JP2003512471A5 - - Google Patents
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- Publication number
- JP2003512471A5 JP2003512471A5 JP2001533142A JP2001533142A JP2003512471A5 JP 2003512471 A5 JP2003512471 A5 JP 2003512471A5 JP 2001533142 A JP2001533142 A JP 2001533142A JP 2001533142 A JP2001533142 A JP 2001533142A JP 2003512471 A5 JP2003512471 A5 JP 2003512471A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- compound according
- pyridine
- alkylene chain
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 31
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 17
- 229910052739 hydrogen Inorganic materials 0.000 description 12
- 125000002947 alkylene group Chemical group 0.000 description 9
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 8
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- 125000003118 aryl group Chemical group 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 5
- 125000002877 alkyl aryl group Chemical group 0.000 description 4
- -1 ruthenium (II) compound Chemical class 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 125000001475 halogen functional group Chemical group 0.000 description 3
- GPHQHTOMRSGBNZ-UHFFFAOYSA-N pyridine-4-carbonitrile Chemical compound N#CC1=CC=NC=C1 GPHQHTOMRSGBNZ-UHFFFAOYSA-N 0.000 description 3
- ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical compound NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 description 2
- RGDQRXPEZUNWHX-UHFFFAOYSA-N 3-methylpyridin-2-amine Chemical compound CC1=CC=CN=C1N RGDQRXPEZUNWHX-UHFFFAOYSA-N 0.000 description 2
- KFDVPJUYSDEJTH-UHFFFAOYSA-N 4-ethenylpyridine Chemical compound C=CC1=CC=NC=C1 KFDVPJUYSDEJTH-UHFFFAOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- WYHXNQXDQQMTQI-UHFFFAOYSA-N n-benzylpyridin-2-amine Chemical compound C=1C=CC=CC=1CNC1=CC=CC=N1 WYHXNQXDQQMTQI-UHFFFAOYSA-N 0.000 description 2
- HUDSSSKDWYXKGP-UHFFFAOYSA-N n-phenylpyridin-2-amine Chemical compound C=1C=CC=NC=1NC1=CC=CC=C1 HUDSSSKDWYXKGP-UHFFFAOYSA-N 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- PONXTPCRRASWKW-UHFFFAOYSA-N 1,2-diphenylethane-1,2-diamine Chemical compound C=1C=CC=CC=1C(N)C(N)C1=CC=CC=C1 PONXTPCRRASWKW-UHFFFAOYSA-N 0.000 description 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 1
- 229910017008 AsF 6 Inorganic materials 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- ZKEMPJKEOSLZCF-UHFFFAOYSA-N OC(=O)C1=CC=NC=C1C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1Cl Chemical compound OC(=O)C1=CC=NC=C1C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1Cl ZKEMPJKEOSLZCF-UHFFFAOYSA-N 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 125000002837 carbocyclic group Chemical group 0.000 description 1
- RCTYPNKXASFOBE-UHFFFAOYSA-M chloromercury Chemical compound [Hg]Cl RCTYPNKXASFOBE-UHFFFAOYSA-M 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9925274.4 | 1999-10-27 | ||
| GBGB9925274.4A GB9925274D0 (en) | 1999-10-27 | 1999-10-27 | Ruthenium (II) compounds |
| GB0016054.9 | 2000-06-30 | ||
| GB0016054A GB0016054D0 (en) | 2000-06-30 | 2000-06-30 | Ruthenium (II) compounds |
| PCT/GB2000/004144 WO2001030790A1 (en) | 1999-10-27 | 2000-10-26 | Half-sandwich ruthenium (ii) compounds comprising nitrogen containing ligands for treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003512471A JP2003512471A (ja) | 2003-04-02 |
| JP2003512471A5 true JP2003512471A5 (https=) | 2007-12-20 |
Family
ID=26244569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001533142A Pending JP2003512471A (ja) | 1999-10-27 | 2000-10-26 | 窒素および配位子を含む癌治療用の半サンドイッチ状ルテニウム（ｉｉ）化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6750251B2 (https=) |
| EP (1) | EP1224192B1 (https=) |
| JP (1) | JP2003512471A (https=) |
| AT (1) | ATE303393T1 (https=) |
| DE (1) | DE60022372T2 (https=) |
| DK (1) | DK1224192T3 (https=) |
| ES (1) | ES2248136T3 (https=) |
| WO (1) | WO2001030790A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001030790A1 (en) * | 1999-10-27 | 2001-05-03 | The University Court, The University Of Edinburgh | Half-sandwich ruthenium (ii) compounds comprising nitrogen containing ligands for treatment of cancer |
| GB0215526D0 (en) * | 2002-07-05 | 2002-08-14 | Univ Edinburgh | Anticancer compounds |
| DK1618116T3 (da) | 2003-04-30 | 2008-09-08 | Univ Edinburgh | Ruthenium(II)-komplekser til behandling af tumorer |
| GB0418643D0 (en) * | 2004-08-20 | 2004-09-22 | Univ Edinburgh | Ruthenium (II) compounds |
| GB0604602D0 (en) * | 2006-03-07 | 2006-04-19 | Univ Edinburgh | Ruthenium (II) compounds |
| US9018199B2 (en) | 2006-05-09 | 2015-04-28 | Ecole Polytechnique Federale De Lausanne (Epfl) | Transition metal complexes for inhibiting resistance in the treatment of cancer and metastasis |
| GB0610062D0 (en) * | 2006-05-19 | 2006-06-28 | Univ Edinburgh | Ruthenium (ll) compounds |
| CA2775356C (en) | 2009-10-08 | 2016-04-26 | Angus Chemical Company | Low-voc polyamines |
| US8383673B2 (en) * | 2010-03-19 | 2013-02-26 | City University Of Hong Kong | Nitridoosmium(VI) complexes for treatment of cancer |
| WO2013038395A1 (en) | 2011-09-16 | 2013-03-21 | Universidade De Lisboa | Transition metal complexes for pharmaceutical applications |
| WO2013136296A2 (en) | 2012-03-14 | 2013-09-19 | Universidade De Lisboa | Water-soluble organometallic ruthenium and iron compunds presenting heteroaromatic ligands |
| US9290528B1 (en) | 2013-03-15 | 2016-03-22 | University Of Kentucky Research Foundation | Light-activated compounds |
| US9751081B2 (en) | 2014-12-01 | 2017-09-05 | Clemson University | Self-regenerating antioxidant catalysts and methods of using the same |
| US10053480B1 (en) | 2017-10-11 | 2018-08-21 | King Saud University | Anti-quorum and DNA cleaving agent |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980472A (en) | 1983-06-23 | 1990-12-25 | American Cyanamid Company | Method of making (3-amino-1H-pyrazol-4-yl) (aryl)methanones |
| EP0188585A1 (de) | 1984-07-24 | 1986-07-30 | Byk Gulden Lomberg Chemische Fabrik GmbH | Tumorhemmend wirkende rutheniumverbindungen |
| EP0191096B1 (de) | 1984-07-24 | 1989-09-13 | ASTA Pharma AG | Tumorhemmend wirkende rutheniumverbindungen |
| US4980473A (en) * | 1985-01-18 | 1990-12-25 | The Trustees Of Columbia University In The City Of New York | Chemical probes for left-handed DNA and chiral metal complexes as Z-specific anti-tumor agents |
| US5225556A (en) | 1985-01-18 | 1993-07-06 | The Trustees Of Columbia University In The City Of New York | Chemical probes for left-handed DNA and for A-DNA; chiral metal complexes as Z-specific antitumor agents and as double strand cleavers |
| US4699978A (en) | 1985-01-18 | 1987-10-13 | The Trustees Of Columbia University In The City Of New York | Site-specific chiral ruthenium (II) and cobalt (III) antitumor agents |
| US5386044A (en) | 1993-11-30 | 1995-01-31 | E. I. Du Pont De Nemours And Company | Polyhaloaromatic ruthenium complexes and reactions thereof |
| WO1996013510A1 (en) | 1994-10-28 | 1996-05-09 | Procept, Inc. | Ruthenium complexes and their use as immunosuppressive agents |
| US5708022A (en) | 1994-10-28 | 1998-01-13 | Procept, Inc. | Method for inhibiting immune response |
| JPH11209314A (ja) * | 1997-09-30 | 1999-08-03 | Takasago Internatl Corp | シクロオクタジエン類の製造方法 |
| WO2001030790A1 (en) * | 1999-10-27 | 2001-05-03 | The University Court, The University Of Edinburgh | Half-sandwich ruthenium (ii) compounds comprising nitrogen containing ligands for treatment of cancer |
| GB0016052D0 (en) * | 2000-06-30 | 2000-08-23 | Univ Edinburgh | Ruthenium (II) compounds |
| GB0028025D0 (en) | 2000-11-17 | 2001-01-03 | Univ York | Compounds |
| GB0215526D0 (en) * | 2002-07-05 | 2002-08-14 | Univ Edinburgh | Anticancer compounds |
-
2000
- 2000-10-26 WO PCT/GB2000/004144 patent/WO2001030790A1/en not_active Ceased
- 2000-10-26 ES ES00971599T patent/ES2248136T3/es not_active Expired - Lifetime
- 2000-10-26 AT AT00971599T patent/ATE303393T1/de not_active IP Right Cessation
- 2000-10-26 DK DK00971599T patent/DK1224192T3/da active
- 2000-10-26 JP JP2001533142A patent/JP2003512471A/ja active Pending
- 2000-10-26 DE DE60022372T patent/DE60022372T2/de not_active Expired - Fee Related
- 2000-10-26 EP EP00971599A patent/EP1224192B1/en not_active Expired - Lifetime
-
2002
- 2002-04-26 US US10/134,404 patent/US6750251B2/en not_active Expired - Fee Related
-
2004
- 2004-05-18 US US10/848,416 patent/US6979681B2/en not_active Expired - Fee Related
-
2005
- 2005-06-23 US US11/165,372 patent/US20050239765A1/en not_active Abandoned
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