JP2003510349A - 線条体機能に必要な遺伝子、その使用、およびそれを調節するための化合物 - Google Patents
線条体機能に必要な遺伝子、その使用、およびそれを調節するための化合物Info
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- JP2003510349A JP2003510349A JP2001527780A JP2001527780A JP2003510349A JP 2003510349 A JP2003510349 A JP 2003510349A JP 2001527780 A JP2001527780 A JP 2001527780A JP 2001527780 A JP2001527780 A JP 2001527780A JP 2003510349 A JP2003510349 A JP 2003510349A
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- pde10a
- disease
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- cag
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Psychology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
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US15804399P | 1999-10-07 | 1999-10-07 | |
US60/158,043 | 1999-10-07 | ||
CA2,285,690 | 1999-10-07 | ||
CA 2285690 CA2285690A1 (fr) | 1999-10-07 | 1999-10-07 | Gene necessaire a la fonction du striatum et utilisations connexes |
US21776500P | 2000-07-12 | 2000-07-12 | |
US60/217,765 | 2000-07-12 | ||
PCT/CA2000/001188 WO2001024781A2 (fr) | 1999-10-07 | 2000-10-06 | Gene necessaire a la fonction striatale, ses applications et composes permettant de moduler ce gene |
Publications (1)
Publication Number | Publication Date |
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JP2003510349A true JP2003510349A (ja) | 2003-03-18 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2001527780A Pending JP2003510349A (ja) | 1999-10-07 | 2000-10-06 | 線条体機能に必要な遺伝子、その使用、およびそれを調節するための化合物 |
Country Status (4)
Country | Link |
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EP (1) | EP1223937A2 (fr) |
JP (1) | JP2003510349A (fr) |
AU (1) | AU7766300A (fr) |
WO (1) | WO2001024781A2 (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1666886A3 (fr) * | 2001-04-20 | 2006-06-21 | Pfizer Products Inc. | Méthode d'identification d'un inhibiteur sélectif de la PDE10 |
IL149106A0 (en) * | 2001-04-20 | 2002-11-10 | Pfizer Prod Inc | Therapeutic use of selective pde10 inhibitors |
DE10130167A1 (de) * | 2001-06-22 | 2003-01-02 | Bayer Ag | Imidazotriazine |
DE10130151A1 (de) * | 2001-06-22 | 2003-01-02 | Bayer Ag | Neue Verwendung für PDE 10A-Inhibitoren |
WO2004042391A2 (fr) * | 2002-11-08 | 2004-05-21 | Bayer Healthcare Ag | Diagnostics et traitements de maladies associees a la phosphodiesterase 10a humaine (pde10a) |
GB0228079D0 (en) * | 2002-12-02 | 2003-01-08 | Laxdale Ltd | Huntington's Disease |
EP1570847B1 (fr) | 2002-12-03 | 2012-04-25 | Kyorin Pharmaceutical Co., Ltd. | Inhibiteurs de phosphodiesterase 10a pour le traitement de la maladie de parkinson, de la maladie de huntington et de la schizophrénie |
US8338420B1 (en) | 2002-12-04 | 2012-12-25 | Mitsubishi Tanabe Pharma Corporation | Treatment of Parkinson's disease and enhancement of dopamine signal using PDE 10 inhibitor |
WO2004090126A2 (fr) * | 2003-04-03 | 2004-10-21 | Memory Pharmaceuticals Corporation | Isoformes de la phosphodiesterase 10a7 et leurs methodes d'utilisation |
US20050202550A1 (en) * | 2004-03-12 | 2005-09-15 | Pfizer Inc | Crystal structure of 3', 5'-cyclic nucleotide phosphodiesterase (PDE10A) and uses thereof |
WO2008029829A1 (fr) | 2006-09-06 | 2008-03-13 | Kyorin Pharmaceutical Co., Ltd. | Dérivé de pyrazolopyridine et inhibiteur de la phosphodiestérase (pde) qui le contient en tant que matière active |
WO2008047340A1 (fr) * | 2006-10-19 | 2008-04-24 | Mor Research Applications Ltd. | Thérapies combinées d'antipsychotiques et de tétracyclines dans le traitement de troubles psychiatriques |
US7786139B2 (en) | 2006-11-21 | 2010-08-31 | Omeros Corporation | PDE10 inhibitors and related compositions and methods |
EP2348018A4 (fr) | 2008-09-25 | 2012-04-25 | Kyorin Seiyaku Kk | Dérivé biarylique hétérocyclique et inhibiteur de pde le renfermant en tant qu'ingrédient actif |
WO2010041711A1 (fr) | 2008-10-09 | 2010-04-15 | 杏林製薬株式会社 | Dérivé d'isoquinoléine et inhibiteur de la pde le comportant en tant qu’ingrédient actif |
WO2015006689A1 (fr) * | 2013-07-12 | 2015-01-15 | University Of South Alabama | Traitement et diagnostic du cancer et d'états précancéreux à l'aide d'inhibiteurs de pde10a et procédés pour mesurer l'expression de pde10a |
US20160222021A1 (en) * | 2013-09-11 | 2016-08-04 | Bristol-Myers Squibb Company | Aryl ether-base kinase inhibitors |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2459046A1 (fr) * | 1979-06-15 | 1981-01-09 | Griffon Henri | Procede de preparation de solutions aqueuses stables d'alloxane et solutions en resultant |
DE3000979A1 (de) * | 1980-01-12 | 1981-07-23 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue dipyridamol-retardformen und verfahren zu ihrer herstellung |
US5750376A (en) * | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
US5843641A (en) * | 1993-02-26 | 1998-12-01 | Massachusetts Institute Of Technology | Methods for the daignosis, of familial amyotrophic lateral sclerosis |
US5461068A (en) * | 1993-09-29 | 1995-10-24 | Corwood Laboratories, Inc. | Imidazole derivative tincture and method of manufacture |
GB9514465D0 (en) * | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
US5798246A (en) * | 1996-03-25 | 1998-08-25 | Incyte Pharmaceuticals, Inc. | Cyclic nucleotide phosphodiesterase |
US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
EP1001987B1 (fr) * | 1997-08-01 | 2010-12-15 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Composition et nouveau procede pour depister les maladies dues a la formation d'agregats de proteines ou de fibrilles du type amyloide |
GB2333041A (en) * | 1998-01-13 | 1999-07-14 | Johnson & Johnson Medical Ltd | Wound Composition |
JP2002504341A (ja) * | 1998-02-23 | 2002-02-12 | アイコス コーポレイション | ホスホジエステラーゼ10 |
AU2852699A (en) * | 1998-03-20 | 1999-10-18 | Senju Pharmaceutical Co., Ltd. | Pharmaceutical composition containing a cysteine protease inhibitor for prophylaxis and therapy of brain tissue impairment |
US20030083242A1 (en) * | 1998-11-06 | 2003-05-01 | Alphonse Galdes | Methods and compositions for treating or preventing peripheral neuropathies |
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2000
- 2000-10-06 WO PCT/CA2000/001188 patent/WO2001024781A2/fr active Search and Examination
- 2000-10-06 AU AU77663/00A patent/AU7766300A/en not_active Abandoned
- 2000-10-06 EP EP00967473A patent/EP1223937A2/fr not_active Withdrawn
- 2000-10-06 JP JP2001527780A patent/JP2003510349A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2001024781A3 (fr) | 2002-02-07 |
AU7766300A (en) | 2001-05-10 |
EP1223937A2 (fr) | 2002-07-24 |
WO2001024781A2 (fr) | 2001-04-12 |
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