JP2003500051A5 - - Google Patents
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- Publication number
- JP2003500051A5 JP2003500051A5 JP2000620079A JP2000620079A JP2003500051A5 JP 2003500051 A5 JP2003500051 A5 JP 2003500051A5 JP 2000620079 A JP2000620079 A JP 2000620079A JP 2000620079 A JP2000620079 A JP 2000620079A JP 2003500051 A5 JP2003500051 A5 JP 2003500051A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- class
- fragment
- complementation system
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 23
- 239000012634 fragment Substances 0.000 claims 16
- 230000000295 complement effect Effects 0.000 claims 12
- 108010038807 Oligopeptides Proteins 0.000 claims 9
- 102000015636 Oligopeptides Human genes 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 108090000204 Dipeptidase 1 Proteins 0.000 claims 5
- 125000000539 amino acid group Chemical group 0.000 claims 5
- 102000006635 beta-lactamase Human genes 0.000 claims 5
- 210000004900 c-terminal fragment Anatomy 0.000 claims 5
- 210000004898 n-terminal fragment Anatomy 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 4
- 230000007026 protein scission Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 102000002933 Thioredoxin Human genes 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 230000008707 rearrangement Effects 0.000 claims 1
- 108060008226 thioredoxin Proteins 0.000 claims 1
- 150000003952 β-lactams Chemical class 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13592699P | 1999-05-25 | 1999-05-25 | |
| US60/135,926 | 1999-05-25 | ||
| US17596800P | 2000-01-13 | 2000-01-13 | |
| US60/175,968 | 2000-01-13 | ||
| PCT/US2000/007108 WO2000071702A1 (en) | 1999-05-25 | 2000-03-16 | Interaction-activated proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003500051A JP2003500051A (ja) | 2003-01-07 |
| JP2003500051A5 true JP2003500051A5 (https=) | 2005-07-28 |
Family
ID=26833822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000620079A Pending JP2003500051A (ja) | 1999-05-25 | 2000-03-16 | 相互作用活性化タンパク質 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1183347A1 (https=) |
| JP (1) | JP2003500051A (https=) |
| AU (1) | AU6045900A (https=) |
| CA (1) | CA2374476A1 (https=) |
| WO (1) | WO2000071702A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6828099B2 (en) * | 1998-02-02 | 2004-12-07 | Odyssey Thera Inc. | Protein fragment complementation assay (PCA) for the detection of protein-protein, protein-small molecule and protein nucleic acid interactions based on the E. coli TEM-1 β-Lactamase |
| US8148110B2 (en) | 1999-03-15 | 2012-04-03 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of molecular interactions by β-lactamase reporter fragment complementation |
| US7252952B2 (en) * | 2000-03-06 | 2007-08-07 | Rigel Pharmaceuticals, Inc. | In vivo production of cyclic peptides for inhibiting protein—protein interaction |
| US7566765B2 (en) | 2000-03-06 | 2009-07-28 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds containing a nine-membered carbon-nitrogen ring |
| US7378248B2 (en) | 2000-03-06 | 2008-05-27 | Rigel Pharmaceuticals, Inc. | In vivo production of cyclic peptides for inhibiting protein-protein interaction |
| AU2002227112A1 (en) * | 2000-10-30 | 2002-05-15 | Kalobios, Inc. | Affinity maturation by competitive selection |
| KR100440746B1 (ko) * | 2001-02-07 | 2004-07-23 | (주)비엠에스 | 항생물질 내성균 선별을 위한 유전형 분석키트 |
| EP1392870B1 (en) * | 2001-05-09 | 2008-02-27 | Discoverx, Inc. | Screening for enzyme inhibitors |
| WO2003040670A2 (en) * | 2001-11-07 | 2003-05-15 | Sensor Technologies Llc | Method of identifying energy transfer sensors for analytes |
| US20030157579A1 (en) * | 2002-02-14 | 2003-08-21 | Kalobios, Inc. | Molecular sensors activated by disinhibition |
| US7432063B2 (en) | 2002-02-14 | 2008-10-07 | Kalobios Pharmaceuticals, Inc. | Methods for affinity maturation |
| US7335478B2 (en) | 2002-04-18 | 2008-02-26 | Kalobios Pharmaceuticals, Inc. | Reactivation-based molecular interaction sensors |
| WO2004072266A2 (en) * | 2003-02-13 | 2004-08-26 | Kalobios Inc. | Antibody affinity engineering by serial epitope-guided complementarity replacement |
| WO2007001420A2 (en) * | 2004-10-22 | 2007-01-04 | Genencor International, Inc. | Isolating human antibodies |
| WO2007054658A1 (en) * | 2005-11-14 | 2007-05-18 | King's College London | Control of immune responses |
| US8426138B2 (en) | 2006-12-26 | 2013-04-23 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of sub-cellular compartment localization of a molecule using a reduced affinity enzyme complementation reporter system |
| US8101373B2 (en) | 2007-10-12 | 2012-01-24 | Discoverx Corporation | β-galactosidase donor fragments |
| WO2013119579A1 (en) | 2012-02-06 | 2013-08-15 | Discoveryx Corporation | Detection of intracellular binding events by measuring protein abundance |
| ES2778033T3 (es) | 2012-11-16 | 2020-08-07 | Poseida Therapeutics Inc | Enzimas específicas de sitio y métodos de uso |
| JP2017518083A (ja) * | 2014-06-17 | 2017-07-06 | ポセイダ セラピューティクス， インコーポレイテッド | ｉｎ ｖｉｖｏでの非共有結合的連結のための方法および組成物 |
| EP2975126A1 (en) | 2014-07-15 | 2016-01-20 | Institut Pasteur | In vivo detection of proteins interaction based on adenylate cyclase hybrid system |
| EP3929286A1 (en) | 2015-06-17 | 2021-12-29 | Poseida Therapeutics, Inc. | Compositions and methods for directing proteins to specific loci in the genome |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5585245A (en) * | 1994-04-22 | 1996-12-17 | California Institute Of Technology | Ubiquitin-based split protein sensor |
| US5741657A (en) * | 1995-03-20 | 1998-04-21 | The Regents Of The University Of California | Fluorogenic substrates for β-lactamase and methods of use |
| CA2196496A1 (en) * | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| US6342345B1 (en) * | 1997-04-02 | 2002-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of molecular interactions by reporter subunit complementation |
| US6333154B1 (en) * | 1997-12-04 | 2001-12-25 | Institut Pasteur | Bacterial multi-hybrid system and applications thereof |
| EP1027608B1 (en) * | 1998-07-30 | 2010-01-20 | Odyssey Thera, Inc. | Protein fragment complementation assays |
-
2000
- 2000-03-16 EP EP00946748A patent/EP1183347A1/en not_active Withdrawn
- 2000-03-16 AU AU60459/00A patent/AU6045900A/en not_active Abandoned
- 2000-03-16 WO PCT/US2000/007108 patent/WO2000071702A1/en not_active Ceased
- 2000-03-16 CA CA002374476A patent/CA2374476A1/en not_active Abandoned
- 2000-03-16 JP JP2000620079A patent/JP2003500051A/ja active Pending
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