DE60043779D1 - Genetisch veränderte dendritische zellen, die mit adeno-assoziiertem virus transduziert wurden, verfahren zur herstellung dieser zellen und ihre verwendungen - Google Patents

Genetisch veränderte dendritische zellen, die mit adeno-assoziiertem virus transduziert wurden, verfahren zur herstellung dieser zellen und ihre verwendungen

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Publication number
DE60043779D1
DE60043779D1 DE60043779T DE60043779T DE60043779D1 DE 60043779 D1 DE60043779 D1 DE 60043779D1 DE 60043779 T DE60043779 T DE 60043779T DE 60043779 T DE60043779 T DE 60043779T DE 60043779 D1 DE60043779 D1 DE 60043779D1
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DE
Germany
Prior art keywords
dendritic cells
adeno
associated virus
heterologous gene
aav
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60043779T
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German (de)
English (en)
Inventor
Paul L Hermonat
Alessandro D Santin
Yong Liu
Michael Mane
Groesbeck P Parham
Maurizio Chiriva-Internati
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Arkansas at Fayetteville
University of Arkansas at Little Rock
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University of Arkansas at Fayetteville
University of Arkansas at Little Rock
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Publication of DE60043779D1 publication Critical patent/DE60043779D1/de
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Expired - Lifetime legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/19—Dendritic cells
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4224—Molecules with a "CD" designation not provided for elsewhere
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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DE60043779T 1999-08-05 2000-08-07 Genetisch veränderte dendritische zellen, die mit adeno-assoziiertem virus transduziert wurden, verfahren zur herstellung dieser zellen und ihre verwendungen Expired - Lifetime DE60043779D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14726399P 1999-08-05 1999-08-05
PCT/US2000/021410 WO2001011067A1 (en) 1999-08-05 2000-08-07 Genetically altered dendritic cells transduced with adeno-associated virus (aav), methods of producing said cells and uses thereof

Publications (1)

Publication Number Publication Date
DE60043779D1 true DE60043779D1 (de) 2010-03-18

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ID=22520891

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DE60043779T Expired - Lifetime DE60043779D1 (de) 1999-08-05 2000-08-07 Genetisch veränderte dendritische zellen, die mit adeno-assoziiertem virus transduziert wurden, verfahren zur herstellung dieser zellen und ihre verwendungen

Country Status (7)

Country Link
EP (1) EP1206563B1 (https=)
JP (1) JP2003506095A (https=)
AT (1) ATE456662T1 (https=)
AU (1) AU6894300A (https=)
CA (2) CA2309313A1 (https=)
DE (1) DE60043779D1 (https=)
WO (1) WO2001011067A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ522840A (en) 2000-06-01 2004-12-24 Univ North Carolina A parvovirus vector that carries a duplexed genome resulting in co-packaging of strands of plus and minus polarity tethered together
AU2003231281A1 (en) * 2002-04-30 2003-11-17 University Of Florida Methods and compositions for expressing a nucleic acid in a dendritic cell
US20060239962A1 (en) * 2002-12-04 2006-10-26 Banchereau Jacques F Rapid one-step generation of antigen loaded dendritic cell vaccine from precursors
SE0301109D0 (sv) * 2003-04-14 2003-04-14 Mallen Huang Nucleotide vaccine composition
US9085807B2 (en) * 2004-09-14 2015-07-21 Argos Therapeutics, Inc. Strain-independent amplification of pathogens and vaccines thereto
US8877206B2 (en) 2007-03-22 2014-11-04 Pds Biotechnology Corporation Stimulation of an immune response by cationic lipids
CA2721366C (en) 2008-04-17 2017-06-06 Elizabeth Ann Vasievich Stimulation of an immune response by enantiomers of cationic lipids
WO2013174760A1 (en) 2012-05-25 2013-11-28 Deutsches Krebsforschungszentrum Optimized aav-vectors for high transduction rates in dendritic cells
CN105163753B (zh) 2012-06-15 2018-12-21 Pds生物科技公司 阳离子脂质疫苗组合物和使用方法
CN105101991A (zh) 2012-09-21 2015-11-25 Pds生物科技公司 改进的疫苗组合物和使用方法
WO2017083820A1 (en) 2015-11-13 2017-05-18 Pds Biotechnology Corporation Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy
MA46959A (fr) 2016-12-02 2019-10-09 Juno Therapeutics Inc Cellules b modifiées et compositions et méthodes associées
CA3084957A1 (en) 2017-12-05 2019-06-13 Pds Biotechnology Corporation Methods and compositions comprising cationic lipids for stimulating type 1 interferon genes
MX2023004182A (es) * 2020-10-15 2023-06-22 Aavocyte Inc Vectores de virus adenoasociados recombinantes con promotor de cumulo de diferenciacion 14 (cd14) y uso de los mismos.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6504596A (en) * 1995-07-21 1997-02-18 Rhone-Poulenc Rorer Pharmaceuticals Inc. Adeno-associated viral liposomes and their use in transfecting dendritic cells to stimulate specific immunity
JP2000505650A (ja) * 1996-02-08 2000-05-16 アメリカ合衆国 樹状突起細胞を形質転換し、そしてｔ細胞を活性化するための方法及び組成物
AU5588298A (en) * 1996-12-02 1998-06-29 Cell Genesys, Inc. Adeno-associated viral vector-mediated delivery of dna to cells of the liver
ID27813A (id) * 1998-01-28 2001-04-26 Corixa Corp Senyawa-senyawa untuk terapi dan diagnosa kanker paru-paru dan metoda untuk penggunaannya

Also Published As

Publication number Publication date
CA2381293A1 (en) 2001-02-15
ATE456662T1 (de) 2010-02-15
EP1206563B1 (en) 2010-01-27
CA2309313A1 (en) 2001-02-05
WO2001011067A1 (en) 2001-02-15
EP1206563A1 (en) 2002-05-22
JP2003506095A (ja) 2003-02-18
AU6894300A (en) 2001-03-05

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