JP2003304830A - Seaweed-containing composition, kit product and use thereof - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a composition having useful actions such as blood fluidity improving, further hypotensive, antiobese, blood glucose level lowering, neutral fats reducing, antihyperlipemic and anticancer actions and to provide a kit product. <P>SOLUTION: The composition comprises (A) an extract or powder of seaweed and (B) mineral water derived from deep seawater. The kit product is composed of (A) the extract or powder of the seaweed and (B) the mineral water derived from the deep seawater. A food and drink is composed of the composition or the kit product. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a seaweed-containing composition, and more specifically, to improvement in blood fluidity, blood pressure reduction, antiobesity action, blood glucose level reduction, neutral fat reduction, antihyperlipidemia. The present invention relates to a seaweed-containing composition and a kit product having actions such as the above. The present invention also relates to a seaweed food / drink having improved taste and a method for producing the same.

[0002]

2. Description of the Related Art Blood fluidity reflects a person's health condition, and a decrease in blood fluidity induces many lifestyle-related diseases.

Originally, the cause of the decrease in blood fluidity is not related to aging and is strongly influenced by daily eating habits, lack of exercise, smoking, mental stress and other lifestyle habits. Therefore, in order to improve blood fluidity, it is sufficient to return to a proper lifestyle, avoiding overeating, unbalanced eating, eating at irregular times, lack of exercise, mental stress, etc., and returning to a healthy lifestyle. Good. However, since the habitualized lifestyle pattern cannot be easily recovered, such a symptom has been recently called a lifestyle-related disease.

The prodrome of lifestyle-related diseases is first manifested by a decrease in blood flow. If blood fluidity continues to decline for a long time, hyperlipidemia, thrombosis, diabetes starting with obesity, hypertension, arteriosclerosis, angina, myocardial infarction,
Cerebral infarction and cerebral hemorrhage are caused.

Further, blood fluidity is closely related to blood pressure. Hypertension of unknown cause, rather than a specific disease, is called essential hypertension. When the human body is in a condition where blood is difficult to flow, it tries to compensate by raising blood pressure to maintain the flow. However, by raising the blood pressure and forcing the blood to flow, great mechanical stress is applied to the vascular endothelium and the circulatory system including blood cells. Particularly, platelets are sensitive to stress, and it is thought that a vicious cycle is formed in which platelets themselves promote aggregation and blood fluidity further decreases. After all, if the state where the blood fluidity is lowered continues for a long time, hypertension is induced, and cardiovascular diseases such as arteriosclerosis, angina, myocardial infarction, and cerebral hemorrhage are likely to occur.

[0006] Such a rapid increase in lifestyle-related diseases means the existence of an enormous number of preliminary patients on the verge of illness, and further, bedridden elderly people due to sequelae of cardiovascular diseases,
It has become a major social problem in terms of nursing care for patients with dementia, etc.

[0007] Blood fluidity is strongly influenced by blood itself, as well as the state of the heart as a circulatory organ and the state of blood vessels which are flexible elastic bodies that contract and relax depending on the situation.

Blood, which makes up about 8% of human body weight, is a suspension in which small blood cell components are dispersed in a body fluid called plasma, and in normal human blood, most of the blood cell components have a diameter of about 7 μm. It is a red blood cell having a thickness of 1 to 2 μm and having a concave shape in the center, which is highly deformable, and is composed of white blood cells of 1/600 or less and platelets of 1/800 or less of the total number of blood cell components. On the other hand, plasma, which is a liquid in which blood cell components are dispersed, contains 90% water, about 7% protein, and other organic and inorganic compounds.

The flow of arterioles and capillaries having a diameter of 100 μm or less is called microcirculation, and nutrient substances and gases carried by blood flow are exchanged with surrounding tissues, which is important for maintaining the living body. It plays a very important role and is closely related to lifestyle-related diseases of the circulatory system.

In capillaries, red blood cells having a diameter of 7 μm flow while being greatly deformed in blood vessels having a diameter of 5 to 8 μm. White blood cells having a diameter of 7 to 22 μm also flow while rolling over a thin vascular endothelium, but in some cases, they easily attach to the wall surface of the vascular endothelium. Furthermore, platelets with a diameter of about 2 μm also aggregate with each other in the presence of hyperlipidemia or some stress, forming aggregates and adhering to the wall surface of vascular endothelium.
Occasionally deposits as spotted thrombus with lipid.

As described above, the fluidity of blood at the microcirculation site is governed by various factors. From the blood side, the deformability of red blood cells, the adhesion of leukocytes, the aggregating ability of platelets, and the hematocrit value. , Plasma viscosity, etc. Therefore, it is considered that blood fluidity is improved by changing and normalizing these individual factors.

[0012] However, it can be said that it is practically difficult to judge which factor and to what degree the human blood works strongly.

[0013] In recent years, as foods for improving blood fluidity, black vinegar, black bean juice, red wine, plum extract,
Traditional foods such as buckwheat noodles are reported to be effective. However, there are few cases where the active ingredient was isolated and identified, and there is little knowledge about the continuity and homeostasis of their effectiveness.

Further, a tablet containing a seaweed component as a main ingredient is already on the market as a health supplement having an improving effect on hypertension, hyperlipidemia, cancer and the like ("Sawayaka Genki", September 2001, September). No., 266). However, unpleasant odors and odors peculiar to seaweed remained, and it was often difficult to take them, and there were almost no quantitative reports on their effectiveness. further,
The fact that ingestion of seaweed and its components improves blood fluidity was completely unknown.

On the other hand, the salt-removed deep sea water (hereinafter referred to as "Amami water", which we have already developed.
-129061 and the like) are frequently used as the above-mentioned beverages for improving blood fluidity, but the mechanism thereof is under study. Moreover, there is no knowledge about the combined effect of seaweed or its components and mineral water derived from deep sea water.

[0016] In addition, a composition comprising ginseng and eucommia tea is widely used in combination with ginseng and tea.
7353), tea containing ginseng extract obtained by further adding licorice to ginseng (JP-A-63-39547),
Blending kelp powder, ginseng (JP-A-54-101459), and roasted brown rice into ginseng (JP-A-7-71).
No. 327603), and ginseng with kumazasa and pine needles (Japanese Patent Publication No. 62-2176).
No. 8) and the like, examples in which the taste of ginseng is improved, examples for the purpose of recovery from fatigue and enhancement of physical strength, etc. have been reported. There is also a report on an example of mixing ingredients such as oolong tea, pearl barley tea, and armchair tea with respect to American ginseng (Japanese Patent Laid-Open No. 61-122218). However, the present situation is that nothing is known about the addition of a tea component for the purpose of improving the taste, to the composition of seaweed and mineral water derived from deep sea water.

[0017]

In view of the above points, the present invention is to improve blood fluidity, further lower blood pressure, antiobesity action, lower blood glucose level, lower neutral fat, antihyperlipidemia, It is an object to provide a composition and a kit product having a useful action such as anticancer. More specifically, the object of the present invention is to provide compositions and kit products with improved odor and taste.

[0018]

Means for Solving the Problems As a result of diligent efforts to solve the above problems, the inventors of the present invention have taken a combination of seaweed extract or powder and mineral water derived from deep water, It was surprisingly found that both components act synergistically and have the effect of constantly improving blood fluidity in a short time. In addition, it was found that the roasting processing can surprisingly eliminate the odor characteristic of seaweed, and it was also found that by mixing a tea component, the palatability was significantly improved, and the present invention was found. Was completed.

That is, the present invention relates to a composition comprising (A) a seaweed extract or powder and (B) mineral water derived from deep sea water.

The present invention also relates to a kit product comprising (A) seaweed extract or powder and (B) mineral water derived from deep sea water.

In the above composition and kit product, the seaweed extract or powder (A) is preferably processed into microcapsules.

In the above composition and kit product, it is preferable to use the seaweed powder which has been previously roasted.

In the above composition and kit product, it is preferable to contain a tea extract.

The present invention further relates to a method for producing the above composition, which comprises processing the seaweed extract or powder (A) into microcapsules and mixing the microcapsules with the mineral water (B).

In the above manufacturing method, it is preferable to use an edible polymer selected from the group consisting of alginic acid, carrageenan, methoxypectin, konjac potato extract, curdlan, sodium alginate, agar, gelatin and starch as the capsule material.

In the above production method, when the seaweed extract or powder (A) is processed into a macrocapsule, the coagulant is selected from the group consisting of calcium chloride, magnesium chloride, potassium chloride, calcium phosphate, magnesium sulfate and calcium sulfate. Preferably.

The present invention also relates to a food or drink for improving blood fluidity comprising (A) seaweed extract or powder and (B) mineral water derived from deep sea water.

Further, the present invention relates to a food or drink for improving symptoms associated with a decrease in blood fluidity, which comprises (A) a seaweed extract or powder and (B) mineral water derived from deep sea water.

In the present invention, the symptom associated with decreased blood fluidity is hypertension, obesity, hyperlipidemia or hypertriglyceride.
It also relates to the food and drink.

[0030]

DETAILED DESCRIPTION OF THE INVENTION The contents of the present invention will be described in detail below.

The composition of the present invention is characterized by comprising a seaweed extract or powder (A) component and mineral water derived from deep sea water (hereinafter abbreviated as deep sea water) (B).

As the seaweed used in the present invention, any edible seaweed may be used, for example, kelp, seaweed, seaweed, tengusa, Japanese fungus, seaweed, seaweed, white jellyfish, Hime-nori, Examples include sea urchin, mozuku, hijiki, mirin, arame, sugi seaweed, miru, and blue sea bream. Among these, kelp, seaweed, seaweed, seaweed, tengu, and seaweed paste are preferable from the viewpoint of their efficacy. These seaweeds may be used alone or in combination of two or more.

As a method for preparing an extract from seaweed,
As a typical method, seaweed is dried, then crushed into pieces of about 0.5 mm, and decocted with a solvent such as hot water or ethanol for 30 minutes to 5 to 6 hours. Further, if necessary, extraction with an alkaline solution is performed for 1 to 2 hours, unnecessary substances are filtered off, and then neutralized to obtain a seaweed extract.

Although the method for producing the seaweed powder is not particularly limited, for example, the seaweed itself, which has been dried to a high degree by heating or the like and has a high hardness, or a crushed piece of the seaweed, is grinded with a grinder such as a stone mill and shaken. It is produced by a method of pulverizing with a mill such as a pole mill, a pole mill, etc., an impact type crusher such as a jet mill, a hammer mill, a pin mill, or a method of freezing undried raw seaweed and then freeze-milling. be able to.

Further, in the present invention, in order to enhance the deodorizing effect, the seaweed powder which has been previously roasted can be used. The roasting treatment can be performed either before or after pulverizing the seaweed. Specifically, seaweed is roughly crushed to a size of about 2 to 5 cm and then 60 to 500 ° C., preferably 80 to 200.
℃, more preferably 90-130 ℃ adjusted to a room, room, table, movable belt, etc.
Roast for 1 minute to 1 hour, preferably 2 to 20 minutes, more preferably 5 to 15 minutes. This heating treatment can be performed by either a dry method or a wet method, but it is preferable that the dry heating has a great effect of improving the flavor. As the roasting device, enamel containers and pots, metal containers and pots that have been used for tea leaves, etc. can be used, and a continuous belt conveyor type roasting device is also used. it can. Besides, well-known materials can be used.

In the kit product of the present invention, examples of the form of the seaweed extract or powder (A) include an extract obtained by extracting seaweed with hot water or water containing 5 to 20% ethanol. In the case of powders, seaweeds having an average particle size of 10 to 200 microns are pulverized and mixed. Among these, in the case of an extract, it is preferable to fill the small bottle with the extract obtained by the hot water extraction method for the reason of easy extraction operation, and in the case of a powder, in order to facilitate ingestion, powder After being sufficiently dried, it is preferable to wrap it in a small bag of about 2 to 5 g or pack it in a tea bag before use.

Deep water used in the present invention (for example, trade name:
To prepare "Amami's water", etc., see JP-A 2000-1
29061 or JP 2000-295974.
The method described in “Beverage using seawater and method for producing the same” in Japanese Patent Publication No. That is, deep seawater is desalted, separated into water and a concentrated liquid, and then a water-soluble mineral component is added to the separated water, or a water-soluble mineral component obtained from the concentrated liquid is finally added. It can be manufactured by adjusting the hardness.

In the composition of the present invention, the seaweed extract or powder is processed into microcapsules in order to eliminate the odor peculiar to seaweed and facilitate ingestion, and to easily retain the natural color peculiar to seaweed. Preferably.

As a method for producing the above-mentioned microcapsules, it is recommended to carry out by modifying the technique for immobilizing enzymes and microorganisms, because it has excellent industrial properties. That is,
It can be produced by mixing a seaweed extract itself or a suspension of seaweed powder in water or deep water with an aqueous solution of a capsule material, and dropping the mixture into an aqueous solution containing a coagulant. Further, finer microcapsules can be obtained by dropping the dropped mixture by a method of spraying from a small nozzle.

Examples of capsule materials include edible polymers such as alginic acid, carrageenan, methoxypectin, konjac potato extract, curdlan, sodium alginate, agar, gelatin and starch. Above all,
Sodium alginate is preferable from the viewpoint of moldability of microcapsules.

Examples of the coagulant include calcium chloride, magnesium chloride, potassium chloride, calcium phosphate, magnesium sulfate, calcium sulfate and the like, and calcium phosphate and calcium sulfate are preferable from the viewpoint of moldability of microcapsules. Further, instead of using the aqueous solution to which these coagulants are added, deep layer water having high hardness may be used.

The content of the seaweed extract or powder in the microcapsule molding is preferably 0.1 to 5.0% by weight, more preferably 0.2 to 1.0% by weight, based on the water or the deep water. If the content of the seaweed extract or powder is less than 0.1% by weight, it tends to be difficult to form microcapsules, and if it exceeds 5% by weight, it tends to be difficult to form homogeneous spherical microcapsules.

The amount of the capsule material used in the microcapsule molding is 0.1 to 0.1% with respect to water or deep water.
10% by weight is preferable, and 0.5 to 2% by weight is more preferable. If the amount of the capsule material used is less than 0.1% by weight, it tends to be difficult to form a microcapsule shape, and if it is more than 10% by weight, the viscosity of the liquid increases and stable ejection of droplets from the nozzle becomes difficult, resulting in a uniform Tend to be difficult to be a spherical microcapsule.

The concentration of the coagulant in the aqueous solution containing the coagulant in the microcapsule molding is preferably 0.1 to 5%, more preferably 0.5 to 3%. If the concentration of the coagulant is lower than 0.5%, coagulation tends to be difficult,
If it is lower than 0.1%, it tends to be difficult to form microcapsules, and if it is higher than 5%, it tends to be difficult to form homogeneous and spherical microcapsules.

In the microcapsule molding, various additives can be added to the seaweed extract or fine powder obtained as described above. Examples of the additive include creamy powder, maltose, cellulose powder, sugar ester, sodium starch glycolate, volley powder, cyclodextrin, starch such as tapioca starch, and the like. preferable.

The taste and taste of the kit products and compositions of the present invention can be improved by further adding a tea extract. That is, by adding tea extract,
The taste is familiar, the unpleasant odor peculiar to seaweed can be improved, and it becomes easy to drink.

The tea extract of the present invention is, for example, green tea, oolong tea, banaba tea, eucommia tea, iron kannon tea, pearl barley tea,
It can be produced by mixing and brewing one or more kinds, preferably 1 to 3 kinds, from amachadzu tea, macomo tea, kelp tea and the like. A standard method may be used for brewing tea.

In the present specification, "food and drink" is defined to include not only general food and drink but also health food, food for specified health use and the like.

Examples of the food or drink of the present invention include juice, jelly, drinks, frozen drinks (ice), cookies, powders or kit products of tablets and deep water, and the like. Drinks are preferred because of their goodness and ease of distribution process.

For example, a drink is prepared by mixing the above-mentioned seaweed extract or powder and deep water as main components. When an extract and deep water are used, a clean drink is obtained, but when a seaweed powder is used, a cloudy drink is obtained. In the latter case, it is preferable to add a little thickening agent such as alginic acid, sodium alginate, and carrageenan for the purpose of preventing rapid sedimentation of the powder.

When the seaweed extract or powder and the deep sea water are separately ingested by the kit product according to the present invention, the same effect as ingesting the composition according to the present invention can be expected. That is, for example, a composition comprising a seaweed extract or powder, for example, 5 to 10 tablets in the form of tablets molded into a tablet,
It is possible to recommend a method in which it is divided into twice a day, morning and evening, and taken with a cup of deep water, for example, trade name: "Amami's water, hardness 1000" (manufactured by Ako Kasei Kogyo Co., Ltd.). The composition comprising the seaweed extract or powder may be the seaweed extract or powder itself.

The intake amount of the food or drink of the present invention is not particularly limited and can be appropriately selected according to the form, age, weight and symptom of the food or drink, but in view of expected physiological effects,
Seaweed extract or powder (A) and deep water (B) as active ingredients are preferably 50 to 600 ml / day, and 100
-400 ml / day is more preferable. Further, the intake of the seaweed extract or powder is preferably 0.2 to 10% by weight, more preferably 0.5 to 5% by weight, based on the depth water.

Next, the method for measuring blood fluidity in the present specification will be described with reference to specific examples.

<Test Method for Blood Fluidity> First, a device for measuring blood fluidity (Yuji Kikuchi; Cell, 30 (7), 27-).
30 (1998)).

Width 7 μm, depth 4.5 μm, length 30 μm, 8736 formed by processing the surface of a silicon single crystal substrate.
MC-FAN (manufactured by Suntree Kiko Co., Ltd.) in which a flow path corresponding to a pseudo-capillary was formed by pressing a microchip consisting of parallel grooves of a book with an optically polished glass substrate.
The test blood and the control blood were caused to flow with a pressure difference of 20 cm of water column, and a transit time of 100 μL was determined, and at the same time, the television monitor was observed. The obtained whole blood transit time is
The standard passage time of 100 μL of physiological saline measured immediately before was corrected for 12 seconds for conversion. In addition, the measurement of MC-FAN was carried out within 1 hour immediately after blood collection.

When the whole blood transit time is shortened by this method, it is considered that it has the effect both on the improvement of the red blood cell deformability in the blood and on the suppression of the platelet aggregation ability.

<Measurement Method of Obesity> The anti-obesity effect was evaluated by so-called BMI value.

BMI = (weight (kg)) / (height (m)) ²

<Measurement of Triglyceride and Hyperlipidemia> Diagnosis of triglyceride and hyperlipidemia was conducted by measuring total cholesterol level (T-Ch
o), triglyceride level (TG), LDL cholesterol level (LDL-Cho), HDL cholesterol level (HDL-Cho), phospholipid (PL), free fatty acid (NEFA), comprehensively judged by comparison with standard values did.

Measurement of these biochemical values, total amount of protein in blood, alkaline phosphatase (ALP),
Glutamic acid-oxaloacetate transaminase (GO
T), gamma-glutamine transpeptidase (gamma GTP), etc. were measured by a clinical laboratory through a hospital.

The food or drink of the present invention has an effect of improving blood fluidity, and particularly improves the fluidity of blood at the microcirculation site, and thus prevents various diseases in which the fluidity of blood is decreased as a pathological condition. Useful for. Examples include peripheral circulatory insufficiency, arteriosclerosis, hypertension, thrombosis, hyperlipidemia, diabetes, and ischemic symptoms, but the application target is not limited to these.

[0062]

EXAMPLES The present invention will be described in more detail with reference to production examples, examples and comparative examples, but the present invention is not limited thereto. The part in each example shows a weight part.

Production Example 1 Production of Seaweed Extract 20 parts of commercially available dried plate paste, 70 parts of wakame seaweed, and 10 parts of kelp are each cut into about 1 to 2 cm square. 1000 water on this
After adding 0 part, the mixture is boiled for about 10 minutes while being kept in the range of 60 to 90 ° C. by steam heating. After allowing to cool to 30 ° C or lower, a seaweed extract was obtained by filtering with a cloth.

Production Example 2 Production of Seaweed Powder 65 parts of cut seaweed dried to a water content of 10% or less, 1
ACM-D which is an air flow classification type impact crusher by mixing 15 parts of kelp cut into 2 cm squares and 2 parts of mung bean paste
(Manufactured by Hosokawa Micron Co., Ltd.), classification rotation speed 70
Blowing hot air at 00 rpm, 120 ° C, throughput 15k
It processed on condition of g / h. The particle size of the obtained mixed seaweed powder was D50 = 14 μm, 80 μm all-pass.

A commercially available seaweed powder mixture was obtained by thoroughly mixing 18 parts of a commercially available Nori ultrafine pulverized product (manufactured by Kishosha Co., Ltd.) with the powder.

Production Example 3 Production of Seaweed Powder 10 parts of kelp dried with a water content of 10% or less, 50 wakame seaweed
Parts, 5 parts of funori, 25 parts of paste, and 10 parts of mill are cut into about 0.5 to 3 cm squares,
This was placed in an attritor (manufactured by Mitsui Mining Co., Ltd.), which is a media agitation type crusher in which stainless steel balls having a diameter of 3/8 inch are enclosed, and treated for 30 minutes. The particle size of the obtained powder is D
50 = 6 μm, 88 μm all pass.

Example 1 1 part of seaweed extract of Nori seaweed, seaweed, and kelp obtained in Production Example 1 and 9 parts of deep sea water (trade name: "Amami water, hardness 50", manufactured by Ako Kasei Co., Ltd.) Mixed. The blood passage time was measured using MC-FAN for the effect on the blood flow of the human body when the obtained composition was taken for a long period of time. Venous blood was collected from the upper arm of a healthy male in his 50s with heparin 5%, and the passage time of 100 μl of fresh blood was measured.
It was measured as described in the above-mentioned blood fluidity test method.
As a result, the whole blood passage time after one month was 45.6 seconds, 46.7 seconds, and 44.3 seconds when measured three times.

Comparative Example 1 A blood fluidity test was conducted in the same manner as in Example 1 except that a composition using distilled water instead of deep water was taken. As a result, the whole blood passage time was 67 seconds.

Example 2 and Comparative Examples 2, 3 and 4 Every day, 2 g of the seaweed powder obtained in Production Example 2 was added to deep water (trade name "Amami's water / hardness 250", manufactured by Ako Kasei Co., Ltd.).
Beverage (Example 2) dispersed in 00 ml, tap water 500
ml (Comparative Example 2), a drink prepared by dispersing 2 g of the seaweed powder obtained in Production Example 2 in 500 ml of tap water (Comparative Example 3) or 250 ml of tap water and deep water (trade name "Amami's water / hardness 250"). , Manufactured by Ako Kasei Co., Ltd.) (Comparative Example 4) and mixed with 250 ml of male and female 32 aged 40 to 60 years.
Subjects were divided into groups of 8 persons and each subject was allowed to drink, and changes in blood passage time were observed over a long period of time.

The results are summarized in Table 1 as an average value.

[0071]

[Table 1]

From Table 1, seaweed powder 2 obtained in Production Example 2
The shortest blood passage time was observed in the group that ingested the beverage in which g was dispersed in 500 ml of deep-layer water (trade name "Amami's water / hardness 250", manufactured by Ako Kasei Co., Ltd.).
That is, it was shown that the blood fluidity was significantly improved by the combined use of seaweed and deep water.

Example 3 5 g of the seaweed powder obtained in Production Example 2, 5 g of sodium alginate (manufactured by Kimika Co., Ltd.) and 0.5 g of tapioca starch were dispersed in 1 L of tap water. The resulting mixture was added to a 0.6% aqueous calcium chloride solution with stirring. The obtained microcapsules were filtered and washed with water. Then,
A composition was obtained by mixing with 1 L of deep water (trade name "Amami's water / hardness 1000", manufactured by Ako Kasei Co., Ltd.).

Example 4 10 ml of an alginic acid aqueous solution (10%) was added to 50 ml of the seaweed extract obtained in Production Example 1, and tap water was added to 40 ml.
ml was added and mixed. This was added to a 1% calcium chloride aqueous solution with stirring. The obtained microcapsules were washed and then filtered. Then, it was mixed with 1 L of deep-layer water (trade name “Amami's water / hardness 1000”, manufactured by Ako Kasei Co., Ltd.) to obtain a composition.

Example 5 900 g of anhydrous lactose was added to the mixed seaweed powder obtained in Production Example 2.
50 g of sucrose fatty acid ester and 20 g of tricalcium phosphate were mixed and compressed with a tableting machine to obtain tablets having a diameter of 5 mm and a weight of 100 mg.

Example 6 The first group took 300 ml of the composition obtained in Example 3 divided into three times a day, and the second group took 300 ml of the composition obtained in Example 4 for one day. Ingested in 3 divided doses, and 3rd
The group was prepared by taking 6 to 9 tablets obtained in Example 5 3 times a day.
Each cup was ingested together with 1 cup of deep water (trade name “Amami no water, hardness 250”, Ako Kasei Co., Ltd.). The test was conducted with the cooperation of 10 volunteers (boys in their 50s) in each group.

Blood was collected before ingestion and one month and two months after ingestion, and each blood index shown in Table 2 was measured and shown as an average value.

[0078]

[Table 2]

Example 7 and Comparative Examples 5 and 6 (Blood Pressure Measurement) The seaweed extract obtained in Production Example 1 and deep sea water (trade name: "Amami's water / hardness 1000", manufactured by Ako Kasei Co., Ltd.) were used in a weight ratio. In a ratio of 1:25 (Example 7), tap water (Comparative Example 5), and the seaweed extract obtained in Production Example 1 and tap water in a ratio of 1:25 by weight ( The difference in blood pressure lowering effect when each of Comparative Example 6) was taken was verified. Twenty-four untreated essential hypertensive patients aged 40 to 60 years were used as subjects, and these were divided into 3 groups of 8 persons each, and the subjects were allowed to drink 300 ml between meals every day without notifying the contents. .

For one month, the blood pressure of the upper arm is once a week, and after resting for 5 minutes or more, an automatic blood pressure measuring device (manufactured by Matsushita Electric Works, Ltd.,
EW245W), and the average value of each group is shown in Table 3.

[0081]

[Table 3]

As a result, a decrease in blood pressure was also observed in Comparative Example 6, but the decrease in blood pressure was particularly large in the group of Example 7.

Example 8 and Comparative Example 7 (Measurement of Obesity) The effect of combined ingestion of the tablet obtained in Example 5 and mineral water derived from deep water was examined using obesity as an index. Males aged 35 to 50 with obesity tendencies (untreated) with a BMI value of 25 or more were divided into 2 groups of 5 persons each, and deep water (trade name: "Amami water, hardness 250", Ako Kasei Co., Ltd.) 400 ml of tablets (manufactured by the company) and 5 to 8 tablets (Example 8), and 400 ml of tap water and 5 to 8 tablets of tablets (Comparative Example 7) were ingested daily for 3 months. Height, weight and abdominal circumference were measured every month, and the average value of each group is shown in Table 4.

[0084]

[Table 4]

As a result, the remarkable effect was not observed in Comparative Example 7, but the BMI value was decreased in Example 8 and the antiobesity effect was observed.

Example 9 and Comparative Examples 8 and 9 (measurement of hyperlipidemia and neutral fat) The seaweed powder obtained in Production Example 3 was mixed in deep water (trade name: "Amkai" at a ratio of 1: 100 by weight). Water / hardness 1000 ", manufactured by Ako Kasei Co., Ltd.) (Example 9), tap water (Comparative Example 8), and the seaweed powder obtained in Production Example 3 at a weight ratio of 1: 100. The mixed liquid (Comparative Example 9) was examined for the difference in antihyperlipidemic effect when ingested. Thirty untreated patients with hyperlipidemia aged 35 to 45 years were used as test subjects, and these were divided into three groups of 10 subjects each, and the subjects were allowed to drink 250 ml each day without notifying the contents. Every month, we collect early morning fasting peripheral blood,
The indexes shown in Table 5 such as total cholesterol in serum, neutral fat, and free fatty acid were measured, and the average value of each group was shown.

[0087]

[Table 5]

As a result, in Comparative Example 9 and Example 9, the amount of neutral fat and LDL-cholesterol decreased, which was a significant difference compared to Comparative Example 8 containing only tap water.

Example 13 (Improvement of taste) 1 part of the seaweed extract obtained in Example 1 and deep water (trade name:
"Amami's water, hardness 1000", manufactured by Ako Kasei Co., Ltd. 5
In addition to the drink prepared by mixing and dissolving 0 parts, Table 6
The decoctions of the various teas shown in 5 were mixed in 5 parts and 5 parts, and a sensory test was conducted by 20 panelists. For the inspection, the panelists should drink the additive-free products first, and then take the various items shown in Table 6 (including the additive-free products) without clearly indicating the content, and then use the questionnaire method. evaluated. The numerical values in the table indicate the number of people who answered “good”, “bad”, and “no change” among 20 people, respectively.

[0090]

[Table 6]

As a result, in all cases, the taste odor was significantly improved as compared with the case where the tea decoction was not added. Little bitterness and astringency were noticed, indicating improved ease of drinking.

[0092]

EFFECTS OF THE INVENTION The composition of the present invention is a food which can be expected to have a so-called lifestyle-related disease preventive effect by basically ingesting it daily. The place where it stands is that seaweed, which is thought to be able to act synergistically, on the combined effects of various mineral components contained in deep water and the effects of cardiovascular and blood effects such as calcium antagonism represented by magnesium among others. There is a physiological action effect of the component. In addition, the kit of the present invention also exhibits the same effects as the composition of the present invention by using the component (A) and the component (B) together.

Further, the food or drink of the present invention has an effect of improving blood fluidity, and particularly improves the fluidity of blood at the microcirculation site, so that it can be used as a pathological condition for various diseases in which the fluidity of blood is decreased. Useful for prevention. Examples include peripheral circulatory insufficiency, arteriosclerosis, hypertension, thrombosis, hyperlipidemia, diabetes, and ischemic symptoms, but the application target is not limited to these.

Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A23L 2/38 A23L 2/38 B (72) Inventor Mizuho Kakizaki 9-62 Sakata, Aioi City, Hyogo Prefecture (72) Inventor Rikiya Sakamoto 1-9-2, Ojudai, Himeji City, Hyogo Prefecture (72) Sakae Kawakami 15-6A5, Minamikamiya Minami, Ako City, Hyogo Prefecture (72) Inventor, Hiroshi Nakajima 11-10 F Term, Miyamae Town, Ako City, Hyogo Prefecture (reference) ) 4B017 LC03 LE10 LK02 4B018 LB10 LE03 LE05 MD01 MD67 MD68 ME04 MF14 4B019 LC05 LE09 LK01 LP04 LP07 LP13

Claims (13)

[Claims] 1. A seaweed extract or powder (A),
(B) A composition comprising deep water-derived mineral water. 2. (A) Seaweed extract or powder,
(B) A kit product consisting of deep-water-derived mineral water. 3. The seaweed extract or powder (A) is processed into a microcapsule form.
The composition as described. 4. The kit product according to claim 2, wherein the seaweed extract or powder (A) is processed into microcapsules. 5. The seaweed powder which has been previously roasted is used as the seaweed powder.
The composition as described. 6. The seaweed powder, which has been previously roasted, is used.
Kit product as described. 7. The composition according to claim 1, 3 or 5 containing a tea extract. 8. The method for producing a composition according to claim 3, wherein the seaweed extract or powder (A) is processed into a microcapsule shape, and the microcapsule is mixed with the mineral water (B). 9. The edible polymer selected from the group consisting of alginic acid, carrageenan, methoxypectin, konjac potato extract, curdlan, sodium alginate, agar, gelatin and starch is used as the capsule material. 8. The manufacturing method according to 8. 10. When the seaweed extract or powder (A) is processed into a macrocapsule, the coagulant is selected from the group consisting of calcium chloride, magnesium chloride, potassium chloride, calcium phosphate, magnesium sulfate and calcium sulfate. A method for producing the composition according to claim 9. 11. (A) Seaweed extract or powder,
(B) A food or drink for improving blood fluidity, which comprises mineral water derived from deep water. 12. (A) Seaweed extract or powder,
(B) A food or drink for improving symptoms associated with a decrease in blood fluidity, which comprises mineral water derived from deep water. 13. The symptom associated with the decrease in blood fluidity is
The food or drink according to claim 12, which has high blood pressure, obesity, hyperlipidemia or high neutral fat.