JP2003518010A - Preformed self-adhesive sheet-like device suitable for topical application - Google Patents

Abstract

  (57) [Summary] A pre-formed, sheet-like device comprising (a) less than 10% of a polysaccharide mixture consisting of (i), (ii), (iii) below; (i) a red alga polysaccharide; (ii) Polysaccharides containing mannose selected from galactomannan, glucomannan, and derivatives or mixtures thereof; (iii) fermented polysaccharides or derivatives thereof; and (b) about 30% to about 99.5% water. And the device comprises less than 10% of the total polysaccharide. The preformed sheet-like device of the present invention is suitable for topical application and improves the desired amount of syneresis and / or mechanical properties such as strength or flexibility, and excellent humidification, hydration, cooling Is shown. Furthermore, the device of the present invention is easy to handle, unobtrusive and conforms to the contour of the area of interest when applied.

Description

Detailed Description of the Invention

TECHNICAL FIELD The present invention relates to new, preformed sheet-like devices and compositions thereof. In particular, the invention relates to a self-adhesive device comprising an aqueous polysaccharide mixture, the invention being suitable for topical application and having a desired amount of syneresis and / or improved mechanical properties such as strength or flexibility. In addition, it exhibits excellent humidifying property, hydrating property, and cooling property. Moreover, the device of the present invention is easy to handle, unobtrusive, and conforms to the contours of the surface of interest when applied. The desired properties can be obtained by selecting the chemical composition and rheological properties of the polysaccharide mixture.

BACKGROUND OF THE INVENTION There are numerous conventional methods for delivering beneficial agents to the skin, hair or nails by use of creams, gels or lotions and the like. These forms are not always convenient to apply, they do not control release of a beneficial drug to a certain area, and they have a desired drug effect on the application area due to external environmental factors. It is also not effective for delivery. Moreover, some beneficial agents are not stable in these aforementioned product forms, which makes it difficult to formulate chemically and physically stable compositions.

It is recognized in the art the convenience of using the device for patching or other skin care to overcome the above mentioned disadvantages associated with creams and lotions and the like. A variety of cosmetic patches or devices are commercially available and are described as useful for delivering skin care actives such as vitamins, anti-acne agents, moisturizers and the like. Patches and devices have also been described in the literature and have entered the medical market as a useful means for transdermal administration of drugs. However, many of these patches or devices have deficiencies in their physical product form, which results in consumers or users noticing unpleasant properties during use. For example, one embodiment, EP-A-392,845, describes a method of making a gel patch that requires in situ shaping of the skin, but is cumbersome to apply. EP-B-309,309 describes dry patches which require the skin to be moistened or the patch to be moistened so that the patch is hydrated and adheres to the skin. On the contrary, other patches or devices may be too moisturized or sticky so that gelling agents containing such patches or devices may not form a solid gel structure, which is awkward to handle Also, it is difficult to apply to the skin.

Some patches or devices are too dry and lack flexibility to fit well to the contours of the surface to which they are applied. Alternatively, there may be patches or devices that are strongly tacky and are tight and uncomfortable to wear and remove, and many patches effectively release the beneficial agent and may not penetrate.

Polysaccharide compositions are known to be used per se in adhesive patches or devices. For example, EP-A-682938, International Patent Publication WO96 / 25923, E
PA-750905, International Patent Publication WO98 / 17263, EP-A-850.
649, EP-A-674913 and WO 84/02466 disclose various polysaccharides that are useful in adhesive patches or devices. Furthermore,
Many of the adhesive patches or devices described in the above mentioned documents optionally contain cosmetic or therapeutic active substances.

GB 1,341,999 discloses a gel-like medium suitable for the treatment of burns, which comprises a liquid phase, a burn healing agent and a considerable amount of gel-forming agent. Gelled media are described as being flexible and plastic to conform to an essentially dry, continuous, non-stick surface and body. The preferred gel former is disclosed as a combination of xanthan and locust bean gum. It also discloses an example of a burn treatment disinfecting pad containing agarose, water and silver nitrate. Here, we consider that a small amount of syneresis in a gel-like medium helps to wet the surface with burn-treatment substances and facilitates removal of the medium from the human body.

JP-B2-2761936 discloses an aqueous sheet pack containing xanthan gum and locust bean gum in combination with a water-soluble solvent. The sheet-like pack agent of the invention is disclosed as having extremely excellent shape-retaining properties at high temperature, providing a moisturizing feeling, and having a high moisturizing effect on the skin. It is disclosed in the examples that the pack may further contain 0.1% skin cosmetic ingredients.

EP-A-161681 discloses a gel plate containing an aqueous solution of a polysaccharide and a polyhydric alcohol. Among them, a preferred polysaccharide for gel plates is a blend of carrageenan and galactomannan or carrageenan alone. The composition may optionally contain pharmaceutical ingredients such as skin irritants, anti-inflammatory agents, analgesics and antibiotics. The gel plate is transparent or unobtrusive and is disclosed to have a refreshing feel and sufficient tackiness, as well as sufficient elasticity, stretchability and strength.

WO 97/17944 discloses soluble alginate (0.1-5%)
A harmonious mixture of agar (0.01-0.5%), pectin (0.01-0.5%), xanthan gum (0.05-1%) and a balance of water-containing polysaccharides. A cosmetic formulation composed of a gel substance consisting of The gel material is optionally enriched with water-soluble or water-dispersible active ingredients. Gel materials can be manufactured to form the structural gels disclosed which are easy to handle and which are well-compatible with the skin surface.

International Patent Publication WO 90/14110 describes the shape of a free-standing scrub, pad or wafer of desired size, shape and thickness comprising a water insoluble alginate such as xanthan gum alone or a combination of xanthan gum and locust bean gum. It discloses pharmaceutical products that can take Gellan gum is also disclosed as a more useful suspending agent. Suspending agents in the product may also act as gelling agents. The product may optionally include anti-inflammatory or antiseptic agents, iodine. Products in the form of slabs or wafers may be flexible and may be exposed or gauze-covered gel and lined with plastic to form an integrated surgical article. The gel product may include a calcium source in combination with alginate which acts to absorb exudates from skin lesions or wounds. The product may also be left in place on the skin and replaced once or twice a week.

[0011] JP-A-5492618 discloses a wet pap containing aqueous calcium ions crosslinked with an alginate gel as a base, a substance having an antiphlogistic and analgesic action and water. Example 5 discloses a wet pap containing locust bean gum, konjac powder, a 3% sodium alginate solution, a source of calcium phosphate monohydrate and a mixture of styrene-butadiene copolymer latices. The above document shows that the addition of a water-soluble polymer increases the shape retention of the pap, and that the addition of locust bean gum and konjak mannan or carrageenan alone results in a highly elastic gel. However, the addition of water-soluble polymers such as konjak and locust bean gum, among others, to wet paps has been shown to interfere with water release. Furthermore, it has been shown that the wet pap gel-containing base of the invention described above does not readily release water.

Patches and devices from the cosmetics and medical fields have made progress in reaching the desired physical and in-use properties with the polysaccharide gels, but they have found that certain aqueous polysaccharide mixtures according to the invention A device comprising, i.e. having improved mechanical properties and / or
Demonstrate the desired amount of syneresis to deliver a self-adhesive patch or device, as well as the beneficial agents and water contained in the polysaccharide matrix, such as hydration during use, humidification and convenience of handling. It does not suggest such a device that effectively releases the given ingredients.

Surprisingly, red algal polysaccharides; mannose-containing polysaccharides or mixtures thereof;
And an aqueous polysaccharide mixture of less than 10% consisting of a fermented polysaccharide or a derivative thereof, provides a preformed sheet-like device with excellent properties in use, improved syneresis, and / or mechanical properties. Was found. Devices containing the above-mentioned aqueous polysaccharide mixture are self-supporting, sheet-like devices with a high degree of flexibility to match the contours of skin, hair or nails are thin, easy to handle and easy to apply on the surface of interest. Form a high strength structure. The aqueous polysaccharide mixture is further selected to provide a preformed sheet-like device with the desired amount of syneresis.

(Summary of the Invention) The present invention relates to a preformed sheet-shaped device, wherein (a) a polysaccharide mixture composed of the following (i), (ii) and (iii) is less than 10%; (I) a red algae polysaccharide; (ii) a mannose-containing polysaccharide selected from galactomannan, glucomannan, and derivatives or mixtures thereof; (iii) fermented polysaccharides or derivatives thereof; and (b) about 30% to about 99.5% water; and the device comprises less than 10% of the total polysaccharide.

The preformed sheet-like device of the present invention exhibits a desired amount of syneresis and is excellent in terms of unobtrusiveness, ease of handling, compatibility, hydration, humidification and cooling in topical application. Provide usage characteristics. Further, the preformed sheet-like device of the present invention has excellent mechanical properties and also forms high strength structures from thin aqueous polysaccharide blends that have considerable elasticity and flexibility.

A second aspect of the present invention is to provide a cosmetic care method comprising applying a preformed sheet-like device to the skin, hair or nails.

The third aspect of the present invention is to improve the strength, syneresis or flexibility of a preformed sheet-shaped device containing water, (i) red algal polysaccharide; (ii) galactomannan, gluco A mannose-containing polysaccharide selected from mannan and its derivatives or products; and (iii) the use of a polysaccharide mixture consisting of a fermented polysaccharide or its derivatives.

DETAILED DESCRIPTION OF THE INVENTION The preformed sheet-like device of the present invention comprises a particular polysaccharide mixture with water as well as various optional ingredients as set forth below. All concentrations and ratios are by weight of the total composition of the device, unless otherwise indicated. When a substrate is used as an adjunct to the device, the total weight of the device composition is calculated not including the weight of the substrate.

As used herein, the term “preformed” means that the device so described has been manufactured into a product form having a predetermined thickness, shape and size,
This means that it may be removed from the package with fingers and placed on the surface of interest or covered loosely, without the need for spreading, rubbing or covering in its product form.

As used herein, the term “sheet-like device” means a patch or mask for cosmetic or medical use in which the described device has a planar or non-planar shape, wherein The patch is a continuous one-layer, two-layer, or multi-layered plate-shaped sheet, which has a shape predetermined by the specific area of the skin, hair, or nails to be maintained,
And a mask is a non-continuous, one-, two-, or multi-layered plate-like sheet that covers a face area having openings for the eyes, nose, or mouth.

As used herein, the term “syneresis” means the process by which a gel contracts with the exudation of liquid on standing. Without being bound by theory, it is believed that the gel composition forms a three-dimensional matrix that binds or encapsulates the other components in the composition. Syneresis is believed to involve the spontaneous separation of the initially homogeneous, cohesive gel phase into a liquid. The exudate is a solution whose composition depends on the composition contained in the original gel. When the device of the invention is applied to a subject, the device releases the bound components within the gel matrix, such as water or beneficial agent, to the target area, and some of its volume to penetrate the target area. lose.

As used herein, the term “polysaccharide” means a linear or branched polymer of naturally derived or synthetically produced monosaccharide units, which has a low concentration (dry basis). When dispersed in water, it swells and gels the aqueous phase.

As used herein, the term “non-occlusive” refers to the preformed sheet-like device so described as essentially allowing the passage of air and moisture through the surface of the skin, hair or nails. It means not to shut off. The preformed sheet-like device is suitable for topical application to the skin, hair or nails.

Polysaccharide Mixture As an essential component of the preformed sheet-like devices described herein, the device comprises a particular polysaccharide mix.

The polysaccharide mixture of the present invention forms a self-supporting, self-adhesive sheet-like device. Optionally, an occlusive or non-occlusive backing material (often referred to as the "substrate") may be used as an adjunct to the device to further complete the device. To provide additional strength to the preformed sheet-like device, substances that act as gel tougheners, such as monovalent or polysalts, may be incorporated into the polysaccharide mixture. Suitable cations for the monovalent or polyvalent salts may be selected from potassium, sodium, ammonium, zinc, aluminum, calcium and magnesium ions or mixtures thereof. Suitable anions paired with the above cations may be selected from chloride, citrate, sulphate, carbonate, borate and phosphate anions or mixtures thereof.

It has been found that certain blends of polysaccharides in combination with water form gels with desired cosmetic and use properties. Furthermore, the polysaccharides of the inventive mixture may be combined together in various percentages or ratios to modify the physical properties of the preformed sheet-like device. The polysaccharide mixture herein provides syneresis or improvement of mechanical properties such as flexibility and strength of aqueous preformed sheet devices. In a preferred embodiment, the polysaccharide mixture of the present invention improves the flexibility, strength and syneresis of preformed sheet devices.

The preformed sheet-like device of the present invention contains less than 10% total polysaccharides. In general, the preformed sheet-like device of the present invention comprises a polysaccharide mixture, preferably less than 10% by dry weight, more preferably less than 5%, and especially less than 3%, and preferably 0%.
． More than 5%, more preferably more than 0.7%.

The polysaccharide mixture of the device herein comprises a mannose-containing polysaccharide selected from (i) red algal polysaccharides, (ii) galactomannans, glucomannans and their derivatives or mixtures thereof; and ( iii) Consists of fermented polysaccharide or its derivative.

Red algal polysaccharides: Polysaccharides classified as red algal polysaccharides are Rhodop
hyceae) isolated from a marine plant species belonging to the class. Red algal polysaccharides provide mechanical strength to aqueous gels. Suitable red algae polysaccharides for use in the present invention include a variety of Gelidium plant species or closely related red algae derived (CTFA) designations in the industry.
"Agar Agar 100" or "Agar Agar 150" from agar known as agar agar flake [TIC Gums (Belcamp, Md., Md., USA)] or "Agar Agar 150" )
, Or Gumix International Inc.,
From Fort Lee, NJ, USA "Agar Agar K-
Marketed as "100 (Agar Agar K-100)";"Sea Plaque,
(Registered trademark) "from FMC (Philadelphia, PA, USA), and" Agarose Type 1-b "from Sigma-Aldrich Co. Ltd., Pool, United Kingdom ( Poole)) agarose; a carrageenan containing lambda, iota, and kappa fractions, which are water extracts obtained from various species of the Gigartinaceae or Solieriaceae families (in the industry (( CTFA) Known as chondrus, known as "Gelcarin (registered trademark) LA"
, “Seakem® 3 / LCM”, or “Viscarin
, Trademark) XLV ", all commercially available from FMC (Philadelphia, PA, USA); and Gum Technology Corporation,
Tucson, Arizona, USA and Continental Colloids (Cont
Furcellaran commercially available from inental Colloids Inc., Chicago, Illinois, USA, or mixtures thereof. Preferably, the red algae polysaccharides used herein are selected from agar, agarose, kappa-carrageenan and fluceraran or mixtures thereof. More preferably, the red algae polysaccharides used herein are selected from agar and agarose or mixtures thereof.

As already indicated, carrageenan is not a chemically homogeneous product, but contains a product group of galactan sulphate proportional to the galacto-pyranose residue part present as 3,6-anhydrogalactose residues. Certain fractions of carrageenan are chemically defined with respect to their structure and can be separated from red algae extracts indicated by the Greek letters. Only lambda, iota, and kappa carrageenan are of industrial importance. These different properties can be explained mainly in terms of the difference in the content of anhydrous galactose and sulfate ester groups. Furthermore, it is concluded that the presence of sulfate groups modifies the properties of carrageenan as an anionic polysaccharide by the presence of cations in aqueous systems. Therefore, the gelling properties of kappa-carrageenan are greatly affected by potassium ions, and the gelling properties of iota-carrageenan are greatly affected by calcium ions.

On the other hand, agar, an electrically neutral galactan having a high anhydrous galactose content, gels regardless of the addition of cations. Kappa-carrageenan has the highest anhydrous galactose content and the lowest sulfate content of carrageenan, and consequently the strongest gel-forming properties.

Galactomannan: Galactomannan is a plant storage polysaccharide found in the endosperm cells of numerous seeds of Leguminosae. The collective term "galactomannan" includes all polysaccharides made of galactose and mannose residues. Galactmannan is a (1 → 4) -linked β-D-mannopyranosyl (mannopyr
is a polysaccharide containing mannose to contain a linear main chain of anosyl) units. Branches are attached to these rings which are separated as galactopyranose residues by ∝- (1,6) -glucosidic bonds. The galactomannan may also contain small amounts of other sugar residues. Suitable galactomannans for use herein include fenugreek gum; alfalfa; clover; for example in the industry (CT
FA) Known as carob bean rubber, known as "Seagull L (
Seagul L) "locust bean gum marketed by FMC (Philadelphia, PA, USA); Starlight Produc
ts, France, Rouen or Bunge Foods, USA,
Tara gum, commercially available from Atlanta, Georgia; ground of cyamopsis tetragonolobus
derived from endosperm) and T as "Burtonite V7E"
From IC rubber (TIC Gums, Belcamp, Maryland, USA),
Rhone-Poulenc, USA, as "Jaguar C"
From Marietta, Georgia, or "Superc
"Aqualon, Wilmington, Delaware, USA (W
guar gum commercially available from ilmington); and Cassia gum commercially available from Starlight Products, Rouen, France, or a mixture thereof. Preferably, the galactomannans used herein are substituted with an average of 1 to about 5 mannosyl units per (1 → 6) -bond-∝-D-galactopyranosyl units. And selected from guar gum, locust bean gum, and cassia gum, or mixtures thereof.

Glucomannan: Glucomannan is essentially a mannose-containing polysaccharide containing a linear backbone of β (1 → 4) -linked glucose and mannose residues. The C-6 portion of the mannose or glucose residue in the polysaccharide backbone may be replaced with an acetyl group. One acetyl group is usually found every 6 to 20 sugar residues. The preferred glucomannan or derivative thereof for use herein has a mannose to glucose ratio of about 0.2 to about 3. Preferred glucomannans for use herein include konjac mannan [Amorphophallus konjac plant (a generic name for powders made by crushing tuber roots of elephant yam, trade name “Nutricol ( Nutricol® konjac powder ”, commercially available from FMC (Philadelphia, PA, USA);
And deacetylated konjak mannan; or mixtures thereof.

Fermented Polysaccharides or Derivatives Thereof: Fermented polysaccharides are polysaccharides that are produced commercially by fermentation of microorganisms in a medium containing carbon and nitrogen sources, buffers and trace constituents. Suitable fermented polysaccharides or derivatives thereof for use in the present invention include (
CTFA) Gellan known as gum gellan
a high molecular weight heteropolysaccharide gum produced by pure culture fermentation of carbohydrates and Pseudomonas elodea, "Kelcogel"
Commercially available from Kelco, San Diego, Calif.]; Carbohydrates and Xanthomonas campes
xanthan gum, which is a high molecular weight heteropolysaccharide gum produced by pure culture fermentation of tris) [known in the industry as (CTFA) name xanthan.
Keltrol CG1000 / BT / F / GM / RD / SF / T / TF (Keltrol
CG 1000 / BT / F / GM / RD / SF / T / TF) ”, all commercially available from Calgon (Pittsburgh, PA, USA) or“ Kelzan ”as Kelco (
Available from Kelco, San Diego, Calif., USA]; Natto gum; pullulan; rhamsan gum; curdlan; succinoglycan; welan gum; dextran ["Sepha" Commercially available from Pharmacia Fine Chemicals, Piscataway, NJ, USA as "Sephadex G-25"] and its derivatives; and sclerotium gum ["Amigel" As Alban Mueller International (
Commercially available from Alban Muller International, Montreil, France] or mixtures thereof. Preferred fermented polysaccharides or derivatives thereof for use in the polysaccharide mixture herein are selected from xanthan gum and gellan gum, or mixtures thereof. More preferably, the fermenting polysaccharide or derivative thereof is xanthan gum.

When the fermenting polysaccharide was gellan gum, it was revealed by the present inventor that varying the amount of gellan gum in the polysaccharide mixture can change the syneresis exhibited by the sheet-like device of the present invention. .. Adding gellan gum to a sheet-like device containing red algae polysaccharides generally reduces the amount of liquid that exudes from the cohesive gel phase.

When the polysaccharide mixture comprises xanthan gum as the fermenting polysaccharide, a synergistic interaction is formed between the xanthan gum and the mannose-containing polysaccharide. Although the synergistic interaction results in changing the elasticity of the aqueous gel, the interaction does not unduly impair the mechanical strength provided by the red algal polysaccharide to the gel. From the standpoint of providing improved syneresis and mechanical properties of the preformed sheet-like device, preferably the ratio of xanthan gum to mannose containing polysaccharide is from about 2: 1 to about 1: 4.

In a preferred embodiment, the polysaccharide mixture comprises a polysaccharide containing mannose which is a mixture of galactomannan and glucomannan or its derivatives.

In the polysaccharide mixture containing glucomannan and / or galactomannan, the polysaccharide-containing mannose is believed to complement the red algal polysaccharide. This synergistic effect is believed to be enhanced by the interaction between the polysaccharides. Red algal polysaccharides form a double helix structure, while glucomannans and galactomannans have relatively unsubstituted regions on the polymer backbone. Such relatively non-substituted regions on the polymer backbone interact with the red algal polysaccharide helix and contribute to the mechanical strength and flexibility of the preformed sheet-like device of the present invention.

All gels undergo some degree of syneresis (as previously defined herein). Syneresis provides a mechanism for delivering beneficial agents to the area of interest. The liquid phase that exudes on the surface of the cohesive gel phase helps to diffuse easily, helping to reduce the equipment wear time. The preformed sheet-like device of the present invention desirably exhibits a moderate amount of syneresis, and preferably the device herein is wet to the touch. Moderate amounts of syneresis have been found by the inventor to be a highly desirable property of devices containing polysaccharide mixtures. This is because the liquid that exudes on the surface of the gelled device is more likely to adhere to the target surface, thus requiring the need for either an additional adhesive or an adhesive coated substrate to overcoat the gelled form. It is to lose it. By comparison, if the gelled device exhibits too little syneresis, the device is unlikely to provide sufficient tack to the area of interest, even if it wets the area, while excessive amounts of syneresis It will be an ineffective and unattractive product.

From the standpoint of providing improved syneresis and mechanical properties of the preformed sheet-like device, preferably the ratio of red algal polysaccharide to mannose-containing polysaccharide in the polysaccharide mixture is about. 20: 1 to about 1: 5, and more preferably about 7: 1 to
It is about 1: 2.

Water A further essential ingredient of the preformed sheet-like device of the present invention is water. The total water content of the preformed sheet device of the present invention is from about 30% to about 99.5% by weight of the device.
Preferably about 40% to about 95%, more preferably about 50% to about 85%.

Substrate In a preferred embodiment of the present invention, the preformed sheet-like device herein comprises a substrate. The substrate is an occlusive or non-occlusive sheet and is added for integrity and supports the device.

Preferably the substrate is non-occlusive. The liquid aqueous polysaccharide mixture may be coated or molded onto the substrate surface.

A wide variety of substances are used as substrates. The following characteristics, (i) sufficient wet strength when used, (ii) sufficient flexibility, (iii) sufficient bulk and porosity, (iv)
) Sufficient thickness, (v) hydrophilic enough to allow the polysaccharide gel mixture to diffuse or infiltrate into the substrate, (vi) sufficient compatibility with the polysaccharide mixture to prevent tearing into thin layers,
(Vii) sufficient transparency or translucency, and (viii) suitable size are desired.

Examples of suitable substrates that meet the above criteria are woven and non-woven materials; polymeric sheets such as apertured thermoplastic films, formed films, apertured plastic films, and hydraulically formed thermoplastic films; Examples include, but are not limited to, natural sponges; synthetic sponges; polymer mesh sponges; paper substrates; polymer porous foams; collagen sheets; polymer scrims. Preferred substrates for use herein are paper substrates, non-woven materials and formed films, especially apertured formed films, because they are economical and readily available for a wide variety of materials.

By non-woven fabric is meant a manufacturing sheet, web, mat, pad or padding material in which directional or randomly oriented fibers are bound by friction and / or agglomeration and / or cohesion. Such materials are usually woven, knitted, tufted,
Excluded are products that are partially sewn together with woven yarns or filaments for joining, or that have been ground from a wet state into felt (whether additionally needled or unsewn). The nonwoven material can consist of a combination of ragged fiber layers and carded fiber layers. The fibers may be naturally derived or synthetic. Furthermore,
They may be fibers or continuous monofilaments or may be formed in situ.

The non-woven material may include a wide variety of natural and synthetic fibers. By natural is meant that the fiber is derived from plants, animals, insects or by-products of plants, animals and insects. By synthetic is meant that the fibers are obtained primarily from a variety of artificial materials, or from much modified natural materials. Conventional underlying starting materials are usually fibrous fabrics containing any conventional synthetic or natural fabric length fibers or mixtures thereof.

Natural fibers useful in the present invention include keratin fibers such as silk fibers, wool fibers, camel coat fibers and wood pulp fibers, cotton fibers, hemp fibers, jute fibers, flax fibers, and mixtures thereof. Cellulose fibers included.

Synthetic fibers useful in the present invention include acetate fibers, acrylic fibers, cellulose ester fibers, acrylic fibers, polyamide fibers, polyester fibers, polyolefin fibers, polyvinyl alcohol fibers, rayon fibers, polyurethane foam, and mixtures thereof. Is mentioned. Some examples of such synthetic fibers and other suitable fibers and non-woven materials produced therefrom are given in WO WO.
98/18444 (incorporated herein by reference), and
Acrylan, Cressulan and Acrylonitrile fibers, acrylic products such as Auron; Cellulose ester fibers such as Cellulose Acetate, Arnel and Acele; and Polyamides such as Nylon (eg Nylon 6, Nylon 66, Nylon 610). To be

Methods for making non-woven materials are well known in the art, and generally in WO98.
/ 18444, which is incorporated herein by reference. In the present invention, the nonwoven layer can be produced by a variety of processes including wet entanglement, dry entanglement, thermal bonding or thermal bonding and combinations of these processes. Further, the substrate of the present invention can be composed of a single layer or multiple layers. In addition, multi-layer substrates can include films and other non-fibrous materials.

Nonwoven materials made of synthetic fibers useful in the present invention can also be obtained from a wide variety of sources. Examples of suitable non-woven layer materials useful herein are WO98 / 1.
8444, HEF 40-047 [about 50% rayon and 50
% Polyester containing perforated wet entanglement material, basis weight about 51 g / m ² (gsm), commercially available from Veratec, Inc., Walpole, Mass.]; Novonet® 149- 616 [heat-bonded latticed material containing about 100% polypropylene, and basis weight of about 60 gsm, commercially available from Veratech, Inc. (Walport, MA)]; and HEF Nubtex.
ex, registered trademark) 149-801 [a perforated wet entangled material with a nep containing about 100% polyester, and a basis weight of about 84 gsm, commercially available from Veratech, Inc. (Walpol, MA)].

Paper substrates made of natural materials most commonly consist of webs or sheets formed from ultrafine wire screens from liquid suspensions of fibers. C. A. Hampel (CA
Hampel) "The Encyclopedia of Chemistry," Third Edition, 19
1973, pp. 793-795 (1973), "American Encyclopedia (The Ency
clopedia Americana) 21: 376-383 (1984), and G. A
． G. A. Smook's Handbook of Pulp and Paper Technology
Pulp and Paper Technologies ”Technical Associa
tion for the Pulp and Paper Industry) (1986), all of which are incorporated herein by reference. Paper substrates made of natural materials useful in the present invention can be obtained from a wide variety of sources. Suitable commercial paper substrates useful herein include "Kimwipes EX-L" commercially available from Kimberley-Clark Corp., Roswell, Ga., USA; James River ( James River, Green Bay, Wis.) Airtex® (a punched aeolian cellulosic layer having a basis weight of about 85 gsm); S. A. (Walkisoft (registered trademark) commercially available from Mount Holly, North Carolina, Walkisoft USA, [embossed aerated cellulose having a basis weight of about 90 gsm]].

Alternatively, the substrate can be a polymeric sheet material. Examples include, but are not limited to, perforated molded thermoplastic films, molded films, perforated molded films, perforated plastic films and hydraulically molded thermoplastic films. Polymer sheet materials can be made by methods well described in the patent literature. For example, US-A-4,3 of Mullane and Smith.
According to the process described in No. 24,246 (issued April 13, 1982),
Heat at a temperature at which a sample of a thermoplastic material, such as a polyethylene film 0.0038 cm thick, is molded or cast and above the softening point, which is below the melting point of the material. Then, the shape of the heated thermoplastic sheet is brought into contact with the heated forming screen. The forming screen is preferably a perforated wire mesh screen having the desired pore size, pattern and arrangement. A vacuum is applied to stretch the heated film on the forming screen and shape it. The film is thereby formed into this screen with the desired pattern and pore size. On the other hand, a vacuum is still applied to the film, and a jet of hot air passes over the film. A jet of hot air perforates the film in the pattern and size of the holes in the forming screen. Mullane (
The liquid permeable sheet produced by the method of the Mullane) patent is conveniently referred to as the "molded film". Such sheet material may also be made using a similar process method with a jet of water passing over the film. Such materials are commonly referred to as "hydroformed films". Further examples of such materials are Curro
U.S. Pat. No. 4,609,518 (issued Sep. 2, 1986), all of which are incorporated herein by reference in their entirety.

Another formed film substrate useful herein is a perforated formed film [which has a fibrous appearance and feel to an elastic three-dimensional web and comprises a liquid impermeable plastic material, said web comprising a number of webs. Of Radel and Thompson, US-A-4,342, having pores (pores are defined by a number of intersecting fiber-like elements).
, 314 (issued Aug. 3, 1982, incorporated herein by reference)]. The sheet material described in US-A-4,342,314 can be manufactured using hydrophobic plastics such as polyethylene, polypropylene, PVC, and used in absorbent products such as sanitary products. It is well known that Examples of such materials are the molded films described in the above patents, and Procter and Gamble C
It is marketed by ompany as a "DRI-WEAVE" sanitary napkin. In addition, such materials can be surfaces that have been treated to reduce their hydrophobicity.

Alternatively, the substrate is EP-A-702550 and WO98 / 1844.
Polymer mesh sponges such as those described in No. 4 (all incorporated herein by reference) are possible.

The substrate is also Des Marais US-A-5,260,345 (
(Published November 9, 1993) and Koroman US-A-4,394.
, 930 (issued July 26, 1983), and may be polymeric porous foams, which are incorporated herein by reference. Polymer foams are generally polymerisable when the relatively monomer-free gas or relatively monomer-free liquid is dispersed as a foam in a polymerizable monomer-containing liquid and then in the monomer-containing liquid surrounding the foam. It is characterized as a structure that polymerizes with monomers. The resulting polymerized dispersion can take the form of a porous solidified structure that is an assembly of cells (cell boundaries or walls containing solid polymeric material). The cell itself contains a relatively monomer-free gas or a relatively monomer-free liquid that has formed "bubbles" in the liquid dispersion prior to polymerization. Specifically, soft, flexible microporous (open or closed cell) foam materials with surface hydrophilicity and liquid retention properties are particularly suitable for this application. Examples of polymeric foam materials are those made by polymerizing certain types of water-in-oil emulsions. Such emulsions are formed from a relatively small amount of a polymerizable monomer-containing oil phase and a relatively large amount of a relatively monomer-free aqueous phase. The relatively monomer-free discontinuous "internal" aqueous phase thus forms a dispersed "foam" surrounded by a continuous polymerizable monomer-containing oil phase. Subsequent polymerization of the monomers in the continuous oil phase forms a foamy foam structure. The aqueous liquid retained in the foam structure formed by polymerization can be removed by pressing and / or drying the foam. This type of polymerized emulsion is generally known in the art as a high internal phase emulsion or "HIPE" foam.

Polymeric porous foams, including foams made from the water-in-oil emulsions herein, may or may not have cell walls or boundaries (ie, cell windows) filled or receiving polymeric material. Depending on the extent to which it does, it can be relatively closed cells or open cells in nature. Polymeric porous foams useful in the present invention are those that are relatively open cells in which most of each cell of the foam is not completely separated from each other by the polymeric material of the cell walls. Thus, the cells within the foam structure of such substantially open cells are within a cell structure that is large enough to facilitate the transfer of liquid from one cell to another within the foam structure. It has an opening or "window".

In a substantially open cell structure of the type useful herein, the foam is generally a mesh with each cell defined by a plurality of interconnected three-dimensionally branched webs. It has a shape-like property. The strand polymer material that builds the branched web of the open cell foam structure can be represented as a "strut." In addition to being open cell, preferably the polymeric porous foams useful herein are hydrophilic in nature.

The polymeric porous foams herein must be hydrophilic enough to allow the polysaccharide gel mixture to diffuse and infiltrate the substrate, and to prevent the thin layers from peeling off There must be sufficient compatibility. Polymeric porous foams as previously described herein are designed for use in a variety of liquid handling items such as diapers, sanitary products, and incontinence products, but materials of this type Is useful as a substrate in the present invention.

As another example, suitable porous substrate materials are also made from the formation of thin, flexible, porous collagen sheets using the freeze-drying process. This step creates a sheet of collagen material having an internal structure of porous foam. Such materials are strong, flexible, highly compatible with polysaccharide gels, and have sufficient transparency or translucency to make them suitable as substrates for the present invention. Examples of suitable commercially available collagen sheets useful herein include Beaute A
"Collagen Fiber Mask" commercially available from ttica, Inc., Redmond, Washington, USA; Luminescence (L
uminescence, "Professional Collagen Masks" available from Maple Plain, Minnesota, USA
) ”; Five Star Formulators, Inc.,
"Pure Soluble Collagen Liftin" available from Palo Alto, CA, USA
g Masque ”; and“ Pure Collagen Masks (Pure Collagen Masks, commercially available from Maybrook Inc., Lawrence, Mass., USA).
Collagen Masks) ”.

The base materials are Tuthill, Yeazell and Girard.
ot) US-A-5,715,561 (issued February 10, 1998, incorporated herein by reference), polymer scrims (molded meshes) are also possible. . The polymer scrim may be tubular, and such polymer scrim properties may be represented by the physical dimensions of the resulting structure (internodal distance, molecular chain length and average weight of repeating units). Tubular scrim materials can have diamond shaped, squared, pentagonal, or other shaped mesh openings, and can be made from a variety of strongly flexible polymers such as low density polyethylene. For example, a diamond mesh scrim is a plastic mesh made by an extrusion process using counter-rotating die heads, each having a plurality of extrusion openings located at the end of each die. The double reversal of the punching head causes extrusion of monofilaments or strands into a tubular shape, which causes extrusion in two directions at longitudinal angles. The strands regularly intersect to form nodules. The two strand directions are typically acutely angled with each other so that the strands form a diamond pattern of knots at each corner. Livingston US-A-3,957,565 describes this process in more detail. Although these polymer scrims (molded meshes) were designed as personal cleansing products, this type of scrim can be used as the substrate in the present invention.

[0062] The substrate made in a wide variety of shapes and forms (planar pad, thick pads, includes a thin sheet, having a size in the range surface area of about 0.25 square cm ² ~ about 1,000 cm ²⁾ be able to. The exact size and shape will depend on the intended use and product properties. Particularly convenient is a shape that can be designed to fit the user's face, neck, hands, feet and other body parts comfortably and easily. These shapes may be represented as square, circle, triangle, rectangle, oval or "pickle", "butterfly", "moon", "semicircle", "doughnut" or other. It can take other forms that are composites of any shape possible.

The substrate of the present invention can include two or more layers, each layer having a different weave. Different textures are different material combinations,
Or it can be made by different manufacturing processes or a combination thereof. Furthermore, substrates with separate layers can be processed in different colors, which allows the user to better distinguish the surfaces.

Beneficial Agents In a further preferred embodiment of the invention, the preformed sheet-like device herein comprises a safe and effective amount of one or more beneficial agents.

As used herein, the term “safe and effective amount” delivers a beneficial effect on the skin, hair, or nails that is sufficient or desired to alter the condition to be treated. A sufficient amount, and yet low enough to avoid serious side effects, means a beneficial amount of drug at a reasonable ratio of risk to advantage within sound medical judgment. A safe and effective amount of a beneficial agent is the specific agent, the transdermal, or permeation of the agent into or on the hair and / or nails, the age of the user, the health of the user, and the skin and hair of the user. Or it will change depending on the condition of the nail and other factors.

Beneficial agents include pharmaceutically acceptable salts, where "pharmaceutically acceptable salt" means human tissue without toxicity, irritation, incompatibility, instability, or allergic reaction. Means any commonly used salt suitable for use in contact with.

Generally, the preformed sheet-like device of the present invention will contain at least one beneficial agent or mixture thereof from about 0.01% to about 40%, preferably about 0.05% by weight of the device.
To about 30%, most preferably about 0.1% to about 20%.

Beneficial agents useful herein are categorized by their therapeutic benefit or their desired mode of action. However, it should be understood that the beneficial agents useful herein may, in some cases, provide therapeutic benefits or act in multiple modes of action. Therefore, the classification herein is for convenience only and is not intended to limit the beneficial agent to any particular application or listed application. The following beneficial agents are useful in the preformed sheet device of the present invention.

Anti-acne agents: Anti-acne agents can be effective in the treatment and prevention of acne vulgaris (chronic disease of pilosebaceous follicles). This condition involves inflammation of the pilosebaceous apparatus and the resulting lesions, which can include papules, pustules, cysts, comedones and severe scarring. Bacteria of Corynebacterium acnes and Staphylococcus epidermis are usually present as pus contents. Examples of useful anti-acne agents include WO98 / 18444
The keratolytic agents described in 1. Further useful active substances are retinoids such as retinoic acid (eg cis and / or trans) and its derivatives (eg esters); retinol and its esters (eg retinyl propionate,
Retinyl acetate); abietic acid, adapalene, tazarotenes
otene), allantoin, aloe extract, abietic acid and its salts, ASEBIOL (Laboratories Serobiol)
ogiques, commercially available from Somerville, NJ), azaleic acid, barberry extract, bareberry extract, belamcanda chinensis, benzoquinolinone, benzoyl peroxide, berberine, biodermin (BIODERMINE, (Commercially available from Sederma, Brooklyn, NY), bioflavonoids, bisabolol, s-
Carboxymethyl cysteine, carrot extract, cassin oil, clove extract, citral, citronellal, climazole, COMPLETECH MBAC-OS, Lipo (Paterson, NJ) (Commercially available), Cremogen M82 (CREMOGEN M82,
Dragoco (commercially available from Dragoco, Totowa, NJ), cucumber extract, dehydroacetic acid and its salts, dehydroepiandrosterone and its sulfate derivatives, dichlorophenylimidazole dioxolane, d-l-valine and its esters, dmdm hydantoin. , Erythromycin, escinol (es
cinol), ethylhexyl monoglyceryl ether, ethyl 2-hydroxyundecanoate, farnesol, farnesyl acetate, geraniol, geranylgeraniol, glabridin, gluconic acid, gluconolactone, glyceryl monocaprate, glycolic acid, grape seed extract , Gugu lipid,
HEDERAGENIN (commercially available from Maruzen, Morristown, NJ), hesperitin, hinokitol, hop extract, hydrogenated rosin, 10-hydroxydecanoic acid, ichtiol, interleukin- 1α antagonist, KAPILARINE,
Greentech (commercially available from Saint Beauzire, France), ketoconazole, lactic acid, lemongrass oil, locochalcone LR15 (LOCH
OCHALCONE LR15, Maruzen, Morristown, NJ
listown)), linoleic acid, Lipaside C8CO (commercially available from LIPACIDE C8CO, Seppic, Paris, France), lovastatin, 4-methoxysalicylic acid, metronidazole, minocycline, mukurossi, neem seed oil, nicotinic acid. Amides, nicotinic acid and its esters, nisin (nisi
n), panthenol, 1-pentadecanol, peonia extract, peppermint extract, phelladendron extract, 2-phenyl-
Benzothiophene derivative, phloretin, PHLOROGIN
E, Secuma (commercially available from Pontrieux, France), phosphatidylcholine, proteolytic enzyme, quercetin, rosewood extract, rosemary extract, rutin, sage extract, salicin, salicylic acid, serine, skullcap extract, shiverhegne (Siber hegner) extract, Siberian yukinoshita extract, silicol, sodium lauryl sulfate, sodium sulfoacetamide, sophora extract (commercially available from SOPHORA EXTRACT, Maruzen, Morristown, NJ), sorbin Acid, Sulfur, sunder vati extract, rye oil, tetrahydroabietic acid, threonine, thyme extract, tioxolone, tocopherol and its ester, 6-undecylenate Loin, 3 tridecene-2-ol, triclosan, tropolone (Tropolone), Uni tri enol T27 (UNITRIENOL T27, Yunikemu (Unichem, commercially available from Chicago, IL))
, Vitamin D ₃ and its analogs, white thyme oil, willow bark extract, wogonin, ylang ylang oil, zinc glycerate, zinc linoleate, zinc oxide, zinc pyrithione, zinc sulfate, zwitterionic surfactants (eg, Cetyl dimethyl betaine) and mixtures thereof.

Non-steroidal anti-inflammatory drug (NSAIDS): NS suitable for use herein
Examples of AIDS and their esters are described in WO98 / 18444, which is incorporated herein by reference. Non-steroidal anti-inflammatory drug (
Further examples of NSAIDS) are flufenamic acid; panthenol and its ether and ester derivatives, such as panthenol ethyl ether, panthenyl triacetate; pantothenic acid and its salts and ester derivatives, especially calcium pantothenate; aloe vera, bisabolol, allantoin. And licorice (Glycyrrhizia
And compounds of the Glycyrrhiza glabra genus / species family, including glycyrrhetinic acid, glycyrrhizinic acid and its derivatives (eg salts such as ammonium glycyrrhizinate and esters such as stearyl glycyrrhetinate). It is not limited to this.

Local Anesthetics: Examples of suitable local anesthetics for use herein are benzocaine and bupivacaine. Further suitable examples are described in WO98 / 18444, which is incorporated herein by reference.

Artificial tanning and accelerating agents: Artificial tanning agents can help to simulate natural tanning by increasing melanin in the skin or by creating the appearance of increased melanin in the skin. Examples of artificial tanning agents and promoters are glucose tyrosine and acetyltyrosine, bradylin, caffeine, coffee extract, DNA fraction, isobutylmethylxanthine, methylxanthine, phototan (PHOTOTAN, laboratory cellobiologic (Laboratoires Serobio
logiques, commercially available from Somerville, NJ), prostaglandins, tea extracts, theophylline, unipertan P2002 (UNIPERTAN)
P2002, Unichem (available from Unichem, Chicago, IL) and Unipertan P
27 (commercially available from UNIPERTAN P27, Unichem (Chicago, Ill.)); And mixtures thereof. Further useful artificial tanning agents herein are described in WO98 / 18444.

Disinfectants: Examples of disinfectants suitable for use herein include alcohols, benzoic acid, sorbic acid and mixtures thereof.

Antimicrobial and antifungal agents: Antimicrobial and antifungal agents can be effective in preventing the growth and growth of bacteria and fungi. Examples of antimicrobial and antifungal agents are ketoconazole, ciclopirox, benzoyl peroxide, tetracycline, azelaic acid and its derivatives, ethyl acetate, allanto lactone, isoallant lactone, alcanna extract (alaninin), Anise, rabbit chrysanthemum extract (helenalin acetate and 11,13 dihydrohelenalin), menma extract (extract containing fluoro-lucinol), barberry extract (berberine hydrochloride), bay sweet Extract, bayberry bark extract (myricitrin), benzalkonium chloride, benzethonium chloride, benzoic acid and its salts, benzoin, benzyl alcohol, blessed thistle, bretilla tuber
, Astragalus, Boadrose oil, Burdock, Butylparaben, Juniper oil, CAE (commercially available from Ajinomoto, Teaneck, NJ), Kaepto oil, cangzhu, oleander oil, Cascailla bark (trade name: Essential Oil (ESSENTIAL OIL) )), Cedarleaf oil, chamomile, chaparral, chlorophenesin, chlorxylenol, cinnamon oil, citronella oil, clove oil, dehydroacetic acid and its salts, dill seed oil, dawicil 20
0 (DOWICIL 200, Dow Chemical, Midland, MI (M
(commercially available from idland), echinacea, elenolic acid
), Epimedium, Ethylparaben, FO-TI, Garbanum, Garden Waremoko, GERMALL 115 and GERMALL II (I)
SP Sutton Labs (available from ISP-Sutton Labs, Wayne, NJ), German chamomile oil, giant knotweed (giant knotwe)
ed), GLYDANT, marketed by Lonza, Fairlawn, NJ, GLYDANT PLUS, marketed by Lonza, Fairlawn, NJ, grapefruit seed oil, hexamidine diisethionate, hinokitiol. , Honey, honeysuckle flowers, hops, permanent flowers, iodopropyl butylcarbamide (commercially available from IODOPROPYNL BUTYL CARBAMIDE, Lonza (Fairlawn, NJ)), isobutylparaben, isopropylparaben, JM ACTICARE, microvial system international ( (Commercially available from Microbial Systems International, Nottingham, UK), Nezu fruit, KATHON CG, Rohm and Hath
as, commercially available from Philadelphia, PA, USA), Labdanum, lavender, yamaha oil, lemongrass, methylparaben, mint, plum, mustard, myrrh, neem seed oil, orthophenylphenol, olive leaf extract (OLIVE LEAF EXTRACT, Bio Botanica (commercially available from Hauppauge, NY), parsley, patchouli oil, button root, phenonip (commercially available from PHENONIP, Nipa Labs, Wilmington, Del.), Phito Sphingosine, pine oil (pi
ne needle oil), plan servative (PLANSERVATIVE)
Commercially available from Research, Raffles Quay, Singapore),
Propylparaben, purslane, quillaira, rhubarb, scented oil, rosemary, sage, salicylic acid, sassafras, savory, sichuan lovage, sodium metabisulfite, sodium sulfite, sophiliances (SOPHOLIANCE, soliances Soliance, commercially available from Compiegne, France), sorbic acid and its salts, sphingosine, stevia, soy aroma, tannic acid, tea, gyeolubaye oil (caept oil),
Examples include, but are not limited to, thyme, triclosan, triclocarban, tropolone, terpentine, umbelliferone (antifungal), and yucca or mixtures thereof. Further examples of antimicrobial and antifungal agents useful herein are described in WO98 / 18444.

Skin soothing agents: Skin soothing agents can be effective in preventing or treating skin inflammation. Sedatives enhance the skin's cosmetic benefits of the present invention, eg, such agents contribute to a more uniform and acceptable skin texture and tone. Examples of skin soothing agents include abscintium, acacia, aescin, horse chestnut extract,
Allantoin, Aloe, APT (commercially available from Centerchem, Stamford, Connecticut), Ragweed, Astragalus, Astragalus root extract, Azulene, Baicalin SR15 (BANETIN SR 15, Barnet Products Dist., New Jersey) Englewo State
od))), Baikal gypsophila, baizhu, Canada balsam, bee pollen, biophytex (BIOPHYTEX, Laboratories Serobiologiques, Somerville, NJ), bisabolol, Cohosh (Perennial genus Perennial), Cohosh (Perennial genus Perennial) extract, Cohosh (Louis bouillon), Cohosh (Louis volumina) extract, Hydrangea vulgaris, Luriticia, Luriticia oil, Luriticia seed oil, Bromelain, Calendula, Calendula Extract, CANADIAN WILLOWBARK EXTRACT
Available from Fytokem, Candelia wax, canju (cangz
hu), canola phytosterol, capsicum, carboxypeptidase, celery seed, celery stem extract, centaurium, cederma (Sederma)
, Brooklyn, NY), centaury extract,
Chamazulene, chamomile, chamomile extract, chaparr
al), Italian carrot, Italian carrot extract, chickweed, chicory root, chicory root extract, chirata, chishao, collodial oatmeal, comfrey, comfrey extract ,
CROMIST CM GLUCAN, available from Croda, Parsippany, NJ, Darutoside
side), Dehurian angelica, Devil's Crow (D
EVIL'S CLAW, MMP, available from Plainfield, NJ)),
Divalent metals (like magnesium, strontium, manganese), doglas (
doggrass, dogwood, air shave (EASHAVE, Pentapharm,
(Commercially available from Basel, Switzerland), Eleuthello (eleuthero), ELHIBIN (commercially available from Pentafarm (Switzerland, Basel)), Enterelin 2 (SECE, France, Pontrieux) (Commercially available), ephedra, esculoside, esculoside, evening primrose, black primrose, extract LE-100 (commercially available from EXTRACT LE-100, Sino Lion, New York World Trade Center), fanfeng (fangfeng) ), Feverfew, ficin, forsythia fruit, Ganoderma (ganode
rma), gaoben, GATULINE A, Gattefosse
fosse, commercially available from Saint Priest, France), gentian root, germanium extract, gingko bilboa, ginkgo, ginseng extract, hydrastice, goat extract, gotu cola (gotu) k
ola), grapefruit extract, guaia cypress oil, guggal extract, helenalin ester, helena linden, honeysuckle flower, mint extract, horse chestnut, horsetail, huzhang, iris flowers, ichchiol, perennial flower, turmeric, juzdama. Jujube, cola extract, LANACHRYS 28 (commercially available from LANACHRYS 28, Lana Tech, Paris, France)
, Lemon oil, lianqiao, licorice root, ligusticam (ligust
icum), Astragalus spp., Lavage root, loofah, nutmeg flower, magnolia flower, manjistha extract, margaspidin (m
argaspidin), Matricin, Microat IRC
, From Nurture (Missoula, Montana)), mint, mistletoe, modulene (MODULENE, from Sephorga, France, Sophia Antipolis), mung bean extract, musk, Oat extract, orange, panthenol, papain, button bark, button root, PHYTOPLENOLIN (commercially available from Bio Botanica, Hauppauge, NY), PREREGEN,
Commercially available from Pentafarm (Basel, Switzerland)), purslane, Quench T (
QUENCH T, Centerchem, Stamford, Connecticut
(commercially available from rd)), quillaia, lantana, rehmannia
), Rhubarb, rosemary, rosmarinic acid, royal jelly, henruda, rutin, sandalwood, sanki (sanqi), salsaparilla,
Saw Palmetto, SENSILINE (commercially available from Silab, Brive, France), SIEGESBECKIA, Sederma
erma, commercially available from Brooklyn, NY), stearyl glycyrrhetinate, Stimutex (STIMUTEX, commercially available from Pentafarm (Basel, Switzerland)), Suika, Renta birch oil, Kurabasou, Manjugiku, tea extract,
Thyme extract, tienchi ginseng, tocopherol, tocopheryl acetate, triclosan, turmeric, urimei, ursolic acid,
Examples include, but are not limited to, strobe pine bark, witch hazel, xinyi, yarrow, yeast extract, yucca and mixtures thereof.

Sunscreens: Examples of suitable sunscreens useful herein are described in WO98 / 18444, incorporated herein by reference. Further examples of sunscreens useful herein include p-methoxycinnamic acid diethanolamine, dioxybenzone, ethyldihydroxypropyl PABA, aminobenzoic acid, glyceryl, lawsome and dihydroxyacetone, menthyl anthranilate, Methyl anthranilate, octyl dimethyl PABA, red petroleum, sulisobenzone, triethanolamine salicylate, and mixtures thereof.

Skin Barrier Repair Aids: Skin barrier repair aids are skin care aids that can help repair or supplement the natural moisture barrier function of the epidermis. Preferable examples of the skin barrier repairing aid include bradycasterol, caffeine, campesterol, canola-derived sterol, CERAMAX (commercially available from Quest, Quest, Ashford, UK), ceramide 2 (
CERAMIDE 2, commercially available from Sederma (Brooklyn, NY),
Ceramide HO3TM (CERAMIDE HO3TM, commercially available from Sederma (Brooklyn, NY)), Ceramide II (CERAMIDE II, commercially available from Quest (Ashford, UK)), Ceramide III (commercially available from CERAMIDE III, Quest (Ashford, UK)), Ceramide IIIB (CERAMIDE IIIB, from Cosmoferm, Delft, The Netherlands), Ceramide IS37
73 (CERAMIDE IS 3773, Laboratory Cello Biologic (Laboratories S
commercially available from erobiologiques, Somerville, NJ),
CERAMINOL (available from Inocosm, Chatenay Malabry, France), Cerasol (available from CERASOL, Pentapharm, Switzerland, Basel), CEPHALIP, Pentafarm (Switzerland) , Basel)), cholesterol, cholesterol hydroxystearate, cholesterol isostearate,
7-dehydrocholesterol, Dermatein BRC (commercially available from Hormel, Austin, Minn.), Dermatein GS
L (DERMATEIN GSL, commercially available from Homel (Austin, Minnesota)), ELDEW CL 301 (ELDEW CL 301, Ajinomoto, Teaneck, NJ)
eck))), ELDEW PS 203 (ELDEW PS 203, Ajinomoto, Teaneck, NJ)), FITROBROSIDE (Pentafarm (Basel, Switzerland)), Generol 122 (GENEROL 12
2, commercially available from Henkel, Hoboken, NJ),
Glyceryl serinamide, lactic acid, lactamide (LACTOMIDE, pentafarm (
(Commercially available from Basel, Switzerland)), lanolin, lanolin alcohol, lanosterol, lauric acid n-lauryl glucamide, lipoic acid, n-acetyl cysteine, serine, n-acetyl-L-serine, n-methyl-L-serine, NET. Sterol-ISO (NET STEROL-ISO, available from Barnet Products, Englewood, NJ), nicotinic acid amide,
Nicotinic acid and its ester, nicotinyl alcohol, palmitic acid, panthenol, panthetine, phosphodiesterase inhibitor, PHYTO
/ CER (commercially available from PHYTO / CER, Intergen, Purchaser, NY), phytoglycol lipid millet extract (P
HYTOGLYCOLIPID MILLET EXTRACT, Barnet Products Sales Agent (Barnet
Products Distributer, available from Inglewood, NJ), PHYTOSPHINGOSINE, available from Gist Brocades, King of Prussia, Pennsylvania), Brooks Industry (PSENDOFILAGGRIN). Indust
ries, available from South Plainfield, NJ), QuestMIDE H (available from QUESTAMIDE H, Ashford, UK), serine, stigmasterol, sitosterol, stigmasteranol, soybean derived sterols, Sphingosine, s-lactoyl glutathione, stearic acid, supersterol ester (SUPER STEROL ESTERS, commercially available from Croda, Parsippany, NJ)
, Thioctic acid, THSC ceramide oil (THSC CERAMIDE OIL, commercially available from Campo Research, Singapore, Raffles Quay), trimethylglycine, tocopheryl nicotinate, vitamin D3 and its analogs or derivatives, and Y2 (Y2, Ocean Pharmaceuticals (Ocean
Pharmaceutical) or mixtures thereof.

Anti-wrinkle and anti-skin atrophy actives: Anti-wrinkle and anti-skin atrophy actives can be effective in replenishing or rejuvenating the epithelial and / or dermal layers. Such actives typically enhance or maintain the natural process of desquamation and / or build the skin matrix components (eg, collagen and glycosaminoglycans) to provide the desired benefits of such skin care. provide. Examples of anti-wrinkle and anti-skin atrophy actives include, but are not limited to, nicotinic acid and its esters, nicotinyl alcohol, estrogens, and estrogen compounds or mixtures thereof. Further suitable anti-wrinkle and anti-skin atrophy actives useful herein are described in WO 98/18444.

Skin repair actives: Skin repair actives can be effective in repairing epithelial and / or dermal layers. Examples of skin repair actives include actein 27
) -Deoxyactein cimicifugoside
(Cimigoside, adapalene, tazarotene (t
azarotene), ademethionine, adenosine, aletris
etris) extract, aloe-derived lectin, 3-aminopropyl dihydrogen phosphate, AMADORINE, Barnet Products,
(Commercially available from Englewood, NJ), anise extract,
AOSINE (Secma, France, Pontrieux)
Commercially available), arginine aminobenzoate, ASC III (commercially available from ASC III, E. Merck, Darmstadt, Germany), ascorbic acid, ascorbyl palmitate, asiatic acid, asiaticocide. (Asiaticosides), ARLAMOL GEO (commercially available from ARLAMOL GEO, ICI, Wilmington, Del.), Azaleic acid (azalei
acid, benzoic acid derivative, bertholletia extract, betulinic acid, BIOCHANIN A, biopeptide CL (BIOPEPTIDE CL,
Sederma (commercially available from Brooklyn, NY), biopeptide EL (BIOPEPTIDE EL, cederma (commercially available from Brooklyn, NY)), biotin, blackberry bark extract, myrtle extract, perennial herb extract, peony extract , Butanoyl betulinate, catecholamine, chalcone, carrot extract of Italy, cis-retinoic acid, citric acid ester, clover extract, coenzyme Q10 (ubiquinone), coumestrol (
coumestrol), CPC peptide (CPC PEPTIDE, commercially available from Barnet Products (Inglewood, NJ)), daidzein, Dan
Gui (dang gui) extract, darutoside, debromo laurinterol, 1-decanoyl-glycero-phosphonic acid, dehydrocholesterol, dehydrodicresol, dehydrodioeugenol, dehydroepiandrosterone, delmolectin (DERMOLECTINE, commercially available from Sederma (Brooklyn, NY)), dehydroascorbic acid, dehydroepiandrosterone sulfate, dianetole, 2,4-dihydroxybenzoic acid, diosgenin, disodium ascorbyl phosphate, dodecanenic acid, edarine ( EDERLINE, Seporga, France, Sophia Antipolis (S
(commercially available from ophia Antipolis)), ELESERYL SH (commercially available from Laboratories Serobiologiques, Somerville, NJ), ENDONUCLEINE, Laboratory Serobiologiques, Somerville, NJ ), Equol, ergosterol, eriodictyol, estrogen and its derivatives, ethocyn, and eislobinic acid (e.
ythrobic acid), farnesol, farnesyl acetate, fennel extract, fibrastil (FIBRASTIL, commercially available from Sederma, Brooklyn, NY), fibrosity murin S and P (commercially available from FIBROSTIMULINES S AND P, Sederma, Brooklyn, NY), Pharmogen IS8445 (FIRM
OGEN IS 8445, commercially available from Laboratory Cellobiologic (Somerville, NJ), flavonoids (especially flavanones such as unsubstituted flavanones and unsubstituted chalcones and chalcones such as monohydroxy and dihydroxy chalcones), formononetin. , Forsythia fruit extract, gallic acid ester, γ-aminobutyric acid, GATULINE RC
efosse, commercially available from Saint Priest, France), genistein, genisteine, genistic acid
id), gentisyl alcohol, ginkgo bilbo
a) extract, ginseng extract, ginsenoside, RO,
_{R 6~1, R 6~2, R 6~3} , R C, R D, R E, R F, R F~2, R G~1, R G~2, glucopyranosyl -l- ascorbate, Glutathione and its esters, glycitein, eptyloxy 4 salicylic acid
), Hesperitin, hexahydrocurcumin
in), HMG-Coenzyme A Reductase I
nhibitors), hop extract, 11-hydroxyundecanoic acid, 10-hydroxydecanoic acid, 25-hydroxycholesterol, isofabone SG10 (ISOFAVONE
SG 10 Burnet Products (commercially available from Inglewood, NJ)
, Kinetin, L-2-o oxo-thiazolidine-4-carboxylic acid ester,
Lactate dehydrogenase inhibitor, 1-lauryl-lyso-phosphatidylcholine, lectin, licochalcon LR15 (LICHOCHALCONE LR15, commercially available from Maruzen, Morristown, NJ), licorice extract, lipoic acid, lumisterol, luteolin , Magnesium ascorbate, melatonin, melibiose, metalloproteinase inhibitor, mesoprene, mesoprenic acid, 4-methoxysalicylic acid, mevalonic acid, MPC complex (commercially available from MPC COMPLEX, CLR, Berlin, Germany), N- Acetyl cysteine, N-methyl serine, N-methyl taurine, N, N ¹ -bis (
Lactyl) cysteamine, naringenin, neothiogogenin (ne
otigogenin), 5-octanoylsalicylic acid, O-desmethylangoiensin, oleic acid, pantetheine, phenylalanine,
Photoanethone, phytic acid and its salts, piperidine, placental extract, platencein (pratensein), pregnenolone, pregnenolone acetate, pregnenolone succinate, premarin, quillaic acid, raloxifene, repair factor 1 (REPAIR FACTOR 1, commercially available from Sederma (Brooklyn, NY)), Repair Factor SPC (REPAIR
FACTOR SPC, commercially available from Sederuma (Brooklyn, NY)), retinal, retinoic acid ester (C ₂ -C ₂₀ alcohol ester), retinol, retinyl acetate, retinyl glucuronide sulfonates, retinyl linoleate, retinyl palmitate, propionate Retinyl acidate, revitalin BT (REVITALIN BT, commercially available from Pentapharm, Basel, Switzerland), s-carboxymethyl cysteine, salicylic acid, sinamin FP (SEANAMINE FP, laboratory
Cellobiologic (commercially available from Somerville, NJ), sodium ascorbyl phosphate, soybean extract, pancreatic extract, tachysterol, taurine, tazarotene, thymulen, thymus extract, thyroid hormone, tigogenin. ), Tocopheryl-retinoate, toxifolin (t
oxifolin), trans-retinoic acid, traumatic acid, tricholine citrate, trifoside, uracil derivatives, ursolic acid, vitamin D ₃ and its analogs, vitamin K, vitex extract , Yam extract, yamogenin and zeatin, or mixtures thereof, but are not limited thereto.

Lipids: Examples of suitable lipids include cetyl ricinoleate, cholesterol hydrostearate, cholesterol isostearate, CREMEROL,
Commercially available from Amerchol, Edison, NJ
, ELDEW C1301, commercially available from ELDEW C1301, Ajinomoto, Teaneck, NJ, Lanolin, Modulan
Commercially available from Edison, NJ), Orlan (commercially available from OHLAN, Amcor (Edison, NJ)), Vaseline, phytantriol and super sterol ester (SUPER STEROL ESTERS, Croda, commercially available from Parsippany, NJ), Alternatively, a mixture thereof may be used.

Skin lightening agents: Skin lightening agents can substantially reduce the amount of melanin in the skin, or provide such effects by other mechanisms. Suitable skin lightening agents for use herein are described in EP-A-758,882 and EP-A-748,307, which are also incorporated herein by reference. A further example of a skin lightening agent is adapalene.
, Aloe extract, aminotyrosine, ammonium lactate, anethole derivative, apple extract, arbutin, ascorbic acid, ascorbyl palmitate, azelaic acid, bamboo extract, bearberry extract, bretilla tuber (bletilla tub
er), Mishima Psycho Extract, Waremoko Extract, Burnett Powder (BURNET P
OWDER, Barnet Products (commercially available from Barnet Products, Englewood, NJ), butylhydroxyanisole, butylhydroxytoluene, chuanxiong, dang-gui,
Deoxyarbutin, 1,3-diphenylpropane derivative, 2,5 dihydroxybenzoic acid and its derivative, 2- (4-acetoxyphenyl) -1,3-ditan,
(2- (4-acetoxyphenyl) -1,3 dithane) 2- (4-hydroxyphenyl) -1
, 3 ditan (2- (4-hydroxyphenyl) -1,3 dithane), ellagic acid, escinol, estragol derivative, esculoside, esculetin, fade out (FADEOUT, Pentapharm, Switzerland, Basel) (Commercially available from (Basel)), fanfang, fennel extract, gallic acid and its derivatives, ganoderma extract, gaoben (gaobe)
n), GATULINE WHITENING, Gattefosse
sse, commercially available from Saint Priest, France), genistic acid and its derivatives, gentisyl alcohol, glabridin and its derivatives, gluco pyranosyl-l-ascorbic acid, gluconic acid , Glucosamine, glycolic acid, glycyrrhizic acid, green tea extract,
4-hydroxy-5-methyl-3 [2h] -furanone, hydroquinine, 4-hydroxyanisole and its derivatives, 4-hydroxybenzoic acid derivative, hydroxycaprylic acid, ascorbic acid inositol, kojic acid, lactic acid, lemon extract,
Licorice extract, licorice P-TH (LICORICE P-TH, available from Burnett Products (Inglewood, NJ)), linoleic acid, magnesium ascorbate phosphate, melfade (MELFADE, Pentafarm, Basel, Switzerland) Commercially available), MELAWHITE, Pentafarm (commercially available from Basel, Switzerland), Morus alba extract, mulberry root extract, nicotinic acid amide, nicotinic acid and its esters, nicotinyl alcohol, 5-octa Noylsalicylic acid, parsley extract, Phellinus lint
eus) extract, placenta extract, pyrogallol derivative, retinoic acid, retinol, retinyl ester (acetate, propionate, palmitate, linoleate), 2
, 4 resorcinol derivative, 3,5 resorcinol derivative, rose extract, rucinol, salicylic acid, song-yi extract, Sophora powder (SOPHORA POWDER, Barnet Products (Inglewood, NJ) Commercially available), 4-thioresorein, 3,4,5 trihydroxybenzyl derivative, tranexamic acid, TYROSLAT10, 11 (availa
ble from Fytokem), vitamin D ₃ and analogs thereof, yeast extract or a mixture thereof.

Sebum inhibitors: Sebum inhibitors can reduce the production of sebum in the sebaceous glands. Examples of suitable sebum inhibitors include aluminum hydrochloride and acebiol (ASEBIO
L, commercially available from Laboratories Serobiologiques (Somerville, NJ), Biodermin (BIODERMINE, commercially available from Sederma, Brooklyn, NY), Climasol (cli)
mbazole), COMPLETECH MBAC-OS (COMPLETECH MBAC-OS, Lipo (Lip
o, commercially available from Paterson, NJ), corticosteroids, cucumber extract, dehydroacetic acid and its salts, dichlorophenylimidazole dioxolane, ketoconazole, licochalcon LR15 (commercially available from LICHOCHALCONE LR15, Maruzen), nicotinic acid amide, Nicotinic acid and its ester, nicotinyl alcohol, phloretin, PHLOROG
INE, Sekuma (commercially available from Pontrieux, France), pyridoxine and its derivatives, s-carboxylmethyl cysteine, SEPICONTROL AS, spironolactone, tioxolone, tocopherol, unitrienol T27 (UNITRIENOL). T27, Unichem
, Chicago, IL) and ZINCIDONE, UCIB, Clifton, NJ, or mixtures thereof.

Sebum-stimulating substances: Sebum-stimulating substances can increase the production of sebum by the sebaceous glands. Examples of sebum stimulants include bryonolic acid, COMPLETECH MBAC-DS, Lipo (commercially available from Lipo, Paterson, NJ), dehydroepiandrosterone (DHE).
(Also known as A), oryzanols, and mixtures thereof.

Skin sensation agents: examples of skin sensation agents suitable for use herein include camphor, thymol, 1-menthol and its derivatives, eucalyptus, agents that impart a cooling sensation, such as carboxamide; Menthane ether and menthane ester; and cayenne tincture agent, cayenne extract, cayenne powder, nonanoic acid vanillylamide, nicotinic acid derivative (benzylnicotinate, methylnicotinate, phenylnicotinate), capsaicin, Dutch pepper (nasturtium officinale) extract,
Examples include, but are not limited to, agents that impart a warming sensation, such as Zanthoxylum piperitum extract and ginger extract, or a mixture thereof.

Protease Inhibitors: Protease inhibitors are compounds that inhibit proteolysis, a process that cleaves proteins into smaller peptide fractions and amino acids. Examples of suitable protease inhibitors include AE COMPLE
X, Barnet Products (available from Barnet Products, Englewood, NJ), ALE (ALE, Laboratory Seposia)
ratoires Seporgia, France, Sophia Antipolis
)), Allicin, AOSAINE (commercially available from Secma, France, Pontrieux), aprotinin (commercially available from APROTININ, Pentapharm AG, Basel, Switzerland), areca catechu Extract, BLUE ALGAE EXTRACT (commercially available from Collaborative Labs Inc., East Setauket, NY), CENTAURIUM,
Commercially available from Sederma (Brooklyn, NY), CMST (commercially available from Bioetica Inc., Portland, MA), DERMOPROTECTINE (commercially available from SEDERMA, Brooklyn, NY), Jisacoside HF60 (DISACOSIDE HF60, commercially available from Barnet Products (Inglewood, NJ)), Elhibin (EL
HIBIN, commercially available from Pentafarm AG (Basel, Switzerland), FLUID OUT COLLOID (commercially available from Vegetech, Glendale, CA), HYPOTAURINE, Sogo Pharmaceutical Co. Ltd., Chiyoda-ku, Tokyo, Insight Heather (IN C
YTE HEATHER, available from Collaborative Labs Inc. (East Settucket, NY), Micromerol (available from MICROMEROL, Collaborative Labs Inc. (East Settucket, NY)), Pefabloc SP (PEFABL
OC SP, Pentafarm AG (commercially available from Basel, Switzerland), SepiControl AS (commercially available from SEPICONTROL AS, Seppic, Paris, France), SIEGESBECKIA (commercially available from SEEGESBECKIA, Sederma (Brooklyn, NY)), Sopholine (commercially available from SOPHORINE, Barnet Products (Inglewood, NJ)), Thiotine (THIOTAINE, commercially available from Burnett Products, Inglewood, NJ), and mixtures thereof.

Skin tightening agents: Examples of skin tightening agents include BIOCARE SA,
Commercially available from Amerchol, Edison, NJ
, Egg albumin, Flexan 130, National Starch (Nation
Al Starch, commercially available from Bridgewater, NJ, GATULINE LIFTING, Gattefosse,
Commercially available from Saint Priest, France), Pent Care HP (
PENTACARE HP, Pentapharm AG, Basel, Switzerland (Basel
))), Begeseryl (VEGESERYL, Laboratories Serobiologiques, Somerville, NJ)
, And mixtures thereof, but are not limited thereto.

Anti-itch ingredient: An example of an anti-itch ingredient is STIMU-
TEX, commercially available from Pentapharm AG, Basel, Switzerland), Takanal (TAKANAL, commercially available from Ikeda-Distributor, Tokyo, Japan), Ichithiol (ICHTHYOL, International Sourcing Distributor ( International Sourcing-Distributor, available from Upper Saddle River, NJ), OXYGENATED GLYCERYL TRIESTERS, Laboratoires Seporgia, France, Sophia Antipolis More commercially available), and mixtures thereof, but are not limited thereto.

Hair growth inhibitors: Suitable examples of hair growth inhibitors include 17β-estradiol, adamantyguanidines, and adamantyla.
midines), adenylosuccinate synthase inhibitor, anti-vascular steroid, aspartate transcarbamylase inhibitor, betamethasone valerate, bisabolol, copper ion, turmeric extract, cyclooxygenase inhibitor, cysteine pathway inhibitor, dehydroacetic acid, dehydroepi Androsterone, diopyros leak extract, epidermal growth factor, epigallocatechin, essential fatty acids,
Evening primrose oil, γ-glutamyl transpeptidase inhibitor, ginger oil,
Sugar metabolism inhibitor, glutamine metabolism inhibitor, glutathione, green tea extract, heparin, capyran (commercially available from KAPILANNE, International Sourcing-Distributor, Upper Saddle River, NJ), L, 5 Diaminopentanoic acid, L-
Asparagine synthase inhibitor, linoleic acid, lipoxygenase inhibitor, longa extract, mimosinamine dihydrochloride, mimosin, nitric oxide synthase inhibitor, non-steroidal anti-inflammatory drug, ornithine decarboxylase inhibitor, ornithine aminotransferase inhibitor Substance, panthenol, foreture (phorhe
tur), phosphodiesterase inhibitor, pleione extract, protein kinase C inhibitor, 5-α-reductase inhibitor, sulfhydryl-reactive compound, tioxolone, transforming growth factor β1, urea, zinc ion and mixtures thereof. But is not limited thereto.

5-α-reductase inhibitor: As an example of the 5-α-reductase inhibitor, clove 55
(CLOVE 55, available from Barnet Products, Englewood, NJ), ethinyl estradiol, genisteine, genistin, licochalcon LR-15 (Licochalcone L).
R-15), saw palmetto extract, sophora extract (SOPHORA EXTR
ACT, Marzen (Morristown, NJ)
Commercially available), commercially available from ZINCIDONE, UCIB, Clifton, NJ, and mixtures thereof, but are not limited thereto.

Exfoliating enzyme enhancers: These agents enhance the activity of endogenous exfoliating enzymes. Examples of stripping enzyme enhancers include, but are not limited to, N-methylserine, serine, trimethylglycine and mixtures thereof.

Anti-glycation agents: Anti-glycation agents prevent the induction of sugar cross-linking of collagen. Examples of suitable anti-glycation agents include AMADORINE, Barnet Products, Englewood, NJ
commercially available from wood)).

Preferred examples of beneficial agents useful herein are salicylic acid, nicotinamide, panthenol, tocopheryl nicotinate, benzoyl peroxide, 3-hydroxybenzoic acid, flavonoids (eg flavanone, chalcone), Farnesol, phytantriol, glycolic acid, lactic acid, 4-hydroxybenzoic acid, acetylsalicylic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-
Hydroxyhexanoic acid, cis-retinoic acid, trans-retinoic acid, retinol, retinyl ester (eg, retinyl propionate), phytic acid, N
-Acetyl-L-cysteine, lipoic acid, tocopherol and its ester (for example, tocopheryl acetate), azelaic acid, arachidonic acid, tetracycline, ibuprofen, naproxen, ketoprofen, hydrocortisone, acetaminophen, resorcinol, phenoxyethanol, phenoxypropanol,
Phenoxyisopropanol, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichlorocarbanilide, octopirox, lidocaine hydrochloride, clotrimazole, miconazole, ketoconazole, neomycin sulfate, theophylline, And those selected from the group consisting of mixtures thereof. Nicotinamide, panthenol, glycolic acid, lactic acid, salicylic acid, acetylsalicylic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, retinol and its ester, tocopherol and its ester, and mixtures thereof. More preferred are those selected from the group.

For cosmetic care of the skin, hair or nails, the beneficial agents are preferably anti-wrinkle and anti-skin atrophy agents, anti-acne agents, artificial tanning and accelerating agents, skin repair actives, skin barrier repair aids. From agents, skin lightening agents, skin sensation agents, skin soothing agents, lipids, sebum inhibitors, sebum stimulants, sunscreens, protease inhibitors, skin tightening agents, anti-itch ingredients and exfoliating enzyme enhancers, or mixtures thereof To be selected.

Humectant A preferred preformed sheet-like device comprises at least one humectant. Humectants can be added to have a plasticizing effect and to increase the moisturizing properties of the preformed sheet-like device when applied to the target surface. Certain humectants, such as hexylene glycol, may also contribute to the antimicrobial properties and attributes of the preformed sheet device of the present invention. Furthermore, although not wishing to be limited by theory, it is believed that incorporating a humectant into the preformed sheet-like device of the present invention enhances device stability so that it is less susceptible to decomposition under extreme temperature conditions. Has been.

Generally, the preformed sheet-like devices of the present invention will contain about 1.0% to about 45% by weight humectant, preferably about 5% to about 40%, more preferably about 10% to about 30%. % Included.

Moisturizers suitable for use in the present invention are WO 98/22085, International Publication WO
98/18444 and WO 97/01326, all of which are incorporated herein by reference. More preferable moisturizers include amino acids such as proline and arginine aspartate and derivatives thereof, 1,3-
Butylene glycol, propylene glycol and water and codium tomentosum extract, collagen amino acids or peptides, creatinine, diglycerol, biosaccharide gum-1, glucamate, glucuronate, glutamate, glycerin (eg glyceres ( glycereth) 20
) Polyethylene glycol ether, glycerin, glycerol monopropoxylate, glycogen, hexylene glycol, honey,
And extracts or derivatives thereof, hydrogenated starch hydrolysates, hydrolyzed mucopolysaccharides, inositols, keratin amino acids, LAREX A-200
, Commercially available from Larex), glycosaminoglycan, methoxy PEG1
0, Methylgluceth-10 and -20 (both Amarchol
rchol, commercially available from Edison, NJ), methyl glucose, 3-methyl-1,3-butanediol, N-acetylglucosamine salt, panthenol, polyethylene glycol and its derivatives (PEG15 butanediol, PEG4, PEG5 penta). Erythitol, PEG6, P
EG8, PEG9), pentaerythitol, 1,2-pentanediol, PPG-1 glyceryl ether, PPG-9, 2-pyrrolidone-5
-Carboxylic acids and their salts glyceryl pca, sugar isomerates, seacare (SEACARE,
(Commercially available from Secma), celsin, silk amino acid, sodium acetyl hyaluronate, sodium hyaluronate, sodium polyaspartate, sodium polyglutamate, sorbeth 20, sorbeth 6, sugars and sugar alcohols and glucose, mannose and poly. Their derivatives such as glycerol, sorbitol, trehalose, triglycerol, trimethylpropane,
Mention may be made of tri (hydroxymethyl) aminomethane salt and yeast extract, or mixtures thereof.

Preferably, the humectant used herein is selected from glycerin, butylene glycol, hexylene glycol, panthenol and polyethylene glycol and their derivatives, or mixtures thereof.

Emulsifier / Surfactant The preformed sheet-like device of the present invention may also optionally include one or more surfactants and / or emulsifiers. Emulsifiers and / or surfactants usually help the discontinuous phase disperse and suspend within the continuous phase. Surfactants can also be useful if the product is intended to cleanse the skin. For convenience, hereinafter emulsifiers will be referred to by the term "surfactant", and thus "surfactant" will be used for purposes such as emulsifiers or other surfactants such as skin washes. Shall be used to represent the surface activator. Known or conventional surfactants can be used in the composition so long as the selected surfactant physically and chemically matches the essential components of the composition and provides the desired properties. Suitable surfactants include silicone materials, non-silicone materials and mixtures thereof.

The composition of the present invention preferably comprises a surfactant or mixture of surfactants of about 0.0.
Includes 1% to about 15%. The exact surfactant or surfactant mixture selected will depend on the pH of the composition and other components present.

Preferred surfactants are nonionic. Nonionic surfactants useful herein include condensation products of alkylene oxides and fatty acids (ie, alkylene oxide esters of fatty acids). Such materials have the general formula RCO (X) _n OH,
In the formula, R is a C _10-30 alkyl group, X is —OCH ₂ CH ₂ — (that is, derived from ethylene glycol or oxide) or —OCH ₂ CHCH ₃ — (that is, derived from s propylene glycol or oxide). And n is an integer from about 6 to about 200. Other nonionic surfactants are condensation products of alkylene oxides with 2 moles of fatty acids (ie alkylene oxide diesters of fatty acids). Such materials have the general formula RCO (X) _n OOCR, alkyl group wherein R is C _{10 to 30,} X is -OCH ₂ CH ₂ - (i.e., derived from ethylene glycol or oxide)
Or —OCH ₂ CHCH ₃ — (ie, derived from propylene glycol or oxide), and n is an integer from about 6 to about 100. Other nonionic surfactants are condensation products of alkylene oxides and aliphatic alcohols (ie alkylene oxide ethers of aliphatic alcohols). Such materials have the general formula R (X
) _N OR, _where R is a C _10-30 aliphatic group and X is —OCH ₂ CH ₂ — (
That is, derived from ethylene glycol or oxide) or -OCH ₂ CHCH ₃ -
(Ie, derived from propylene glycol or oxide), and n is about 6
To an integer of about 100 and R is H or a C10-30 aliphatic group, for example PEG40 hydrogenated castor oil (trade name "Cremophore RH40 (Cremop
hor RH 40) ”as BASF (Parsipp, NJ, USA)
commercially available from any)); PEG60 hydrogenated castor oil (trade name "Cremophore RH
"60 (Cremophor RH 60)" marketed by BASF (Parsipany, NJ, USA); isoceteth-20, ICI under the trade name "Arlasolve 200" (Wilmington, Mass., USA) Commercially available); and Oles-20 (trade name "Volpo N20") (commercially available from Croda Chemicals Ltd., North Humberside, UK, Goole). Still other nonionic surfactants are condensation products of alkylene oxides of both fatty acids and fatty alcohols [ie, the polyalkylene oxide moiety is esterified with a fatty acid at one end and an aliphatic end at the other end. It is etherified with alcohol (that is, it binds with an ether bond). Such materials have the general formula FCO (X) _n OR, _where R and R are C _10-30 alkyl groups,
S is —OCH ₂ CH ₂ (ie derived from ethylene glycol or oxide) or —OCH ₂ CHCH ₃ — (derived from propylene glycol or oxide), and n is an integer from about 6 to about 100, Examples are Ceteth-6 and Ceteth-10
, Ceteth-12, ceteareth-6, ceteareth-10, ceteareth-12, steareth-6, steareth-10, steareth-12, PEG-6 stearate,
PEG-10 stearate, PEG-100 stearate, PEG-12 stearate, PEG-20 glyceryl stearate, PEG-80 glyceryl tallowate, PEG-10 glyceryl stearate, PEG-30 glyceryl cocoate, PEG-80 glyceryl cocoate, PEG -200 glyceryl tallowate, PEG-8 dilaurate, PEG-10 distearate, and mixtures thereof.

Other nonionic surfactants useful herein are WO98 / 18.
444 (incorporated herein by reference) and alkyl glucosides and alkyl polyglucosides.

Other useful nonionic surfactants further include polyhydroxy fatty acid amide surfactants, which are described in more detail in WO98 / 04241.

Other nonionic surfactants suitable for use herein include sugar esters and polyesters, alkoxylated sugar esters and polyesters, C ₁ -C _30.
Fatty acid esters of C ₁ -C ₃₀ aliphatic alcohols, alkoxylated derivatives of C ₁ -C ₃₀ fatty acid esters of aliphatic alcohols of C ₁ -C _30, aliphatic alkoxylated ethers of alcohols of C1-C30, C polyglyceryl esters of ₁ -C ₃₀ fatty acid, esters of C ₁ -C ₃₀ polyhydric alcohols, ethers of C ₁ -C ₃₀ polyhydric alcohols, alkyl phosphates, polyoxyalkylene fatty ether phosphates,
Included are fatty acid amides, lactylates and mixtures thereof.
Examples of these non-silicone-containing surfactants include polysorbate 20, polyethylene glycol 5 soy sterols, steareth-20, ceteareth-20,
PPG-2 methyl glucose ether distearate, polysorbate 80; polysorbate 60, trade name "Tween 60", ICI (commercially available from Wilmington, Massachusetts, USA; glyceryl stearate, sorbitan monolaurate, Mention may be made of sodium polyoxyethylene 4-lauryl ether stearate, polyglyceryl-4 isostearate, hexyl laurate, PPG-2 methyl glucose ether distearate and mixtures thereof.

Preferred nonionic surfactants include ceteareth-12, sucrose cocoate,
Some are selected from the group consisting of steareth-100, polysorbate 60, PEG-60 hydrogenated castor oil, isoceteth-20, oleth-20, PEG-100 stearate, and mixtures thereof.

[0105]   Other suitable emulsifiers used herein are polyoxypropylene, aliphatic alkanes.
Cole's polyoxyethylene ether. Such materials have the general formula R (CH ₂ CHCH₃O)_x-(CH₂CH₂O)_y-H, where R is OC_Ten~ C₃₀The al
Kill group or C_Ten~ C₃₀Is an alkyl group of x, has an average value of 1 to 20, and y is
It has an average value of 1 to 30, as an example PPG-6-decyltetradeceth-30 (
PPG-6-Decyltetradeceth-30), trade name "Pen 4630 (Pen 4630)"
Commercially available from Nikko Chemicals Co. Ltd. (Tokyo, Japan); PP
G-6-decyltetradeceth-20 (PPG-6-Decyltetradeceth-20), trade name "
Marketed by Nikko Chemical Co., Ltd. (Tokyo, Japan) as "Pen 4620"
Sales; and PPG-5-Ceteth-20, product name "Procetyl AWS
) ”As Croda Chemicals Ltd., North Ha
North Humberside, Goole).

Another emulsifier useful herein is a mixture of sorbitan or sorbitol fatty acid ester and sucrose fatty acid ester as described in further detail in WO98 / 22085, which is incorporated herein by reference. It is a fatty acid ester blend based on.

Hydrophilic surfactants useful herein include, alternatively or additionally, a wide variety of cationic, anionic, zwitterionic and amphoteric surfactants as are known in the art. Both can be mentioned. For example, "McCutcheon's, Detergents and Emulsifiers", North American version (1986) Alred Publishing Corporation (Al.
Lured Publishing Corporation Publisher: US-A-5, Ciotti
011,681 (issued April 30, 1991); US of Dixon-
A-4,421,769 (issued December 20, 1983); and US-A-3,
755,560 (published August 28, 1973); (all four references are incorporated herein by reference in their entirety).

A wide variety of cationic surfactants are useful herein. Suitable cationic surfactants for use herein are disclosed in WO98 / 18444.

[0109]   A wide variety of anionic surfactants are also useful herein. For example, Rollin (
Laughlin) US-A-3,929,678 (issued December 30, 1975, see
For the sake of consideration, all are incorporated herein as they are). Typical Yin-io
Alkyl isethionate (for example, C₁₂~ C₃₀, A
Alkyl and alkyl ether sulphates and their salts, alkyl and alkyl ethers
Telluric acid salts and salts thereof, alkyl methyl taurates of fatty acids (for example, C ₁₂ ~ C₃₀), And soaps (eg, alkali metal salts such as sodium or potassium).
Um salt)).

Amphoteric and zwitterionic surfactants are also useful herein. Examples of amphoteric and zwitterionic surfactants that can be used in the compositions of the present invention can be those where the aliphatic group is linear or branched and one of the aliphatic substituents is from about 8 to about 22 carbon atoms. (Preferably C _{8 to} C ₁₈ ) and one is widely used with derivatives of aliphatic secondary and tertiary amines containing anionic water solubilizing groups such as carboxy, sulfonate, sulfate, phosphate, or phosphonate. It is described. Examples are alkyliminoacetates, and iminodiaalkanoates and aminoalkanoates, imidazolinium and ammonium derivatives. Other suitable amphoteric and zwitterionic surfactants include betaines, sultaines, hydroxy sultaine, alkyl sarcosinate (e.g., C ₁₂ -C ₃₀₎ are those selected from the group consisting of and alkanoyl sarcosinates.

The preformed sheet-like device of the present invention optionally contains an emulsifier or surfactant-containing silicone. A wide variety of silicone emulsifiers are useful herein. Such silicone emulsifiers are generally organically modified organopolysiloxanes, also known to those skilled in the art as silicone surfactants. Useful silicone emulsifiers include dimethicone copolyol. Such materials contain, for example, polyethylene oxide chains, polypropylene oxide chains, mixtures of such side chains and polyether side chains, such as polyether chains containing moieties derived from both ethylene oxide and propylene oxide. It is a polydimethylsiloxane modified as described above. In other instances, dimethicone copolyol and alkyl-modified, i.e., compounds which contain C ₂ -C ₃₀ pendant side chains. Still other useful dimethicone copolyols include materials with a variety of cation, anion, zwitterion, and zwitterionic pendant moieties.

Oily Conditioning Agents The present invention can also optionally include an oily conditioning agent. Examples of conditioning agents useful as oily conditioning agents include mineral oil, petrolatum, C7-40 branched chain hydrocarbons, C1-C30 carboxylic acid C1-C3.
0 alcohol ester, C2-C30 dicarboxylic acid C1-C30 alcohol ester, C1-C30 carboxylic acid monoglyceride, C1-C30 carboxylic acid diglyceride, C1-C30 carboxylic acid triglyceride, C1-
C30 carboxylic acid ethylene glycol monoester, C1 to C30 carboxylic acid ethylene glycol diester, C1 to C30 carboxylic acid propylene glycol monoester, C1 to C30 carboxylic acid propylene glycol diester, C1 to C30 carboxylic acid monoester Polyesters of esters and sugars, polydialkyl siloxanes, polydiallyl siloxanes, polydialkaryl siloxanes, silicone rubbers (for example, dimethiconol having 3 to 9 silicon atoms, cyclomethicone), vegetable oils, hydrogenated vegetable oils, polypropylene glycols C4
To C20 alkyl ethers, diC8 to C30 alkyl ethers, and mixtures thereof.

Such agents are described in further detail in WO98 / 18444, which is incorporated herein by reference.

Thickening Polymer The preformed sheet-like device of the present invention preferably comprises from about 0.01% to about 5% by weight thickening polymer, more preferably from about 0.05% to about 3%, and Most preferably it comprises from about 0.1% to about 2%.

Thickening polymers may be combined with the polysaccharide blends described herein to modify the properties of the gel. The thickening polymer may be chemically or physically crosslinked,
Alternatively, it may be used in the polysaccharide mixture itself.

Suitable thickening polymers useful herein include polyvinylpyrrolidone, poly-2-ethyl-2-oxazoline, polyvinyl alcohol, polyethylene oxide, polyvinyl ethers, polyvinyl ethers and copolymers of polyvinylpyrrolidone and its derivatives, Copolymers of methyl vinyl ether and maleic anhydride, ethylene and maleic anhydride; acrylic acid-based polymers or derivatives thereof such as polyacrylic acid; such as polyethylene glycol monomethacrylate, polydimethylacrylamide, ammonium polyacrylate and sodium polyacrylate. And polyacrylamide; and copolymers of acrylamide and N, N ¹ -methylenebisacrylamide and polyacrylamide; and polyacrylamide.

Additional Polysaccharides The preformed sheet-like device of the present invention can also include additional polysaccharides. As described herein above, the sheet-like device of the present invention comprises less than 10% total polysaccharides (
(By dry weight). The additional polysaccharide, if present, contributes to the total dry weight of the polysaccharide making up the device.

Suitable additional polysaccharides include algin, alginic acid, alginates (salts such as calcium, potassium, aluminum or sodium) and brown algae polysaccharide salts such as propylene glycol alginate; chitosan and hydroxypropyl chitosan and derivatives. Extracts of marine invertebrates such as; Starch or its derivatives; Natural fruit extracts such as pectin and arabian; Natural plant exudates; and resin gums such as shellac gum, dammer gum, copal gum and rosin gum; or mixtures thereof.

Further suitable examples of additional polysaccharides useful herein are WO 97/28.
Cellulose and its derivatives as described in 785, which are hereby incorporated by reference.

Light Scattering Agents The devices of the present invention also include matte or light scattering agents, particularly organic or nylon-12 powders, silicone elastomer powders (eg dimethicone / vinyl dimethicone crosslinked polymers) and polyalkylsilsesquioxane.
) Powder (GE Silicones Tospearl®)
Organosiloxane microparticles such as 145A) can be included.

Other Optional Ingredients The compositions of the present invention can include a wide variety of other optional ingredients. Such additional ingredients are pharmaceutically acceptable. CTFA Cosmetic Ingredient Handbook (
CTFA Cosmetic Ingredient Handbook: 2nd Edition (1992), which is incorporated herein by reference in its entirety, is commonly used in the cosmetics industry and is suitable for use in the compositions of the present invention. A wide variety of cosmetic and pharmaceutical ingredients have been described, but are not limited thereto. Examples of functional classes of ingredients are set forth on page 537 of this reference, but are not limited thereto. Examples of such and other functional classes include abrasives, absorbents, antibiotics,
Anti-pressurizing agent, anti-dandruff agent, antiperspirant, antioxidant, vitamin, biological additive, bleach, bleach activator, brightener, filler, buffer, chelating agent, chemical additive , Colorants, cosmetics, cleansers, cosmetic astringents, cosmetic biocides, modifiers, dental care agents, deodorants, peeling active substances, depilatory agents, medicinal astringents, dyes, dye modifiers,
Enzymes, topical analgesics, fragrances, film-forming agents, fragrance ingredients, insect repellents, fungicides, opacifying agents, oxidative dyes, oxidizing agents, pest control ingredients, pH adjusters, pH buffers, pharmaceutically active substances, plasticizers Agents, preservatives, radical scavengers, skin, hair or nail bleaches,
Mention may be made of skin, hair or nail penetration enhancers, stabilizers, surface conditioners, reducing agents, temperature lowering agents, and thermogenic agents.

Also useful herein are cosmetic ingredients such as colorants, essential oils and skin rejuvenating agents.

Other optional materials herein include pigments. Suitable pigments for use in the compositions of the present invention are organic and / or inorganic. The term pigment further includes matte finishes, and also low-toning or low-gloss substances such as light-scattering agents. Examples of suitable pigments are iron oxides, aciglutamate iron oxides, titanium dioxide, ultramarine blue, D & C dyes, carmine, and mixtures thereof. Depending on the type of composition, a mixture of pigments is used as it is normally used.

The pH of the sheet-like devices herein is preferably from about 3 to about 9, more preferably about 4.
~ About 8.

The preformed sheet-like device of the present invention is a patch or mask of a size and shape adapted to fit the desired area of interest. The exact size and shape will depend on the intended use and characteristics of the product. The preformed sheet-like device herein is suitable for topical application of nails or cuticles, hair or scalp, human face or parts thereof, feet, hands, arms, legs or human torso. The devices herein may be of other shapes, for example square, circular, rectangular, oval, or a composite of the shapes described by the “semi-circular”, “donuts”. The surface area of the device made to fit the face is in the range of 0.25 cm ² to about 500 cm ² , preferably about 1 cm ² to about 400 cm ² . The device herein is about 0.5 mm to about 20 mm, preferably about 1 mm to about 5 mm.
Has a thickness of.

The preformed sheet-like device of the present invention may also be made and used in the form of handwear, footwear or body wrap. Generally, handwear includes gloves for the hand or any part thereof, and footwear includes socks for the foot or any part thereof. As used herein, the term "glove" is meant to include "mittens". Preferably, the handwear comprises a glove body comprising a central portion, a one-to-four-finger insertion portion connected to the central portion, a thumb insertion portion connected to the central portion, a palm side and an opposite back side. Preferably, the footwear comprises a sock body portion forming a tubular leg portion having a closed end and an open end. The device of the present invention may also be made and used in the form of a body wrap. The body wrap is radially wrapped around any part of the body that has a long axis. The ends may be connected to each other or their length may be short so that they only partially cover. In both cases, the wrap must exhibit very good comfort for the shape of the body part. Typically, such a body part is the user's back,
Upper arm, forearm, upper thigh, leg, neck and torso.

After application of the device, the device may remain in the area of interest for about 3 hours, preferably for about 1 hour, more preferably for less than 15 minutes. Then, the preformed sheet-shaped device
All can be removed with one sheet.

Depending on the beneficial agent (or beneficial agents) contained therein, the preformed sheet-like device of the present invention may have at least one of the following uses: Application of the device Hydration of the skin, hair or nails in the targeted area created; smoothing of fine lines and wrinkles;
Cosmetic acne treatment; skin tightening; strengthening; softening; exfoliation; skin tone and / or texture improvement and / or leveling; skin, hair or nail lightening; skin or hair conditioning; sunburn; pores Reduction of the appearance of; absorption or suppression of secretions; prevention and / or sedation of skin, hair or nails, muscles, acne or pain; reduction of swelling and / or dark circles; promotion of wound healing; warming, refreshing or cooling of skin Relieving inflammation; Lightening complexion; Relieving congestion; Reducing swelling; Treating dermatological conditions; Cushioning; Cleansing; Aroma effects; Reducing bacterial or microbial growth; Healing; Insect repellent; Unwanted Removal of hair, dirt, or make-up; and coloring or bleaching of areas of interest. Preferably, the preformed sheet-like device herein is used for hydration of skin, hair or nails, smoothing of fine lines and wrinkles, improvement and / or leveling of skin tone and / or texture.

Method Exudate Release Assay The amount of syneresis of the preformed sheet-like device of the present invention is measured by an exudate release assay on the polysaccharide gel mixture containing the device.

Exudate release data from the gels presented herein were generated by the following method. The desired gel formulation is manufactured as follows. While the liquid is hot (> 80 ° C), add 9g (+/- 0.1g) to a shallow container with a diameter of 91mm (for example, Falcon).
) -1029 Petri dish lid). The container is closed to prevent loss due to evaporation. Allow the gel to solidify while cooling to room temperature. The gel is left overnight at room temperature until measurement. Remove the cover and subtract the weight of the empty container containing the sample (+/- 0.005g). 3 sheets of filter paper (9.0 cm, Whatman-
114, wet strength) on a flat gel surface. A 200 g weight having a flat bottom with a diameter of 9.0 cm is brought into close contact with the gel surface and placed on the filter paper. After 1 minute, remove the weight and gently peel the filter paper from the gel. The filter paper should give the surface of the gel a distinctly matt appearance, which confirms sufficient contact with the filter paper. Reweigh the sample and calculate the amount lost by the difference. This is recorded as the number of grams of exudate released on the 9 cm diameter gel described above.

Gel compression dehiscence test The mechanical properties of the preformed sheet-like device of the present invention are measured by compression failure of the gel. The parameters of interest are gel strength (measured by the compression force required to cleave a gel molded into a cylinder) and gel flexibility (measured by the degree of gel compression during cleavage). A more detailed description of the inspection method is given below.

The compression failure test is conducted by Stable Micro Systems (SMS).
Texture Analyzer (TA) [Model number TA-XT2i, Stable Micro Systems Ltd, UK, Surr.
ey), commercially available from Godalming). This system is an SMS texture expert exce
Controlled by SMS's Texture Expert Exceed software (version 2.03). A 100 mm diameter aluminum compression plate (P-100 probe) is attached to a 50 kg load cell. This is a TA probe carrier
It is installed on a carrier and its vertically moving extension arm is controlled by a computer.

To make the test sample, the gel formulation of interest is prepared as follows. An exact solid cylindrical (diameter 26 mm, depth 12 mm) gel disk is formed in a casting mold.
The sink containing the sample should be sealed to prevent evaporation during storage. Such gel discs are left overnight at room temperature. Immediately before inspection, each gel disc is removed from the casting mold and visually inspected for defects. All gel discs with defects (eg air bubble inclusions) are discarded as such defects can have a strong effect on the mechanical properties to be measured. The defect-free gel disc is then centered under a P-100 compression plate.

Prepare the Texture Expert Exceed software in force / compression mode. Set the compression plate at the starting height of 12.0 mm. Down rate 0.8 mm /
Seconds, adjust the total distance traveled to 10.8 mm (ie the measurement stops when the gel disc is compressed to 90% of its original height). Data is automatically collected at 200 pps (times / sec) for each compression plate force and position. The software is pre-tuned to mark the position of the compression plate that has reached maximum force. The maximum force is the tear strength, that is, the force required to tear the gel disc. The distance traveled by the plate from the original starting height to the position where the gel cleaves represents the amount of gel deformation. The maximum force at dehiscence is averaged between the samples (typically repeated 5 times) and recorded in Newtons.

Uniaxial deformation (compression) at the gel tear position is expressed as a percentage of the original molded height. That is,

% Compression = [plate travel distance at maximum force (measured in mm) / 12 mm (original molded sample height)] × 100

If the gel does not cleave by the end of the 10.8 mm stroke (ie, 90% compression), the gel is classified as “non-cleavage” under these test conditions.

[0138]   The invention is illustrated by the following examples.

[0139]

[Table 1]

1. Kelgum ™ is a 1: 1 mixture of xanthan gum and locust bean gum and is supplied by Kelco (San Diego, Calif., USA). 2. "Kimwipes EX-L" is Kimberly-Clark (Kim
berley-Clark Corp., Roswell, Georgia, USA). 3. "Collagen Fiber Mask" is a beauty
Beaute Attica, Inc., Redmond, WA, USA
)).

The polysaccharide gum is mixed with water to form a uniform dispersibility, which can be facilitated by predispersing the polysaccharide in a non-solvent, eg a polyhydric alcohol, And add all additional ingredients. The mixture is heated with stirring to a first temperature (about 90 ° C.) above the point where the mixture gels so that the polysaccharide gum is fully hydrated. The liquid gel is then poured into a suitable shaped sink. Preferably, the liquid gel is obtained by injection molding. This eliminates any defects that may be induced by cutting the gel and improves the robustness of the device. Injection molding also facilitates molding of the device while varying the range of thickness and other structural characteristics. Alternatively, the liquid gel is formed into a sheet. The liquid gel is then below the first temperature to build a gel structure, or below the point where the mixture gels (eg,
Room temperature) Cool to a second temperature. The device may then be removed from the casting mold or the gel sheet may be cut into patches of suitable shape. The device herein is then placed in a container of low water vapor permeable material to minimize drying of the device during storage.
Suitable containers for the devices herein include bags or sealed trays. If the device is packaged, it is preferably protected until use. This protection can be provided by a release liner such as a plastic film, providing easy release to the device.

If a substrate is used (Examples 1, 4, and 6), it may be placed in a suitable shaped sink prior to pouring the gel, or on the surface of the liquid gel during the cooling step. You can leave it.

In some compositions, metal ions (eg, Ca ²⁺ , K ⁺ ) are included in the formulations (Examples 3 and 4) to increase the gel strength of the device. In this case, the metal ions are added in the form of an aqueous solution and finally added to the mixture and mixed into the hydrated liquid gel with stirring.

The above method may be modified as necessary depending on the state of any additional components. For example, if non-aqueous components are present, the liquid gel may be homogenized immediately prior to casting or shaping to ensure dispersion of the non-aqueous components. Similarly, if the heat sensitive ingredients are mixed, the formulation is cooled to the appropriate temperature (depending on the ingredients) after the hydration step of the rubber and then the heat sensitive ingredients are added at this stage.

The liquid gel may be degassed (eg, by applying a vacuum) to remove air bubbles dispersed in the liquid. This degassing step, if done, is the final step immediately prior to removing the liquid gel.

As described above, the preformed sheet-like device has the desired amount of syneresis, strength or flexibility.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61F 13/10 A61F 13/10 A 13/14 13/14 Z A61K 7/043 A61K 7/043 9/70 405 9/70 405 45/00 45/00 47/36 47/36 A61L 15/58 C08J 5/18 CEP C08J 5/18 CEP C08L 5:00 // C08L 5:00 A61L 15/06 (81) Designated country EP (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE), OA (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG), AP (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW) , EA (A , AZ, BY, KG, KZ, MD, RU, TJ, TM), AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU , CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK , SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW (72) Inventor Deckner, George Endel, Cincinnati, Ohio, USA Tennessee, Hills, Drive 10572 ( 72) Inventor Jenkins, De Sumifanui UK, Sally, Tidabru 2,09 NQ, Eagam, Menor, Way 41 (72) Inventor Kite, Kenneth Eugene United States Ohio, Lebanon, Lencroft, Court 571 F Term (Reference) 4C076 AA09 AA74 BB31 CC04 CC05 CC09 CC18 CC29 EE01A EE30P FF35 FF68 4C081 AA03 AA12 CA291 CD011 CD012 CE02 DA02 4C083 AB342 AC122 AC152 AC432 AC442 AC482 AC532 AC642 AC852 AD072 AD162 AD211 AD212 AD352 AD662 NA08MA05 NA32MA41 MA08 NA0514 ZC201 4F071 AA08 AH19 BB05 BC01

Claims (17)

[Claims] 1. A preformed sheet-like device, comprising: (a) less than 10% of a polysaccharide mixture consisting of the following (i), (ii) and (iii); (i) a red algal polysaccharide. (Ii) a mannose-containing polysaccharide selected from galactomannan, glucomannan, and derivatives thereof or mixtures thereof; (iii) fermented polysaccharides or derivatives thereof; and (b) from about 30% to about 99. 5% water; wherein the device comprises less than 10% of total polysaccharides. 2. A preformed sheet-like device according to claim 1, wherein the red algal polysaccharide is selected from agar, agarose, kappa-carrageenan and furcellaran or mixtures thereof. 3. The preformed sheet-like device according to claim 1 or 2, wherein the red algal polysaccharide is selected from agar and agarose or a mixture thereof. 4. The preformed sheet-like device according to claim 1, wherein the galactomannan is selected from locust bean gum, guar gum and cassia gum, or a mixture thereof. 5. The preformed sheet-like device according to claim 1, wherein the glucomannan is selected from konjak mannan and deacetylated konjak mannan, or a mixture thereof. 6. The preformed sheet-like device according to claim 1, wherein the fermented polysaccharide or derivative thereof is selected from xanthan gum and gellangum, or a mixture thereof. 7. The composition according to claim 1, which contains less than 5% of the polysaccharide mixture.
The preformed sheet-like device according to the item. 8. The ratio of the red algal polysaccharide and the mannose-containing polysaccharide is 20.
The preformed sheet-like device according to any one of claims 1 to 7, wherein: 1 to about 1: 5. 9. The ratio of the red algal polysaccharide to the mannose-containing polysaccharide is 7:
9. The preformed sheet-like device of any one of claims 1-8, which is 1 to about 1: 2. 10. An anti-wrinkle and anti-skin atrophy active substance, an anti-acne agent, an artificial tanning agent and a promoter, a skin repair active substance, a skin barrier repair aid, a skin lightening agent, a skin sensation agent, a skin soothing agent, an antimicrobial agent. And antifungal agents, lipids, sebum inhibitors, sebum stimulants, sunscreens, antiseptics, local anesthetics, steroids, nonsteroidal anti-inflammatory agents, protease inhibitors, skin tightening agents, anti-itch ingredients, hair growth inhibition 10. A preformed article according to any one of claims 1-9, further comprising a beneficial agent selected from agents, 5-alpha reductase inhibitors, anti-glycation agents, and exfoliating enzyme enhancers, or mixtures thereof. Sheet-shaped device. 11. An anti-wrinkle and anti-skin atrophy active substance, anti-acne agent, artificial tanning agent and promoter, skin repair active substance, skin barrier repair aid, skin lightening agent, skin sensation agent, skin soothing agent, antimicrobial agent. And a beneficial agent selected from antifungal agents, lipids, sebum inhibitors, sebum stimulants, sunscreens, protease inhibitors, skin tightening agents, anti-itch ingredients, and exfoliating enzyme enhancers, or mixtures thereof. A preformed sheet-like device according to any one of claims 1 to 9 including. 12. The preformed sheet-like device according to claim 1, further comprising a substrate. 13. The preformed sheet-like device according to claim 1, further comprising at least one moisturizer. 14. A nail or cuticle, hair or scalp, human face or part thereof, foot or arm, leg, or mask or patch in the form of a patch having a size and shape adapted to conform to the human torso. The preformed sheet-like device according to any one of claims 1 to 13. 15. Skin, hair, or nails according to claims 1-9, 11, 12, 13,
Or a cosmetic care method comprising applying the preformed sheet-like device according to 14. 16. For improving the strength, syneresis or flexibility of a preformed sheet-shaped device containing water, (i) a red algal polysaccharide; (ii) galactomannan, glucomannan and its derivatives or their derivatives. Use of a polysaccharide mixture consisting of a mannose-containing polysaccharide selected from a mixture; and (iii) a fermented polysaccharide or a derivative thereof. 17. A preformed sheet-like device according to any one of claims 1 to 13 in a form selected from the group consisting of handwear; footwear; and body wrap.