JP2003514030A5 - - Google Patents
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- Publication number
- JP2003514030A5 JP2003514030A5 JP2001537983A JP2001537983A JP2003514030A5 JP 2003514030 A5 JP2003514030 A5 JP 2003514030A5 JP 2001537983 A JP2001537983 A JP 2001537983A JP 2001537983 A JP2001537983 A JP 2001537983A JP 2003514030 A5 JP2003514030 A5 JP 2003514030A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- antigen
- escherichia coli
- mucoadhesive
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 description 10
- 102000036639 antigens Human genes 0.000 description 10
- 108091007433 antigens Proteins 0.000 description 10
- 101710146739 Enterotoxin Proteins 0.000 description 8
- 241000588724 Escherichia coli Species 0.000 description 8
- 239000000147 enterotoxin Substances 0.000 description 8
- 231100000655 enterotoxin Toxicity 0.000 description 8
- 241000124008 Mammalia Species 0.000 description 6
- 230000003232 mucoadhesive effect Effects 0.000 description 6
- 241000712461 unidentified influenza virus Species 0.000 description 4
- 101710154606 Hemagglutinin Proteins 0.000 description 3
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 3
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 3
- 101710176177 Protein A56 Proteins 0.000 description 3
- 239000000185 hemagglutinin Substances 0.000 description 3
- 241001500351 Influenzavirus A Species 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 206010022000 influenza Diseases 0.000 description 2
- 230000035772 mutation Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16002899P | 1999-10-18 | 1999-10-18 | |
| US60/160,028 | 1999-10-18 | ||
| PCT/US2000/041241 WO2001035993A2 (en) | 1999-10-18 | 2000-10-18 | Compositions and methods for stimulating an immune response against infectious agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003514030A JP2003514030A (ja) | 2003-04-15 |
| JP2003514030A5 true JP2003514030A5 (https=) | 2007-11-22 |
| JP4889175B2 JP4889175B2 (ja) | 2012-03-07 |
Family
ID=22575185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001537983A Expired - Fee Related JP4889175B2 (ja) | 1999-10-18 | 2000-10-18 | 感染性因子に対する免疫応答を刺激するための組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20090130141A1 (https=) |
| EP (1) | EP1221970B1 (https=) |
| JP (1) | JP4889175B2 (https=) |
| CA (1) | CA2388054C (https=) |
| ES (1) | ES2462532T3 (https=) |
| WO (1) | WO2001035993A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101679974B (zh) | 2007-03-27 | 2015-09-30 | 航道生物技术有限责任公司 | 包含抗体替代轻链序列的构建体和文库 |
| JP2011516423A (ja) | 2008-03-28 | 2011-05-26 | シー レーン バイオテクノロジーズ， エルエルシー | ウイルス抗原に対する中和分子 |
| CA2761681A1 (en) | 2009-05-13 | 2010-11-18 | Sea Lane Biotechnologies, Llc | Neutralizing molecules to influenza viruses |
| EP2736928B1 (en) | 2011-07-28 | 2019-01-09 | i2 Pharmaceuticals, Inc. | Sur-binding proteins against erbb3 |
| US9975956B2 (en) | 2011-12-22 | 2018-05-22 | I2 Pharmaceuticals, Inc. | Surrogate binding proteins which bind DR4 and/or DR5 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6413523B1 (en) * | 1989-06-02 | 2002-07-02 | The United States Of America As Represented By The Secretary Of The Navy | Pharmaceutical composition of escherichia coli heat-labile enterotoxin adjuvant and methods of use |
| US6019982A (en) * | 1994-08-26 | 2000-02-01 | The Administrators Of The Tulane Educational Fund | Mutant enterotoxin effective as a non-toxic oral adjuvant |
| WO1996009757A1 (en) * | 1994-09-28 | 1996-04-04 | Biocine Spa | Mouse model for helicobacter pylori infection |
| US6818222B1 (en) * | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
| EP0919243A1 (en) * | 1997-11-25 | 1999-06-02 | Duphar International Research B.V | Vaccine containing B subunits of heat-labile enterotoxin (LTB) of Escherichia coli as an adjuvant |
-
2000
- 2000-10-18 JP JP2001537983A patent/JP4889175B2/ja not_active Expired - Fee Related
- 2000-10-18 WO PCT/US2000/041241 patent/WO2001035993A2/en not_active Ceased
- 2000-10-18 ES ES00992122.2T patent/ES2462532T3/es not_active Expired - Lifetime
- 2000-10-18 EP EP00992122.2A patent/EP1221970B1/en not_active Expired - Lifetime
- 2000-10-18 CA CA2388054A patent/CA2388054C/en not_active Expired - Fee Related
-
2008
- 2008-11-03 US US12/290,741 patent/US20090130141A1/en not_active Abandoned
-
2012
- 2012-11-06 US US13/669,914 patent/US20130315951A1/en not_active Abandoned
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