JP6537887B2 - Vertigo improving agent - Google Patents

Description

  The present invention relates to a dizziness improving agent.

  Propolis is known to have many physiological activities such as antibacterial activity and antitumor activity (for example, Patent Documents 1 to 4).

JP, 2005-22994, A Japanese Patent Application Publication No. 2005-60242 JP 2007-131592 A JP 2008-214235 A

  The present invention aims to provide a novel use of propolis.

  The present inventors have found that propolis has an action to improve dizziness. The present invention is based on this novel finding.

  That is, the present invention provides a dizziness improving agent containing propolis or a treated product thereof as an active ingredient.

  The dizziness improving agent of the present invention can also be used as a dizziness improving food, a health food, a functional labeling food (functional food), a nutritional supplement, a supplement or a food for specific health or a medicine. Propolis is conventionally used as a food or the like, and its safety to the living body has been established. Therefore, the food for improving dizziness, health food, functional indication food (functional food), dietary supplement, supplement, or food for specific health use or medicine can be taken continuously for a long period of time.

  According to the present invention, there is provided a dizziness improving agent containing propolis or a treated product thereof as an active ingredient.

  Hereinafter, modes for carrying out the present invention will be described in detail. However, the present invention is not limited to the following embodiments.

  The dizziness improving agent of the present invention contains propolis or a treated product thereof as an active ingredient.

  Propolis is a resinous or waxy substance that constitutes the nest wall of a bee nest. It is known that propolis contains cinnamic acid derivatives, flavonoids, vitamins, minerals and the like. The propolis may be of any origin, such as Brazil, China, European countries, Oceania, American, etc. In addition, propolis may be derived from any plant, such as derived from alexin or eucalyptus. Among these, propolis from Brazil is preferable because the plant of origin is Baccharis dracunculifolia (Baccharis dracunculifolia) of the genus Asteraceae and contains a large amount of cinnamic acid derivative such as altepilin C. Also, propolis may be any rank such as super green and ultra green. There are no particular limitations on the type of honey bee used to collect propolis, and examples include honey bees and African bee bees. Among these, African bee honeybees (Apis mellifera; crosses between African honeybees and honeybees) that produce propolis from Brazil are preferable. Propolis can be obtained, for example, as a beekeeping product in accordance with the ordinary law.

  The propolis may be a propolis raw mass, and the propolis raw mass is subjected to processing such as grinding, supercritical extraction, extraction of water or hydrophilic organic solvent, concentration or pulverization of extract, granulation of powder, etc. It may be a propolis treated product. Among these, the hydrophilic organic solvent extract obtained by the hydrophilic organic solvent extraction of propolis is preferable because the active ingredient of propolis is efficiently extracted in a short time and in a well-balanced manner. As a hydrophilic organic solvent used for extraction, ethanol is preferable.

  The propolis or propolis treated products may be commercially available ones. Specific examples of propolis or propolis treated products include, for example, Propolis 300 from Yamada Apiary, Propolis Solution 30 (Brazil), Propolis Help, Propolis Granules, Propolis Granule APC, Propolis Mild, Propolis Drink, etc. .

  For the vertigo improving agent of the present invention, the above-mentioned propolis raw mass or a treated product of propolis may be used in the form of only one type, or two or more types of forms may be used in combination.

  Since the dizziness improving agent of the present invention contains propolis or a treated product of propolis as an active ingredient, it improves dizziness, that is, suppressing the occurrence of dizziness, reducing the frequency of occurrence of dizziness, and dizziness Can reduce the symptoms of

  The dizziness improving agent of the present invention may contain only the active ingredient propolis or a treated product of propolis, and may further contain other components as long as the effects of the present invention are not impaired. As other ingredients, for example, pharmaceutically acceptable ingredients (eg, excipients, binders, lubricants, disintegrants, emulsifiers, surfactants, bases, solubilizers, suspending agents) Food-acceptable ingredients (eg, minerals, vitamins, flavonoids, quinones, polyphenols, amino acids, nucleic acids, essential fatty acids, refreshing agents, binders, sweeteners, disintegrants, lubricants, coloring agents Perfumes, stabilizers, preservatives, sustained release modifiers, surfactants, solubilizers, wetting agents).

  The dizziness improving agent of the present invention can be used at a dose of 1 mg or more and 10 g or less per day for adults weighing 60 kg, preferably 50 mg or more and 8 g or less, preferably 150 mg or more and 3 g or less. It is more preferable to use a dose, and it is further preferable to use a dose of 150 mg or more and 1.5 g or less. The said dose can be suitably set within the said range according to factors, such as a person's health condition ingested, a method of administration, and a combination with other agents.

  The dizziness improving agent of the present invention may be administered orally (ingested) or parenterally. The dizziness improving agent of the present invention may be administered once a day, or twice a day, three times a day, etc., as long as the amount of active ingredient per day is within the above range. It may be administered.

  Since the dizziness improving effect is more remarkably exhibited, the dizziness improving agent of the present invention is orally administered once a day at a dose of 150 mg or more and 1.5 g or less to an adult weighing 60 kg in terms of the active ingredient amount. Preferably it is used.

  The dizziness improving agent of the present invention may be in any form of solid, liquid, paste and the like. The form of the dizziness improving agent of the present invention may be, for example, uncoated tablets, dragees, granules, powders, tablets, capsules (hard capsules, soft capsules, seamless capsules). The dizziness improving agent of the present invention can be prepared, for example, by mixing the active ingredient propolis or the treated product of propolis with other ingredients as needed, and shaping into the above dosage form.

  The dizziness improving agent of the present invention can be used as a medicine, quasi-drug and food itself as well as being added to medicine, quasi-drug and food. The food is preferably a food in which the tertiary function of the food (physical conditioning function, ie, dizziness improving function, etc.) is emphasized. Examples of the food in which the tertiary function of the food is emphasized include health food, functional indication food (functional food), nutritional supplements, supplements and food for specific health use.

  The medicine, quasi-drug or food comprising the vertigo improving agent of the present invention, or the medicament, quasi-drug or food comprising the vertigo improving agent of the present invention may be for improving vertigo; "" Etc. may be attached.

  The content of the dizziness improving agent of the present invention in medicines, quasi-drugs and foods depends on the type of medicine, quasi-drugs and food, etc., so that the amount of active ingredient to be ingested per day falls within the above-mentioned range. It may be set appropriately.

  When the vertigo improving agent of the present invention is used as food itself or added to food, the form of the food is not particularly limited. For example, beverages (coffee, juice, tea beverages, soft drinks such as jelly beverages, milk, milk) Beverages, lactic acid bacteria beverages, yogurt beverages, carbonated beverages etc., spreads (custard cream etc.), pastes (fruit paste etc.), confectionery (chocolate, donuts, pies, cream puffs, gums, jellies, candies, cookies, cakes, Pudding, etc.) Japanese confectionery (Dafuku, rice cake, sea bream, castella, anthlet, sheep meal etc.), ice confectionery (ice cream, ice candy, sherbet etc.), foods (curry, beef porridge, risotto, miso soup, soup, meat sauce, Pasta, pickles, jam, etc., seasonings (dressing, sprinkle, umami seasoning, soup ingredients, etc.) It may be.

  The vertigo improving agent of the present invention is used as a food (for example, health food, functional display food (functional food), nutritional supplement, supplement or food for specific health use) in which the tertiary function of food is emphasized, or in food In addition to the food form mentioned above, the form of the food in which the tertiary function of the food is emphasized is, for example, uncoated tablet, sugar-coated tablet, granules, powder, when added to the food in which the tertiary function is emphasized and used. It may be a tablet or capsule (hard capsule, soft capsule, seamless capsule).

  When the dizziness improving agent of the present invention is used as a drug or quasi drug itself or added to a drug or quasi drug, the form of the drug or quasi drug is not particularly limited. For example, uncoated tablets, It may be a sugar-coated tablet, granule, powder, tablet, capsule (hard capsule, soft capsule, seamless capsule).

  The preparation method of the medicine, quasi-drug or food product to which the vertigo improving agent of the present invention is added is not particularly limited, and any known method can be appropriately used. For example, the vertigo improving agent of the present invention is mixed with an intermediate product or final product in the manufacturing process of pharmaceutical products, quasi-drugs or food to obtain pharmaceuticals, quasi-drugs or food used for the above-mentioned applications. Can.

  Hereinafter, the present invention will be more specifically described based on examples. However, the present invention is not limited to the following examples.

〔Test method〕
Three hundred propolis 300 tablets (226.8 mg / 3 granules propolis extract from Brazil, manufactured by Yamada Apiary Co., Ltd.) were given daily for eight weeks to 150 healthy volunteers. A questionnaire was conducted to evaluate the degree of symptoms of dizziness before and after drinking with a 3-level score (1: present, 2: slightly present, 3: none). From the questionnaire results, cross tabulation table is created with "1: Yes" and "2: Somewhat" as "Yes" and "3: No" as "No", and McNemar's test for the presence or absence of symptoms before and after drinking It analyzed.

  Table 1 shows the analysis results. The shaded area in the table indicates that the improvement was seen after 8 weeks of drinking.

By drinking propolis, it was observed that the frequency of occurrence of dizziness symptoms was reduced or the occurrence of symptoms was suppressed, and it was shown that the symptoms of dizziness were significantly improved.

Claims (3)

A dizziness improving agent comprising one or more of propolis or a treated product thereof as an active ingredient ,
The treated product is obtained by subjecting a propolis mass to processing such as grinding, supercritical extraction, water or hydrophilic organic solvent extraction, concentration or pulverization of an extract, or granulation of a powder. .   A food for improving dizziness, a health food, a functional indication food, a nutritional supplement, a supplement or a food for specific health comprising the dizziness improving agent according to claim 1.   A pharmaceutical product for improving dizziness comprising the dizziness improving agent according to claim 1.