JP2003517006A5 - - Google Patents
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- Publication number
- JP2003517006A5 JP2003517006A5 JP2001544774A JP2001544774A JP2003517006A5 JP 2003517006 A5 JP2003517006 A5 JP 2003517006A5 JP 2001544774 A JP2001544774 A JP 2001544774A JP 2001544774 A JP2001544774 A JP 2001544774A JP 2003517006 A5 JP2003517006 A5 JP 2003517006A5
- Authority
- JP
- Japan
- Prior art keywords
- helix
- concentration
- syncytium
- syncytium formation
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17104299P | 1999-12-16 | 1999-12-16 | |
| US60/171,042 | 1999-12-16 | ||
| US23457200P | 2000-09-22 | 2000-09-22 | |
| US60/234,572 | 2000-09-22 | ||
| PCT/US2000/034194 WO2001044286A2 (en) | 1999-12-16 | 2000-12-15 | Five-helix protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003517006A JP2003517006A (ja) | 2003-05-20 |
| JP2003517006A5 true JP2003517006A5 (https=) | 2008-10-02 |
| JP4925540B2 JP4925540B2 (ja) | 2012-04-25 |
Family
ID=26866680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001544774A Expired - Fee Related JP4925540B2 (ja) | 1999-12-16 | 2000-12-15 | ５−ヘリックスタンパク質 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7053179B2 (https=) |
| EP (1) | EP1237912B1 (https=) |
| JP (1) | JP4925540B2 (https=) |
| AT (1) | ATE380822T1 (https=) |
| CA (1) | CA2395291C (https=) |
| DE (1) | DE60037450T2 (https=) |
| ES (1) | ES2296665T3 (https=) |
| WO (1) | WO2001044286A2 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6841657B2 (en) | 1997-04-17 | 2005-01-11 | Whitehead Institute For Biomedical Research | Inhibitors of HIV membrane fusion |
| US6818740B1 (en) | 1997-04-17 | 2004-11-16 | Whitehead Institute For Biomedical Research | Inhibitors of HIV membrane fusion |
| US6150088A (en) | 1997-04-17 | 2000-11-21 | Whitehead Institute For Biomedical Research | Core structure of gp41 from the HIV envelope glycoprotein |
| US7960504B2 (en) | 1998-07-30 | 2011-06-14 | Whitehead Institute For Biomedical Research | Inhibitors of HIV membrane fusion |
| US6747126B1 (en) * | 1998-07-30 | 2004-06-08 | Whitehead Institute For Biomedical Research | Peptide inhibitors of HIV entry |
| JP2003529319A (ja) * | 1999-01-08 | 2003-10-07 | キャロル ディ． ウエイス， | ＨＩＶ−１ｇｐ４１を標的化する広範に中和する抗体を誘発する方法 |
| US7053179B2 (en) | 1999-12-16 | 2006-05-30 | Whitehead Institute For Biomedical Research | Five-Helix protein |
| US20030082525A1 (en) * | 1999-12-16 | 2003-05-01 | Whitehead Institute For Biomedical Research | Five-Helix protein |
| US6861253B2 (en) | 2001-01-05 | 2005-03-01 | Aventis Pasteur S.A. | Polypeptide inducing antibodies neutralizing HIV |
| FR2819256B1 (fr) * | 2001-01-05 | 2004-04-30 | Aventis Pasteur | Polypeptide induisant des anticorps neutralisant le vih |
| US7741453B2 (en) | 2001-05-31 | 2010-06-22 | Conjuchem Biotechnologies, Inc. | Long lasting fusion peptide inhibitors for HIV infection |
| AU2002314111A1 (en) | 2001-06-15 | 2003-01-02 | F. Hoffmann-La Roche Ag | Method for the recombinant production of peptidic antiviral fusion inhibitors, and acetylation of gb41 fragments |
| US20030125515A1 (en) * | 2001-07-11 | 2003-07-03 | Genfa Zhou | End-locked five-helix protein |
| JP2005507995A (ja) * | 2001-09-27 | 2005-03-24 | テイボテク・フアーマシユーチカルズ・リミテツド | 抗抑制アッセイ |
| EP1442124B1 (fr) * | 2001-10-05 | 2006-12-20 | Sanofi Pasteur | ANTIGENE POLYPEPTIDIQUE FORMANT UNE STRUCTURE MIMANT L'ETAT INTERMEDIAIRE DE gp41 |
| US20030219451A1 (en) * | 2001-10-29 | 2003-11-27 | Whitehead Institute For Biomedical Research | Stable helical C peptides and uses therefor |
| FR2832715A1 (fr) * | 2001-11-29 | 2003-05-30 | Hippocampe | Polypeptides inhibiteurs de l'infectivite des virus de l'immunodeficience humaine |
| US20060241027A1 (en) * | 2002-02-07 | 2006-10-26 | Hans-Peter Hauser | Hiv inhibiting proteins |
| US7056519B2 (en) | 2002-05-17 | 2006-06-06 | Aventis Pasteur S.A. | Methods for inducing HIV-neutralizing antibodies |
| US20040076637A1 (en) * | 2002-09-27 | 2004-04-22 | Delmedico Mary Kay | HIV-derived HR1 peptides modified to form stable trimers, and their use in therapy to inhibit transmission of human immunodeficiency virus |
| CA2443365C (en) * | 2002-11-19 | 2010-01-12 | F. Hoffmann-La Roche Ag | Methods for the recombinant production of antifusogenic peptides |
| AU2003265420A1 (en) * | 2003-08-14 | 2005-03-10 | The Government Of The United States Of America, As Represented By The Department Of Health And Human Services | Polypeptide multimers having antiviral activity |
| JP2008505059A (ja) * | 2004-05-06 | 2008-02-21 | コンジュシェム バイオテクノロジーズ インコーポレイティド | 特異的ウイルス標的用化合物 |
| US7744887B2 (en) * | 2004-06-01 | 2010-06-29 | Merck & Co., Inc. | Human antibodies interacting with HIV gp41 |
| EP1755667B1 (en) * | 2004-06-01 | 2013-07-17 | Merck Sharp & Dohme Corp. | Stable peptide mimetic of hiv gp41 fusion intermediate |
| US7491489B2 (en) * | 2004-11-22 | 2009-02-17 | The University Of Hong Knog | Synthetic peptide targeting critical sites on the SARS-associated coronavirus spike protein responsible for viral infection and method of use thereof |
| CA2602654A1 (en) * | 2005-04-05 | 2006-10-12 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Method for shielding functional sites or epitopes on proteins |
| CN101088557A (zh) | 2006-06-12 | 2007-12-19 | 天津市扶素生物技术有限公司 | 用于预防或治疗hiv感染的药用组合物及其应用 |
| EP2125876A1 (en) * | 2007-03-12 | 2009-12-02 | Thomas Jefferson University | Tighter-binding c-peptide inhibitors of hiv-1 entry |
| US9217011B2 (en) * | 2007-09-07 | 2015-12-22 | Complix Nv | Non-natural proteinaceous scaffold made of three non-covalently associated peptides |
| GB0720503D0 (en) * | 2007-10-22 | 2007-11-28 | Angeletti P Ist Richerche Bio | New compound |
| GB2471692A (en) * | 2009-07-08 | 2011-01-12 | Complix Nv | HIV gp41-binding single-chain coiled-coil peptide comprising heptad repeats |
| US9050063B2 (en) * | 2012-03-30 | 2015-06-09 | Sandance Technology Llc | Systems and methods for determining suitability of a mechanical implant for a medical procedure |
| CN106946994B (zh) * | 2017-03-09 | 2019-11-26 | 中国医学科学院病原生物学研究所 | 一种抑制丙型肝炎病毒感染的蛋白及其应用 |
| CN110551179B (zh) * | 2018-05-31 | 2022-03-15 | 中国科学院微生物研究所 | 一种经修饰的抗hiv多肽及其制备方法和用途 |
| WO2023213758A1 (en) | 2022-05-03 | 2023-11-09 | F. Hoffmann-La Roche Ag | Hiv gp41 variants for immunodiagnostic assays |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5444044A (en) | 1992-03-26 | 1995-08-22 | New York Blood Center | Synthetic polypeptides as inhibitors of HIV-1 |
| JP4010560B2 (ja) | 1992-07-20 | 2007-11-21 | ドューク ユニバーシティー | Ｈｉｖ複製を阻害する化合物 |
| US5464933A (en) | 1993-06-07 | 1995-11-07 | Duke University | Synthetic peptide inhibitors of HIV transmission |
| US5780221A (en) * | 1995-05-03 | 1998-07-14 | Whitehead Institute For Biomedical Research | Identification of enantiomeric ligands |
| AU723537B2 (en) * | 1995-06-07 | 2000-08-31 | Trimeris Inc. | The treatment of HIV and other viral infections using combinatorial therapy |
| JP3903503B2 (ja) | 1996-11-18 | 2007-04-11 | 住友電気工業株式会社 | 可溶性ポリペプチド |
| WO1998032848A1 (en) | 1997-01-28 | 1998-07-30 | The Regents Of The University Of California | Peptide probes to coil proteins and methods for making the same |
| US6818740B1 (en) * | 1997-04-17 | 2004-11-16 | Whitehead Institute For Biomedical Research | Inhibitors of HIV membrane fusion |
| US6150088A (en) | 1997-04-17 | 2000-11-21 | Whitehead Institute For Biomedical Research | Core structure of gp41 from the HIV envelope glycoprotein |
| US6841657B2 (en) | 1997-04-17 | 2005-01-11 | Whitehead Institute For Biomedical Research | Inhibitors of HIV membrane fusion |
| US6090911A (en) | 1997-10-22 | 2000-07-18 | University Of Massachusetts | Reversible hydrogels |
| US6656906B1 (en) | 1998-05-20 | 2003-12-02 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
| EP1100818B1 (en) | 1998-07-30 | 2013-01-02 | Whitehead Institute For Biomedical Research | Inhibitors of hiv membrane fusion |
| US7960504B2 (en) * | 1998-07-30 | 2011-06-14 | Whitehead Institute For Biomedical Research | Inhibitors of HIV membrane fusion |
| US6747126B1 (en) * | 1998-07-30 | 2004-06-08 | Whitehead Institute For Biomedical Research | Peptide inhibitors of HIV entry |
| JP2003529319A (ja) * | 1999-01-08 | 2003-10-07 | キャロル ディ． ウエイス， | ＨＩＶ−１ｇｐ４１を標的化する広範に中和する抗体を誘発する方法 |
| US20030082525A1 (en) | 1999-12-16 | 2003-05-01 | Whitehead Institute For Biomedical Research | Five-Helix protein |
| US7053179B2 (en) * | 1999-12-16 | 2006-05-30 | Whitehead Institute For Biomedical Research | Five-Helix protein |
| DE60143668D1 (de) | 2000-09-22 | 2011-01-27 | Whitehead Biomedical Inst | Peptidinhibitoren gegen den eintritt von hiv in zellen |
-
2000
- 2000-12-15 US US09/738,945 patent/US7053179B2/en not_active Expired - Fee Related
- 2000-12-15 JP JP2001544774A patent/JP4925540B2/ja not_active Expired - Fee Related
- 2000-12-15 WO PCT/US2000/034194 patent/WO2001044286A2/en not_active Ceased
- 2000-12-15 DE DE60037450T patent/DE60037450T2/de not_active Expired - Lifetime
- 2000-12-15 ES ES00986475T patent/ES2296665T3/es not_active Expired - Lifetime
- 2000-12-15 EP EP00986475A patent/EP1237912B1/en not_active Expired - Lifetime
- 2000-12-15 AT AT00986475T patent/ATE380822T1/de not_active IP Right Cessation
- 2000-12-15 CA CA2395291A patent/CA2395291C/en not_active Expired - Fee Related
-
2005
- 2005-06-13 US US11/151,598 patent/US7504224B2/en not_active Expired - Fee Related
-
2009
- 2009-01-20 US US12/321,300 patent/US8058012B2/en not_active Expired - Fee Related
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