JP2012092022A - External skin patch - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an external skin patch containing an antioxidative component in a water-soluble state and having an excellent preventing effect on skin aging.SOLUTION: The external skin patch contains the following components (a)-(f): (a) an antioxidative component; (b) a hyaluronic acid or a salt thereof; (c) glycerin; (d) agar; (e) locust bean gum; and (f) xanthan gum and has a water-containing plaster body having a pH of 10-12.

Description

  The present invention relates to a skin external patch excellent in skin aging prevention effect.

Antioxidants such as astaxanthin and coenzyme Q ₁₀ prevents aging of the skin, enhance the elasticity of the skin, since it prevents wrinkles, are widely used in a variety of cosmetics and supplements (Patent Document 1 2).

  On the other hand, the patch is a widely used dosage form in the pharmaceutical field because its medicinal components remain in the local area where it has been applied for a long time compared to ointments and creams. is there. However, the outermost layer of the skin is covered with a stratum corneum and acts as a barrier that prevents external substances from entering the body. Therefore, it is a strong barrier for external preparations, and the effects of the prescribed active ingredients are fully demonstrated. The reality is that you can't.

JP 2004-99564 A JP 2006-348035 A

The present inventors have attempted to apply the astaxanthin and coenzyme Q ₁₀ in patch, these antioxidants have low water solubility, can not be stably maintained in the aqueous plaster in, also due to low percutaneous absorbability, It has been found that a sufficient effect cannot be obtained even when a normal aqueous plaster is used.
Accordingly, an object of the present invention is to provide an external skin patch containing an antioxidant component in a soluble state in water and having an excellent anti-aging effect on skin.

  Therefore, the present invention has been variously studied for solubilization of an antioxidant component in a plaster and its effectiveness when used as a patch. As an antioxidant component, hyaluronic acid or a salt thereof, glycerin, agar, locust bean gum and xanthan gum And by adjusting the pH of the aqueous plaster to 10-12, it was found that an external skin patch excellent in skin aging prevention effect was obtained, and the present invention was completed.

That is, the present invention includes the following components (a) to (f):
(A) an antioxidant component,
(B) hyaluronic acid or a salt thereof,
(C) glycerin,
(D) Agar,
The present invention provides an external skin patch having a water-containing plaster containing (e) locust bean gum and (f) xanthan gum and having a pH of 10-12.

  The external skin patch of the present invention is stably held in a state where the antioxidant component is dissolved in water, and has an excellent anti-aging effect on the skin. Such an effect of the present invention is that hyaluronic acid or a salt thereof, glycerin, agar, locust bean gum, xanthan gum and pH 10-12 aqueous paste are used in combination to remove sebum in the stratum corneum, and skin on the patch. This is considered to be because the transfer of antioxidant components to the skin is promoted by the movement of moisture to form a saturated state of the moisture in the stratum corneum and lowering the barrier function of the stratum corneum. In addition, the patch of the present invention has a good feeling of use and an excellent sustained action.

  The external skin patch of the present invention comprises (a) an antioxidant component, (b) hyaluronic acid or a salt thereof, (c) glycerin, (d) agar, (e) locust bean gum, and (f ) Contains xanthan gum.

The (a) an antioxidant component used in the present invention may be any component having an antioxidant activity, astaxanthin, coenzyme Q ₁₀ are preferred. These can be used alone or in combination. Astaxanthin may be astaxanthin itself, but may also be an extract from shrimp, crab, sockeye salmon and the like containing astaxanthin. Moreover, Coenzyme Q ₁₀ is a ubidecarenone or coenzyme UQ10 also referred ubiquinone. Coenzyme Q ₁₀ is a component of the original human origin, it is possible to use chemical synthesis products. All of these are known to have a stronger antioxidant power than vitamin E, have an anti-skin aging effect, and are known to have an effect of imparting moisture and elasticity to the skin.

The component (a) is preferably contained in the plaster in an amount of 0.05 to 10% by mass, more preferably 0.05 to 5% by mass, from the viewpoint of the effect of preventing skin aging. More preferably, it is contained by mass%. Among these, the content of astaxanthin is preferably 0.05 to 1% by mass in the plaster, more preferably 0.05 to 0.5% by mass, and further preferably 0.05 to 0.25% by mass. The content of coenzyme Q ₁₀ is preferably 0.1 to 2% by mass in the plaster, more preferably 0.1 to 1% by mass, and still more preferably 0.1 to 0.5% by mass.

(B) Hyaluronic acid or a salt thereof used in the present invention is preferably hyaluronic acid or sodium hyaluronate. Hyaluronic acid or a salt thereof may be derived from chicken Tosaka or obtained by fermentation. Further, the molecular weight of hyaluronic acid or a salt thereof is not particularly limited, and those with 100,000 to 1,500,000 can be used. From the viewpoint of properties and transdermal absorbability of component (a).
The component (b) is contained in the plaster in an amount of 0.5 to 3.5% by mass, more preferably 0.5 to 3% by mass, and particularly 1 to 2.5% by mass. It is preferable from the viewpoint of skin absorbability.

  As (c) glycerin used in the present invention, concentrated glycerin is preferably used. Glycerin has a moisturizing effect and, as a result, contributes to improvement of the transdermal absorbability of component (a). The content of the component (c) is 30 to 50% by mass, more preferably 30 to 45% by mass, and particularly 35 to 45% by mass in the plaster, for the moisturizing effect and the transdermal absorbability of the component (a). This is preferable.

  The (d) agar used in the present invention is not particularly limited as long as the mucus extracted from red algae such as Amakusa is coagulated and dried. Agar contributes to the formation of the plaster skeleton. The content of the component (d) is preferably 0.3 to 2% by mass, more preferably 0.3 to 1.5% by mass, and particularly preferably 0.5 to 1.5% by mass in the plaster.

  (E) Locust bean gum used in the present invention is a polysaccharide made from the endosperm portion of seeds taken from a carob tree of the leguminous family, and its structure is an average of 4 to 1 mannose main chain and galactose side chain To form a linear galactomannan bonded at a ratio of Locust bean gum is not particularly limited as long as it is a purified type exhibiting high odorless transparency. The physical properties of the paste obtained with agar only are agar-like pasapasa and are not sticky and easily collapse due to external pressure. By formulating locust bean gum, the agar-only paste has thickened elasticity and water retention The content of the component (e) that imparts stability and stability is preferably 0.5 to 3% by mass, more preferably 0.5 to 2.5% by mass, and particularly preferably 0.5 to 2% by mass in the plaster.

  (F) Xanthan gum used in the present invention is a natural polysaccharide produced from a microorganism (Xanthomonas campestris), and its structure shows a branched structure in which the side chain of mannose and glucuronate is bonded to the main chain of glucose. It is a polysaccharide. When component (f) is formulated simultaneously with the locust bean gum, it synergistically imparts gel, thickening elasticity, moisture retention, stability, etc. to the plaster. The content of the component (f) is preferably 0.1 to 0.8 mass%, more preferably 0.1 to 0.7 mass%, and particularly preferably 0.2 to 0.6 mass% in the plaster.

The plaster of the patch of the present invention is a water-containing plaster having a pH of 10 to 12 and is important in terms of solubilization, stability and transdermal absorbability of the component (a). The pH of the plaster can be directly measured with a pH meter or the like. In order to adjust the pH of the plaster to 10 to 12, an alkali such as sodium hydroxide, potassium hydroxide, diethanolamine or the like may be added, but it may be adjusted by adding alkaline ionized water. The alkaline ionized water has antibacterial, degreased cleaning, deodorizing, antibacterial action, and the like, and does not contain metal ions (Na ⁺ or K ⁺ ), so the safety when applied to the skin is extremely high. The content of water in the plaster is preferably 40 to 70% by mass, more preferably 45 to 65% by mass, and particularly preferably 45 to 60% by mass.

  In addition to the above-mentioned components, the plaster of the patch of the present invention contains L-ascorbic acid and its derivatives (L-ascorbic acid glycoside, L-ascorbic acid monophosphate, etc.) sodium palmitate, placenta extract, aloe extract, Pantotenyl ethyl ether, tranexamic acid and its derivatives, arbutin, kojic acid and the like can be blended. Further, as the base component, gum arabic, tragacanth gum, carrageenan, mannan as vegetable polymer, gelatin, albumin, collagen and the like as animal polymer can be blended.

When the hardness and viscoelasticity of the plaster are sufficiently high, the patch of the present invention can be used only with the plaster. On the other hand, when the hardness and viscoelasticity of the plaster are not sufficiently high, it is preferable from the viewpoint of ease of use that the plaster is supported on a support, and the physical properties of the support are stretchable nonwoven fabric, plastic film Etc.
Moreover, you may use the film which has a moisture-proof function as a covering of the plaster | support which carry | supported the support body. In order to maintain the quality of the patch, it is preferably supplied in a state of being stored in a packaging material having excellent airtightness.

  Since the patch of the present invention is used after being applied to the skin for the purpose of preventing skin aging, the shape of the entire face, around the eyes, around the eyes, around the mouth, etc. (face pack, partial pack) Is preferable.

  EXAMPLES Next, although an Example is given and demonstrated further in detail, this invention is not limited to these Examples. In the following formulas, “%” means “% by mass” unless otherwise specified.

Examples 1-5
A patch comprising a paste with the formulation shown in Table 1 was produced.

Test Example 1 (Measurement of dynamic viscoelasticity of plaster and degree of improvement in skin elasticity at the corner of the eye and around the mouth and feeling of use)
The dynamic viscoelasticity of the plaster of the patch of Example 5 described in Table 1 was measured. In addition, after applying the patch of Example 5 shown in Table 1 to the subjects (34 people in their 20s to 50s) once a day after face-washing, applying the patch to the area around the corner of the eye and around the mouth, and continuously using it for 1 month The degree of improvement in skin elasticity was evaluated by using a cutometer to evaluate the degree of improvement in skin elasticity. In addition, regarding the feeling of use (moist feeling), the skin symptoms before and after adaptation were evaluated on a 5-point scale (5: very good, 4: good, 3: normal, 2: slightly bad, 1: bad). .
As a result, as shown in Table 2, Example 5 was proved to be an excellent patch with good elasticity and favorable improvement tendency in any test item. Moreover, when the patches of Examples 1 to 4 were affixed to the corners of the eyes, an excellent skin elasticity improving effect was obtained.

Claims (4)

The following components (a) to (f):
(A) an antioxidant component,
(B) hyaluronic acid or a salt thereof,
(C) glycerin,
(D) Agar,
(E) An external skin patch having a water-containing plaster containing locust bean gum and (f) xanthan gum and having a pH of 10-12. One or external skin patch according claim 1 is two or more selected from components (a) astaxanthin and coenzyme Q _10.   In the plaster, component (a) is 0.05 to 10% by mass, component (b) is 0.5 to 3.5% by mass, component (c) is 30 to 50% by mass, and component (d) is 0. The external skin patch according to claim 1 or 2, comprising 3 to 2% by mass, 0.5 to 3% by mass of component (e), and 0.1 to 0.8% by mass of component (f).   The skin external patch according to any one of claims 1 to 3, wherein the plaster contains 40 to 70% by mass of water.