JP2003510349A - 線条体機能に必要な遺伝子、その使用、およびそれを調節するための化合物 - Google Patents

線条体機能に必要な遺伝子、その使用、およびそれを調節するための化合物

Info

Publication number
JP2003510349A
JP2003510349A JP2001527780A JP2001527780A JP2003510349A JP 2003510349 A JP2003510349 A JP 2003510349A JP 2001527780 A JP2001527780 A JP 2001527780A JP 2001527780 A JP2001527780 A JP 2001527780A JP 2003510349 A JP2003510349 A JP 2003510349A
Authority
JP
Japan
Prior art keywords
pde10a
disease
expression
sequence
cag
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001527780A
Other languages
English (en)
Japanese (ja)
Inventor
ハロルド,エー. ロバートソン
デノヴァン−ライト,アイリーン,エム.
Original Assignee
ノヴァ−ニューロン インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA 2285690 external-priority patent/CA2285690A1/fr
Application filed by ノヴァ−ニューロン インコーポレーテッド filed Critical ノヴァ−ニューロン インコーポレーテッド
Publication of JP2003510349A publication Critical patent/JP2003510349A/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2001527780A 1999-10-07 2000-10-06 線条体機能に必要な遺伝子、その使用、およびそれを調節するための化合物 Pending JP2003510349A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US15804399P 1999-10-07 1999-10-07
US60/158,043 1999-10-07
CA2,285,690 1999-10-07
CA 2285690 CA2285690A1 (fr) 1999-10-07 1999-10-07 Gene necessaire a la fonction du striatum et utilisations connexes
US21776500P 2000-07-12 2000-07-12
US60/217,765 2000-07-12
PCT/CA2000/001188 WO2001024781A2 (fr) 1999-10-07 2000-10-06 Gene necessaire a la fonction striatale, ses applications et composes permettant de moduler ce gene

Publications (1)

Publication Number Publication Date
JP2003510349A true JP2003510349A (ja) 2003-03-18

Family

ID=27171056

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001527780A Pending JP2003510349A (ja) 1999-10-07 2000-10-06 線条体機能に必要な遺伝子、その使用、およびそれを調節するための化合物

Country Status (4)

Country Link
EP (1) EP1223937A2 (fr)
JP (1) JP2003510349A (fr)
AU (1) AU7766300A (fr)
WO (1) WO2001024781A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1666886A3 (fr) * 2001-04-20 2006-06-21 Pfizer Products Inc. Méthode d'identification d'un inhibiteur sélectif de la PDE10
IL149106A0 (en) * 2001-04-20 2002-11-10 Pfizer Prod Inc Therapeutic use of selective pde10 inhibitors
DE10130167A1 (de) * 2001-06-22 2003-01-02 Bayer Ag Imidazotriazine
DE10130151A1 (de) * 2001-06-22 2003-01-02 Bayer Ag Neue Verwendung für PDE 10A-Inhibitoren
WO2004042391A2 (fr) * 2002-11-08 2004-05-21 Bayer Healthcare Ag Diagnostics et traitements de maladies associees a la phosphodiesterase 10a humaine (pde10a)
GB0228079D0 (en) * 2002-12-02 2003-01-08 Laxdale Ltd Huntington's Disease
EP1570847B1 (fr) 2002-12-03 2012-04-25 Kyorin Pharmaceutical Co., Ltd. Inhibiteurs de phosphodiesterase 10a pour le traitement de la maladie de parkinson, de la maladie de huntington et de la schizophrénie
US8338420B1 (en) 2002-12-04 2012-12-25 Mitsubishi Tanabe Pharma Corporation Treatment of Parkinson's disease and enhancement of dopamine signal using PDE 10 inhibitor
WO2004090126A2 (fr) * 2003-04-03 2004-10-21 Memory Pharmaceuticals Corporation Isoformes de la phosphodiesterase 10a7 et leurs methodes d'utilisation
US20050202550A1 (en) * 2004-03-12 2005-09-15 Pfizer Inc Crystal structure of 3', 5'-cyclic nucleotide phosphodiesterase (PDE10A) and uses thereof
WO2008029829A1 (fr) 2006-09-06 2008-03-13 Kyorin Pharmaceutical Co., Ltd. Dérivé de pyrazolopyridine et inhibiteur de la phosphodiestérase (pde) qui le contient en tant que matière active
WO2008047340A1 (fr) * 2006-10-19 2008-04-24 Mor Research Applications Ltd. Thérapies combinées d'antipsychotiques et de tétracyclines dans le traitement de troubles psychiatriques
US7786139B2 (en) 2006-11-21 2010-08-31 Omeros Corporation PDE10 inhibitors and related compositions and methods
EP2348018A4 (fr) 2008-09-25 2012-04-25 Kyorin Seiyaku Kk Dérivé biarylique hétérocyclique et inhibiteur de pde le renfermant en tant qu'ingrédient actif
WO2010041711A1 (fr) 2008-10-09 2010-04-15 杏林製薬株式会社 Dérivé d'isoquinoléine et inhibiteur de la pde le comportant en tant qu’ingrédient actif
WO2015006689A1 (fr) * 2013-07-12 2015-01-15 University Of South Alabama Traitement et diagnostic du cancer et d'états précancéreux à l'aide d'inhibiteurs de pde10a et procédés pour mesurer l'expression de pde10a
US20160222021A1 (en) * 2013-09-11 2016-08-04 Bristol-Myers Squibb Company Aryl ether-base kinase inhibitors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2459046A1 (fr) * 1979-06-15 1981-01-09 Griffon Henri Procede de preparation de solutions aqueuses stables d'alloxane et solutions en resultant
DE3000979A1 (de) * 1980-01-12 1981-07-23 Dr. Karl Thomae Gmbh, 7950 Biberach Neue dipyridamol-retardformen und verfahren zu ihrer herstellung
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
US5843641A (en) * 1993-02-26 1998-12-01 Massachusetts Institute Of Technology Methods for the daignosis, of familial amyotrophic lateral sclerosis
US5461068A (en) * 1993-09-29 1995-10-24 Corwood Laboratories, Inc. Imidazole derivative tincture and method of manufacture
GB9514465D0 (en) * 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
US5798246A (en) * 1996-03-25 1998-08-25 Incyte Pharmaceuticals, Inc. Cyclic nucleotide phosphodiesterase
US5789395A (en) * 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
EP1001987B1 (fr) * 1997-08-01 2010-12-15 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Composition et nouveau procede pour depister les maladies dues a la formation d'agregats de proteines ou de fibrilles du type amyloide
GB2333041A (en) * 1998-01-13 1999-07-14 Johnson & Johnson Medical Ltd Wound Composition
JP2002504341A (ja) * 1998-02-23 2002-02-12 アイコス コーポレイション ホスホジエステラーゼ10
AU2852699A (en) * 1998-03-20 1999-10-18 Senju Pharmaceutical Co., Ltd. Pharmaceutical composition containing a cysteine protease inhibitor for prophylaxis and therapy of brain tissue impairment
US20030083242A1 (en) * 1998-11-06 2003-05-01 Alphonse Galdes Methods and compositions for treating or preventing peripheral neuropathies

Also Published As

Publication number Publication date
WO2001024781A3 (fr) 2002-02-07
AU7766300A (en) 2001-05-10
EP1223937A2 (fr) 2002-07-24
WO2001024781A2 (fr) 2001-04-12

Similar Documents

Publication Publication Date Title
JP2003510349A (ja) 線条体機能に必要な遺伝子、その使用、およびそれを調節するための化合物
EP1848436A2 (fr) Methodes de diagnostique et de traitement de l'asthme, de la rhinite allergique et d'autres maladies respiratoires mettant en oeuvre une association d'haplotypes
US6800436B1 (en) Diagnostic method, diagnostic reagent and therapeutic preparation for diseases caused by variation in LKB1 gene
US20070060606A1 (en) Compounds and methods for modulating phosphodiesterase 10A
JP2002525081A (ja) 低酸素により調節される遺伝子転写に特徴的な配列
AU3383499A (en) Methods and compositions for the diagnosis and treatment of neuropsychiatric disorders
US20040152106A1 (en) Gene necessary for striatal function, uses thereof, and compounds for modulating same
US5955355A (en) Chromosome 18 marker
US20090269814A1 (en) Method of Analyzing a BRCA2 Gene in a Human Subject
JP2003525579A (ja) ヒト染色体15q24−25の重複と不安病との関連、並びにそれらを検出する診断方法
EP0977768A1 (fr) Procedes et compositions s'appliquant au diagnostique et au traitement des troubles neuropsychiatriques
WO1998042362A9 (fr) Procedes et compositions s'appliquant au diagnostique et au traitement des troubles neuropsychiatriques
US6458541B1 (en) BDNF polymorphism and association with bipolar disorder
JP2001505430A (ja) フラビンモノオキシゲナーゼをコードするヌクレオチド配列、これに相当するタンパク質ならびに診断および治療領域におけるそれらの使用
CA2373466C (fr) Application du gene codant pour l'aprataxine au diagnostic et au traitement de l'ataxie spinocerebelleuse a debut precoce (avec apraxie oculomotrice et hypoalbuminemie)
US5939316A (en) Chromosome 18 marker
Akhmedov et al. Cloning and characterization of the canine photoreceptor specific cone-rod homeobox (CRX) gene and evaluation as a candidate for early onset photoreceptor diseases in the dog
EP2275574B1 (fr) Codage d'haplotypes de séquence du gène BRCA2 humain
WO1999051762A9 (fr) Procedes et compositions servant a diagnostiquer et a traiter des maladies neuropsychiatriques
JP2004516832A (ja) 髄鞘障害に関するペリアキシンの欠損
CA2298474A1 (fr) Procedes et compositions permettant le diagnostic et le traitement de troubles neuropsychiatriques
JP2002521062A (ja) ヒトニューロキニン1レセプター遺伝子における遺伝子多形性および疾病の診断および処置におけるその使用
CA2320400A1 (fr) Gene necessaire a la fonction du striatum et utilisations connexes, et composes utilises pour la modulation de ce gene
WO2010019687A1 (fr) Multiples variants de sapap3 dans la trichotillomanie et dans les troubles obsessionnels compulsifs
US20060154272A1 (en) Novel coding sequence haplotypes of the human BRCA2 gene