers. Generally, the preformed gel sheet device of the present invention comprises less than 30%, preferably less than 20%, more preferably 1% of the total weight of the mixture of water-soluble polymer gel formers.
Includes less than 0%, and especially less than 5%.

The water-soluble polymer gel formers can be self-gelling or can form gels only in combination with other substances such as sugars, alcohols, or mono- or polyvalent salts. The monovalent or polyvalent salts may additionally act as gel toughening agents which impart additional strength to the preformed gel sheet devices herein. Suitable cations for mono- or polyvalent salts may be selected from potassium, sodium, ammonium, zinc, aluminum, calcium and magnesium ions or mixtures thereof. Suitable anions paired with the above cations may be selected from chloride, citrate, sulphate, carbonate, borate and phosphate anions or mixtures thereof.

The water-soluble polymer gel former used in the present invention is selected from synthetic or natural polymers and mixtures thereof.

Synthetic Polymers Suitable synthetic polymers for use herein are nonionic water soluble polymers,
Examples thereof include acrylic acid-based polymers or derivatives thereof, or cellulose derivatives, and mixtures thereof. Synthetic polymers useful herein can be classified by their charge or their constituent monomers. However, it should be understood that the classifications herein are made for convenience and there may be overlap between the classifications.

Nonionic Water-Soluble Polymers : Suitable nonionic water-soluble polymers for use herein are polydimethylacrylamide, polyvinylpyrrolidone, polyethylene glycol monomethacrylate, poly-2-ethyl-2-oxazoline, polyvinyl alcohol. , Polyethylene oxide, polyvinyl ether, copolymers of polyvinyl ether and polyvinyl pyrrolidone and its derivatives, methyl vinyl ether and maleic anhydride, copolymers of ethylene and maleic anhydride, and mixtures thereof. Further suitable nonionic water-soluble polymers for use herein include "HEMA" copolymers and US-A-5,804,107, col. 14, lines 36-67 and col. 15, lines 1-34. Incorporate in the specification)
2-Hydroxyethylmethacrylate ("HEMA")-based copolymers that include another comonomer as described in.

Acrylic Acid Polymers or Derivatives Thereof : Suitable acrylic acid polymers or derivatives thereof include polyacrylic acid, salts of polyacrylic acid such as ammonium polyacrylate and sodium polyacrylate, acrylamide and N, N. Included are copolymers of ¹ -methylenebisacrylamide and polyacrylamide, and polyacrylamide, or mixtures thereof.

Cellulose Derivatives : Examples of suitable cellulose derivatives for use herein are carboxymethyl hydroxyethyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, cellulose acetate propionate carboxylate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl. Cellulose, methyl cellulose, sodium methyl cellulose,
Hydroxypropylmethyl cellulose, methyl hydroxyethyl cellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof. Cellulose substituted with alkyl groups are also useful herein. Among these polymers, the hydroxy groups of the cellulosic polymers are hydroxyalkylated (preferably hydroxyethylated or hydroxypropylated) to make hydroxyalkylated celluloses and further C10-C3 via ether linkages.
It is modified with 0 straight or branched chain alkyl groups. Typically these polymers are ethers of C10-C30 straight or branched chain alcohols with hydroxyalkyl cellulose. Examples of alkyl groups useful herein include stearyl, isostearyl, lauryl, myristyl, cetyl, isocetyl, cocoyl (i.e., alkyl groups derived from the alcohol of coconut oil), palmityl, oleyl, linoleyl, linolenyl, ricinoleyl, behenyl, And those selected from the group consisting of mixtures thereof. Preferred among the alkyl hydroxyalkyl cellulose ethers are the substances whose CTFA designation is cetyl hydroxyethyl cellulose, an ether of cetyl alcohol and hydroxyethyl cellulose. This material is Natrosol® CS Plus
It is commercially available from Aqualon Corporation under the product name.

Natural Polymers Natural polymers suitable for use herein include gelatin, polysaccharides, and mixtures thereof. The polysaccharide used in the device of the present specification is preferably red algal polysaccharide, galactomannan, glucomannan, fermented polysaccharide or derivative thereof, brown algal polysaccharide, marine invertebrate extract, starch or derivative thereof, natural fruit. It is selected from extracts, plant fiber derivatives, kelps, natural plant exudates, and resinous gums, or mixtures thereof.

When the device herein contains one or more polysaccharides, the device comprises less than 10%, preferably less than 5%, and more preferably less than 2% by total dry weight of the polysaccharide. .

Gelatin : When gelatin is used in the device herein, high molecular weight gelatin is combined with low molecular weight gelatin to control solubility characteristics. Gelatin having a low molecular weight of 20,000 or less has a low gelling ability.

Brown algal polysaccharides : Polysaccharides classified as brown algal polysaccharides are Phaebop
hyceae) is isolated by extraction from a marine plant species belonging to the class Hyceae. Suitable brown algae polysaccharides for use herein include algin, alginic acid, ammonium alginate, calcium alginate, potassium alginate, sodium alginate, propylene glycol alginate, and mixtures thereof.

Red algal polysaccharides : Polysaccharides classified as red algal polysaccharides are Rhodophyc
eae) isolated from a marine plant species belonging to the class. Red algal polysaccharides provide mechanical strength to aqueous gels. Suitable red algae polysaccharides for use in the present invention include, in the industry, a variety of Gelidium plant species or closely related red algae-derived (CTFA) name “aga-
Agar known as agar agar flake [TIC Gum (TIC G
ums, Maryland, USA, Belcamp)
(Agar Agar 100) or "Agar Agar 150", or from Gumix International Inc., Fort Lee, NJ, USA as "Agar Agar K-100". Agar K
-100) ”]; F as“ Sea Plaque ”
From MC (Philadelphia, PA, USA) and "Agarose
"Type 1-b (Agarose Type 1-b)" as Sigma-Aldrich
agarose commercially available from Drich Co. Ltd., Poole, UK; Lambda, Iota, and Kappa, water extracts from various species of the Gigartinaceae or Solieriaceae families Carrageenan containing fractions [known in the industry (CTFA) under the name chondrus, “Gelcarin® LA”, “Seakem® 3 / LCM”, or “Viscarin” (Viscarin® XLV, all commercially available from FMC (Philadelphia, PA, USA)]; and Gum Technology Corporation (Tucson, Arizona, USA)
ucson)) and Continental Colloids Inc., USA,
Furcellaran or mixtures thereof, which are commercially available from Chicago, Illinois. Preferably, the red algae polysaccharides used herein are selected from agar, agarose, kappa-carrageenan and furcellaran or mixtures thereof. More preferably, the red algae polysaccharides used herein are selected from agar and agarose or mixtures thereof.

Glucomannan : Glucomannan is essentially a mannose-containing polysaccharide containing a linear backbone of β (1 → 4) -linked glucose and mannose residues. The C-6 portion of the mannose or glucose residue in the polysaccharide backbone may be replaced with an acetyl group.
One acetyl group is usually found every 6 to 20 sugar residues. The preferred glucomannan or derivative thereof for use herein has a mannose to glucose ratio of about 0.2 to about 3. Preferred glucomannans for use herein include:
Konjac Mannan (Amorphophallus) Konjac plant (a generic name for a powder made by crushing tuber roots of elephant yam, a trademark "
Nutricol® konjak powder "is commercially available from FMC (Philadelphia, PA, USA); and deacetylated konjak mannan; or mixtures thereof.

Galactomannan : Galactomannan is a plant storage polysaccharide found in the endosperm cells of the vast majority of leguminosae seeds. The generic term "galactomannan" includes all polysaccharides made of galactose and mannose residues.
Galactmannan is a (1 → 4) -linked β-D-mannopyranosyl (mannopyranosy).
l) A mannose-containing polysaccharide so that it contains a linear backbone of units. Attached as a branch to these rings, the galactopyranose residue is separated by the-(1,6) -glucosidic bond. The galactomannan may also contain other sugar residues in small amounts. Galactomannan suitable for use herein is fenugreek gum (fen
ugreek gum); alfalfa; clover; for example known in the industry as (CTFA) carob bean gum and marketed by FMC (Philadelphia, PA, USA) as “Seagul L”. Locust bean gum; Starlight Products (France,
(Rouen) or Bunge Foods (Bunge Foods, Atlanta, Georgia, USA) tara gum (tara gum), which is commercially available; From "TIC Gums" (Belcamp), TIC Gums as "Burtonite V7E", to Rhone-Poulenc as "Jaguar C" (Rhone-Poulenc, Georgia, USA) , Marietta
etta)) or as "Supercol" (Aqualon,
Guar gum commercially available from Wilmington, Del., USA; and Cassia gum commercially available from Starlight Products, Rouen, France, or mixtures thereof. Preferably, the galactomannans used herein have, on average, 1 (1 → 6) -linkage of every 1 to about 5 mannosyl units-D-galactopyranosyl (galactop).
yranosyl) unit, guar gum, locust bean gum, and cassia gum,
Or selected from mixtures thereof.

Fermented Polysaccharides or Derivatives Thereof : Fermented polysaccharides are polysaccharides that are produced commercially by fermentation of microorganisms in a medium containing carbon and nitrogen sources, buffers and minor constituents. Suitable fermented polysaccharides or derivatives thereof for use in the present invention include (C
TFA) Gellan gu, also known as gum gellan
m) [high molecular weight heteropolysaccharide gum produced by pure culture fermentation of carbohydrates and Pseudomonas elodea, commercially available from Kelco (San Diego, Calif., USA) as "Kelcogel") ];
Xanthan gum, a high molecular weight heteropolysaccharide gum produced by pure culture fermentation of carbohydrates and Xanthomonas campestris [known in the industry as (CTFA) Xanthan, for example, "Celtrol C
G 1000 / BT / F / GM / RD / SF / T / TF (Keltrol CG 1000 / BT / F /
GM / RD / SF / T / TF) "all available from Calgon (Pittsburgh, PA, USA) or" Kelzan "from Kelco (San Diego, CA)]; Natto Gum; pullulan;
Rhamsan gum; curdlan; succino
glycan); welan gum; dextran ["Sephadex G-25
(Sephadex G-25) "as Pharmacia Fine C
hemicals, commercially available from Piscataway, NJ, USA] and its derivatives; and sclerotium gum [Alban Muller International (Montreil, France) as "Amigel"). More commercially available] or a mixture thereof. Preferably, the fermented polysaccharide or derivative thereof is selected from gellan gum and xanthan gum, or mixtures thereof. More preferably, the fermenting polysaccharide is xanthan gum.

Marine Invertebrate Extracts : Polysaccharides from marine invertebrates, in particular the exoskeleton of such invertebrates consists mainly of N-acetyl-D-glucosamine residues. Examples of such polysaccharides suitable for use herein include: chitosan (eg, commercially available from Ajinomoto, Teaneck, NJ, USA as "Marine Dew") and hydroxy. Propyl chitosan (for example, as "HPCH Liquid", Ichimaru Pharcos,
(Commercially available from Gifu prefecture Yama prefecture county)) and derivatives, or a mixture thereof.

Starch or its Derivatives : Starch is a polysaccharide consisting of two parts of glucose polymer, amylose and amylopectin. Suitable materials for use herein include starch, amylopectin, and dextrin (commercially available from National Starch, Bridgewater, NJ, USA as "Nadex 360") and derivatives. Or the mixture thereof is mentioned.

Natural Fruit Extracts : Examples of natural fruit extracts suitable for use herein include pectin, and arabian, or mixtures thereof.

Plant Fiber Derivative : A preferred example of a plant fiber derivative for use herein is cellulose.

Natural plant exudates : Suitable polysaccharides derived from natural plant exudates for use herein include karaya gum, tragacanth gum, gum arabic, tamarind gum, and ghatty gum, or mixtures thereof. Is mentioned.

Resinous gums : Examples of resinous gums suitable for use herein include shellac gum, dummar gum, obtained from the resinous secretions of the insect Laccifer (Tachardia) lacca, Examples include copal gum and rosin gum, or mixtures thereof.

Preferably, the mixture of at least two water soluble polymer gel formers of the present invention forms a solid, self-supporting and self-adhesive structure. In general, gels formed from one water-soluble polymeric gel former may exhibit one or two of the desired physical properties described herein, but not all three. Gels formed from the synthetic polymer itself often take a long time to solidify, requiring removal of water from the reaction mixture before formation of the continuous phase. As a result, the gel product is dry to the touch and does not exhibit a sufficient amount of syneresis. We have found that polysaccharide gels made from individual polysaccharides have the desired syneresis, strength and flexibility parameters (described herein).
I also found that it does not fit into. For example, red algal polysaccharides alone form gels of sufficient strength, but the resulting gels are too brittle and inflexible to match the contours of the surface of interest. Gellan gum also forms gels of reasonable strength, which are moist to the touch, but often brittle and inflexible, peeling off or lifting off non-planar target surfaces. . In order to reduce the brittleness of the gel and thereby increase its flexibility, locust bean gum and other polysaccharides such as xanthan gum or humectants may be mixed into the gel, but this will increase the amount of syneresis exhibited by the gel. May change. Gels formed from gelatin and brown algal polysaccharides have sufficient strength, but additional additives are required to form the desired amount of syneresis and, in the case of brown algal polysaccharides, flexible gels. . Galactomannan, glucomannan and xanthan gum do not themselves form gels when used individually, but show synergism when combined. A gel containing 1% locust bean gum and xanthan gum may have a sufficient moist feel, but it is very elastic, deformable and liable to hold in sheet form. The higher the total gum concentration, the more gel formed will retain its shape but may be too dry. Therefore, the inventors have discovered that gels formed from a synergistic mixture of water soluble polymeric gel formers exhibit the desired mechanical strength and syneresis properties described herein. Such properties differ from those achievable by the individual gel former components.

The present inventors have also found that in order to obtain a gel having a desired amount of syneresis and mechanical strength and flexibility, the water-soluble polymer gel-forming agent selected according to the strength is a moisturizer or other gel. It has been found that the total concentration of the water-soluble polymer gel-forming agent mixture should be kept as low as possible without compromising mechanical strength and flexibility when combined with agents that reduce the brittleness of. It is believed that the low total polymer concentration provides an open gel structure that allows the other components of the original gel to freely diffuse without tightly binding within the gel network.

Preferably the mixture of water soluble polymer gel formers comprises at least one polysaccharide. The mixture thus comprises at least one polysaccharide and a water-soluble polymer gel former selected from one or more nonionic water-soluble polymers, one or more acrylic acid-based polymers or derivatives thereof, one or more thereof. The above polysaccharides,
And mixtures thereof. For example, the water-soluble polymer gel-forming agent mixture herein may include one or more polysaccharides and a nonionic water-soluble polymer, or alternatively may include two or more polysaccharides. . More preferably, the mixture of at least two water soluble polymer gel formers is a polysaccharide mixture. Preferably, the polysaccharide mixture is (1) at least one red algal polysaccharide, brown algal polysaccharide or mixture thereof, and (2) at least one fermented polysaccharide, galactomannan, glucomannan, natural plant exudate, or natural. Includes fruit extracts and their derivatives or mixtures. More preferably, the polysaccharide mixture comprises (1) at least one red algal polysaccharide,
And (2) at least one fermenting polysaccharide, galactomannan, glucomannan,
And their derivatives or mixtures.

In a preferred embodiment, the mixture of at least two water-soluble polymer gel formers according to the invention is a mixture of polysaccharides consisting of (1) red algal polysaccharides and (2) mannose-containing polysaccharides, wherein the device is Contains less than 2% total polysaccharides. Preferably, the red algae polysaccharides are selected from agar and agarose or mixtures thereof, and preferably the mannose containing polysaccharides are selected from galactomannans, glucomannans and derivatives, or mixtures thereof. Without wishing to be bound by theory, it is believed that the galactomannan or glucomannan in the polysaccharide mixture complements the red algal polysaccharide and contributes to the mechanical strength and flexibility of the preformed gel sheet device of the present invention. It is considered. This synergistic effect is believed to be enhanced by the interaction between the polysaccharides. Red algal polysaccharides form a double helix structure, and glucomannans and galactomannans have relatively unsubstituted regions on the polymer backbone. Such relatively non-substituted regions on the galactomannan and glucomannan backbones act synergistically on the helices of the red algal polysaccharide. The polysaccharide mixture may additionally comprise xanthan gum in an amount equal to or less than the amount of mannose-containing polysaccharide. Further, in view of providing a moderate amount of syneresis and improvement of mechanical properties in the preformed gel sheet device, preferably the ratio of red algal polysaccharide and mannose-containing polysaccharide in the polysaccharide mixture. Is about 1: 1 to about 10: 1, and more preferably about 2: 1 to about 7: 1.

The preformed gel sheet device of the present invention exhibits a moderate amount of syneresis,
And preferably the device herein is wet to the touch. As mentioned above, devices containing gels always do some syneresis, but excessive amounts of syneresis make ineffective and unattractive products. To assess the desired amount of syneresis exhibited by the gel of a preformed gel sheet device as described herein, the amount of syneresis is measured by the exudate release test described in the "Methods". To do.

Preformed gel sheet device, wherein the gel containing the device has an exudate release of greater than 0.7 g, and preferably greater than 0.8 g and also less than 1.3 g, preferably less than 1.2 g And more preferably less than 1.1 g.

The mechanical properties of the preformed gel sheet device of the present invention are measured by compression failure of the gel. The parameters of interest are strength (measured by the compressive force required to break a gel molded into a cylinder) and flexibility (measured by the degree of gel compression at break).

Further preferred features of the preformed gel sheet device of the present specification include:
The gel containing the device is to have a percent compression at break of greater than 45%, preferably greater than 50%, and less than 90%, preferably less than 80%.

As an even more preferred feature of the preformed gel sheet device of the present invention, the gel containing the device has a force of greater than 30 N, preferably 6 to break.
Forces greater than 0N, and more preferably greater than 80N are required.

[0060] Water gel sheet-like device that is preformed in the present invention contains water as an essential feature. The total water content of the preformed gel sheet device of the present invention is from about 30% to about 9% by weight of the device.
9.5%, preferably about 40% to about 95%, more preferably about 50% to about 85%.
Is.

Beneficial Agents In a preferred embodiment of the present invention, the preformed gel sheet device herein comprises a safe and effective amount of one or more beneficial agents.

As used herein, the term “safe and effective amount” delivers a beneficial effect to the skin, hair, or nails that is sufficient or desired to alter the condition to be treated. Is a sufficient amount, yet low enough to avoid serious side effects, and within the bounds of sound medical judgment, means a beneficial amount of the drug at a reasonable rate of risk for efficacy. A safe and effective amount of a beneficial agent is the specific agent, the transdermal, or permeation of the agent into or on the hair and / or nails, the age of the user, the health of the user, and the skin and hair of the user. Or it will change depending on the condition of the nail and other factors.

[0063] Beneficial agents include pharmaceutically acceptable salts, and "pharmaceutically acceptable salts" means without causing toxicity, irritation, incompatibility, instability, hypersensitivity or allergic reaction. By any commonly used salt suitable for use in contact with human tissue.

Generally, the preformed gel sheet device of the present invention will contain at least one beneficial agent or mixture thereof from about 0.01% to about 40%, preferably about 0.0% by weight of the device.
5% to about 30%, most preferably about 0.1% to about 20%.

Beneficial agents useful herein are classified by their therapeutic effect or their desired mode of action. However, it should be understood that the beneficial agents useful herein may, in some cases, provide multiple therapeutic effects or act in multiple modes of action. Therefore, the classification herein is for convenience only and is not intended to limit the beneficial agent to any particular application or listed application. The following beneficial agents are useful in the preformed gel sheet device of the present invention.

Anti-acne agents : Anti-acne agents can be effective in treating and preventing acne vulgaris (chronic disease of the pilosebaceous follicles). This condition involves inflammation of the pilosebaceous apparatus and the resulting lesions, which can include papules, pustules, cysts, comedones and severe scarring. Bacteria of Corynebacterium acnes and Staphylococcus epidermis are usually present as pus contents. Examples of useful anti-acne agents include the keratolytic agents described in WO98 / 18444. Further useful active substances are retinoids such as retinoic acid (eg cis and / or trans) and its derivatives (eg esters);
Retinol and its esters (eg retinyl propionate, retinyl acetate);
Abietic acid, adapalene, tazarotene, allantoin, aloe extract, arbietic acid and its salts, ASEBIOL, LABORATORIES Serobiolog
iques, commercially available from Somerville, NJ), azaleic acid, barberry extract, bearberry extract, belamcanda chinensis, benzoquinolinone, benzoyl peroxide, berberine, biodermin (BIODERMINE, (Commercially available from Sederma, Brooklyn, NY), bioflavonoids, bisabolol, s-carboxymethyl cysteine, carrot extract, cassin oil, clove extract, citral, citronellal, climazole, completec MBAC-OS (COMPLETECH MBAC-OS, commercially available from Lipo, Paterson, NJ), Cremogen M82 (CREMOGEN M82, Dragoco (Dr
agoco, commercially available from Totowa, NJ), cucumber extract, dehydroacetic acid and its salts, dehydroepiandrosterone and its sulfate derivatives,
Dichlorophenylimidazole dioxolane, d, l-valine and its ester, dmdm hydantoin, erythromycin, escinol, ethylhexyl monoglyceryl ether, ethyl 2-hydroxyundecanoate, farnesol, farnesyl acetate, geraniol, geranylgeraniol, glabridin. , Gluconic acid, gluconolactone, glyceryl monocaprate, glycolic acid, grape seed extract, gugu lipid, hederagenin (HEDERA
GENIN, Marristown, Morristown, NJ
Commercially available), hesperitin, hinokitol, hop extract, hydrogenated rosin, 10-hydroxydecanoic acid, ichitiol, interleukin-1α antagonist, capillarine (KAPILARINE, Greentech (Greentech)
, Commercially available from Saint Beauzire, France), ketoconazole, lactic acid, lemongrass oil, LOCHOCHALCONE LR15, Marzen (Ma
ruzen, commercially available from Morristown, NJ), linoleic acid, Lipaside C8CO (commercially available from LIPACIDE C8CO, Seppic, Paris, France), lovastatin, 4-methoxysalicylic acid, metronidazole,
Minocycline, mukurossi, neem seed oil, nicotinic acid amide,
Nicotinic acid and its ester, nisin, panthenol, 1-pentadecanol, peonia extract, peppermint extract, ferradendron (p
helladendron) extract, 2-phenyl-benzothiophene derivative, phloretin (ph
loretin), PHLOROGINE, Sekuma (Secma, France, Pontoreau (
(Pontriux)), phosphatidylcholine, proteolytic enzyme, quercetin, rosewood extract, rosemary extract, rutin, sage extract, salicin, salicylic acid, serine, skullcap extract, Siberian hegner extract, Siberia Yukinoshita extract, silicol, sodium lauryl sulfate, sodium sulfoacetamide, sophora extract (SOPHORA EXTRAC
T, Maruzen (commercially available from Morristown, NJ), sorbic acid, sulfur, sunder vati extract, gyeol oil, tetrahydroabietic acid, threonine, thyme extract, tioxolone. , Tocopherol and its ester, trehalose 6-undecylenate, 3-tridecen-2-ol, triclosan, tropolone
), UNITRIENOL T27 (commercially available from UNITRIENOL T27, Unichem (Chicago, Illinois)), vitamin D ₃ and its analogs, white thyme oil, willow bark extract, wogonin, ylang-ylang oil, glyceric acid Zinc, zinc linoleate, zinc oxide, zinc pyrithione, zinc sulfate, zwitterionic surfactants (eg cetyl dimethyl betaine) and mixtures thereof.

Non-steroidal anti-inflammatory drug (NSAIDS) : NSA suitable for use herein
Examples of IDS and their esters are described in WO 98/18444, which is incorporated herein by reference. Non-steroidal anti-inflammatory drug (NSAIDS)
Further examples of flufenamic acid; panthenol and its ether and ester derivatives such as panthenol ethyl ether, panthenyl triacetate; pantothenic acid and its salts and ester derivatives, especially calcium pantothenate; aloe vera, bisabolol, allantoin and licorice ( Gurichirurichia glabra (Gl ycyrrhiza glabra) genus / species plants) group of the compound (glycyrrhetinic acid, glycyrrhizic acid and its derivatives (e.g., esters such as salts, such as ammonium glycyrrhizinate and glycyrrhetinic acid stearyl) and the like) is Examples include, but are not limited to:

Local Anesthetics : Examples of suitable local anesthetics for use herein are benzocaine and bupivacaine. Further preferred examples are described in WO98 / 18444,
Incorporated herein by reference.

Artificial tanning and accelerating agents : Artificial tanning agents can help to simulate natural tanning by increasing melanin in the skin or by creating the appearance of increased melanin in the skin. Examples of artificial tanning agents and promoters are glucose tyrosine and acetyltyrosine, bradylin, caffeine, coffee extract, DNA fraction, isobutylmethylxanthine, methylxanthine, phototan (PHOTOTAN, Laboratoires Serobiolo).
giques, commercially available from Somerville, NJ), prostaglandins, tea extracts, theophylline, UNIPERTAN P200
2. Unichem (available from Unichem, Chicago, IL) and Unipertan P27
(UNIPERTAN P27, commercially available from Unichem (Chicago, Ill.)); And mixtures thereof. Further useful artificial tanning agents herein are described in WO 98/18444.

Disinfectants : Examples of disinfectants suitable for use herein include alcohol, benzoic acid, sorbic acid and mixtures thereof.

Antibacterial and antifungal agents : Antibacterial and antifungal agents can be effective in preventing the growth and growth of bacteria and fungi. Examples of antibacterial and antifungal agents are ketoconazole, ciclopirox, benzoyl peroxide, tetracycline, azelaic acid and its derivatives, ethyl acetate, allanto lactone, isoallant lactone, alcanna extract (alaninin), Anise, rabbit chrysanthemum extract (helenalin acetate and 11,13 dihydrohelenine
alin)), Menma extract (extract containing flororcinol), Barberry extract (berberine hydrochloride), Bay sweet extract, bayberry bark extract (myricitrin), benzalkonium chloride, chloride Benzethonium,
Benzoic acid and its salts, benzoin, benzyl alcohol, blessed thistle (bless
ed thistle), bretilla tuber, red grass, boadrose oil, burdock, butyl paraben, linseed oil, CAE (commercially available from Ajinomoto, Teaneck, NJ), capeto oil, cangzhu, white fennel Oil, Cascarilla bark (sold as trade name ESSENTIAL OIL), cedarleaf oil, chamomile, chaparral, chlorophenesin, chlorxylenol, cinnamon oil, citronella oil, clove oil, dehydroacetic acid and its salts, dill Seed oil, DOWICIL 200, Dow Chemical (commercially available from Dow Chemical, Midland, MI), Echinacea (
echinacea), elenolic acid, epimedium, ethylparaben, F
O-TI, Galvanum, Garden Waremokou, GERMALL 115
And GERMALL II (available from ISP-Sutton Labs, Wayne, NJ), German chamomile oil, giant knotweed, GLYDANT, Lonza.
, Available from Fairlawn, NJ), GLYDANT PLUS, Lonza, Fairlawn, NJ
)), Grapefruit seed oil, hexamidine diisethionate, hinokitiol, honey, honeysuckle flower, hops, permanent flowers, iodopropylbutylcarbamide (commercially available from IODOPROPYNL BUTYL CARBAMIDE, Lonza, Fairlawn, NJ) , Isobutylparaben, isopropylparaben, JM ACTICARE (commercially available from Microbial Systems International, Nottingham, UK),
Peanut, Katong CG (commercially available from KATHON CG, Rohm and Haas, Philadelphia, PA), Labdanum, lavender, Atlantic mint oil, lemongrass, methylparaben, mint, plum, mustard, myrrh, neem Seed oil, orthophenylphenol, olive leaf extract (OLIVE LEAF EXTRACT, commercially available from Bio Botanica, Hauppauge, NY), parsley, patchouli oil, button root, phenonip (PHENONIP, Naipa Lab ( Nipa Labs, commercially available from Wilmington, Del.), Phytosphingosine, pine needle oil
), Plan serverative (PLANSERVATIVE, Campo Research,
(Singapore, commercially available from Raffles Quay)), propylparaben, purslane, quillaira, rhubarb, scented oil,
Rosemary, sage, salicylic acid, sassafras, savory, sichuan lavage
(sichuan lovage), Sodium metabisulfite, Sodium sulfite, SOPHLIANCE, SOLIANCE, France Campigne (Comp.
iegne)), sorbic acid and its salts, sphingosine, stevia, soy sauce, tannic acid, tea, gyeol oil (caept oil), thyme, triclosan, triclocarban, tropolone, terpentine, umbelliferone (umbelliferone). ) (Antifungal), and yucca or mixtures thereof, but are not limited thereto. Further examples of antibacterial and antifungal agents useful herein are described in WO 98/18444.

Skin soothing agents : Skin soothing agents can be effective in preventing or treating skin inflammation. Sedatives enhance the skin's cosmetic benefits of the present invention, eg, such agents contribute to a more uniform and acceptable skin texture and tone. Examples of skin soothing agents include abscintium, acacia, aescin, horse chestnut extract, allantoin, aloe, APT (commercially available from Centerchem, Stamford, Connecticut), Rabbitum, Astragalus, Astragalus root extract Stuff, Azulene, Baicalin SR15 (commercially available from Barnet Products Dist., Englewood, NJ), Baikal Sorrel, baizhu, Canada balsam, bee pollen, Biophytex (commercially available from Laboratories Serobiologiques, Somerville, NJ), bisabolol, cohosh (perennial herb), cohosh (perennial herb) extract, Hosshu (Louis iodine button), cohosh (Louis iodine button) extract, Eupatorium, borage, borage oil,
Rurichisha seed oil, bromelain, calendula, calendula extract, CANADIAN WILLOWBARK EXTRACT, phytochem (
Marketed by Fytokem), candela wax, canju (cangzhu), canola phytosterols, capsicum, carboxypeptidase, celery seeds, celery stalk extract, centaurium (marketed by CENTAURIUM, Sederma, Brooklyn, NY), centaury. Extract, chamazu
lene), chamomile, chamomile extract, chaparral, Italian carrot, Italian carrot extract, chickweed, chicory root, chicory root extract,
Chirata, chishao, colonial oatmeal (collodi
al oatmeal), comfrey, comfrey extract, chromist CM glucan (CROMI
ST CM GLUCAN, Croda, Parsippa, NJ
ny))), Darutoside, Dehulian Angelica (
dehurian angelica), Devils Crow (commercially available from DEVIL'S CLAW, MMP, Plainfield, NJ), divalent metals (such as magnesium, strontium, and manganese), doggrass, dogwood, air shave (EASH).
AVE, Pentapharm (commercially available from Basel, Switzerland), Eleuther, ELHIBIN, Pentapharm,
(Commercially available from Basel, Switzerland), Enteren 2, Sekuma (S
ecma (commercially available from Pontrieux, France), ephedra, esculoside, esculoside, evening primrose, stag beetle, extract LE-100 (EXTRACT LE-100, Sino Lion, NY World Trade) (Commercially available from the center), fanfeng, feverfew,
Ficin, Forsythia fruit, ganoderma, gaoben, GATULINE A, Gattefosse, France, Saint Priest
(Saint Priest)), gentian root, germanium extract, ginkgo
Bilboa (gingko bilboa), Ginkgo, Ginseng extract, Hydrastis, Goat extract, Gotu kola, Grapefruit extract, Guaia cypress oil, Guggal extract, Helenalin ester, Tsumagureinoki, Honeysuckle flower, Mint minnow extract, horse chestnut, horse chestnut, fusan (h
uzhang), Hypericum, Ichthyol, Permanent flower, Turmeric, Juuzdama, Jujube, Chocolat extract, LANACHRYS 28, Lana Tech
, Commercially available from Paris, France), lemon oil, lianqiao, licorice root, ligusticum, botanaceae, lavage root, loofah, nutmeg flower, magnolia flower, manjistha extract Objects, margaspidin, matricin, microat I
RC (MICROAT IRC, Missoura, Nurture, MT)
More commercially available), mint, mistletoe, modulene (MODULENE, Seporga,
Commercially available from Sophia Antipolis in France), mung bean extract, musk, oat extract, orange, panthenol, papain, button bark, button root, phytoprenoline (PHYTOPLENOLIN, bio botanica (Bio B)
otanica, commercially available from Hauppauge, NY), Preregen (PR
EREGEN, available from Pentapharm (Basel, Switzerland)
, Purslane, QUENCH T (commercially available from Centerchem, Stamford, CT), quillaia, lantana,
Rehmannia, rhubarb, rosemary, rosemary acid (rosmarinic
acid), royal jelly, henruda, rutin, sandalwood, sanki (sanqi),
Sarsaparilla, Saw Palmetto, SENSILINE, Silab
, From France, Brive), SIEGESBECKIA,
(Commercially available from Sederma, Brooklyn, NY), Stearyl glycyrrhetinate, STIMUTEX, Pentaparm (Pentap
harm, marketed in Switzerland, Basel), Sugoka, Lentil birch oil, Kurabasou, Tagetes, tea extract, thyme extract, tienchi yak yao carrot, tocopherol, tocopheryl acetate, triclosan, turmeric, urimei. ), Ursolic acid, strobe pine bark, witch hazel, xinyi, yarrow, yeast extract, yucca and mixtures thereof, but are not limited thereto.

Sunscreens : Examples of suitable sunscreens useful herein are WO98 / 18.
444, which is incorporated herein by reference. Further examples of sunscreens useful herein include p-methoxycinnamic acid diethanolamine, dioxybenzone, ethyldihydroxypropyl PABA, glyceryl aminobenzoate, lawsomes and dihydroxyacetone, menthyl anthranilate, anthranilic acid. Methyl, octyl dimethyl PABA, red petroleum, sulisobenzone, triethanolamine salicylate, and mixtures thereof.

Skin Barrier Repair Adjuvant : A skin barrier repair aid is a skin care aid that can help repair or replenish the natural moisture barrier function of the epidermis. Preferable examples of the skin barrier repairing aid include bradycasterol, caffeine, campesterol, canola-derived sterol, CERAMAX, Quest (Q
uest, commercially available from Ashford, United Kingdom), Ceramide 2 (CERAM
IDE 2, commercially available from Sederma, Brooklyn, NY), Ceramide HO3TM (commercially available from CERAMIDE HO3TM, Cederma, Brooklyn, NY), Ceramide II (CERAMIDE II, Quest, UK,
Commercially available from Ashford), Ceramide III (CERAMIDE III, commercially available from Quest, Ashford, United Kingdom), Ceramide IIIB (CERAMIDE IIIB, Cosmoferm, Netherlands, Delft (D)
(commercially available from elft), ceramide IS3773 (CERAMIDE IS 3773, laboratory)
Serobiologiques (available from Somerville, NJ), CERAMINOL, Ainocosm (I
Nocosm, marketed by Chatenay Malabry in France)
CERASOL, Pentapharm, Switzerland, Basel
), CEPHALIP, from Pentapharm, Basel, Switzerland), cholesterol, cholesterol hydroxystearate, cholesterol isostearate, 7-dehydrocholesterol, Dermatein BRC, Hormel. , Commercially available from Austin, Minn.), Dermatein GSL (commercially available from Hormel, Austin, Minn.), Eldew CL30
1 (ELDEW CL 301, commercially available from Ajinomoto, Teaneck, NJ), Eldew PS203 (commercially available from ELDEW PS 203, Ajinomoto, Teaneck, NJ), phytrobroside (FITROBROSIDE, Pentapharm, Commercially available from Basel, Switzerland), Generol 1
22 (GENEROL 122, Henkel, Hoboken, NJ
), Glyceryl serine amide, lactic acid, lactamide (commercially available from LACTOMIDE, Pentapharm, Basel, Switzerland), lanolin, lanolin alcohol, lanosterol, lauric acid n-lauryl glucamide,
Lipoic acid, n-acetyl cysteine, serine, n-acetyl-L-serine, n-methyl-L-serine, NET sterol-ISO (NET STEROL-ISO, Barnet Products, Englewood, NJ )
), Nicotinic acid amide, nicotinic acid and its ester, nicotinyl alcohol, palmitic acid, panthenol, panthetine, phosphodiesterase inhibitor, PHYTO / CER (PHYTO / CER, Intergen (Interge)
n, marketed by Purchaser, NY), PHYTOGLYCOLIPID MILLET EXTRACT, marketed by Barnet Products Distributer, Englewood, NJ, Phyto. Sphingosine (PHYTOSPHINGOSINE
, Gist Brocades (commercially available from King of Prussia, PA), PSENDOFILAGGRIN (commercially available from Brooks Industries, South Plainfield, NJ), Quest Maid H (QUESTAMI
DE H, Quest (available from Quest, Ashford, United Kingdom),
Serine, stigmasterol, sitosterol, stigmasteranol, soybean-derived sterol, sphingosine, s-lactoyl glutathione, stearic acid, super sterol ester (SUPER STEROL ESTERS, commercially available from Croda, Parsippany, NJ), Thioctic acid, THSC ceramide oil (THSC CERAMIDE OIL, commercially available from Campo Research, Raffles Quay, Singapore), trimethylglycine, tocopheryl nicotinate, vitamin D3 and its analogs or derivatives, and Y2.
(Y2, Ocean Pharmaceutical, or mixtures thereof.

Anti-wrinkle and anti-skin atrophy actives : Anti-wrinkle and anti-skin atrophy actives include epithelial and / or
Or it can be effective in replenishing or rejuvenating the dermal layer. Such actives usually enhance or maintain the natural process of desquamation and / or build the skin matrix components (eg collagen and glycosaminoglycans) to achieve the desired benefits of such skin care. provide. Examples of anti-wrinkle and anti-skin atrophy actives include, but are not limited to, nicotinic acid and its esters, nicotinyl alcohol, estrogens, and estrogen compounds or mixtures thereof. Further suitable anti-wrinkle and anti-skin atrophy actives useful herein are described in WO 98/18444. Skin repair actives : Skin repair actives can be effective in repairing epithelial and / or dermal layers. Examples of skin repair active substances include actein 27-
Deoxyactein cimicifugoside (cimigoside), adapalene, tazarotene
), Ademethionine, adenosine, aletris extract, aloe-derived lectin, 3-aminopropyl dihydrogen phosphate, AMADORINE, Barnet Products, Englewood, NJ (Commercially available from (Englewood)), anise extract, AOSINE (AOSINE
, Sekuma (commercially available from Pontrieux, France), arginine aminobenzoate, ASC III (ASC III, commercially available from E. Merck, Darmstadt, Germany), ascorbic acid, palmitin Acid ascorbyl, asiatic acid, asiaticosides
), ARLAMOL GEO, ICI, Wilmington, Del.
(Commercially available from Wilmington), azaleic acid, benzoic acid derivative, bertholletia extract, betulinic acid, BIOCHANIN A
), Biopeptide CL (BIOPEPTIDE CL, Sederma (commercially available from Sekulein, NY)), biopeptide EL (BIOPEPTIDE EL, Sederma)
erma (commercially available from Plucklin, NY), biotin, blackberry bark extract, Amaranthaceae extract, Perennial extract of the genus Saliciana, Rhubarb beet extract, butanoyl betulinate, catecholamines, chalcone, carrot extract from Italy, cis- Retinoic acid, citrate ester, clover extract, coenzyme Q10 (ubiquinone), coumestrol, CPC peptide (CPC PEPTIDE, commercially available from Barnet Products, Englewood, NJ), Daidzein, dang gui extract, darutoside, debromo laurinterol
(debromo laurinterol), 1-decanoyl-glycero-phosphonic acid, dehydrocholesterol, dehydrodicresol, dehydrodioigenol, dehydroepiandrosterone, dermolectin (DERMOLECTINE, commercially available from Sederma (Brooklyn, NY)), dehydroascoli Binic acid, dehydroepiandrosterone sulfate, dianetole, 2,4-dihydroxybenzoic acid, diosgenin, disodium ascorbyl phosphate, dodecanedioic acid,
EDERLINE (commercially available from Sephorga, Sophia Antipolis, France), ELESERYL SH (commercially available from Laboratories Serobiologiques, Somerville, NJ), Endone Crane (Commercially available from ENDONUCLEINE, Laboratories Serobiologiques, Somerville, NJ), equol, ergosterol, eriodictythiol, estrogen and its derivatives, ethocyn, and ethrobinic acid (ey).
throbic acid), farnesol, farnesyl acetate, fennel extract, fibrastil (available from FIBRASTIL, Sederma, Brooklyn, NY), fibrocity murin S and P (FIBROSTIMULINES S AND P, Sederma, Brooklyn, NY) More commercially available), Pharmogen I
S8445 (FIRMOGEN IS 8445, laboratory cello biologic (Laborato
ries Serobiologiques, Somerville, NJ), flavonoids (especially flavanones and unsubstituted chalcones such as unsubstituted flavanones and chalcones such as monohydroxy and dihydroxychalcones), formononetin (f
ormononetin), forsythia fruit extract, gallic acid ester, γ-aminobutyric acid, GATULINE RC (commercially available from Gattlefosse, France, Saint Priest), genistein, genistein (genistein)
genisteine), genistic acid, gentisyl alcohol, gingko bilboa extract, ginseng extract, ginsenoside, RO, R _6-1 , R _6-2 , R _6-3 , R _C , R _D , R _E , R _F ,
R _F-2 , R _G-1 , R _G-2, glucopyranosyl _{-1 -} ascorbate, glutathione and its ester, glycitein, eptyloxy 4 salicylic acid (ep
tyloxy 4 salicylic acid), hesperitin, hexahydrocurcumin, HMG-Coenzyme A reductase inhibitor (HMG-Coenz)
yme A Reductase Inhibitors), hop extract, 11-hydroxyundecanoic acid,
10-hydroxydecanoic acid, 25-hydroxycholesterol, isofabone SG
10 (ISOFAVONE SG 10 from Barnet Products (Englewood, NJ)), kinetin, L-2-o oxo-thiazolidine-4-carboxylic acid ester, lactate dehydrogenase inhibitor, 1 −
Lauryl-lyso-phosphatidylcholine, lectin, lycochalcone LR15 (LI
CHOCHALCONE LR15, Maruzen, Morristown, NJ
(commercially available from rristown)), licorice extract, lipoic acid, lumisterol, luteolin, magnesium ascorbyl phosphate, melatonin, melibiose, metalloproteinase inhibitor, mesoprene, mesoprenic acid, 4-
Methoxysalicylic acid, mevalonic acid, MPC COMPLEX, CL
R, commercially available from Berlin, Germany), N-acetyl cysteine, N-methylserine, N-methyltaurine, N, N ¹ -bis (lactyl) cysteamine, naringenin, neothiogogenin (neotigogenin), 5-octanoylsalicylic acid , O-desmethylangoiensin, oleic acid, pantetheine, phenylalanine, photoanethone, phytic acid and its salts, piperidine, placenta extract, platencein, pregnenolone, pregnenolone acetate, Pregnenolone succinate, premarin, quillaic acid, raloxifene, repair factor 1 (R
EPAIR FACTOR 1, Sederma (available from Sederma, Brooklyn, NY)
Repair factor SPC (REPAIR FACTOR SPC, commercially available from Sederuma (Sederma, Brooklyn, NY)), retinol, retinoic acid ester (C ₂ -C ₂₀
Alcohol ester), retinol, retinyl acetate, retinyl glucuronate, retinyl linoleate, retinyl palmitate, retinyl propionate, revitalin BT (REVITALIN BT, Pentapharm, Switzerland, Basel)
(Commercially available from (Basel)), s-carboxymethyl cysteine, salicylic acid, SEINAMINE FP, Laboratory Cellobiologic (Laboratories S
erobiologiques (commercially available from Somerville, NJ)), sodium ascorbyl phosphate, soybean extract, pancreatic extract, tachysterol, taurine, tazarotene, thymulen, thymus extract, thyroid hormone, tigogenin, Tocopheryl-retinoate, toxifolin,
Trans retinoic acid, traumatic acid (traumatic acid), citric acid three choline, triforine side (trifoside), uracil derivatives, ursolic acid, vitamin D ₃ and its analogs, vitamin K, Vitex (Vitex) extract, yam extract Thing, yamogenin (ya
mogenin) and zeatin, or mixtures thereof, but are not limited thereto.

Lipids : Examples of suitable lipids include cetyl ricinoleate, cholesterol hydrostearate, cholesterol isostearate, CREMEROL (commercially available from Amerchol, Edison, NJ), Eldew C1301 (ELDEW). C1301, Ajinomoto, Teanek, NJ
(commercially available from aneck)), lanolin, modulan (MODULAN, Amercho
l, commercially available from Edison, NJ), Orlan (OHLAN, commercially available from Amerchol, Edison, NJ), Vaseline, phytantriol and super sterol ester (SUPER STEROL EST)
ERS, Croda (commercially available from Croda, Parsippany, NJ), or mixtures thereof.

Skin lightening agents : Skin lightening agents can substantially reduce the amount of melanin in the skin, or provide such effects by other mechanisms. Suitable skin lightening agents for use herein are EP-A-758,882 and E.
P-A-748,307, which is incorporated herein by reference as a quantitative patent. Further examples of skin lightening agents include adapalene,
Aloe extract, aminotyrosine, ammonium lactate, anethole derivative, apple extract, arbutin, ascorbic acid, ascorbyl palmitate, azelaic acid, bamboo extract, bearberry extract, bretilla tuber
, Mishima Psycho Extract, Waremoko Extract, Burnett Powder (BURNET POWDE
R, Barnet Products (commercially available from Barnet Products, Englewood, NJ), butylhydroxyanisole, butylhydroxytoluene, chuanxiong, dang-gui, deoxyarbutin, 1 , 3-Diphenylpropane derivative, 2,5-dihydroxybenzoic acid and its derivatives, 2- (4-acetoxyphenyl) -1,3-ditan, (2- (4-acet
oxyphenyl) -1,3 dithane) 2- (4-hydroxyphenyl) -1,3 ditan (2-
(4-hydroxyphenyl) -1,3 dithane), ellagic acid, escinol, escinol derivative, esculoside, esculetin, fade-out (FADEOUT, Pentapharm (Pentapharm, Switzerland, Basel) Basel) ), Fanfeng, fennel extract, gallic acid and its derivatives, ganoderma extract, gaoben, gutulin whitening (GAT
ULINE WHITENING, Gattefosse (France, Saint Priest (
Saint Priest)), genistic acid and its derivatives, gentisyl alcohol, glabridin and its derivatives, glucopyranosyl-1-ascorbic acid, gluconic acid, glucosamine, glycolic acid, glycyrrhizinic acid. , Green tea extract, 4-hydroxy-5-methyl-3 [2h]
-Furanone, hydroquinine, 4-hydroxyanisole and its derivatives, 4-
Hydroxybenzoic acid derivative, hydroxycaprylic acid, inositol ascorbate, kojic acid, lactic acid, lemon extract, licorice extract, licorice P-TH (LI
CORICE P-TH, Barnet Products (commercially available from Barnet Products, Englewood, NJ), linoleic acid, magnesium ascorbyl phosphate, melfade (MELFADE, Pentapharm, Switzerland,
Commercially available from Basel), Melwhite (MELAWHITE, Pentafarm (Pen
commercially available from Tapharm, Basel, Switzerland), bmorus alba
) Extract, mulberry root extract, nicotinic acid amide, nicotinic acid and its ester, nicotinyl alcohol, 5-octanoylsalicylic acid, parsley extract, Felinus linteus extract, placenta extract, pyrogallol derivative,
Retinic acid, retinol, retinyl ester (acetate, propionate, palmitate, linoleate), 2,4 resorcinol derivative, 3,5 resorcinol derivative, rose extract, rucinol, salicylic acid, sono・ I (song-yi)
Extract, Sophora Powder (SOPHORA POWDER, Barnet Products
Products, commercially available from Englewood, NJ), 4-thioresorein, 3,4,5 trihydroxybenzyl derivative, tranexamic acid, TYROSLAT10,11 (available from Fytokem), vitamin D ₃ and The analog, the yeast extract, or its mixture is mentioned.

Sebum inhibitors : Sebum inhibitors can reduce the production of sebum in the sebaceous glands.
Examples of suitable sebum inhibitors include aluminum hydrochloride and acebiol (ASEBIOL
, Commercially available from Laboratories Serobiologiques, Somerville, NJ, BioDermine, commercially available from Sederma, Brooklyn, NY, Climbazole.
zole), COMPLETECH MBAC-OS (COMPLETECH MBAC-OS, Lipo,
Commercially available from Paterson, NJ), corticosteroids, cucumber extract, dehydroacetic acid and its salts, dichlorophenylimidazole dioxolane, ketoconazole, licochalcon LR15 (LICHOCHALCONE LR15, Marzen)
(Commercially available from Maruzen), nicotinic acid amide, nicotinic acid and its ester, nicotinyl alcohol, phloretin, PHLOROGINE (commercially available from Secma, France, Pontrieux), pyridoxine and its derivatives, s -Carboxymethyl cysteine, Sepicontrol AS (SEPICON
TROL AS), spironolactone, tioxolone, tocopherol, Unitrienol T27 (UNITRIENOL T27, available from Unichem, Chicago, Ill.) And ZinCIDONE (UCIB, Clifton, NJ), or These mixtures are mentioned.

Sebum-stimulating substances : Sebum-stimulating substances can increase the production of sebum by the sebaceous glands. Examples of sebum stimulants include bryonolic acid, Completech MBAC-DS (COMPLETECH MBAC-DS, Lipo, commercially available from Paterson, NJ), dehydroepiandrosterone (also known as DHEA). ), Oryzanol and mixtures thereof.

Skin-sensing agents : examples of skin-sensing agents suitable for use herein include cold-sensing agents such as camphor, thymol, 1-menthol and its derivatives, eucalyptus, carboxamide, and the like; Menthane ether and menthane ester; and cayenne tincture, cayenne extract, cayenne powder, nonanoic acid vanillylamide, nicotinic acid derivatives (benzylnicotinate, methylnicotinate, phenylnicotinate, etc.), capsaicin, nasturtium officinale extract Agents such as Zanthoxylum piperitum extract and ginger extract, or a mixture thereof.

Protease Inhibitors : Protease inhibitors are compounds that inhibit proteolysis, the process of cleaving a protein into smaller peptide fractions and amino acids. Examples of suitable protease inhibitors include AE COMPLEX
, Barnet Products (available from Barnet Products, Englewood, NJ), ALE (ALE, Laboratory Seposia)
toires Seporgia, commercially available from Sophia Antipolis, France), allicin, Aosain (AOSAINE, commercially available from Secma, France, Pontrieux), aprotinin (APROTININ, Pentafarm AG)
(Commercially available from Pentapharm AG, Basel, Switzerland), Areca catechu extract, BLUE ALGAE EXTRACT, Collaborative Labs Inc., East Setauket, NY ))), Centaurium (CENTAURIUM, commercially available from Sederma, Brooklyn, NY), CMST (commercially available from Bioetica Inc., Portland, MA), DERMOPROTECTINE, Commercially available from Sederma (Brooklyn, NY), DISACOSIDE HF 60, Burnett
Products (Barnet Products, Englewood, NJ)
(Commercially available), ELHIBIN (commercially available from Pentapharm AG, Basel, Switzerland), FLUID OUT COLLO
ID, commercially available from Vegetech, Glendale, CA, HYPOTAURINE, Sogo Pharmaceutical Co. Ltd.
, Chiyoda-ku, Tokyo, IN CYTE HEATHER, Collaborative Labs Inc., East Setakuket, NY (Ea
from St Setauket)), Micromerol (MICROMEROL, collaborative
Collaborative Labs Inc., East Sett, NY
Setauket)), Pefabloc SP (PEFABLOC SP, Pentapharm AG, Basel, Switzerland), Sepicontrol AS (Seppic, Paris, France). ), SIEGESBECKIA (commercially available from Sederma, Brooklyn, NY), SOPHORINE, Barnet Products (Barne
t Products, available from Englewood, NJ), Thiotine (THIOTAINE, available from Barnet Products, Englewood, NJ), and mixtures thereof.

Skin tightening agents : Examples of skin tightening agents include Biocare SA (BIOCARE SA, commercially available from Amerchol, Edison, NJ), egg albumin, Flexan 130, National Starch.
tarch, available from Bridgewater, NJ, GATULINE LIFTING, available from Gattefosse, Saint Priest, France), PENTACARE
HP, commercially available from Pentapharm AG, Basel, Switzerland), VEGESERYL, Laboratory cellobiologic
Serobiologiques, Somerville, NJ), and mixtures thereof.

Anti-itch ingredient : An example of the anti-itch ingredient is STIMU-TE.
X, commercially available from Pentapharm AG (Basel, Switzerland), TAKANAL (Ikeda-Distributor, Tokyo, Japan)
Available from ICHTHYOL, International Sourcing-Distributor, Upper Saddle River, NJ, OXYGENATED GLYCERYL TRIESTERS, Laboratory Seposia. Seporgia, France, Sophia Antipolis
Antipolis))), and mixtures thereof.

Hair growth inhibitors : Preferred examples of hair growth inhibitors are 17β-estradiol, adamantyguanidines, and adamantylamidin.
es), adenylosuccinate synthase inhibitor, anti-vascular steroid, aspartate transcarbamylase inhibitor, betamethasone valerate, bisabolol,
Copper ion, turmeric extract, cyclooxygenase inhibitor, cysteine pathway inhibitor, dehydroacetic acid, dehydroepiandrosterone, diopiros leak (dio
pyros leak) extract, epidermal growth factor, epigallocatechin, essential fatty acid, evening primrose oil, γ-glutamyl transpeptidase inhibitor, ginger oil, sugar metabolism inhibitor, glutamine metabolism inhibitor, glutathione, green tea extract, heparin, capyran (KAPILANNE, International Sourcing Distributor (Inter
national Sourcing-Distributor, Upper Saddle River, NJ (Up
per Saddle River)), L, 5 diaminopentanoic acid, L-asparagine synthase inhibitor, linoleic acid, lipoxygenase inhibitor, longa
Extract, mimosinamine dihydrochloride, mimosin, nitric oxide synthase inhibitor, non-steroidal anti-inflammatory drug, ornithine decarboxylase inhibitor, ornithine aminotransferase inhibitor, panthenol, phorhetur, phosphodiesterase inhibitor, pleione extract , Protein kinase C inhibitor,
5-α-reductase inhibitor, sulfhydryl-reactive compound, tioxolone
lone), transforming growth factor β1, urea, zinc ions and mixtures thereof, but are not limited thereto.

5-α-reductase inhibitor : As an example of the 5-α-reductase inhibitor, clove 55 (
CLOVE 55, Barnet Products (commercially available from Barnet Products, Englewood, NJ), ethinyl estradiol, genistein, genistin, licochalcon LR-15,
Saw Palmetto Extract, SOPHORA EXTRACT (commercially available from Maruzen, Morristown, NJ), ZINCIDONE, UCIB, Clifto, NJ
n)), and mixtures thereof.

Exfoliating enzyme potentiators : These agents enhance the activity of endogenous exfoliating enzymes. Examples of stripping enzyme enhancers include, but are not limited to, N-methylserine, serine, trimethylglycine and mixtures thereof.

Anti-glycation agents : Anti-glycation agents prevent the induction of sugar cross-linking of collagen. Examples of suitable anti-glycation agents include AMADORINE, Barnet Products, Englewoo, NJ
commercially available from d)).

Preferred examples of beneficial agents useful herein include salicylic acid, nicotinamide, panthenol, tocopheryl nicotinate, benzoyl peroxide, 3-hydroxybenzoic acid, flavonoids (eg flavanone, chalcone), Farnesol, phytantriol, glycolic acid, lactic acid, 4-hydroxybenzoic acid, acetylsalicylic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-
Hydroxyhexanoic acid, cis-retinoic acid, trans-retinoic acid, retinol, retinyl ester (eg, retinyl propionate), phytic acid, N
-Acetyl-L-cysteine, lipoic acid, tocopherol and its ester (for example, tocopheryl acetate), azelaic acid, arachidonic acid, tetracycline, ibuprofen, naproxen, ketoprofen, hydrocortisone, acetaminophen, resorcinol, phenoxyethanol, phenoxypropanol,
Phenoxyisopropanol, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichlorocarbanilide, octopirox, lidocaine hydrochloride, clotrimazole, miconazole, ketoconazole, neomycin sulfate, theophylline, And those selected from the group consisting of mixtures thereof.

For cosmetic care of the skin, hair or nails, the beneficial agents are preferably anti-wrinkle and anti-skin atrophy agents, anti-acne agents, artificial tanning and accelerating agents, skin repair actives, skin barrier repair aids. From agents, skin lightening agents, skin sensation agents, skin soothing agents, lipids, sebum inhibitors, sebum stimulants, sunscreens, protease inhibitors, skin tightening agents, anti-itch ingredients and exfoliating enzyme enhancers, or mixtures thereof To be selected.

[0090] Humectants Preferred preformed gel sheet-like device comprises at least one humectant.
Moisturizers can be added to reach the plasticizing effect and to increase the moisturizing properties of the preformed sheet-like device when applied to the target surface.
Certain humectants, such as hexylene glycol, may also contribute to the antibacterial properties and attributes of the preformed gel sheet device of the present invention. Furthermore, although not wishing to be bound by theory, incorporating a humectant into the preformed gel sheet device of the present invention enhances device stability such that it is less prone to decomposition under extreme temperature conditions. It is considered.

Generally, the preformed gel sheet device of the present invention contains about 1.0% by weight humectant.
To about 45%, preferably about 5% to about 40%, more preferably about 10% to about 30%.
Including.

Moisturizers suitable for use in the present invention are WO98 / 22085, WO98 / 184.
44 and WO 97/01326, all of which are incorporated herein by reference. Further suitable moisturizers include amino acids and their derivatives such as proline and arginine aspartate, 1,3-butylene glycol, propylene glycol and water and codium tomentosum.
Extract, Collagen Amino Acid or Peptide, Creatinine, Diglycerol, Biosaccharide Gum-1, Glucamate, Glucuronate, Glutamate, Polyethylene glycol ether of glycerin (eg glycereth 20), Glycerin, Glycerol monopropoxylate (monopropoxylate)
, Glycogen, hexylene glycol, honey, and their extracts or derivatives, hydrolyzed starch hydrolysates, hydrolyzed mucopolysaccharides, inositol, keratin amino acids, Ralex A-200 (commercially available from LAREX A-200, Larex) )
, Glycosaminoglycan, methoxyPEG10, methylgluceth-1
0 and -20 (both in Amerchol, Edison, NJ
(Commercially available from Edison)), methyl glucose, 3-methyl-1,3-butanediol, N-acetylglucosamine salt, panthenol, polyethylene glycol and its derivatives (PEG15 butanediol, PEG4, PEG5 pentaerythitol). ,), PEG6, PEG8, PEG9), pentaerythritol (
pentaerythitol,), 1,2-pentanediol, PPG-1 glyceryl ether, PPG-9, 2-pyrrolidone-5-carboxylic acid such as glyceryl pca and salts thereof, sugar isomerate, seacare (SEACARE, from Secma) (Commercially available), celsin, silk amino acid, sodium acetyl hyaluronate, sodium hyaluronate, sodium polyaspartate, sodium polyglutamate, sorbes (s
orbeth) 20, sorbeth 6, sugars and sugar alcohols and glucose, mannose and their derivatives such as polyglycerol, sorbitol, trehalose, triglycerol, trimethylpropane, tri (hydroxymethyl) aminomethane salt and yeast extract, or them A mixture of

Preferably, the humectant used herein is selected from glycerin, butylene glycol, hexylene glycol, panthenol and polyethylene glycol and their derivatives, or mixtures thereof.

Emulsifier / Surfactant The preformed gel sheet device of the present invention may also optionally include one or more surfactants and / or emulsifiers. Emulsifiers and / or surfactants usually help disperse and suspend the discontinuous phase within the continuous phase. Surfactants can also be useful if the product is intended for cleaning skin, hair or nails. For convenience, hereinafter emulsifiers shall be referred to by the term "surfactants" and thus "surfactants" may be emulsifiers or other surfactants such as skin, hair or nail washes. Shall be used to represent the surface-activating agent used for that purpose. Known or conventional surfactants can be used in the composition provided that the selected surfactant physically and chemically matches the essential components of the composition and provides the desired properties. Suitable surfactants include silicone materials, non-silicone materials and mixtures thereof.

The composition of the present invention preferably comprises a surfactant or mixture of surfactants of about 0.0.
Includes 1% to about 15%. The exact surfactant or surfactant mixture selected will depend on the pH of the composition and other components present.

[0096]   Preferred surfactants are nonionic. Nonionic surfactants useful herein
The agent is a condensation product of an alkylene oxide and a fatty acid (ie, an alkylene oxide of a fatty acid).
Xide ester). Such materials have the general formula RCO (X)_nHave OH,
Where R is C_{10 to 30}Alkyl group, X is -OCH₂CH₂-(I.e. Ethylene glycol
Or OCH) or -OCH₂CHCH₃-(I.e.
From an oxide or oxide) and n is an integer from about 6 to about 200.
It Other nonionic surfactants are condensation of alkylene oxide and 2 moles of fatty acid.
It is a combined product (ie, an alkylene oxide diester of a fatty acid). like this
Material is general formula RCO (X)_nOOCR, where R is C_{10 to 30}An alkyl group of
X is -OCH₂CH₂-(Ie derived from ethylene glycol or oxide)
Is -OCH₂CHCH₃-(Ie derived from propylene glycol or oxide
) And n is an integer from about 6 to about 100. Other nonionic surfactants
Is the condensation product of an alkylene oxide and an aliphatic alcohol (ie, an aliphatic alcohol
Alkylene oxide ether). Such materials have the general formula R (X) _n OR, where R is C_{10 to 30}Is an aliphatic group of and X is -OCH₂CH₂-(Immediately
From ethylene glycol or oxide) or -OCH₂CHCH₃-(
That is, propylene glycol or oxide), and n is about 6 to
An integer of about 100, and R 2 is H or a C10-30 aliphatic group;
PEG40 hydrogenated castor oil (trade name "Cremophor RH40 (Cremophor
 RH 40) "as BASF (Parsippany, NJ, USA)
) Commercially available); PEG60 hydrogenated castor oil (trade name "Cremophore RH60 (C
remophor RH 60) "as BASF (Pars, NJ, USA)
(commercially available from ippany)); Isoceteth-20 (isoceteth-20), trade name "Arasol
(Arlasolve 200) "as ICI (Wilmin, MA, USA)
Commercially available from Wilmington); and Oles-20 (oleth-20) (trade name "Volpo
N20 (Volpo N20) "(Croda Chemicals Ltd., UK
, Commercially available from North Humberside and Goole).
To be Still other nonionic surfactants are both fatty acids and fatty alcohols.
A condensation product of an alkylene oxide of
Is esterified with a fatty acid, and another end is etherified with an aliphatic alcohol
(That is, they are bound by an ether bond)]. Such materials are of the general formula FCO
(X)_nOR and R and R are C_{10 to 30}X is -O.
CH₂CH₂(Ie derived from ethylene glycol or oxide) or -OCH ₂ CHCH₃-(Derived from propylene glycol or oxide), and n
Is an integer of about 6 to about 100, and examples are Ceteth-6, Ceteth-10, Ceteth.
-12, Ceteareth-6, Ceteareth-10, Ceteareth-12, Steareth-
6, steareth-10, steareth-12, PEG-6 stearate, PEG-
10 stearate, PEG-100 stearate, PEG-12 stearate,
PEG-20 glyceryl stearate, PEG-80 glyceryl tallowate,
PEG-10 glyceryl stearate, PEG-30 glyceryl cocoate, P
EG-80 glyceryl cocoate, PEG-200 glyceryl tallowate, P
EG-8 dilaurate, PEG-10 distearate, and mixtures thereof are listed.
You can

Other nonionic surfactants useful herein are the alkyl glucosides and alkyl polyglucosides described in further detail in WO 98/18444, which is incorporated herein by reference.

Other useful nonionic surfactants further include polyhydroxy fatty acid amide surfactants, which are described in more detail in WO 98/04241.

Other nonionic surfactants suitable for use herein include sugar esters and polyesters, alkoxylated sugar esters and polyesters, C ₁ -C _30.
Fatty acid esters of C ₁ -C ₃₀ aliphatic alcohols, alkoxylated derivatives of C ₁ -C ₃₀ fatty acid esters of aliphatic alcohols of C ₁ -C _30, aliphatic alkoxylated ethers of alcohols of C1-C30, C polyglyceryl esters of ₁ -C ₃₀ fatty acid, esters of C ₁ -C ₃₀ polyhydric alcohols, ethers of C ₁ -C ₃₀ polyhydric alcohols, alkyl phosphates, polyoxyalkylene fatty ether phosphates,
Mention may be made of fatty acid amides, acyl lactylates and mixtures thereof. Examples of these non-silicone containing surfactants include polysorbate 20,
Polyethylene glycol 5 soy sterol, steareth-20, ceteareth-2
0, PPG-2 methyl glucose ether distearate, polysorbate 80
Polysorbate 60, trade name "Tween 60", ICI (commercially available from Wilmington, Mass., USA; glyceryl stearate, sorbitan monolaurate, polyoxyethylene 4-lauryl ether sodium stearate, polyglyceryl- 4 isostearates, hexyl laurate, PPG-2 methyl glucose ether distearate and mixtures thereof.

Preferred nonionic surfactants include ceteareth-12, sucrose cocoate,
Some are selected from Steareth-100, polysorbate 60, PEG-60 hydrogenated castor oil, Isocetes-20, oleth-20, PEG-100 stearate, and mixtures thereof.

[0101]   Other suitable emulsifiers used herein are polyoxypropylene, aliphatic alkanes.
Cole's polyoxyethylene ether. Such materials have the general formula R (CH ₂ CHCH₃O)_x-(CH₂CH₂O)_y-H, where R is OC_Ten~ C₃₀The al
Kill group or C_Ten~ C₃₀Is an alkyl group of x, has an average value of 1 to 20, and y is
It has an average value of 1 to 30, and as an example, PPG-6-decyltetradeceth-30 (P
PG-6-Decyltetradeceth-30), product name "Pen 4630 (Pen 4630)", Nikko
Commercially available from Nikko Chemicals Co. Ltd., Tokyo, Japan; PPG-
6-decyl tetradeceth-20 (PPG-6-Decyltetradeceth-20), trade name "Pen 4
620 (Pen 4620) "as Nikko Chemicals Co. Ltd.
Commercially available from Tokyo, Japan; and PPG-5-Ceteth-20, trade name "Procetyl A"
WS (Procetyl AWS) "by Croda Chemicals Ltd.
Gillis, North Humberside, Goole)
Be done.

Another emulsifier useful herein is based on a mixture of sorbitan or sorbitol fatty acid ester and sucrose fatty acid ester as described in further detail in WO 98/22085, which is incorporated herein by reference. It is a blend of fatty acid esters.

Hydrophilic surfactants useful herein may alternatively or additionally be of a wide variety of cationic, anionic, zwitterionic and amphoteric surfactants as are known in the art. Both can be mentioned. For example, McCutcheon's, Detergents and Emulsifiers , North American version (1986) Allred Publishing Corporation (Allured
Publishing Corporation: US-A-5,011 by Ciotti et al.
, 681 (published April 30, 1991); Dixon et al. US-A-4.
, 421, 769 (issued December 20, 1983); and US-A-3,755.
, 560 (published August 28, 1973); (all four references are incorporated herein by reference in their entirety).

A wide variety of cationic surfactants are useful herein. Suitable cationic surfactants for use herein are disclosed in WO 98/18444.

A wide variety of anionic surfactants are also useful herein. For example, Rollin (L
aughlin) et al., US-A-3,929,678 (issued Dec. 30, 1975, incorporated herein by reference in its entirety). Typical anionic surfactants include alcoyl isethionate (for example, C _{12 to} C ₃₀ ),
Alkyl and alkyl ether sulfates and salts thereof, alkyl and alkyl ether phosphates and salts thereof, alkyl methyl taurates of fatty acids (for example,
C ₁₂ -C _30), and soaps (e.g., alkali metal salts such as sodium or potassium salt)) and the like.

Amphoteric and zwitterionic surfactants are also useful herein. Examples of amphoteric and zwitterionic surfactants that can be used in the compositions of the present invention can be those where the aliphatic group is linear or branched and one of the aliphatic substituents is from about 8 to about 22. having carbon atoms (preferably C ₈ -C ₁₈₎ and 1 contains an anionic water solubilising groups, for example, carboxy, sulfonate, sulfate, phosphate, or an aliphatic secondary and derivatives of tertiary amines containing phosphonate, Is widely described. Examples are alkyliminoacetates, and iminodiaalkanoates and aminoalkanoates, imidazolinium and ammonium derivatives. Other suitable amphoteric and zwitterionic surfactants are those selected from the group consisting of betaines, sultaines, hydroxysultaine, alkyl sarcosinic acids (eg C ₁₂ -C ₃₀ ) and alkanoyl sarcosinic acid. .

The preformed gel sheet device of the present invention optionally contains an emulsifier or surfactant containing silicone. A wide variety of silicone emulsifiers are useful herein. Such silicone emulsifiers are generally organically modified organopolysiloxanes, also known to those skilled in the art as silicone surfactants. Useful silicone emulsifiers include dimethicone copolyol. Such materials contain, for example, polyethylene oxide chains, polypropylene oxide chains, mixtures of such side chains and polyether side chains, such as polyether chains containing moieties derived from both ethylene oxide and propylene oxide. It is a polydimethylsiloxane modified as described above. In other instances, dimethicone copolyol and alkyl-modified, i.e., compounds which contain C ₂ -C ₃₀ pendant side chains. Still other useful dimethicone copolyols include materials with a variety of cation, anion, zwitterion, and zwitterionic pendant moieties.

Oily Conditioning Agents The present invention may also optionally include an oily conditioning agent. Examples of conditioning agents useful as oily conditioning agents include mineral oil, petrolatum, C7-40 branched chain hydrocarbons, C1-C30 carboxylic acid C1-C3.
0 alcohol ester, C2-C30 dicarboxylic acid C1-C30 alcohol ester, C1-C30 carboxylic acid monoglyceride, C1-C30 carboxylic acid diglyceride, C1-C30 carboxylic acid triglyceride, C1-
C30 carboxylic acid ethylene glycol monoester, C1 to C30 carboxylic acid ethylene glycol diester, C1 to C30 carboxylic acid propylene glycol monoester, C1 to C30 carboxylic acid propylene glycol diester, C1 to C30 carboxylic acid monoester Polyesters of esters and sugars, polydialkyl siloxanes, polydiallyl siloxanes, polydialkaryl siloxanes, cyclomethicone having 3 to 9 silicon atoms, vegetable oil, hydrogenated vegetable oil, polypropylene glycol C4 to C20 alkyl ether, diester C8-C30
Examples include, but are not limited to, those selected from the group consisting of alkyl ethers, and mixtures thereof.

Such agents are described in further detail in WO 98/18444, which is incorporated herein by reference.

Other Optional Ingredients The compositions of the present invention can include a wide variety of other optional ingredients. Such additional ingredients are pharmacologically acceptable. CTFA Cosmetic Ingredient Handbook (CTFA Cosmetic Ingredient Handbook): Second Edition (1992) (which is incorporated as it is herein all reference) is commonly used in the cosmetics industry, in the compositions of the present invention A wide variety of cosmetic and pharmaceutical ingredients suitable for use have been described, but are not limited thereto. Examples of functional classes of ingredients are set forth on page 537 of this reference, but are not limited thereto. Examples of such and other functional classes include abrasives, absorbents, antibiotics, anti-pressurizing agents, anti-dandruff agents, antiperspirants, antioxidants, vitamins, biological additives, bleaching. Agents, bleach activators, brighteners, fillers, buffers, chelating agents, chemical additives,
Colorants, cosmetics, cleansers, cosmetic astringents, cosmetic biocides, modifiers, dental care agents, deodorants, peeling active substances, depilatory agents, medicinal astringents, dyes, dye modifiers, enzymes, topical analgesics. Agents, fragrances, film-forming agents, fragrance ingredients, insect repellents, fungicides,
Opacifiers, oxidative dyes, oxidants, pest control ingredients, pH adjusters, pH buffers, pharmaceutically active substances, plasticizers, preservatives, radical scavengers, skin, hair or nail bleaching agents, skin, hair or nail penetration enhancement Examples include agents, stabilizers, surface conditioners, reducing agents, temperature lowering agents, and heat generating agents.

Also useful herein are cosmetic ingredients such as colorants, essential oils and skin, hair and nail healing agents.

Other optional materials herein include pigments. Suitable pigments for use in the compositions of the present invention are organic and / or inorganic. The term pigment further includes matte finishes, and also low-toning or low-gloss substances such as light-scattering agents. Examples of suitable pigments are iron oxides, aciglutamate iron oxides, titanium dioxide, ultramarine blue, D & C dyes, carmine, and mixtures thereof. Depending on the type of composition, a mixture of pigments is used as it is normally used.

Other optional components herein include substrates that are compatible with the properties of the preformed gel sheet device. An example of a suitable substrate is paper, for example "Kimwipes EX-L" (Kimberley-Clark).
e Corp., commercially available from Rosewell, Georgia, USA), and collagen sheets such as "Collagen Fiber Mask".
(Beaute Attica Inc., Redmond, WA, USA), “Professional Collagen Mask (Professional Col
lagen Masks "(commercially available from Luminescence, Maple Plain, Minn., USA)," Pure Soluble Collagen Lifting Masque "(Five Star Formulator) Formulators Inc., Palo, California, USA
Commercially available from Palo Alto), and "Pure Collage Mask (Pure Collage
n Masks ”(commercially available from Maybrook Inc., Lawrence, Mass., USA).

The pH of the sheet-like device herein is preferably about 3 to about 9, more preferably about 4.
~ About 8.

The preformed gel sheet device of the present invention is a patch or mask of a size and shape adapted to fit the desired area of interest. The exact size and shape will depend on the intended use and product characteristics. The preformed gel sheet device herein is suitable for topical application of nails or cuticles, hair or scalp, human face or parts thereof, feet, hands, arms, legs, or human torso. The devices herein may be, for example, squares, circles, rectangles, ovals, or composites of the aforementioned shapes that may be described as "semi-circular,""donuts," and the like. The surface area of the device made to fit the face is in the range of 0.25 cm ² to about 500 cm ² , preferably about 1 cm ² to about 400 cm ² . The device herein is about 0.5 mm to about 20 mm, preferably about 1 mm to about 5.
It has a thickness of mm.

The preformed sheet-like device of the present invention may also be made and used in the form of handwear, footwear or body wrap. Typically, handwear includes gloves for the hand or any part thereof, and footwear includes socks for the foot or any part thereof. As used herein, the term "glove" is meant to include "mittens". Preferably, the handwear comprises a glove body comprising a central portion, a one-to-four-finger insertion portion connected to the central portion, a thumb insertion portion connected to the central portion, a palm side and an opposite back side. Preferably,
The footwear comprises a sock body portion forming a tubular leg portion having a closed end and an open end. The device of the present invention may also be made and used in the form of a body wrap. The body wrap is radially wrapped around any part of the body that has a long axis. The ends may be connected to each other or their length may be short so that they only partially cover. In both cases, the wrap must exhibit very good comfort for the shape of the body part. Typically, such body parts are the user's back, upper arms, forearms, upper legs, legs, neck and torso.

After application of the device, the device may remain in the target area for about 3 hours, preferably about 1 hour, more preferably less than 15 minutes. After that, the preformed gel sheet device can be removed entirely in one piece.

Depending on the beneficial agent (or beneficial agent) contained therein, the preformed gel sheet device of the present invention may have at least one of the following uses: The device is applied Hydration of the skin, hair or nails on the target area; smoothing of fine lines and wrinkles; cosmetic acne treatment; skin tightening; strengthening; softening; exfoliation; skin tone and / or texture improvement and And / or homogenization; lightening of the skin, hair or nails; conditioning of the skin or hair; tanning; reduction of the appearance of pores; absorption or suppression of secretions; prevention of skin, hair or nails, muscles, acne or pain and / or Sedation; Reduction of swelling and / or dark circles; Promotion of wound healing; Warming, refreshing or cooling of the skin;
Relief inflammation; lighten complexion; relieve congestion; reduce swelling; treat dermatological conditions; cushion; cleanse; aroma effects; reduce bacterial or microbial growth; heal; insect repellent; unwanted hair , Stains or makeup removal; and coloring or bleaching of target areas. Preferably, the preformed sheet-like device herein is used for hydration of skin, hair or nails, smoothing of fine lines and wrinkles, improvement and / or leveling of skin tone and / or texture.

Method Exudate Release Assay The amount of syneresis of the preformed gel sheet device of the present invention is measured by an exudate release assay in the gels that make up the device.

Exudate release data from the gels presented herein were generated by the following method. The desired gel formulation is manufactured as follows. While the liquid is hot (> 80 ° C), add 9 g (+/- 0.1 g) to a shallow container with a diameter of 91 mm (for example, Falcon-
Pour 1029 petri dish lid). The container is closed to prevent loss due to evaporation. Allow the gel to solidify while cooling to room temperature. The gel is left overnight at room temperature until measurement. Remove the cover and subtract the weight of the empty container containing the sample (+/- 0.005g). 3 pieces of filter paper (9.0 cm, Whatman-114
, With wet strength) on a flat gel surface. A 200 g weight having a flat bottom with a diameter of 9.0 cm is brought into close contact with the gel surface and placed on the filter paper. After 1 minute, remove the weight and gently peel the filter paper from the gel. The filter paper should give the surface of the gel a distinctly matt appearance, which confirms sufficient contact with the filter paper. Reweigh the sample and calculate the amount lost by the difference. This is recorded as the number of grams of exudate released by the 9 cm diameter gel disc described above.

Gel compression fracture test The compression fracture test is conducted by Stable Micro Systems (SMS).
Texture Analyzer (TA) [Model number TA-XT2i, Stable Micro Systems Ltd (Surre, UK)
y), commercially available from Godalming). This system is an SMS texture expert exceed (SMS's
Texture Expert Exceed) software (version 2.03). 5 aluminum compression plates (P-100 probe) with a diameter of 100 mm
Attach to a 0kg load cell. It is mounted on a TA Probe Carrier and its vertically moving extension arm is computer controlled.

To make a test sample, the gel body of interest is manufactured as follows. A precise cylinder-shaped, solid (diameter 26 mm, depth 12 mm) gel disk is put into a casting mold and molded. The sample sink should be sealed to prevent evaporation during storage. Such gel discs are left overnight at room temperature. Immediately before inspection, each gel disc is removed from the casting mold and visually inspected for defects. Discard all gel discs that have defects (eg air bubble inclusions) as such defects can have a strong effect on the mechanical properties to be measured. The defect-free gel disc is then centered under a P-100 compression plate.

Prepare the Texture Expert Exceed software in force / compression mode. Set the compression plate at the starting height of 12.0 mm. Down rate 0.8 mm /
Seconds, adjust the total distance traveled to 10.8 mm (ie the measurement stops when the gel disc is compressed to 90% of its original height). Data is automatically collected at 200 pps (times / sec) for each compression plate force and position. The software is pre-tuned to mark the position of the compression plate that has reached maximum force. The maximum force is the breaking strength, that is, the force required to break the gel plate. The distance traveled by the plate from the original starting height to the point where the gel breaks represents the amount of gel deformation. The maximum force at break is averaged between the samples (typically repeated 5 times) and recorded in Newtons.

Uniaxial deformation (compression) at the gel break location is expressed as a percentage of the original molded height. That is,

% Compression = [plate travel distance at maximum force (measured in mm) / 12 mm (height of original molded sample)] x 100

If no gel breakage occurs by the end of the 10.8 mm stroke (ie 90% compression), the gel is classified as "non-breakdown" under the test conditions.

[0127]

【Example】

  The invention is illustrated by the following examples.

[0128]   Examples 1-6

[0129]

[Table 1]

1. Kelgum ™ is a 1: 1 mixture of xanthan gum and locust bean gum and is supplied by Kelco (San Diego, Calif., USA).

The polysaccharide gum is mixed with water to form a uniform dispersibility, which can be facilitated by predispersing the polysaccharide in a non-solvent, eg a polyhydric alcohol, And add all additional ingredients. The mixture is heated with stirring to a first temperature (about 90 ° C.) above the point where the mixture gels so that the polysaccharide gum is fully hydrated. The liquid gel is then poured into a suitable shaped sink. Preferably the gel is injected by extrusion. This eliminates any defects that may be induced by cutting the gel and improves the strength of the device. Extrusion also allows the device to be easily molded while varying the range of thickness and other structural attributes. Alternatively, the liquid gel is formed into a sheet. The liquid gel is then cooled to a second temperature below the first temperature or below the point where the mixture gels (eg, room temperature) in order to build the gel structure. The device may then be removed from the casting mold or the gel sheet may be cut into patches of suitable shape. The device herein is then placed in a container of low water vapor permeable material to minimize drying of the device during storage. Suitable containers for the devices herein include bags or sealed trays. If the device is packaged, it is preferably protected until use. This protection can be provided by a release liner, such as a plastic film, that can be easily released from the device.

If a substrate is used, it may be placed in a suitable shaped sink prior to pouring the gel, or on the surface of the liquid gel during the cooling step.

In some compositions, metal ions (eg, Ca ²⁺ , K ⁺ ) may be included in the formulation to enhance the gel strength of the device. In this case, the metal ions are added in the form of an aqueous solution and mixed into the hydrated liquid gel as the last addition to the mixture.

The above method may be modified as necessary depending on the state of any additional components. For example, if non-aqueous components are present, the liquid gel may be homogenized immediately prior to casting or shaping to ensure dispersion of the non-aqueous components. Similarly, if the heat sensitive ingredients are mixed, the formulation is cooled to the appropriate temperature (depending on the ingredients) after the gum hydration step, after which the heat sensitive ingredients are added.

The liquid gel may be degassed (eg, by applying a vacuum) to remove air bubbles dispersed in the liquid. If necessary, this deaeration step is the final step immediately before taking out the liquid gel.

As indicated above, the preformed gel sheet devices herein exhibit the desired amount of syneresis and have exceptional strength and flexibility.

Examples 7-14 Examples 7-14 are comparative examples of gel patches described in the literature, and gels are prepared according to the methods of Examples 1-6 herein. Measurements were made of exudate release from the gel compositions, percent compression at break and force required to break the gel in each example, and the results obtained from these measurements are shown.

As can be seen from these comparative examples, most of the gels that make up the patches examined in the literature are compatible with one or two of the parameters described in the present invention. None of the gels have the desired amount of syneresis, strength and flexibility.

[0139]

[Table 2]

1. Kelgum ™ is a 1: 1 mixture of xanthan gum and locust bean gum and is supplied by Kelco (San Diego, Calif., USA). 2. Orgasol 2002D (trademark) is nylon-12 powder and is commercially available from ELF Atochem (Paris, France).

[0141]   Example 7: WO 90/14110, Example 2-without calcium alginate.

[0142]   Example 8: WO 90/14110, Example 3-without calcium alginate. GB 1,341,999, Example 1-without silver nitrate.

[0143]   Example 9: JP920649, Example 1.

[0144]   Example 10: EP-A-803245, a gel based on the teachings in the text.

[0145]   Example 11: GB 1,341,999, Example 2-without silver nitrate.

[0146]   Example 12: EP-A-161681, Example 1.

Example 13: EP-A-161681, a gel based on the teaching that the polysaccharide gum may comprise a combination of carrageenan and galactomannan.

[0148]   Example 14: US-A-4,661,475, Example 3.

─────────────────────────────────────────────────── ─── Continued front page    (81) Designated countries EP (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, I T, LU, MC, NL, PT, SE), OA (BF, BJ , CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG), AP (GH, GM, K E, LS, MW, MZ, SD, SL, SZ, TZ, UG , ZW), EA (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, C N, CR, CU, CZ, DE, DK, DM, EE, ES , FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, K R, KZ, LC, LK, LR, LS, LT, LU, LV , MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, S I, SK, SL, TJ, TM, TR, TT, TZ, UA , UG, US, UZ, VN, YU, ZA, ZW (72) Inventor Deckner, George Endel             Cincinnati, Ohio, USA             Tenager, Hills, Drive 10572 (72) Inventor Jenkins, Delice Mifani             England, Surrey, T2, 2,09             NQ, Eagum, Menor, Way             41 (72) Inventor Kite, Kenneth Eugene             Lebanon, Ohio, United States             Ncroft, coat 571 F-term (reference) 4C076 AA74 BB31 CC01 CC04 CC05                       CC18 CC19 CC30 CC31 DD37                       DD38 DD39 DD43 DD51 DD52                       DD60 EE01A EE16 EE27                       EE30A EE36A EE58 FF68                 4C083 AB102 AC122 AC152 AC172                       AC482 AC522 AC642 AC852                       AD072 AD152 AD211 AD212                       AD301 AD302 AD351 AD352                       BB36 BB46 BB51 CC02 CC28                       CC31 DD12 EE11 EE12 EE14                       EE21                 4C084 AA17 MA32 MA63 NA10 ZA211                       ZA212 ZA891 ZA892 ZA921                       ZA922 ZB111 ZB112 ZB311                       ZB312 ZB351 ZB352 ZC031                       ZC032

Claims (24)

[Claims] 1. A preformed patch or mask which delivers a beneficial agent to the skin, hair or nails comprising a mixture of about 30% to 99.5% water and at least two water-soluble polymer gel formers. A gel sheet device, wherein the gel comprising the device has an exudate release of greater than 0.7 g and less than 1.3 g, a percent compression at break of greater than 45% and less than 90%, and greater than 30 N at break. Preformed gel sheet device that requires force. 2. A preformed gel sheet device according to claim 1, wherein the exudate release is greater than 0.8 g. 3. A preformed gel sheet device according to claim 1 or 2, wherein the exudate release is less than 1.2 g. 4. The preformed gel sheet device according to claim 1, wherein the force required for breaking is greater than 60 N. 5. The preformed gel sheet device according to claim 1, wherein the force required for breaking is greater than 80 N. 6. A preformed gel sheet device according to claim 1, wherein the percent compression at break is greater than 50%. 7. A preformed gel sheet device according to claim 1, wherein the percent compression at break is less than 80%. 8. A preformed gel sheet device according to claim 1, wherein the device comprises less than 30% of a mixture of water soluble polymeric gel formers. 9. A preformed gel sheet device according to claim 1, wherein the mixture of water-soluble polymer gel formers comprises at least one polysaccharide. 10. The preformed gel sheet device according to claim 1, wherein the water-soluble polymer gel former mixture is a polysaccharide mixture. 11. The polysaccharide mixture comprises: (i) at least one red algae polysaccharide and (ii) at least one fermenting polysaccharide; glucomannan; galactomannan; and their derivatives or mixtures thereof. Item 11. A preformed gel sheet device according to any one of items 1 to 10. 12. A preformed gel sheet device comprising a polysaccharide mixture comprising: (i) red algae polysaccharides; (ii) mannose containing polysaccharides; said device comprising less than 2% total polysaccharides. , And the ratio of the red algal polysaccharide to the mannose-containing polysaccharide is about 1: 1 to about 10: 1, and the gel constituting the device breaks down 60
A preformed gel sheet device that requires a force greater than N. 13. The ratio of red algal polysaccharide to mannose-containing polysaccharide is about 2: 1.
13. The preformed gel sheet device of claim 12, which is about 7: 1. 14. The preformed gel sheet device according to claim 12 or 13, wherein the red algal polysaccharide is selected from agar and agarose, or a mixture thereof. 15. The mannose-containing polysaccharide is selected from galactomannan, glucomannan and their derivatives or mixtures thereof.
The preformed gel sheet device according to any one of 1. 16. The preformed gel sheet device according to claim 12, further comprising xanthan gum. 17. A preformed gel sheet device according to any one of claims 12 to 16 wherein the percent compression of the gel making up the device is greater than 45% and less than 90%. 18. An anti-wrinkle and anti-skin atrophy active substance, an anti-acne agent, an artificial tanning and promoting agent, a skin repair active substance, a skin barrier repair aid, a skin lightening agent, a skin sensation agent, a skin soothing agent, an antibacterial And antifungal agents, lipids, sebum inhibitors, sebum stimulants, sunscreens, antiseptics, local anesthetics, steroids, non-steroidal anti-inflammatory agents, protease inhibitors, skin tightening agents, anti-itch ingredients, hair growth inhibition Agent,
18. Any one of claims 1 to 17 further comprising a beneficial agent selected from 5-alpha reductase inhibitors, anti-glycation agents, and exfoliating enzyme potentiators, or mixtures thereof.
The preformed gel sheet-like device according to the item. 19. An anti-wrinkle and anti-skin atrophy active substance, anti-acne agent, artificial tanning agent and promoter, skin repair active substance, skin barrier repair aid, skin lightening agent, skin sensation agent, skin soothing agent, lipid, 18. Any one of claims 1 to 17 further comprising a beneficial agent selected from sebum inhibitors, sebum stimulants, sunscreens, protease inhibitors, skin tightening agents and exfoliating enzyme enhancers, or mixtures thereof. The preformed gel sheet-like device according to item 1. 20. The preformed gel sheet device of any of claims 1-19, further comprising from about 1% to about 45% humectant. 21. The preformed gel sheet device of any of claims 1-20 having a thickness of about 0.5 mm to about 20 mm. 22. A cosmetic care method comprising applying the preformed gel sheet device according to any one of claims 1 to 17, 19, 20 or 21 to the skin, hair or nails. 23. In the form of a mask or patch having a size and shape adapted to fit a nail or cuticle, hair or scalp, human face or part thereof, foot, arm, leg, or human torso. A preformed gel sheet device according to any one of claims 1 to 21. 24. The preformed gel sheet device according to any one of claims 1 to 21, which is in a form selected from the group consisting of handwear; footwear; and body wrap.