JP2016216391A - Concentration enhancer - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a novel use of propolis.SOLUTION: A concentration enhancer comprises propolis or a processed product thereof as an active ingredient.SELECTED DRAWING: None

Description

  The present invention relates to a concentration enhancer.

  Propolis is known to have many physiological activities such as antibacterial action and antitumor action (for example, Patent Documents 1 to 4).

JP 2005-22994 A Japanese Patent Laid-Open No. 2005-60242 JP 2007-131593 A JP 2008-214235 A

  The object of the present invention is to provide a novel use of propolis.

  The present inventors have found that propolis has an effect of improving concentration. The present invention is based on this novel finding.

  That is, the present invention provides a concentration enhancing agent containing propolis or a processed product thereof as an active ingredient.

  The concentration-enhancing agent of the present invention can also be used as a concentration-enhancing food, health food, functional label food (functional food), dietary supplement, supplement, food for specified health use, or pharmaceutical. Propolis has been conventionally used as food and the like, and safety to living bodies has been established. Therefore, the food for enhancing concentration, health food, functional labeling food (functional food), dietary supplement, supplement, food for specified health use, or medicine can be continuously taken for a long period of time.

  According to the present invention, there is provided a concentration enhancer containing propolis or a processed product thereof as an active ingredient.

  Hereinafter, embodiments for carrying out the present invention will be described in detail. However, the present invention is not limited to the following embodiments.

  The concentration-enhancing agent of the present invention contains propolis or a processed product thereof as an active ingredient.

  Propolis is a resinous or waxy substance that forms the nest wall of the beehive. Propolis is known to contain cinnamic acid derivatives, flavonoids, vitamins, minerals and the like. The propolis may be derived from any production area such as Brazil, China, European countries, Oceania, USA, and the like. Further, the propolis may be derived from any plant such as derived from Aleklin or derived from eucalyptus. Among them, Brazilian propolis is preferable because the source plant is Baccharis dracunculifolia belonging to the genus Bactariaceae and contains a large amount of cinnamic acid derivatives such as Artepilin C. Propolis may have any rank such as super green or ultra green. The kind of bee utilized for collecting propolis is not particularly limited, and examples thereof include honey bees and African bee honey bees. Among these, an African bee that produces Brazilian propolis (Apis mellifera; a hybrid of an African bee and an honey bee) is preferable. Propolis can be obtained, for example, as a beekeeping product according to a conventional method.

  The propolis may be a propolis bulk, and the propolis bulk is subjected to processing such as pulverization, supercritical extraction, water or hydrophilic organic solvent extraction, concentration or pulverization of the extract, and granulation of the powder. It may be a processed propolis. Among these, the hydrophilic organic solvent extract obtained by the hydrophilic organic solvent extraction of propolis is preferable because the active ingredient of propolis is efficiently and well-balanced in a short time. As the hydrophilic organic solvent used for extraction, ethanol is preferred.

  A commercially available product may be used as propolis or a processed product of propolis. Specific examples of propolis or a processed product of propolis include Propolis 300, Propolis liquid 30 (produced in Brazil), Propolis Help, Propolis Granule, Propolis Granule APC, Propolis Mild, Propolis Drink, etc. .

  In the concentration enhancer of the present invention, the above-described propolis bulk or processed product of propolis may be used in only one form, or two or more forms may be used in combination.

  Since the concentration-enhancing agent of the present invention contains propolis or a processed product of propolis as an active ingredient, it can enhance concentration, that is, increase concentration.

  The concentration-enhancing agent of the present invention may contain only propolis which is an active ingredient or a processed product of propolis, and may further contain other ingredients as long as the effects of the present invention are not hindered. . Examples of other components include pharmaceutically acceptable components (for example, excipients, binders, lubricants, disintegrants, emulsifiers, surfactants, bases, solubilizers, suspending agents). , Food-acceptable ingredients (eg minerals, vitamins, flavonoids, quinones, polyphenols, amino acids, nucleic acids, essential fatty acids, cooling agents, binders, sweeteners, disintegrants, lubricants, colorants Fragrances, stabilizers, preservatives, sustained release regulators, surfactants, solubilizers, wetting agents).

  The concentration enhancer of the present invention can be used at a dose of 1 mg or more and 10 g or less per day for an adult weighing 60 kg, preferably in a dose of 50 mg or more and 8 g or less, preferably 150 mg or more and 3 g or less in terms of the amount of active ingredient More preferably, it is used at a dose of 150 mg or more and 1.5 g or less. The dose can be appropriately set within the above-mentioned range depending on factors such as the health condition of the person who ingests, the administration method, and combinations with other agents.

  The concentration enhancing agent of the present invention may be administered orally (ingested) or parenterally, but is preferably used for oral administration. The concentration-enhancing agent of the present invention may be administered once a day as long as the amount of active ingredient per day is within the above-mentioned range, or divided into a plurality of times such as twice a day or three times a day. May be administered.

  Since the concentration enhancing effect is more prominent, the concentration enhancing agent of the present invention is orally administered once a day in an amount of 150 mg to 1.5 g, in terms of active ingredient, to an adult with a body weight of 60 kg. It is preferable to be used.

  The concentration-enhancing agent of the present invention may be in any shape such as solid, liquid, paste and the like. The form of the concentration enhancer of the present invention may be, for example, an uncoated tablet, a sugar-coated tablet, a granule, a powder, a tablet, and a capsule (hard capsule, soft capsule, seamless capsule). The concentration-enhancing agent of the present invention can be prepared by, for example, mixing propolis or a processed product of propolis which is an active ingredient and other components as necessary, and molding the mixture into the above dosage form.

  The concentration-enhancing agent of the present invention can be used as a pharmaceutical, a quasi-drug and a food as well as added to a pharmaceutical, a quasi-drug and a food. The food is preferably a food in which the tertiary function of the food (physical condition adjustment function, ie, concentration enhancement function, etc.) is emphasized. Examples of the food in which the tertiary function of the food is emphasized include health foods, functional indication foods (functional foods), nutritional supplements, supplements, and foods for specified health use.

  The pharmaceutical, quasi-drug or food comprising the concentration enhancer of the present invention, or the pharmaceutical, quasi-drug or food containing the concentration enhancer of the present invention may be for concentration enhancement, An indication such as “improvement” may be attached.

  The content of the concentration-enhancing agent of the present invention in pharmaceuticals, quasi-drugs and foods depends on the types of pharmaceuticals, quasi-drugs and foods, etc. What is necessary is just to set suitably according to.

  When the concentration enhancer of the present invention is used as food itself or added to food, the form of the food is not particularly limited. For example, beverages (soft drinks such as coffee, juice, tea drink, jelly drink, Milk drinks, lactic acid bacteria drinks, yogurt drinks, carbonated drinks, etc., spreads (custard cream etc.), pastes (fruit paste etc.), pastries (chocolate, donuts, pies, cream puffs, gum, jelly, candy, cookies, cakes , Pudding, etc.), Japanese confectionery (Daifuku, rice cake, bun, castella, anmitsu, mutton etc.), ice confectionery (ice cream, popsicle, sherbet, etc.), foods (curry, beef bowl, miso soup, miso soup, soup, meat sauce) , Pasta, pickles, jams, etc.) and seasonings (dressing, sprinkles, umami seasonings, soup ingredients, etc.) It may be.

  The concentration enhancer of the present invention as a food in which the tertiary function of the food is emphasized (for example, health food, functional indication food (functional food), dietary supplement, supplement or food for specified health use) or food In addition to foods with emphasized tertiary function, the form of food with emphasized tertiary function is, for example, uncoated tablets, sugar-coated tablets, granules, powders , Tablet, capsule (hard capsule, soft capsule, seamless capsule).

  When the concentration enhancer of the present invention is used as a pharmaceutical product or quasi-drug itself or added to a pharmaceutical product or quasi-drug, the form of the pharmaceutical product or quasi-drug is not particularly limited. , Sugar-coated tablets, granules, powders, tablets, capsules (hard capsules, soft capsules, seamless capsules).

  The manufacturing method of the pharmaceutical, the quasi-drug, or the food to which the concentration enhancer of the present invention is added is not particularly limited, and can be appropriately followed by a known method. For example, the concentration enhancer of the present invention is mixed with an intermediate product or final product in the manufacturing process of a pharmaceutical product, quasi-drug or food to obtain a pharmaceutical product, quasi-drug or food used in the above-mentioned application. be able to.

  Hereinafter, the present invention will be described more specifically based on examples. However, the present invention is not limited to the following examples.

〔Test method〕
The subjects were 150 healthy volunteers who were allowed to drink 3 capsules of Propolis 300 (manufactured by Yamada Beeyard Co., Ltd., 226.8 mg / 3 capsules of Brazilian propolis extract) every day for 8 weeks. A questionnaire was conducted to evaluate the degree of “not able to concentrate” before and after drinking with a three-level score (1: Yes (can't concentrate), 2: Somewhat (somewhat unable to concentrate), 3: No (can concentrate)). Based on the questionnaire results, a cross tabulation table was created with "1: Yes" and "2: Somewhat" set to "Yes" and "3: No" set to "No", and the presence or absence of symptoms before and after drinking was evaluated using the McNemar test. Analyzed.

  Table 1 shows the analysis results. Shading in the table indicates an improvement after 8 weeks of drinking.

Consumption of propolis was shown to significantly improve concentration.

Claims (3)

  A concentration enhancer containing propolis or a processed product thereof as an active ingredient.   A food for concentration enhancement, a health food, a functional label food, a nutritional supplement, a supplement or a food for specified health use, comprising the concentration enhancer according to claim 1. A pharmaceutical product for enhancing concentration, comprising the concentration enhancer according to claim 1.