JP6717509B2 - Dizziness improver - Google Patents

Description

The present invention relates to a dizziness improving agent.

Royal jelly is known to have many physiological activities such as growth promoting action, life prolonging action, and antitumor action. For example, Patent Document 1 discloses an antidepressant composition containing royal jelly or a water-soluble fraction thereof as an active ingredient.

JP, 2004-131407, A

The present invention aims to provide novel uses of royal jelly.

The present inventors have found that royal jelly has an action of improving the symptoms of "being aware of myself and the surroundings of myself" and the symptoms of "blackout of vision". The present invention is based on this novel finding.

That is, the present invention provides a dizziness improving agent containing royal jelly or a processed product thereof as an active ingredient.

The dizziness improving agent can significantly improve the symptoms of vertigo and dizziness, and thus may be used for improving dizziness or dizziness.

The dizziness improving agent of the present invention can also be used as a dizziness improving food, a health food, a functional food, a dietary supplement, a supplement or a food for specified health use or a medicine. Royal jelly has been conventionally used as a food or the like, and its safety to the living body has been established. Therefore, the dizziness-improving food, health food, functional food, dietary supplement, supplement or food for specified health use or medicine can be continuously taken over a long period of time.

ADVANTAGE OF THE INVENTION According to this invention, the dizziness improving agent which contains royal jelly or its processed material as an active ingredient is provided.

Hereinafter, modes for carrying out the present invention will be described in detail. However, the present invention is not limited to the following embodiments.

The dizziness improving agent of the present invention contains royal jelly or a processed product thereof as an active ingredient.

Royal jelly is a well-known honeybee product. Royal jelly is a milky substance made by adding fatty acids secreted from the maxillary gland to a transparent liquid rich in proteins secreted by the worker bee from the hypopharyngeal gland. It is known that royal jelly contains water, proteins, carbohydrates, lipids, ash, free amino acids, vitamins, minerals and the like.

The treated product of royal jelly is not particularly limited as long as it has the physiological action of royal jelly (for example, dizziness improving action). Specific examples of the processed product of royal jelly include royal jelly concentrate or diluent in which royal jelly is concentrated or diluted, royal jelly powder in which royal jelly is dried and pulverized, and royal jelly ethanol extract such as royal jelly extracted with an organic solvent such as ethanol. Examples include royal jelly organic solvent extracts and royal jelly obtained by treating royal jelly with a proteolytic enzyme. Among these, the enzyme-degraded royal jelly is preferable because it exerts the effect of improving dizziness more significantly.

For the dizziness improving agent of the present invention, the above-mentioned royal jelly and the processed product of royal jelly may be used alone or in combination of two or more kinds.

Royal jelly can be obtained as a beekeeping product according to a conventional method, for example.

The royal jelly concentrate can be obtained, for example, by removing water from royal jelly. The royal jelly dilution can be obtained, for example, by adding water to royal jelly.

The royal jelly powder can be obtained by pulverizing the royal jelly by a method known in the art, such as freeze-drying and spray-drying. Alternatively, the royal jelly powder may be obtained by freeze-drying or spray-drying and then pulverizing with a pulverizer (eg, pin mill, hammer mill, ball mill, jet mill).

The enzyme-degraded royal jelly can be obtained, for example, by treating royal jelly with a proteolytic enzyme. Examples of the proteolytic enzyme include an enzyme having an endopeptidase action, an enzyme having an exopeptidase action, and an enzyme having both an endopeptidase action and an exopeptidase action. The proteolytic enzyme may be an enzyme having at least one of an endopeptidase action and an exopeptidase action, an enzyme having at least an endopeptidase action is preferable, and has both an endopeptidase action and an exopeptidase action. Enzymes are more preferred. Here, the endopeptidase action is an action of degrading a peptide bond of a non-terminal amino acid, and the exopeptidase action is an action of degrading a peptide bond of a terminal amino acid.

Proteolytic enzymes include an enzyme having only an exopeptidase action, an enzyme having only an endopeptidase action, and an enzyme having both an endopeptidase action and an exopeptidase action. An enzyme having both an endopeptidase action and an exopeptidase action is referred to as "an enzyme having an endopeptidase action" when the endopeptidase action is stronger, and an "exopeptidase action when the exopeptidase activity is stronger". And an enzyme having both an endopeptidase action and an exopeptidase action when the exopeptidase action and the endopeptidase action are equal or almost equal. The term “equivalent or almost equivalent” means that the ratio of endopeptidase action to exopeptidase action (activity ratio) is 0.8 to 1.2 times.

Examples of the enzyme having an endopeptidase action include, for example, animal-derived endopeptidase (eg, trypsin, chymotrypsin, etc.), plant-derived endopeptidase (eg, papain, etc.), or lactic acid bacterium, yeast, mold, Bacillus subtilis or actinomycete, etc. Endopeptidase derived from the microorganism of More specific examples of the enzyme having an endopeptidase action include peptidases produced by Bacillus subtilis (trade names: orientase 22BF, nuclysin), peptidases produced by Bacillus licheniformis (trade name). : Alcalase), peptidases produced by Bacillus stearothermophilus (trade name: Protease S), peptidases produced by Bacillus amyloliquefaciens (trade name: peptidases produced by Bacillus amyloliquefaciens), peptidases produced by Bacillus amyloliquefaciens, and peptidases produced by Bacillus pterase. Name: Protamex).

Examples of the enzyme having an exopeptidase action include carboxypeptidase, aminopeptidase, or exopeptidase derived from microorganisms such as lactic acid bacteria, Aspergillus spp. or Rhizopus spp. More specific examples of the enzyme having an exopeptidase action include peptidases produced by Aspergillus oryzae (trade names: Umamizyme G, Promod 192P, Promod 194P, Sumiteam FLAP), Aspergillus sopelus asuper (Aspergillus sopelus). (Product name: Sternzyme B15024), Aspergillus genus-produced peptidase (Product name: Coculase P), Rhizopus oryzae-produced peptidase (Product name: Peptidase R).

Examples of the enzyme having both endopeptidase action and exopeptidase action include pancreatin, pepsin and the like. More specific examples of the enzyme having both endopeptidase action and exopeptidase action include Streptomyces griseus-produced peptidase (trade name: actinase AS) and Aspergillus oryzae produced. Peptidase (trade name: Protease A, flavorzyme) and peptidase produced by Aspergillus melleus (trade name: Protease P) can be mentioned.

Reaction conditions for treating royal jelly with a proteolytic enzyme (amount of proteolytic enzyme used, reaction temperature, pH, reaction time, etc.) may be appropriately set according to the type of proteolytic enzyme to be used. .. As specific reaction conditions, for example, when using actinase AS (Kaken Pharmaceutical Co., Ltd.) having both endopeptidase action and exopeptidase action as a proteolytic enzyme, the amount of the proteolytic enzyme used is 1 g per 100 g of royal jelly, and the temperature during the reaction is For example, 45 to 55° C., pH 8.5 to 9.5, and reaction time 2 to 4 hours can be exemplified.

The royal jelly organic solvent extract can be obtained, for example, by extracting royal jelly using an organic solvent such as ethanol, methanol, propanol, or acetone as a solvent. The extraction time can be appropriately set according to the form of the royal jelly used as a raw material, the type and amount of the solvent, the temperature and the stirring conditions during the extraction, and the like. After extraction, the solid content may be removed by filtration, centrifugation or the like. The extracted solution may be used as it is, or the solvent may be removed from the solution and used as a concentrated liquid or powder. The royal jelly organic solvent extract is preferably a royal jelly ethanol extract.

As the royal jelly and the processed product of the royal jelly, commercially available products may be used. Specific examples of royal jelly and processed products of royal jelly include, for example, royal jelly FD powder (manufactured by Nakahara Co., Ltd.), royal jelly extract SF (manufactured by Matsuura Pharmaceutical Co., Ltd.), deproteinized royal jelly powder F (manufactured by Maruzen Pharmaceutical Co., Ltd.), Deproteinized royal jelly extract (manufactured by API Corporation) and the like can be mentioned.

The dizziness improving agent of the present invention contains royal jelly or a processed product of royal jelly as an active ingredient, and therefore improves dizziness, that is, suppressing the occurrence of dizziness, reducing the frequency of dizziness, dizziness. The symptoms of can be reduced.

Dizziness can be classified into vertigo, floating dizziness, lightheadedness, etc. according to the symptoms. A typical symptom of vertigo is the perception of oneself or the surroundings. A typical symptom of dizziness is that the body feels fluffy with a fluffy feeling, or feels like a staggering, non-rotating wobble. Typical symptoms of light-headedness include bloodiness, dark vision (blackout), and fainting.

The dizziness-improving agent of the present invention can significantly improve the symptom of being aware that oneself or the surroundings are rotating, and the symptom of blackout of the visual field. Therefore, for improving dizziness (that is, dizziness-improving agent). , And can be preferably used as a lightness-improving agent (that is, a lightness-improving agent).

The dizziness improving agent of the present invention may contain only royal jelly or a processed product of royal jelly which is an active ingredient, and may further contain other components as long as the effects of the present invention are not impaired. Other components include, for example, pharmaceutically acceptable components (eg, excipients, binders, lubricants, disintegrants, emulsifiers, surfactants, bases, solubilizers, suspending agents). , Food acceptable ingredients (for example, minerals, vitamins, flavonoids, quinones, polyphenols, amino acids, nucleic acids, essential fatty acids, cooling agents, binders, sweeteners, disintegrating agents, lubricants, coloring agents , Perfumes, stabilizers, preservatives, sustained release regulators, surfactants, solubilizers, wetting agents).

The dizziness improving agent of the present invention can be used in an amount of 1 mg or more and 10 g or less per day for an adult with a body weight of 60 kg, preferably 50 mg or more and 8 g or less, and 300 mg or more and 3 g or less in terms of the amount of active ingredient. More preferably, the dose is 300 mg or more and 1.5 g or less. The dose can be appropriately set within the above range depending on factors such as the health condition of the person who ingests it, the method of administration and the combination with other agents.

The dizziness improving agent of the present invention may be orally (ingested) or parenterally administered. The dizziness improving agent of the present invention may be administered once a day if the amount of the active ingredient per day is within the above range, or divided into a plurality of times such as twice a day, three times a day and the like. It may be administered.

Since the dizziness-improving effect is more prominent, the dizziness-improving agent of the present invention may be orally administered once a day in an amount of 300 mg or more and 1.5 g or less to an adult with a body weight of 60 kg in terms of the amount of active ingredient. It is preferably used.

The dizziness improver of the present invention may be in any form such as solid, liquid and paste. The form of the dizziness improving agent of the present invention may be, for example, a plain tablet, a sugar-coated tablet, a granule, a powder, a tablet, or a capsule (hard capsule, soft capsule, seamless capsule). The dizziness improving agent of the present invention can be prepared, for example, by mixing royal jelly as an active ingredient or a processed product of royal jelly and, if necessary, other ingredients and shaping the mixture into the above dosage form.

The dizziness-improving agent of the present invention can be used as a drug, a quasi drug and a food itself, and can also be added to a drug, a quasi drug and a food for use. The food is preferably a food in which the tertiary function of the food (physical condition adjusting function, that is, dizziness improving function, etc.) is emphasized. Examples of foods in which the tertiary function of foods is emphasized include health foods, functional foods, dietary supplements, supplements, and foods for specified health uses.

Drugs, quasi drugs or foods comprising the dizziness improver of the present invention, or drugs, quasi drugs or foods containing the dizziness improver of the present invention are for dizziness improvement, vertigo dizziness improvement, or dizziness improvement. It may be for use, and a display such as “to improve dizziness” or “to improve lightheadedness” may be attached.

The content of the dizziness improving agent of the present invention in medicines, quasi-drugs and foods depends on the types of medicines, quasi-drugs and foods so that the amount of the active ingredient ingested per day falls within the range described above. And set appropriately.

When the dizziness improver of the present invention is used as a food itself or added to a food, the form of the food is not particularly limited, and examples thereof include beverages (coffee, juice, soft drinks such as tea drinks, milk drinks, lactic acid bacteria. Beverages, yogurt drinks, carbonated drinks, etc.), spreads (custard cream, etc.), pastes (fruit paste, etc.), Western confectionery (chocolate, donuts, pies, cream puffs, gum, jelly, candy, cookies, cakes, puddings, etc.) , Japanese sweets (Daifuku, rice cakes, buns, castella, anmitsu, yokan, etc.), frozen desserts (ice cream, popsicles, sorbets, etc.), foods (curry, beef bowl, porridge, miso soup, soup, meat sauce, pasta, pickles) , Jam, etc.) and seasonings (dressing, sprinkles, umami seasoning, soup base, etc.).

The dizziness improving agent of the present invention is used as a food in which the tertiary function of food is emphasized (for example, a health food, a functional food, a dietary supplement, a supplement or a food for specified health use) itself, or the tertiary function of food is emphasized. When used by adding to foods, the form of the food in which the tertiary function of the food is emphasized is, in addition to the form of the food described above, for example, plain tablets, sugar-coated tablets, granules, powders, tablets, capsules (hard capsules, Soft capsule, seamless capsule).

When the dizziness improving agent of the present invention is used as a drug or quasi drug itself or added to a drug or quasi drug, the form of the drug or quasi drug is not particularly limited, and for example, an uncoated tablet, It may be a sugar-coated tablet, granule, powder, tablet, capsule (hard capsule, soft capsule, seamless capsule).

The method for producing a drug, quasi drug or food to which the dizziness improving agent of the present invention is added is not particularly limited, and a known method can be appropriately used. For example, by mixing the vertigo of the present invention with an intermediate product or final product in the manufacturing process of a drug, a quasi drug or a food, to obtain a drug, a quasi drug or a food used for the above-mentioned use. You can

Hereinafter, the present invention will be described more specifically based on Examples. However, the present invention is not limited to the following examples.

〔Test method〕
250 healthy volunteers were asked to drink enzyme-degraded royal jelly (trade name: apitherapy-prepared royal jelly powder, manufactured by Yamada Apiary Co., Ltd., 1,333 mg/day) every day for 8 weeks. Conducted a questionnaire to evaluate various symptoms at the time of entry (before the start of drinking) and after drinking for 8 weeks with a 4-level score (1: almost none, 2: rare, 3: occasionally, 4: frequent) did.

A cross tabulation table was created from the questionnaire results, and the scores before and after drinking were analyzed by Wilcoxon signed rank sum test.

Table 1 shows the analysis result of the symptom "Are you aware of yourself and the surroundings?" Table 2 shows the analysis result of the symptom "blackout in the field of view".

By drinking royal jelly, a decrease in the frequency of occurrence of symptoms such as "Are you aware of yourself or your surroundings?" or suppression of the occurrence of symptoms was observed, and the symptoms were significantly improved at p=0.0369. (Table 1). Similarly, a decrease in the frequency of occurrence of the "visual blackout" symptom or suppression of the occurrence of the symptom was observed, and the symptom was significantly improved at p = 0.0156 (Table 2).

Claims (1)

A vertigo dizziness or lightheadedness- improving agent containing an enzyme-decomposed royal jelly as an active ingredient.