JP2003267893A - Lubricant for tableting - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a lubricant for tableting, preventing capping, sticking and binding by improving binding force and lubrication effects when tableting a tablet or a tableted confectionery because sometimes the capping which is the phenomenon of peeling like a cap at the upper pestle side of the tablet when releasing the tablet from a mold, the sticking which is the phenomenon of damaging the surface of the tablet caused by sticking the powder to the pestle and hardly releasing the powder at tableting, and the binding which is the phenomenon of ill state when discharging the tablet after tableting because of large friction between the tablet and a mortar are caused, and they prevent smooth tableting when coming off badly. <P>SOLUTION: The lubricant for the tableting contains a peptide. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a lubricant for tableting, which prevents binding such as capping, sticking and binding by improving binding force and lubricity during tableting, and tablets and confectionery using the same. It is about.

[0002]

2. Description of the Related Art In tablets and tablet confectionery, it is necessary to compress raw materials in powder or powder form. During tableting, capping that peels off like a hat on the upper punch side of the tablet during demolding, sticking powder during punching to the punch, resulting in poor punch separation, sticking that scratches the tablet surface, and friction between the tablet and the mortar Is large, and binding that causes poor discharge of the tablet after tableting may occur, and when it becomes severe, tableting cannot be performed smoothly. Therefore, in tableting, a lubricant is used to improve the fluidity of the raw material powder so that a constant amount is filled in the die of the tableting machine, and at the same time, capping, sticking and It is desired to prevent binding and the like and give gloss to the surface of the tablet. Therefore, refined talc, magnesium stearate, hardened vegetable oil, food emulsifiers such as polyglycerin fatty acid ester and sucrose fatty acid ester have been used as lubricants. Among them, magnesium stearate can exert an effect as a lubricant with a small amount of use, but its use is limited to pharmaceuticals because it is not recognized as a food additive. Refined talc is rarely used because its amount used in foods is limited and its effect as a lubricant is small. In addition, since the effect of a lubricant on food emulsifiers is small,
In order to expect a sufficient effect, a large amount must be added, which causes problems such as a decrease in hardness of tablets and deterioration of flavor.

[0003]

SUMMARY OF THE INVENTION The present invention has been made to solve the problems of the prior art, and provides a lubricant for preventing capping, sticking and binding when tableting tablets and tablet confections. The purpose is to

[0004]

Means for Solving the Problems As a result of intensive studies to solve the above-mentioned problems, the present inventor has improved binding force and smoothness by using a vegetable and / or animal peptide and capping. It was found that a tablet or confectionery free from sticking and binding can be obtained, and the present invention has been completed. That is, the present invention relates to a lubricant for tableting, which comprises a plant and / or animal peptide.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be described in detail below. The peptide in the present invention means one obtained by enzymatically decomposing a protein isolated from a plant or an animal, and has an average chain length of 2 to 10,
It is preferable to use 1 as an oligopeptide (excluding free amino acids and undegraded protein) enzymatically decomposed to 2 to 6
One kind or a mixture of two or more kinds.

The protein used as the raw material for the peptide in the present invention is not particularly limited, but soybean, corn and egg yolk are preferable. The enzyme used for degrading the protein in the present invention is not particularly limited, and examples thereof include endo-type protease and exo-type protease. More preferred are those in which an endo-type protease and an exo-type protease coexist, which is preferable because it has little bitterness. For example, Aspergillus
Commercial protease "Protin FN" originating from Olise
(Manufactured by Daiwa Kasei Co., Ltd.) “FPC-30” (manufactured by Kyowa Miles Co., Ltd.), a commercially available protease “Actinase” originating from Streptomyces griseus (Kaken Pharmaceutical Co., Ltd.)
(Manufactured) and the like are preferred because an endo-type protease and an exo-type protease coexist. Further, the food grade emulsifier in the present invention is glycerin fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester,
Examples thereof include sucrose fatty acid ester and the like. Among them, polyglycerin fatty acid ester or sucrose fatty acid ester is preferably used as a mixture of one or more kinds, and polyglycerin fatty acid ester is mixed as one or more kinds. More preferable.

The polyglycerin fatty acid ester in the present invention is not particularly limited, but the fatty acid of polyglycerin has 10 to 22 carbon atoms and a degree of polymerization of 2 to 20.
It is preferable that the hydroxyl value is less than 100. In the case of polyglycerin fatty acid ester having 9 or less carbon atoms,
Since its melting point becomes too low, it is difficult to make it into a fine powder, and the effect as a lubricant is weakened. Further, with the polyglycerin fatty acid ester having 23 or more carbon atoms, the hardness of tablets and tablet confectionery produced using the same becomes low. Also,
Polyglycerin having a degree of polymerization of 21 or more is not practical because the viscosity of the raw material itself is too high and the ester reaction becomes extremely difficult. Further, when the hydroxyl value of the ester is 100 or more, the product yield is deteriorated due to adhesion to the tableting machine and the like.
The sucrose fatty acid ester of the present invention is not particularly limited, but those having a carbon number of sucrose fatty acid of 8 to 22 and an average degree of substitution of 2 or more are preferable. If the carbon number is less than 8, the melting point will be too low, and it will be difficult to make a fine powder, and the effect as a lubricant will be weakened. If the carbon number exceeds 22, the hardness of tablets and confectionery produced using this will be low. With a sucrose fatty acid ester having an average degree of substitution of less than 2, the product yield is deteriorated due to adhesion to a tableting machine and the like.

The mixing ratio of the peptide of the lubricant of the present invention and the food emulsifier is peptide: food emulsifier = 10: 9.
0 to 90:10 is preferable. Further, when the powder particle size of the lubricant of the present invention is large, it is not dispersed uniformly with each powder particle and the fluidity and the yield of the product are reduced, so the particle size is required to be 250 μm or less. The manufacturing process of tablets and tablet confectionery can be divided into a granulating process for manufacturing powder or granules and a tableting process for compression molding. The lubricant in the present invention is generally added after the granulating process. Addition amount is 0.2-5
Although the amount is% by weight, the amount added is not limited depending on the required function. Further, the lubricant in the present invention can be used in either a direct tablet manufacturing method or a wet tablet manufacturing method. Hereinafter, the present invention will be further described with reference to examples, but the scope of the present invention is not limited to these. The evaluation was performed by visual observation.

[0009]

Examples Example 1 Lubricants Example The raw materials were mixed in the following proportions to produce the product of the present invention (lubricant for tableting) 1
20g each of ~ 7 was prepared. Example 1 Soybean peptide = 100 Example 2 Soybean peptide: Decaglycerin Decasterate = 40: 60 Example 3 Soybean peptide: Sugar tristearate = 80: 20 Example 4 Soy peptide: Sugar tristearate = 60: 40 Example 5 York peptide: Decaglycerin decasterate = 20: 80 Example 6 York peptide: Decaglycerin decabehenate = 50: 50 Example 7 York peptide: Decaglycerin decabehenate = 40: 60 Soybean peptide; Fuji Oil refinery Co., Ltd. "High New SMS" York peptide; Taiyo Kagaku Co., Ltd. "Yoke peptide H-2"

Comparative Example 20 g of comparative products (tabletting lubricants) 1 to 4 were prepared using the following raw materials. Comparative Example 1 Decaglycerin Decasterate Comparative Example 2 Sugar Tristearate Comparative Example 3 Rapeseed hydrogenated oil Comparative Example 4 Purified talc

Test Example Lactose 800 g, powdered sugar 180 g, product of the present invention or comparative product 20
After mixing g, a constant molding pressure was applied by a tableting machine by the direct tableting method to give tablets at (300 ± 8) mg / tablet. The tableting time was 10 minutes, and capping, sticking and binding were evaluated by visual observation. The results are shown in Table 1.

[0012]

[Table 1]

Evaluation criteria: ◎ None, ○ Some
Δ Yes, × Very Yes As shown in the evaluation results in Table 1, the tableting lubricant characterized by containing the peptide according to the present invention does not cause capping, sticking and binding as compared with conventional products. A tablet confectionery having good wearing property was obtained.

[0014]

INDUSTRIAL APPLICABILITY According to the present invention, a tableting lubricant capable of preventing capping, sticking and binding can be obtained by enhancing binding force and lubricity when tableting tablets and tablet confections. it can.

Continued front page    (72) Inventor Yuji Kato             9-5 Akahori Shinmachi, Yokkaichi-shi, Mie Solarization             Gaku Co., Ltd. (72) Inventor Nagahiro Yamazaki             9-5 Akahori Shinmachi, Yokkaichi-shi, Mie Solarization             Gaku Co., Ltd. F-term (reference) 4B014 GB08 GK07 GL09                 4C076 AA37 BB01 EE41C FF43                       GG01

Claims (4)

[Claims] 1. A lubricant for tableting, which comprises a peptide. 2. The tableting lubricant according to claim 1, wherein the peptide and a food-grade emulsifier are used in combination. 3. The lubricant for tableting according to claim 2, wherein the peptide and the emulsifier for food are powders. 4. A tablet or confectionery containing the lubricant according to any one of claims 1 to 3.