JP2003503312A - 立体選択的抗原線維形成ペプチドおよびそのペプチド模倣体 - Google Patents
立体選択的抗原線維形成ペプチドおよびそのペプチド模倣体Info
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- JP2003503312A JP2003503312A JP2000616237A JP2000616237A JP2003503312A JP 2003503312 A JP2003503312 A JP 2003503312A JP 2000616237 A JP2000616237 A JP 2000616237A JP 2000616237 A JP2000616237 A JP 2000616237A JP 2003503312 A JP2003503312 A JP 2003503312A
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- 238000007086 side reaction Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13259299P | 1999-05-05 | 1999-05-05 | |
| US60/132,592 | 1999-05-05 | ||
| PCT/CA2000/000515 WO2000068263A2 (en) | 1999-05-05 | 2000-05-04 | Stereoselective antifibrillogenic peptides and peptidomimetics thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003503312A true JP2003503312A (ja) | 2003-01-28 |
| JP2003503312A5 JP2003503312A5 (https=) | 2007-08-02 |
Family
ID=22454745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000616237A Pending JP2003503312A (ja) | 1999-05-05 | 2000-05-04 | 立体選択的抗原線維形成ペプチドおよびそのペプチド模倣体 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1173480B1 (https=) |
| JP (1) | JP2003503312A (https=) |
| AT (1) | ATE384077T1 (https=) |
| AU (1) | AU4529800A (https=) |
| CA (1) | CA2388092A1 (https=) |
| DE (1) | DE60037800D1 (https=) |
| IL (1) | IL146009A0 (https=) |
| WO (1) | WO2000068263A2 (https=) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004500354A (ja) * | 1999-11-29 | 2004-01-08 | ニューロケム インコーポレーティッド | 全ｄ体ペプチドを含む、アルツハイマー病およびアミロイド関連疾患の予防および処置のためのワクチン |
| JP2010537962A (ja) * | 2007-08-30 | 2010-12-09 | ユナイティッド アラブ エミレーツ ユニヴァーシティ | 診断薬剤 |
| WO2014103481A1 (ja) * | 2012-12-27 | 2014-07-03 | 独立行政法人科学技術振興機構 | 環状ペプチド及びこれを含有する医薬 |
| JP2019504615A (ja) * | 2015-11-09 | 2019-02-21 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | アミロイドベータのエピトープおよびそれに対する抗体 |
| JP2019505166A (ja) * | 2015-11-09 | 2019-02-28 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | アミロイドベータ中間領域エピトープおよびそれに対する立体配座選択的抗体 |
| JP2019532028A (ja) * | 2016-08-16 | 2019-11-07 | ニューロ−バイオ リミテッドＮｅｕｒｏ−Ｂｉｏ Ｌｔｄ | 神経変性障害の治療に使用するための改変ペプチド |
| US11779629B2 (en) | 2016-11-09 | 2023-10-10 | The University Of British Columbia | Compositions comprising cyclic peptides derived from an A-beta peptide |
| US12286469B2 (en) | 2017-07-18 | 2025-04-29 | The University Of British Columbia | Humanized antibodies binding to amyloid-beta (A-beta) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997021728A1 (en) | 1995-12-12 | 1997-06-19 | Karolinska Innovations Ab | PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b) |
| US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7588766B1 (en) | 2000-05-26 | 2009-09-15 | Elan Pharma International Limited | Treatment of amyloidogenic disease |
| US6905686B1 (en) | 1997-12-02 | 2005-06-14 | Neuralab Limited | Active immunization for treatment of alzheimer's disease |
| US6913745B1 (en) | 1997-12-02 | 2005-07-05 | Neuralab Limited | Passive immunization of Alzheimer's disease |
| US7179892B2 (en) | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| US6852696B2 (en) | 1999-03-26 | 2005-02-08 | The University Of Texas System | Inhibitors of glycosaminoglycans |
| US7060670B1 (en) | 1999-05-05 | 2006-06-13 | Neurochem (International) Limited | Stereoselective antifibrillogenic peptides and peptidomimetics thereof |
| US20020094335A1 (en) * | 1999-11-29 | 2002-07-18 | Robert Chalifour | Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases |
| IL150374A0 (en) | 1999-12-23 | 2002-12-01 | Neurochem Inc | Compounds and methods for modulating cerebral amyloid angiopathy |
| TWI255272B (en) | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| JP2004532203A (ja) * | 2001-03-21 | 2004-10-21 | ザ、ユニバーシティ、オブ、テキサス、システム | グリコサミノグリカンの阻害剤 |
| DE10117281A1 (de) * | 2001-04-06 | 2002-10-24 | Inst Molekulare Biotechnologie | Peptid zur Diagnose und Therapie der Alzheimer-Demenz |
| GB2380998B (en) * | 2001-08-03 | 2004-10-20 | Marc Kvansakul | D-amino acid peptide for security tagging |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| EP1380290A1 (en) * | 2002-07-09 | 2004-01-14 | Universitair Medisch Centrum Utrecht | Cross-beta structure pathway and its therapeutic relevance |
| EP1585520A1 (en) * | 2002-12-24 | 2005-10-19 | Neurochem (International) Limited | Therapeutic formulations for the treatment of beta-amyloid related diseases |
| PE20050627A1 (es) | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
| WO2006066089A1 (en) | 2004-12-15 | 2006-06-22 | Neuralab Limited | Humanized amyloid beta antibodies for use in improving cognition |
| TW200636066A (en) | 2004-12-15 | 2006-10-16 | Elan Pharm Inc | Humanized antibodies that recognize beta amyloid peptide |
| US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| GB0608960D0 (en) * | 2006-05-05 | 2006-06-14 | St Georges Hosp Medical School | Imaging agent |
| PT2089417E (pt) | 2006-10-12 | 2015-04-14 | Bhi Ltd Partnership | Métodos, compostos, composições e veículos para administrar o ácido 3-amino-1-propanossulfónico |
| EP2089419A2 (en) * | 2006-10-27 | 2009-08-19 | Zapaloid Limited | Inhibition of beta-amyloid aggregation |
| US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| PT2182983E (pt) | 2007-07-27 | 2014-09-01 | Janssen Alzheimer Immunotherap | Tratamento de doenças amiloidogénicas com anticorpos anti-abeta humanizados |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996028471A1 (en) * | 1995-03-14 | 1996-09-19 | Praecis Pharmaceuticals Incorporated | Modulators of amyloid aggregation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997021728A1 (en) * | 1995-12-12 | 1997-06-19 | Karolinska Innovations Ab | PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b) |
| PT929574E (pt) * | 1996-08-27 | 2005-11-30 | Praecis Pharm Inc | Moduladores da agregacao de peptidos beta-amiloides compreendendo d-aminoacidos |
| JPH10182695A (ja) * | 1996-12-27 | 1998-07-07 | Teikoku Seiyaku Co Ltd | ｇｐ１２０に対して親和性を有するペプチド |
-
2000
- 2000-05-04 WO PCT/CA2000/000515 patent/WO2000068263A2/en not_active Ceased
- 2000-05-04 AU AU45298/00A patent/AU4529800A/en not_active Abandoned
- 2000-05-04 IL IL14600900A patent/IL146009A0/xx unknown
- 2000-05-04 DE DE60037800T patent/DE60037800D1/de not_active Expired - Lifetime
- 2000-05-04 CA CA002388092A patent/CA2388092A1/en not_active Abandoned
- 2000-05-04 EP EP00926599A patent/EP1173480B1/en not_active Expired - Lifetime
- 2000-05-04 JP JP2000616237A patent/JP2003503312A/ja active Pending
- 2000-05-04 AT AT00926599T patent/ATE384077T1/de not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996028471A1 (en) * | 1995-03-14 | 1996-09-19 | Praecis Pharmaceuticals Incorporated | Modulators of amyloid aggregation |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004500354A (ja) * | 1999-11-29 | 2004-01-08 | ニューロケム インコーポレーティッド | 全ｄ体ペプチドを含む、アルツハイマー病およびアミロイド関連疾患の予防および処置のためのワクチン |
| JP2010537962A (ja) * | 2007-08-30 | 2010-12-09 | ユナイティッド アラブ エミレーツ ユニヴァーシティ | 診断薬剤 |
| US8613905B2 (en) | 2007-08-30 | 2013-12-24 | United Arab Emirates University | Diagnostic agent |
| WO2014103481A1 (ja) * | 2012-12-27 | 2014-07-03 | 独立行政法人科学技術振興機構 | 環状ペプチド及びこれを含有する医薬 |
| JP2014141445A (ja) * | 2012-12-27 | 2014-08-07 | Japan Science & Technology Agency | 環状ペプチド及びこれを含有する医薬 |
| US9745349B2 (en) | 2012-12-27 | 2017-08-29 | Japan Science And Technology Agency | Cyclic peptide and pharmaceutical product containing same |
| JP2019504615A (ja) * | 2015-11-09 | 2019-02-21 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | アミロイドベータのエピトープおよびそれに対する抗体 |
| JP2019505166A (ja) * | 2015-11-09 | 2019-02-28 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | アミロイドベータ中間領域エピトープおよびそれに対する立体配座選択的抗体 |
| US11905318B2 (en) | 2015-11-09 | 2024-02-20 | The University Of British Columbia | Cyclic compound/peptide comprising an A-beta13-16 peptide and a linker that is covalently coupled to the n-terminus residue and the c-terminus residue of the A-beta13-16 peptide |
| US11970522B2 (en) | 2015-11-09 | 2024-04-30 | The University Of British Columbia | Cyclic compound/peptide comprising an A-beta15-18 peptide and a linker that is covalently coupled to the n-terminus residue and the c-terminus residue of the A-BETA15-18 peptide |
| JP2019532028A (ja) * | 2016-08-16 | 2019-11-07 | ニューロ−バイオ リミテッドＮｅｕｒｏ−Ｂｉｏ Ｌｔｄ | 神経変性障害の治療に使用するための改変ペプチド |
| JP7125143B2 (ja) | 2016-08-16 | 2022-08-24 | ニューロ－バイオ リミテッド | 神経変性障害の治療に使用するための改変ペプチド |
| US11939398B2 (en) | 2016-08-16 | 2024-03-26 | Neuro-Bio Ltd | Modified peptides for use in treating neurodegenerative disorders |
| US11779629B2 (en) | 2016-11-09 | 2023-10-10 | The University Of British Columbia | Compositions comprising cyclic peptides derived from an A-beta peptide |
| US12286469B2 (en) | 2017-07-18 | 2025-04-29 | The University Of British Columbia | Humanized antibodies binding to amyloid-beta (A-beta) |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000068263A3 (en) | 2001-05-03 |
| CA2388092A1 (en) | 2000-11-16 |
| AU4529800A (en) | 2000-11-21 |
| IL146009A0 (en) | 2002-07-25 |
| DE60037800D1 (de) | 2008-03-06 |
| WO2000068263A2 (en) | 2000-11-16 |
| EP1173480B1 (en) | 2008-01-16 |
| ATE384077T1 (de) | 2008-02-15 |
| EP1173480A2 (en) | 2002-01-23 |
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