JP2003300818A - Cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a cosmetic having high impregnation power and humectant action and remarkably suppressing the formation of wrinkles. <P>SOLUTION: The cosmetic contains a low-molecular collagen hydrolyzed with an enzyme, a vitamin C derivative, a copolymer of methacryloyl phosphorylcholine and a hydrophobic monomer, a hyaluronic acid salt and an extract of the stalk of Akebi (Akebia quinata). The low-molecular collagen is a tripeptide having glycine as the N-terminal amino acid, having a molecular weight of about 280 and produced by the specific decomposition of a raw material containing a collagen component or a gelatin component with collagenase. The vitamin C derivative is ascorbyl magnesium phosphate, the hydrophobic monomer is butyl methacrylate and the hyaluronic acid salt is sodium hyaluronate. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic product containing a plurality of cosmetic bases having a moisturizing effect on the skin and collagen having high permeability to suppress the formation of wrinkles. .

[0002]

2. Description of the Related Art When a person judges the age of an opponent by appearance, the amount of wrinkles present on the body, including the eyes, mouth and neck, is a great criterion. If wrinkles are present on the skin, it is likely to be judged as an old age, and it is very important to suppress the formation of wrinkles in order to maintain a youthful appearance. Therefore, conventionally, research has been conducted for the purpose of developing cosmetics having an effect of suppressing wrinkle formation on the skin.

The mechanism of wrinkling has not been fully clarified yet, but it is known that ultraviolet rays, dryness, aging, etc. are factors. Due to the influence of these factors, the ability of collagen to be constituted in the dermis is reduced, and when the collagen is thinned or reduced, the function of maintaining the elasticity of the skin is reduced. As a result, it is believed that the skin layer, which has lost its flexibility and stretchability, is distorted and dented in a directional manner to form wrinkles.

Therefore, in order to suppress the formation of wrinkles, it is important to give the skin a moisturizing power and supply collagen. For this reason, cosmetics having a moisturizing effect on the skin and cosmetics containing collagen have been conventionally produced.

In order to produce a cosmetic product having excellent moisturizing power,
Cosmetics containing various moisturizers have been created. For example, the most commonly used moisturizers at present are water-soluble polyhydric alcohols such as glycerin and propylene glycol. However, there is a problem that these water-soluble polyhydric alcohols tend to produce a noticeable sticky feeling in terms of sensory aspects. In addition, when these polyhydric alcohols are used under low humidity, the moisture in the skin is taken up by the moisturizer, which rather causes the skin to dry. Urea is known as a natural moisturizing factor for the skin, but it has a problem that it is difficult to use in cosmetics applied directly to the skin because it lacks stability, is easily decomposed, and has a unique sensation of irritation.

On the other hand, collagen is a kind of protein that maintains the structure of cells, and has the function of maintaining the morphology of organs and retaining water in cells. In particular, the collagen content of the skin is higher than that of other organs and reaches 70% of the total weight, and as described above, it has a great effect in suppressing the formation of wrinkles in the skin. Therefore, many cosmetics contain collagen. However, since collagen itself is a very large protein and is insoluble, it is difficult to include it in cosmetics as it is. Therefore, usually, atelocollagen, which is solubilized by causing an enzyme to act on collagen, is often used for cosmetics as a cosmetic base material.

However, the molecular weight of atelocollagen is 30.
It is about 10,000 and is relatively large. High molecular weight proteins serve as antigens in immune reactions. Therefore, atelocollagen may cause an allergic reaction. In other words, it has allergenicity. It is also soluble but difficult to dissolve in water. Since the molecule itself is large, there is a problem that it has no permeability to the skin.

[0008]

As described above, the moisturizers that have been used in cosmetics up to now have problems with the moisturizing effect. Therefore, it is difficult to add a large amount of these moisturizers to cosmetics. In addition, there is a limit to the moisturizing power, and it was not possible to obtain a sufficiently moisturizing power. Further, there has been a problem that collagen, which has been contained for the common purpose of inhibiting the formation of wrinkles, has low solubility and has allergenicity.

An object of the present invention is to solve the above-mentioned problems of the prior art, to provide a cosmetic product having a high permeability, a good moisturizing effect, and a high effect of suppressing the formation of wrinkles.

[0010]

Means for Solving the Problems The inventors of the present invention have conducted earnest studies on cosmetics having a higher effect of suppressing the formation of wrinkles, and as a result, a plurality of specific moisturizers, highly permeable collagen, and By including a collagen absorption promoter in cosmetics, the moisturizing effects of various moisturizers work in a complex manner, and collagen is efficiently supplied to skin cells, resulting in an extremely high effect of suppressing the formation of wrinkles. I found that. A plurality of moisturizers are those to which a cellular constituent protein supporting agent, a cell membrane-like film forming agent, and a natural plant extract are added.

In order to achieve the above object, the present invention provides a first
Contains low molecular weight collagen and vitamin C derivative hydrolyzed by an enzyme, a copolymer of methacryloylphosphorylcholine and a hydrophobic monomer, hyaluronate, and akebi stem extract. Second, low molecular weight collagen is a collagen component. Alternatively, it is a tripeptide having a molecular weight of about 280 with N-terminal amino acid as glycine, which is obtained by specifically decomposing a raw material containing a gelatin component with collagenase. Third, the vitamin C derivative is phosphorus. Ascorbyl magnesium acid, fourth, the hydrophobic monomer is butyl methacrylate, fifth, the hyaluronate is sodium hyaluronate, and sixth, low-molecular weight collagen is 0.1.
05-0.20% by weight, vitamin derivative 0.15-
0.30% by weight, 0.025 to 0.040% by weight of a copolymer of methacryloylphosphorylcholine and a hydrophobic monomer, 0.0001 to 0.01% by weight of a hyaluronate, and 0.005 of an akebi stem extract. The gist is to contain 0.025% by weight.

According to the present invention as set forth in claim 1, the enzyme-hydrolyzed low molecular weight collagen and vitamin C derivative, copolymerization of methacryloylphosphorylcholine and a hydrophobic monomer, hyaluronate, and akebi stem extract are contained. It is a featured cosmetic product, which exerts a high effect of suppressing the formation of wrinkles by acting in combination.

According to the present invention of claim 2, in addition to the above-mentioned action, low-molecular weight collagen is obtained by specifically decomposing a raw material containing a collagen component or a gelatin component with collagenase. This low molecular weight collagen has very low antigenicity and allergenicity because it is a tripeptide having a molecular weight of about 280 with glycine as the N-terminal amino acid, and it is very soluble in water, so it can be easily dissolved in water and added. It can be used in cosmetics and does not cause off-flavors or peculiar odors.

According to the third aspect of the present invention, among ascorbate sodium phosphate and magnesium ascorbyl phosphate known as vitamin C derivatives, magnesium ascorbyl phosphate which is less invasive to the skin can be obtained. According to the present invention described in No. 4, since the hydrophobic monomer is butyl methacrylate, it has a particularly high moisturizing effect on the skin in the copolymerization of methacryloylphosphorylcholine and the hydrophobic monomer. According to the present invention described in claim 5, sodium hyaluronate as a hyaluronate is the most easily purified and has a low skin infiltration property.

According to the present invention of claim 6, low molecular weight collagen is 0.05 to 0.20% by weight, vitamin derivative is 0.15 to 0.30% by weight, and methacryloylphosphorylcholine is used in combination with a hydrophobic monomer. 0.025 polymer
~ 0.040 wt%, hyaluronate 0.0001 ~
0.01% by weight, 0.005-0.0 of akebi stem extract
By containing 25% by weight, a composition having a high effect of suppressing the formation of wrinkles can be obtained.

[0016]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described in detail below. The cosmetic product according to the present invention contains enzyme-hydrolyzed low molecular weight collagen and a vitamin C derivative, copolymerization of methacryloylphosphorylcholine and a hydrophobic monomer, hyaluronate, and akebi stem extract.

The low-molecular-weight collagen hydrolyzed by an enzyme is more soluble in water and more permeable to the skin than ordinary collagen. Therefore, collagen can easily reach deep layers of the skin. In particular,
When a tripeptide having a N-terminal amino acid of glycine and a molecular weight of about 280, which is obtained by specifically decomposing a raw material containing a collagen component or a gelatin component as low-molecular weight collagen with collagenase, the molecular weight is Since it is low, the antibody is hard to react, and the antigenicity and allergenicity are very low. In addition, since it is extremely soluble in water, it can be easily used in cosmetics and does not cause an offensive odor or a peculiar odor.

Vitamin C has a highly effective and safe whitening effect by suppressing melanin production and reducing colored melanin to colorless melanin, an anti-aging effect by suppressing DNA damage due to active oxygen, and sebum suppression. In addition to the action of preventing the formation of lipid peroxide and the action of forming acne,
Has a collagen synthesis promoting action. Therefore, the present invention acts together with the highly permeable low molecular weight collagen,
It has the effect of forming firm skin and making the appearance of acne less noticeable as well as suppressing the formation of wrinkles. However, since vitamin C has a chemically unstable structure,
In addition to being easily decomposed in the product, vitamin C is a water-soluble vitamin, and the skin has a waterproof effect on the surface, so it is hardly percutaneously absorbed as it is. On the other hand, the vitamin C derivative used in the present invention is a more stable phosphoric acid ester type of vitamin C, and can be efficiently taken into cells. Furthermore, after being absorbed into the skin, it acts on the cells directly by becoming vitamin C by an enzymatic reaction,
It is possible to efficiently exert various effects.

By containing low molecular weight collagen hydrolyzed by an enzyme and a vitamin C derivative, collagen can be supplied to the dermis layer of the skin and the collagen can be efficiently absorbed by the cells.

The copolymer of methacryloylphosphorylcholine and the hydrophobic monomer has a structure similar to the polar group of phosphatidylcholine constituting the cell membrane, and thus forms a coating similar to the cell membrane. This film is a natural moisturizing factor, has a moisturizing effect, and further acts as an intercellular lipid, so that it has a water barrier effect for preventing the outflow of water. This prevents water loss from the skin surface and maintains water in the skin. In particular, when butyl methacrylate is used as the hydrophobic monomer, the cell membrane-like coating formed is very similar to the cell membrane of the skin, and therefore has a high moisturizing effect on the skin.

Hyaluronic acid salt is formed by neutralizing hyaluronic acid, and its pH is close to that of the skin and has low invasiveness to the skin. On the other hand, hyaluronic acid has a function of binding elastin, which supports collagens, and has a function of maintaining the structure of skin proteins. As a result, it has a high water retention capacity and a water retention capacity of 6000 times its own weight, and this moisturizing power is stable without being affected by various environments such as temperature and humidity.

The raw material of the akebi stalk extract is akebi (Akebia quinata Dence.), Which is a member of the genus Akebia. Akebei stem extract contains stigmasterol, β-sitosterol and its glycosides, and sterols such as betulin as active ingredients, including saponin, tannin, potassium salt, etc. There is. Urea is a natural moisturizing factor for the skin, and is known to have a high water retention ability, a nucleolytic peeling action, and a keratin softening action. However, urea is very unstable and easily decomposes into carbon dioxide and ammonia. In addition, since it has a peculiar stimulating sensation, there is a problem in including it in cosmetics which is directly applied to the skin. However, the akebi stem extract contained in the product of the present invention has an action of activating arginase. Arginase converts L-arginine into L
-Converted to ortinin, producing urea in the process. As a result, urea can be stably supplied to the skin.

Since the moisturizing effects of these moisturizers work in combination, a synergistic moisturizing effect is produced, and a very high moisturizing effect on the skin can be obtained.

Further, below, the blending ratio of the cosmetic base which is empirically obtained by the present inventor and which can most effectively suppress the formation of wrinkles is described. Among cosmetics, low molecular weight collagen is 0.05 to 0.20% by weight, vitamin derivative is 0.15 to 0.30% by weight, and a copolymer of methacryloylphosphorylcholine and a hydrophobic monomer is 0.025 to.
0.040 wt%, hyaluronate 0.0001 ~
0.01% by weight, 0.005-0.0 of akebi stem extract
It is preferably 25% by weight.

Examples using the present invention will be shown below, but the examples do not limit the scope of the present invention.

(Cream) Water 78.38 as all components
2%, BG 5.03%, tri (capryl / caprylic acid)
Glyceryl 5.0%, glyceryl stearate 3.3
%, Stearic acid 3.0%, behenyl alcohol 2.0
%, Cetyl palmitate 0.8%, stearic acid PG
1.2%, hydrolyzed collagen (low molecular weight collagen)
0.1%, magnesium ascorbyl phosphate 0.15
%, Sodium hyaluronate 0.001, tocopherol 0.2%, polymer of methacryloylphosphorylcholine and butyl methacrylate (polyquaternium-51) 0.
035%, allantoin 0.1%, akebi stem extract 0.
005%, hydrogenated lecithin 0.05%, glycyrrhizic acid 2K 0.05%, dimethicone 0.2%, phenoxyethanol 0.047%, methylparaben 0.2%, propylparaben 0.15%.

(Toner Lotion) In this example, the components are provided with appropriate ranges. 93.6-87.3% of water as all its components,
BG 3.0 to 3.5%, glycerin 2.0%, polymer of methacryloylphosphorylcholine and butyl methacrylate (polyquaternium-51) 0.025 to 0.075
%, Rose extract (rose water) 0.8-1.5%, sodium hyaluronate 0.002-0.01%, magnesium ascorbyl phosphate 0.05-0.10%, soybean fermented extract 0.0009-0. 0027%, Capcon extract 0.0015 to 0.003%, Chlorella extract 0.0
005-0.001%, aloe vera extract 0.0005
~ 0.001%, Akebiki stem extract 0.005% ~ 0.0
25%, hydrolyzed collagen (low molecular weight collagen)
0.05-0.2%, jojoba oil 0.2-0.1%, tocopherol 0.05-0.2%, PEG-20 hydrogenated castor oil 0.1-0.6%, carbomer 0.0 ~ 1.0%,
Tamarind gum 0.0-1.0%, xanthan gum 0.
0-1.0%, potassium hydroxide 0.0-0.5%, methylparaben 0.2%, phenoxyethanol 0.01-
It is 0.03%. Within the above range, each component shall be finely adjusted according to the purpose of use so that the total components will be 100%.

[0028]

As described above, the cosmetic of the present invention suppresses the formation of wrinkles on the skin by containing a highly permeable collagen, a collagen absorption enhancer and a moisturizing agent in combination. The effect can be obtained.

Continued front page    (72) Inventor Fumiaki Nakatani             6-17-10 Jingumae, Shibuya-ku, Tokyo Stocks             Company Zix (72) Inventor Sōnosuke Shoda             286-16 Matsuhidai, Matsudo-shi, Chiba Co., Ltd.             Within the point F-term (reference) 4C083 AA111 AA112 AB032 AC122                       AC152 AC172 AC242 AC352                       AC392 AC422 AC482 AC682                       AD042 AD092 AD131 AD132                       AD152 AD331 AD332 AD352                       AD431 AD432 AD532 AD572                       AD641 AD642 AD662 CC04                       CC05 DD23 EE12

Claims (6)

[Claims] 1. A cosmetic comprising a low molecular weight collagen hydrolyzed by an enzyme, a vitamin C derivative, a copolymer of methacryloylphosphorylcholine and a hydrophobic monomer, hyaluronate, and an akebi stem extract. 2. Low molecular weight collagen is obtained by specifically decomposing a raw material containing a collagen component or a gelatin component with collagenase.
The cosmetic product according to claim 1, which is a tripeptide having a molecular weight of about 280 with the terminal amino acid being glycine. 3. The cosmetic product according to claim 1, wherein the vitamin C derivative is magnesium ascorbyl phosphate. 4. The cosmetic product according to claim 1, wherein the hydrophobic monomer is butyl methacrylate. 5. The cosmetic product according to claim 1, wherein the hyaluronate is sodium hyaluronate. 6. A low molecular weight collagen is 0.05 to 0.2.
0% by weight, 0.15 to 0.30% by weight of vitamin derivative, 0.025 to 0.040% by weight of a copolymer of methacryloylphosphorylcholine and a hydrophobic monomer, and 0.0001 to 0.01% of hyaluronate. %, And 0.005 to 0.025% by weight of Akake stalk extract.
6. The cosmetic according to claim 5.