JP2003515534A - がん治療のためのエンド−エクソヌクレアーゼ活性の阻害剤 - Google Patents
がん治療のためのエンド−エクソヌクレアーゼ活性の阻害剤Info
- Publication number
- JP2003515534A JP2003515534A JP2001537928A JP2001537928A JP2003515534A JP 2003515534 A JP2003515534 A JP 2003515534A JP 2001537928 A JP2001537928 A JP 2001537928A JP 2001537928 A JP2001537928 A JP 2001537928A JP 2003515534 A JP2003515534 A JP 2003515534A
- Authority
- JP
- Japan
- Prior art keywords
- endo
- agent
- exonuclease
- patient
- pentamidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
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- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| US60/165,688 | 1999-11-16 | ||
| PCT/CA2000/001355 WO2001035935A2 (en) | 1999-11-16 | 2000-11-16 | Inhibitors of endo-exonuclease activity such as pentamidine for the treatment of cancer |
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| JP2003515534A true JP2003515534A (ja) | 2003-05-07 |
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| CA (1) | CA2388674C (https=) |
| CY (1) | CY1110503T1 (https=) |
| DE (1) | DE60042245D1 (https=) |
| DK (1) | DK1231910T3 (https=) |
| ES (1) | ES2327313T3 (https=) |
| PT (1) | PT1231910E (https=) |
| WO (1) | WO2001035935A2 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006062072A1 (ja) * | 2004-12-10 | 2006-06-15 | Tmrc Co., Ltd. | 転移癌治療剤および癌転移抑制剤 |
| JP2012525371A (ja) * | 2009-05-01 | 2012-10-22 | オンコザイム・ファーマ・インコーポレイテッド | 癌を治療するためのペンタミジンの組み合わせ |
| JP2021503016A (ja) * | 2017-11-16 | 2021-02-04 | モンドレックス・インコーポレーテッド | モノアミジン及びジアミジンのエンド−エキソヌクレアーゼ阻害剤とエンド−エキソヌクレアーゼ活性を阻害する方法 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001097794A2 (en) * | 2000-06-21 | 2001-12-27 | Georgetown University | Inhibitors of matriptase for the treatment of cancer |
| US6569853B1 (en) | 2000-11-06 | 2003-05-27 | Combinatorx, Incorporated | Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders |
| US6693125B2 (en) | 2001-01-24 | 2004-02-17 | Combinatorx Incorporated | Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders |
| US8053477B2 (en) | 2002-03-29 | 2011-11-08 | University Of Maryland, Baltimore | Inhibitors of the S100-p53 protein-protein interaction and method of inhibiting cancer employing the same |
| ITMI20021455A1 (it) * | 2002-07-02 | 2004-01-02 | Ugo Raffaello Citernesi | Formulazioni fosfolipidiche di lexitropsine loro preparazione ed impiego terapeutico |
| US20050054708A1 (en) * | 2003-07-28 | 2005-03-10 | Nichols Matthew James | Combinations of drugs for the treatment of neoplasms |
| US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
| US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
| US20110008327A1 (en) | 2004-03-29 | 2011-01-13 | Cheng Jin Q | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
| US20100028339A1 (en) | 2004-03-29 | 2010-02-04 | Cheng Jin Q | Compositions including triciribine and trastuzumab and methods of use thereof |
| US20100009928A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and taxanes and methods of use thereof |
| AU2005228410A1 (en) | 2004-03-29 | 2005-10-13 | University Of South Florida | Effective treatment of tumors and cancer with triciribine and related compounds |
| US8494661B2 (en) | 2007-12-28 | 2013-07-23 | Server Technology, Inc. | Power distribution, management, and monitoring systems and methods |
| WO2014008592A1 (en) * | 2012-07-13 | 2014-01-16 | Oncozyme Pharma Inc. | Combinations comprising diamidine compounds and parp inhibitors for use iν treating cancer |
| CN115554405B (zh) * | 2020-04-15 | 2023-08-01 | 四川大学华西第二医院 | 一种含有抑制核酸内切酶功能的药物及其抗肿瘤的用途 |
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| DE2145528C3 (de) * | 1971-09-11 | 1981-12-17 | Heinrich Mack Nachf., 7918 Illertissen | Exonuclease und diese enthaltendes cytostatisches Mittel |
| EP0585957A1 (en) * | 1986-08-06 | 1994-03-09 | Ajinomoto Co., Inc. | Recombinant B-cell differentiation factor |
| ATE77947T1 (de) * | 1987-04-09 | 1992-07-15 | Fisons Plc | Pentamidin enthaltende pharmazeutische zusammensetzungen. |
| US5204113A (en) * | 1987-04-09 | 1993-04-20 | Fisons Plc | Pharmaceutical compositions containing pentamidine |
| US5166140A (en) * | 1987-05-05 | 1992-11-24 | City Of Hope | Use of certain nucleoside analogs to attenuate cancer cell resistance to DNA damaging chemotherapy |
| US5585363A (en) * | 1987-05-05 | 1996-12-17 | City Of Hope | Circumvention of human tumor drug resistance |
| US4856528A (en) * | 1987-06-26 | 1989-08-15 | John Hopkins University | Tumor volume determination |
| US5204352A (en) * | 1987-09-29 | 1993-04-20 | The United States Of America As Represented By The Secretary Of The Army | Compounds exhibiting anti-parasitic activity and a method for their use |
| US5084480A (en) * | 1987-11-06 | 1992-01-28 | Fujisawa Usa, Inc. | Pentamidine salts useful in the treatment of pneumocystis carinii pneumonia |
| US5422120A (en) * | 1988-05-30 | 1995-06-06 | Depotech Corporation | Heterovesicular liposomes |
| MX16687A (es) * | 1988-07-07 | 1994-01-31 | Ciba Geigy Ag | Compuestos de biarilo y procedimiento para su preparacion. |
| US5037758A (en) * | 1989-01-11 | 1991-08-06 | Her Majesty The Queen In Right Of Canada, As Represented By The National Research Council Of Canada | Enhanced production of biosurfactant through the use of a mutated B subtilis strain |
| GB8903438D0 (en) * | 1989-02-15 | 1989-04-05 | May & Baker Ltd | New compositions of matter |
| US5352581A (en) * | 1989-03-24 | 1994-10-04 | United States/National Institutes Of Health | Sensitive yeast genetic system for identifying agents causing double-stranded DNA damage |
| AU7162791A (en) * | 1989-12-27 | 1991-07-24 | Miroslav Radman | Novel system for isolating and producing new genes, gene products and dna sequences |
| US5324830A (en) * | 1991-03-26 | 1994-06-28 | United States Of America | Chimeric protein that has a human RHo Motif and deoxyribonuclease activity |
| US5489524A (en) * | 1991-03-26 | 1996-02-06 | The United States Of America As Represented By The Department Of Health And Human Services | Chimeric protein that has a human Rho motif and deoxyribonuclease activity |
| US5283238A (en) * | 1992-04-24 | 1994-02-01 | Immtech International, Inc. | Methods of treating cancer using modified C-reactive protein |
| US5723288A (en) * | 1994-05-06 | 1998-03-03 | The University Of North Carolina At Chapel Hill | Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans, and kits useful therefor |
| US5874283A (en) * | 1995-05-30 | 1999-02-23 | John Joseph Harrington | Mammalian flap-specific endonuclease |
| US5643935A (en) * | 1995-06-07 | 1997-07-01 | The University Of North Carolina At Chapel Hill | Method of combatting infectious diseases using dicationic bis-benzimidazoles |
| US5698556A (en) * | 1995-06-07 | 1997-12-16 | Chan; Carcy L. | Methotrexate analogs and methods of using same |
| US5916779A (en) * | 1995-09-21 | 1999-06-29 | Becton, Dickinson And Company | Strand displacement amplification of RNA targets |
| US5935982A (en) * | 1997-02-28 | 1999-08-10 | The University Of North Carolina At Chapel Hill | Methods of treating retroviral infection and compounds useful therefor |
| US5977311A (en) * | 1997-09-23 | 1999-11-02 | Curagen Corporation | 53BP2 complexes |
| US20020102542A1 (en) * | 1997-10-07 | 2002-08-01 | Daikichi Fukushima | Polypeptide, cdna encoding the polypeptide, and use of the both |
| US7115665B1 (en) * | 2000-11-16 | 2006-10-03 | Onocozyme Pharma, Inc. | Inhibitors of endo-exonuclease activity for treating cancer |
| AU2001240473A1 (en) * | 2000-03-08 | 2001-09-17 | Novozymes A/S | Variants with altered properties |
| US6569853B1 (en) * | 2000-11-06 | 2003-05-27 | Combinatorx, Incorporated | Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders |
| US6693125B2 (en) * | 2001-01-24 | 2004-02-17 | Combinatorx Incorporated | Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders |
| US20040010045A1 (en) * | 2001-09-07 | 2004-01-15 | Taolin Yi | Therapeutic compositions comprised of pentamidine and methods of using same to treat cancer |
| US8053477B2 (en) * | 2002-03-29 | 2011-11-08 | University Of Maryland, Baltimore | Inhibitors of the S100-p53 protein-protein interaction and method of inhibiting cancer employing the same |
-
2000
- 2000-11-16 DK DK00975725T patent/DK1231910T3/da active
- 2000-11-16 AU AU13765/01A patent/AU780538B2/en not_active Ceased
- 2000-11-16 AT AT00975725T patent/ATE431734T1/de active
- 2000-11-16 JP JP2001537928A patent/JP2003515534A/ja active Pending
- 2000-11-16 WO PCT/CA2000/001355 patent/WO2001035935A2/en not_active Ceased
- 2000-11-16 EP EP00975725A patent/EP1231910B1/en not_active Expired - Lifetime
- 2000-11-16 PT PT00975725T patent/PT1231910E/pt unknown
- 2000-11-16 CA CA002388674A patent/CA2388674C/en not_active Expired - Fee Related
- 2000-11-16 DE DE60042245T patent/DE60042245D1/de not_active Expired - Lifetime
- 2000-11-16 ES ES00975725T patent/ES2327313T3/es not_active Expired - Lifetime
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2006
- 2006-05-25 US US11/420,358 patent/US20060276548A1/en not_active Abandoned
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2008
- 2008-08-27 US US12/199,603 patent/US20090068094A1/en not_active Abandoned
-
2009
- 2009-08-11 CY CY20091100855T patent/CY1110503T1/el unknown
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006062072A1 (ja) * | 2004-12-10 | 2006-06-15 | Tmrc Co., Ltd. | 転移癌治療剤および癌転移抑制剤 |
| JP2012525371A (ja) * | 2009-05-01 | 2012-10-22 | オンコザイム・ファーマ・インコーポレイテッド | 癌を治療するためのペンタミジンの組み合わせ |
| JP2021503016A (ja) * | 2017-11-16 | 2021-02-04 | モンドレックス・インコーポレーテッド | モノアミジン及びジアミジンのエンド−エキソヌクレアーゼ阻害剤とエンド−エキソヌクレアーゼ活性を阻害する方法 |
| JP7153734B2 (ja) | 2017-11-16 | 2022-10-14 | モンドレックス・インコーポレーテッド | モノアミジン及びジアミジンのエンド－エキソヌクレアーゼ阻害剤とエンド－エキソヌクレアーゼ活性を阻害する方法 |
| US12239617B2 (en) | 2017-11-16 | 2025-03-04 | Montdorex Inc. | Mono- and di-amidine endo-exonuclease inhibitors and methods for inhibiting endo-exonuclease activity |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001035935A3 (en) | 2002-01-03 |
| DE60042245D1 (de) | 2009-07-02 |
| AU1376501A (en) | 2001-05-30 |
| AU780538B2 (en) | 2005-03-24 |
| WO2001035935A2 (en) | 2001-05-25 |
| DK1231910T3 (da) | 2009-08-31 |
| EP1231910B1 (en) | 2009-05-20 |
| CA2388674A1 (en) | 2001-05-25 |
| CA2388674C (en) | 2005-01-25 |
| CY1110503T1 (el) | 2015-04-29 |
| ATE431734T1 (de) | 2009-06-15 |
| ES2327313T3 (es) | 2009-10-28 |
| PT1231910E (pt) | 2009-08-06 |
| EP1231910A2 (en) | 2002-08-21 |
| US20060276548A1 (en) | 2006-12-07 |
| WO2001035935B1 (en) | 2002-02-07 |
| US20090068094A1 (en) | 2009-03-12 |
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