JP2003517458A5 - - Google Patents
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- JP2003517458A5 JP2003517458A5 JP2000613411A JP2000613411A JP2003517458A5 JP 2003517458 A5 JP2003517458 A5 JP 2003517458A5 JP 2000613411 A JP2000613411 A JP 2000613411A JP 2000613411 A JP2000613411 A JP 2000613411A JP 2003517458 A5 JP2003517458 A5 JP 2003517458A5
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- Japan
- Prior art keywords
- groups
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- alkyl
- group
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 description 13
- -1 2-aminobutyl Chemical group 0.000 description 6
- 125000001931 aliphatic group Chemical group 0.000 description 6
- 125000003342 alkenyl group Chemical group 0.000 description 6
- 125000003545 alkoxy group Chemical group 0.000 description 6
- 125000002723 alicyclic group Chemical group 0.000 description 5
- 125000005157 alkyl carboxy group Chemical group 0.000 description 5
- 125000004414 alkyl thio group Chemical group 0.000 description 5
- 125000003118 aryl group Chemical group 0.000 description 5
- 125000000623 heterocyclic group Chemical group 0.000 description 5
- 0 *N1CC(CCCC2)=C2CC1 Chemical compound *N1CC(CCCC2)=C2CC1 0.000 description 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical group C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- 125000003282 alkyl amino group Chemical group 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 229910052736 halogen Inorganic materials 0.000 description 4
- 150000002367 halogens Chemical class 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 4
- KAESVJOAVNADME-UHFFFAOYSA-N 1H-pyrrole Natural products C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 125000000304 alkynyl group Chemical group 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 description 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- 150000001925 cycloalkenes Chemical class 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- ZSWFCLXCOIISFI-UHFFFAOYSA-N cyclopentadiene Chemical compound C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 description 2
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- 125000003396 thiol group Chemical class [H]S* 0.000 description 2
- KKZUMAMOMRDVKA-UHFFFAOYSA-N 2-chloropropane Chemical group [CH2]C(C)Cl KKZUMAMOMRDVKA-UHFFFAOYSA-N 0.000 description 1
- AUFIRGPROMANKW-UHFFFAOYSA-N CN1CC=CCC1 Chemical compound CN1CC=CCC1 AUFIRGPROMANKW-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 description 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 description 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 description 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- KDUIUFJBNGTBMD-VXMYFEMYSA-N cyclooctatetraene Chemical compound C1=C\C=C/C=C\C=C1 KDUIUFJBNGTBMD-VXMYFEMYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 150000002430 hydrocarbons Chemical group 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 150000002790 naphthalenes Chemical class 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000000962 organic group Chemical group 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229930195734 saturated hydrocarbon Natural products 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13146499P | 1999-04-28 | 1999-04-28 | |
| US60/131,464 | 1999-04-28 | ||
| US13554599P | 1999-05-24 | 1999-05-24 | |
| US60/135,545 | 1999-05-24 | ||
| US14312399P | 1999-07-09 | 1999-07-09 | |
| US60/143,123 | 1999-07-09 | ||
| PCT/CA2000/000494 WO2000064420A2 (en) | 1999-04-28 | 2000-04-28 | Compositions and methods for treating amyloidosis using sulphonate derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003517458A JP2003517458A (ja) | 2003-05-27 |
| JP2003517458A5 true JP2003517458A5 (cg-RX-API-DMAC7.html) | 2011-04-14 |
| JP4726304B2 JP4726304B2 (ja) | 2011-07-20 |
Family
ID=27384158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000613411A Expired - Fee Related JP4726304B2 (ja) | 1999-04-28 | 2000-04-28 | アミロイドーシスを治療するための組成物および方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20040198832A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1276483B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4726304B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR20070094996A (cg-RX-API-DMAC7.html) |
| CN (1) | CN100482233C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE441421T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU4282400A (cg-RX-API-DMAC7.html) |
| BR (1) | BR0010099A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2369997C (cg-RX-API-DMAC7.html) |
| DE (1) | DE60042896D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1276483T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2331905T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL146143A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA01010835A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ543319A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2000064420A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040208875A1 (en) * | 1995-03-15 | 2004-10-21 | Queen's University At Kingston | Method for treating amyloidosis |
| US6562836B1 (en) | 1999-05-24 | 2003-05-13 | Queen's University Of Kingston | Methods and compounds for inhibiting amyloid deposits |
| WO2001003680A2 (en) * | 1999-07-09 | 2001-01-18 | Isis Innovation Limited | Compounds for inhibiting diseases and preparing cells for transplantation |
| US7311893B2 (en) | 2000-07-25 | 2007-12-25 | Neurochem (International) Limited | Amyloid targeting imaging agents and uses thereof |
| US6716589B2 (en) | 2000-11-20 | 2004-04-06 | Alphabeta Ab | Discordant helix stabilization for prevention of amyloid formation |
| WO2004016261A1 (en) * | 2002-08-12 | 2004-02-26 | Yuuichi Murayama | Method for suppressing proliferation of abnormal prion protein with leucine, isoleucine or valine |
| CA2511599A1 (en) * | 2002-12-24 | 2004-07-15 | Neurochem (International) Limited | Therapeutic formulations for the treatment of beta-amyloid related diseases |
| US7244764B2 (en) | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| US7414076B2 (en) | 2003-06-23 | 2008-08-19 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| AU2004249529A1 (en) * | 2003-06-23 | 2004-12-29 | Bellus Health (International) Limited | Methods and compositions for treating amyloid-related diseases |
| JP2007516940A (ja) * | 2003-06-23 | 2007-06-28 | ニューロケム （インターナショナル） リミテッド | 改善された薬剤候補およびその調製法 |
| US20050142191A1 (en) * | 2003-06-23 | 2005-06-30 | Neurochem (International) Limited | Pharmaceutical formulations of amyloid inhibiting compounds |
| AU2011250847B2 (en) * | 2003-06-23 | 2013-06-20 | Bhi Limited Partnership | Methods and compositions for treating amyloid-related diseases |
| US7253306B2 (en) | 2003-06-23 | 2007-08-07 | Neurochem (International) Limited | Pharmaceutical drug candidates and methods for preparation thereof |
| WO2006059252A2 (en) * | 2004-11-12 | 2006-06-08 | Neurochem (International) Limited | Methods and fluorinated compositions for treating amyloid-related diseases |
| CN101103018A (zh) * | 2004-11-16 | 2008-01-09 | 神经化学（国际）有限公司 | 治疗cns和淀粉样蛋白-相关疾病的化合物 |
| US8044100B2 (en) * | 2004-12-22 | 2011-10-25 | Bellus Health Inc. | Methods and compositions for treating amyloid-related diseases |
| TW200716088A (en) | 2005-04-15 | 2007-05-01 | Neurochem Int Ltd | Formulations and methods for treating amyloidosis |
| CN101600730B (zh) | 2006-10-12 | 2014-01-29 | Bhi有限合资公司 | 递送3-氨基-1-丙磺酸的方法、化合物、组合物和载体 |
| KR100883132B1 (ko) | 2006-10-24 | 2009-02-10 | 재단법인서울대학교산학협력재단 | 아밀로이드 형성 펩타이드 또는 단백질의 가용성 회합체에선택적으로 작용하는 절단제 |
| CA2676715A1 (en) | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
| CN102076678A (zh) * | 2008-07-10 | 2011-05-25 | 诺瓦提斯公司 | 作为bace抑制剂的具有氨基苄基取代基的环砜类化合物 |
| KR102657460B1 (ko) | 2015-08-10 | 2024-04-12 | 알제온, 인크. | 신경퇴행성 장애를 치료 및 예방하기 위한 조성물 및 방법 |
| WO2018156845A1 (en) * | 2017-02-24 | 2018-08-30 | Alzheon, Inc. | Methods for treating neurodegenerative disorders |
| USD852236S1 (en) | 2017-08-17 | 2019-06-25 | Samsung Electronics Co., Ltd. | Refrigerator |
| US20250345298A1 (en) | 2022-04-28 | 2025-11-13 | Alzheon, Inc. | Apoe4 correctors and methods of use |
| CN120641092A (zh) | 2022-12-02 | 2025-09-12 | 阿尔泽恩股份有限公司 | 用于用曲米沙特治疗神经变性病症的方法 |
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| US7253306B2 (en) * | 2003-06-23 | 2007-08-07 | Neurochem (International) Limited | Pharmaceutical drug candidates and methods for preparation thereof |
| US20070010573A1 (en) * | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
| US7262223B2 (en) * | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
| US20080038192A1 (en) * | 2004-07-19 | 2008-02-14 | Neurochem Inc. | Diagnostic Methods Of Multiple Organ Amyloidosis |
| US8044100B2 (en) * | 2004-12-22 | 2011-10-25 | Bellus Health Inc. | Methods and compositions for treating amyloid-related diseases |
-
2000
- 2000-04-28 JP JP2000613411A patent/JP4726304B2/ja not_active Expired - Fee Related
- 2000-04-28 IL IL14614300A patent/IL146143A0/xx unknown
- 2000-04-28 DE DE60042896T patent/DE60042896D1/de not_active Expired - Lifetime
- 2000-04-28 CA CA002369997A patent/CA2369997C/en not_active Expired - Fee Related
- 2000-04-28 BR BR0010099-4A patent/BR0010099A/pt not_active IP Right Cessation
- 2000-04-28 EP EP00922395A patent/EP1276483B1/en not_active Expired - Lifetime
- 2000-04-28 WO PCT/CA2000/000494 patent/WO2000064420A2/en not_active Ceased
- 2000-04-28 AT AT00922395T patent/ATE441421T1/de not_active IP Right Cessation
- 2000-04-28 KR KR1020077021102A patent/KR20070094996A/ko not_active Abandoned
- 2000-04-28 AU AU42824/00A patent/AU4282400A/en not_active Abandoned
- 2000-04-28 CN CNB008094152A patent/CN100482233C/zh not_active Expired - Fee Related
- 2000-04-28 ES ES00922395T patent/ES2331905T3/es not_active Expired - Lifetime
- 2000-04-28 DK DK00922395T patent/DK1276483T3/da active
- 2000-04-28 KR KR1020017013824A patent/KR100822525B1/ko not_active Expired - Fee Related
- 2000-04-28 MX MXPA01010835A patent/MXPA01010835A/es active IP Right Grant
- 2000-04-28 NZ NZ543319A patent/NZ543319A/en not_active IP Right Cessation
-
2003
- 2003-08-11 US US10/639,609 patent/US20040198832A1/en not_active Abandoned
-
2008
- 2008-07-07 US US12/217,580 patent/US20090099100A1/en not_active Abandoned
-
2011
- 2011-04-14 US US13/066,451 patent/US20110281951A1/en not_active Abandoned
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