JP2003516967A - 1,3,4−置換ピペリジン類似体および嗜癖の治療におけるそれらの使用 - Google Patents

1,3,4−置換ピペリジン類似体および嗜癖の治療におけるそれらの使用

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Publication number
JP2003516967A
JP2003516967A JP2001544683A JP2001544683A JP2003516967A JP 2003516967 A JP2003516967 A JP 2003516967A JP 2001544683 A JP2001544683 A JP 2001544683A JP 2001544683 A JP2001544683 A JP 2001544683A JP 2003516967 A JP2003516967 A JP 2003516967A
Authority
JP
Japan
Prior art keywords
alkyl
aryl
compound
formulation
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001544683A
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English (en)
Japanese (ja)
Other versions
JP2003516967A5 (https=
Inventor
マイルズ ピー. スミス
Original Assignee
バイオストリーム セラピューティクス
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Publication date
Application filed by バイオストリーム セラピューティクス filed Critical バイオストリーム セラピューティクス
Publication of JP2003516967A publication Critical patent/JP2003516967A/ja
Publication of JP2003516967A5 publication Critical patent/JP2003516967A5/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2001544683A 1999-12-16 2000-12-18 1,3,4−置換ピペリジン類似体および嗜癖の治療におけるそれらの使用 Pending JP2003516967A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17113999P 1999-12-16 1999-12-16
US60/171,139 1999-12-16
PCT/US2000/034504 WO2001044193A1 (en) 1999-12-16 2000-12-18 1,3,4-substituted piperidine analogs and uses thereof in treating addictions

Publications (2)

Publication Number Publication Date
JP2003516967A true JP2003516967A (ja) 2003-05-20
JP2003516967A5 JP2003516967A5 (https=) 2008-02-21

Family

ID=22622694

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001544683A Pending JP2003516967A (ja) 1999-12-16 2000-12-18 1,3,4−置換ピペリジン類似体および嗜癖の治療におけるそれらの使用

Country Status (5)

Country Link
US (1) US20020025967A1 (https=)
EP (1) EP1248770A1 (https=)
JP (1) JP2003516967A (https=)
CA (1) CA2395075A1 (https=)
WO (1) WO2001044193A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
PT1558582E (pt) 2003-07-22 2006-05-31 Arena Pharm Inc Derivados de diaril- e aril-heteroaril-ureia como moduladores do receptor de serotonina 5-ht2a uteis para a profilaxia e tratamento de desordens relacionadas com o mesmo
US8258305B2 (en) 2005-02-23 2012-09-04 Prexa Pharmaceuticals, Inc. Dopamine transporter inhibitors for use in treatment of movement disorders and other CNS indications
US20090054489A1 (en) * 2005-02-23 2009-02-26 Prexa Pharmaceuticals, Inc. Multimediator Dopamine Transport Inhibitors, and Uses Related Thereto
TWI415845B (zh) 2006-10-03 2013-11-21 Arena Pharm Inc 用於治療與5-ht2a血清素受體相關聯病症之作為5-ht2a血清素受體之調節劑的吡唑衍生物
WO2009023253A2 (en) 2007-08-15 2009-02-19 Arena Pharmaceuticals Inc. IMIDAZO[L,2-α]PYRIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
CN104739829B (zh) 2008-10-28 2018-11-06 艾尼纳制药公司 用于治疗5-ht2a5-羟色胺受体相关障碍的5-ht2a5-羟色胺受体调节剂组合物
WO2010062321A1 (en) 2008-10-28 2010-06-03 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
JP6163205B2 (ja) 2012-06-20 2017-07-12 ノバルティス アーゲー 補体経路モジュレーターおよびその使用
US9546151B2 (en) 2014-07-31 2017-01-17 Oregon Health & Science University VMAT inhibitory compounds
DK3212637T3 (da) 2014-10-31 2021-07-12 Indivior Uk Ltd Dopamin-d3-receptorantagonistforbindelser
WO2016201373A1 (en) 2015-06-12 2016-12-15 Axovant Sciences Ltd. Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of rem sleep behavior disorder
WO2017011767A2 (en) 2015-07-15 2017-01-19 Axovant Sciences Ltd. Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1058058B (de) * 1954-02-27 1959-05-27 Basf Ag Verfahren zur Herstellung von Alkylpyridinen
GB850417A (en) * 1957-05-31 1960-10-05 Merck & Co Inc Process for the preparation of 1-(p-nitrophenyl)-4-carboalkoxy-4-phenyl-piperidines
JP2002526528A (ja) * 1998-10-07 2002-08-20 ジョージタウン ユニヴァーシティー 単量体およびニ量体の複素環、ならびにその治療的使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443451A (en) * 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives
DE3441927A1 (de) * 1984-11-16 1986-05-28 Basf Ag, 6700 Ludwigshafen Am stickstoff substituierte 4-(p-tert.butyl-phenyl)-3-methyl-piperidine, dessen quartaere salze sowie deren anwendung als fungizide
US5620993A (en) * 1995-06-07 1997-04-15 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
ES2329739T3 (es) * 1997-04-07 2009-11-30 Georgetown University Analogos de cocaina.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1058058B (de) * 1954-02-27 1959-05-27 Basf Ag Verfahren zur Herstellung von Alkylpyridinen
GB850417A (en) * 1957-05-31 1960-10-05 Merck & Co Inc Process for the preparation of 1-(p-nitrophenyl)-4-carboalkoxy-4-phenyl-piperidines
JP2002526528A (ja) * 1998-10-07 2002-08-20 ジョージタウン ユニヴァーシティー 単量体およびニ量体の複素環、ならびにその治療的使用

Also Published As

Publication number Publication date
EP1248770A1 (en) 2002-10-16
WO2001044193A1 (en) 2001-06-21
CA2395075A1 (en) 2001-06-21
US20020025967A1 (en) 2002-02-28

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