JP2003506095A - アデノ随伴ウイルス(aav)で形質導入された遺伝子改変樹状細胞、該細胞の調製方法および該細胞の使用 - Google Patents

アデノ随伴ウイルス(aav)で形質導入された遺伝子改変樹状細胞、該細胞の調製方法および該細胞の使用

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JP2003506095A
JP2003506095A JP2001515852A JP2001515852A JP2003506095A JP 2003506095 A JP2003506095 A JP 2003506095A JP 2001515852 A JP2001515852 A JP 2001515852A JP 2001515852 A JP2001515852 A JP 2001515852A JP 2003506095 A JP2003506095 A JP 2003506095A
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cells
aav
antigen
cytokine
precursor
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ハーモナツト,ポール・エル
サンテイン,アレツサンドロ・デイ
リウ,ヨン
マーネ,ミハエル
パラム,グロウスベツク・ピー
キリバ−インテルナテイ,マウリツイオ
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ボード・オブ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・アーカンソー
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JP2001515852A 1999-08-05 2000-08-07 アデノ随伴ウイルス(aav)で形質導入された遺伝子改変樹状細胞、該細胞の調製方法および該細胞の使用 Pending JP2003506095A (ja)

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Application Number Priority Date Filing Date Title
US14726399P 1999-08-05 1999-08-05
US60/147,263 1999-08-05
PCT/US2000/021410 WO2001011067A1 (en) 1999-08-05 2000-08-07 Genetically altered dendritic cells transduced with adeno-associated virus (aav), methods of producing said cells and uses thereof

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JP2003506095A true JP2003506095A (ja) 2003-02-18
JP2003506095A5 JP2003506095A5 (https=) 2007-09-27

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EP (1) EP1206563B1 (https=)
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CA (2) CA2309313A1 (https=)
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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006523688A (ja) * 2003-04-14 2006-10-19 フアン マレン ヌクレオチド・ワクチン組成、ヌクレオチド及び細胞ワクチン組成の産出方法、ワクチン組成、ワクチン組成使用、免疫反応産出方法、疾患の治療または予防方法、抗原提示細胞から成るキット
JP2008513009A (ja) * 2004-09-14 2008-05-01 アルゴス セラピューティクス,インコーポレイティド 病原体の株非依存的増幅およびそれに対するワクチン
JP2010522206A (ja) * 2007-03-22 2010-07-01 ピーディーエス バイオテクノロジー コーポレイション カチオン脂質による免疫応答の刺激
US11612652B2 (en) 2015-11-13 2023-03-28 Pds Biotechnology Corporation Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy
JP2023545850A (ja) * 2020-10-15 2023-10-31 アヴォサイト, インコーポレイテッド Cd14プロモーターを有する組換えアデノ随伴ウイルスベクターおよびその使用
US11801257B2 (en) 2008-04-17 2023-10-31 Pds Biotechnology Corporation Stimulation of an immune response by enantiomers of cationic lipids
US11904015B2 (en) 2012-09-21 2024-02-20 Pds Biotechnology Corporation Vaccine compositions and methods of use
US12201685B2 (en) 2012-06-15 2025-01-21 Pds Biotechnology Corporation Methods of modulating immune responses with cationic lipid vaccine compositions
US12551460B2 (en) 2017-12-05 2026-02-17 Pds Biotechnology Coporation Methods and compositions comprising cationic lipids for stimulating type 1 interferon genes

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ522840A (en) 2000-06-01 2004-12-24 Univ North Carolina A parvovirus vector that carries a duplexed genome resulting in co-packaging of strands of plus and minus polarity tethered together
AU2003231281A1 (en) * 2002-04-30 2003-11-17 University Of Florida Methods and compositions for expressing a nucleic acid in a dendritic cell
US20060239962A1 (en) * 2002-12-04 2006-10-26 Banchereau Jacques F Rapid one-step generation of antigen loaded dendritic cell vaccine from precursors
WO2013174760A1 (en) 2012-05-25 2013-11-28 Deutsches Krebsforschungszentrum Optimized aav-vectors for high transduction rates in dendritic cells
MA46959A (fr) 2016-12-02 2019-10-09 Juno Therapeutics Inc Cellules b modifiées et compositions et méthodes associées

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999038973A2 (en) * 1998-01-28 1999-08-05 Corixa Corporation Compounds for therapy and diagnosis of lung cancer and methods for their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6504596A (en) * 1995-07-21 1997-02-18 Rhone-Poulenc Rorer Pharmaceuticals Inc. Adeno-associated viral liposomes and their use in transfecting dendritic cells to stimulate specific immunity
JP2000505650A (ja) * 1996-02-08 2000-05-16 アメリカ合衆国 樹状突起細胞を形質転換し、そしてt細胞を活性化するための方法及び組成物
AU5588298A (en) * 1996-12-02 1998-06-29 Cell Genesys, Inc. Adeno-associated viral vector-mediated delivery of dna to cells of the liver

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999038973A2 (en) * 1998-01-28 1999-08-05 Corixa Corporation Compounds for therapy and diagnosis of lung cancer and methods for their use

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006523688A (ja) * 2003-04-14 2006-10-19 フアン マレン ヌクレオチド・ワクチン組成、ヌクレオチド及び細胞ワクチン組成の産出方法、ワクチン組成、ワクチン組成使用、免疫反応産出方法、疾患の治療または予防方法、抗原提示細胞から成るキット
JP2008513009A (ja) * 2004-09-14 2008-05-01 アルゴス セラピューティクス,インコーポレイティド 病原体の株非依存的増幅およびそれに対するワクチン
US11911359B2 (en) 2007-03-22 2024-02-27 Pds Biotechnology Corporation Stimulation of an immune response by cationic lipids
CN107670031A (zh) * 2007-03-22 2018-02-09 Pds生物科技公司 利用阳离子脂质刺激免疫应答
JP2010522206A (ja) * 2007-03-22 2010-07-01 ピーディーエス バイオテクノロジー コーポレイション カチオン脂質による免疫応答の刺激
US11801257B2 (en) 2008-04-17 2023-10-31 Pds Biotechnology Corporation Stimulation of an immune response by enantiomers of cationic lipids
US12201685B2 (en) 2012-06-15 2025-01-21 Pds Biotechnology Corporation Methods of modulating immune responses with cationic lipid vaccine compositions
US11904015B2 (en) 2012-09-21 2024-02-20 Pds Biotechnology Corporation Vaccine compositions and methods of use
US11911465B2 (en) 2012-09-21 2024-02-27 Pds Biotechnology Corporation Vaccine compositions and methods of use
US11612652B2 (en) 2015-11-13 2023-03-28 Pds Biotechnology Corporation Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy
US11638753B2 (en) 2015-11-13 2023-05-02 PDS Biotechnology Corporalion Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy
US12551460B2 (en) 2017-12-05 2026-02-17 Pds Biotechnology Coporation Methods and compositions comprising cationic lipids for stimulating type 1 interferon genes
JP2023545850A (ja) * 2020-10-15 2023-10-31 アヴォサイト, インコーポレイテッド Cd14プロモーターを有する組換えアデノ随伴ウイルスベクターおよびその使用

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