JP2003246724A - Whitening cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a whitening cosmetic which prevents inflammation due to ultraviolet rays, inhibits melanogenesis due to ultraviolet impairment, accelerates the excretion of a melanin pigment, realizes excellent whitening effects in a short period, and is excellent in usability and storage stability. <P>SOLUTION: This whitening cosmetic contains (A) an extract of Dioscorea composita and (B) at least one plant extract selected from the group consisting of plant extracts obtained from Panax ginseng C.A.Meyer, wheat germs, Pyracantha fortuneana, Olea europaeaL., and apricots. <P>COPYRIGHT: (C)2003,JPO

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to (A) an extract obtained from Dioscorea composita, and (B) a panax ginseng C.
A. Meyer), wheat germ, fire spines (Pyracantha fortunean)
a), olive (Olea europaea L.), has an excellent whitening effect on the skin, such as preventing the occurrence of pigmentation containing one or more selected from the group consisting of plant extracts obtained from apricots. The present invention relates to cosmetics and quasi-drugs which have low skin irritation and good usability. 2. Description of the Related Art Generally, melanocytes are activated by skin irritation, freckles, etc. due to irritation caused by exposure to ultraviolet rays of the sun, hormonal abnormalities or genetic factors. It is caused by abnormal deposition in the skin. Whitening cosmetics aimed at preventing or improving such abnormal deposition of melanin pigments include L-ascorbic acid or derivatives thereof, hydroquinone derivatives, pyridone of kojic acid, placenta extracts such as placenta extract, and glutathione. And colloidal sulfur. [0003] These substances have effects such as suppression of melanin production and pale bleaching action of the produced melanin, and are widely known as substances having a whitening effect. However, these substances have a low melanin production inhibitory effect, or are easily oxidized and unstable, and furthermore, a peculiar smell or precipitation occurs,
In many cases, the intended drug effect cannot be obtained due to deterioration in the formulation,
The whitening effect on the skin was not always sufficient. [0004] For example, L-ascorbic acid and its derivatives are not sufficiently storage-stable, are particularly vulnerable to heat and oxidation in water, are unstable and do not exert their effects sufficiently, and are not suitable for cosmetics over time. There are problems such as decomposition and coloring. Although arbutin has improved stability against heat and oxidation, it has not always been satisfactory in terms of effects and the like. Further, in addition to these substances, cosmetics aiming at a synergistic effect by using in combination with other active ingredients having a whitening effect such as an ultraviolet ray inhibitor, an anti-inflammatory agent or a placenta extract (for example, Japanese Patent Application Laid-Open No. 186324) and L-
A skin lightening cosmetic which aims at synergistic effect by improving the skin permeability of ascorbic acid by blending urea with ascorbic acid and water-soluble L-ascorbic acid (JP-A-5-229)
927) is also disclosed. However, these cosmetics are inferior in usability and storage stability, and it is difficult to exhibit a high whitening effect. SUMMARY OF THE INVENTION The present inventors have found that the extract obtained from Dioscorea composita has a high tyrosinase activity inhibitory effect and that the extract is High stability and excellent storage stability (Patent No. 3072)
267). However, in order to obtain a practically sufficient whitening effect, it is actually required to further improve the effect. An object of the present invention is to provide an excellent whitening effect in a short period of time by suppressing inflammation caused by ultraviolet rays, suppressing melanin production due to ultraviolet damage and promoting excretion of melanin pigments, and further improving usability and storage stability. To provide a good whitening cosmetic. Means for Solving the Problems The present inventors have conducted intensive studies to solve the above-mentioned drawbacks, and as a result, (A) an extract obtained from a Geoscoria compositor (Dioscorea composita); B) Panax ginseng C.
A. Meyer), wheat germ, fire spines (Pyracantha fortunean)
a), olive (Olea europaea L.), by combining one or two or more selected from the group consisting of plant extracts obtained from apricots, suppresses melanin production due to ultraviolet damage more than when used alone. In addition, the present inventors found that excretion of melanin pigment was promoted, and a whitening effect was synergistically exhibited, and the present invention was completed. That is, the present invention relates to (A) Geoscoria
An extract obtained from a compositor (Dioscorea composita), and (B) Panax ginseng CAMe
yer), wheat germ, fire spines (Pyracantha fortuneana), olives (Olea europaea L.), and one or more selected from the group consisting of plant extracts obtained from apricots. Charge. [0010] An embodiment of the present invention is a whitening cosmetic. Hereinafter, the configuration of the present invention will be described in detail. The dioscorea compositor used in the present invention is a plant belonging to the genus Dioscorea or genus Geoscoria, which is naturally or cultivated in Central America and India. The extract obtained from the Dioscorea composita has the following formula (I): [Wherein, R ^{1 to} R ⁴ each independently represent H or —COR, and R represents an alkyl group having 1 to 20 carbon atoms]. It is. [0013] Geoscoria compositor (Dioscorea)
As a solvent for obtaining an extract from composita), generally, water, alcohols such as methanol, ethanol and isopropyl alcohol, polyhydric alcohols such as ethylene glycol, propylene glycol and 1,3-butylene glycol, acetone Or a mixture of two or more of ketones such as ethyl acetate, esters such as ethyl acetate, ethers such as diethyl ether, and aromatic compounds such as benzene. Geoscoria compositor (Dioscorea)
In general, dried or fresh plants are used as they are or cut, and preferably 100 parts of the above-mentioned extraction solvent is used for 5 to 50 parts on a dry matter basis. As the extraction method, room temperature extraction or heat extraction is used, and the extraction method includes ordinary extraction and Soxhlet extraction. The extraction time is not limited, but is generally 1 hour to
One week is preferred. These extracts may be used as they are, but, if necessary, may be used after further concentration treatment and / or fractionation / purification treatment. For example, a concentrated solution obtained by concentrating them under normal pressure or reduced pressure, or a solid obtained by evaporating the solvent in the concentrated solution to dryness can be used.
Further, a solid obtained by crystallizing the concentrated liquid and then drying by filtration or a solid obtained by freeze-drying the concentrated liquid may be used. Geoscoria compositor (Dioscorea)
The amount of the extract from the composita) to the whitening cosmetic based on dry matter is not particularly limited, but is preferably 0.00001 to 10% by mass, based on the total amount of the whitening cosmetic.
It is more preferably 0.0001 to 5% by mass, and still more preferably 0.001 to 1% by mass. Within this range,
It is sufficient to obtain the effects of the present invention, and has good usability, and can stably maintain individual dosage forms. Also,
When an extract is used, the concentration of the extract is not limited at all if the amount of the dry solid as a solute is within the above range. The Panax ginseng (Pana) used in the present invention is
The extract of x ginseng CAMeyer) is preferably obtained from roots. The active ingredient of Panax ginseng is extracted with n-hexane, concentrated, and further extracted with safflower oil or squalane. The active ingredient of wheat germ used in the present invention is extracted with water, propylene glycol, concentrated glycerin or a mixture thereof. The fire spines used in the present invention (Pyracantha for
tuneana) is a member of the Rosaceae Pyracantha genus. As the extract, those obtained from fruits are preferable. The active ingredient of the fire thorn fruit (Chinese medicine name “Aka Yoko”) is extracted with water or a lower alcohol such as methanol, ethanol, propanol, or a mixture thereof. The olive used in the present invention (Olea europ)
aeaL.) is preferably an extract obtained from branches and / or leaves. The active ingredient of olive branches and / or leaves is extracted with water or a lower alcohol such as methanol, ethanol or propanol, or a mixture thereof. The apricot extract used in the present invention includes Prunus armeniaca L., Mocoans (Prunus sibirica L.) and Manshu apricot (Prunus m.
and those obtained from fruits of closely related plants. The active ingredients of these fruits are squeezed or extracted with water, propylene glycol, 1,3-butylene glycol, other lower alcohols, or a mixture thereof. These plant extracts can be used as they are in whitening cosmetics. However, it is preferable to use them after powdering them by freeze-drying or spray-drying. Further, the extract may be purified by means of liquid-liquid distribution, adsorption chromatography or the like, and a liquid or powdered product may be blended. The blending amount is not particularly limited, but is 0.0001 to 10% by mass, preferably 0.001% by mass in terms of the dry solid content of the extract in the total amount of the whitening cosmetic.
To 5% by mass, more preferably 0.01 to 2% by mass. Within this range, each dosage form can be kept stable and a high whitening effect can be obtained. When an extract is used, the concentration of the extract is not limited at all, as long as the amount of the dry solid as a solute is within the above range. In the present invention, it is preferable to further contain a whitening agent, an ultraviolet ray protective agent, an antioxidant, a humectant, a blood circulation promoting agent and the like used in ordinary cosmetics and quasi-drugs. Examples of the whitening agent include water-soluble or oil-soluble ascorbic acid and its derivatives, arbutin, glutathione, placenta extract, saxifrage extract, yoquinin extract, pentagon extract and seaweed extract. Of these, particularly preferred are water-soluble ascorbic acid derivatives. As the water-soluble ascorbic acid derivative, for example, L-ascorbic acid and its sodium salt, potassium salt, magnesium salt, calcium salt,
Barium salt, ammonium salt, monoethanolamine salt, diethanolamine salt, triethanolamine salt,
Monoisopropanolamine salt, triisopropanolamine salt, sodium salt, potassium salt, magnesium salt, calcium salt of L-ascorbic acid-2-phosphate,
Barium salt, ammonium salt, monoethanolamine salt, diethanolamine salt, triethanolamine salt,
Monoisopropanolamine salt, triisopropanolamine salt; sodium, potassium, magnesium, calcium, barium, ammonium, monoethanolamine salts of L-ascorbic acid-2-sulfate;
Diethanolamine salts, triethanolamine salts, monoisopropanolamine salts, triisopropanolamine salts; and ascorbic acid sugar derivatives such as L-ascorbic acid-2-O-glucoside. Among these water-soluble ascorbic acid derivatives, sodium L-ascorbic acid phosphate, magnesium L-ascorbic acid phosphate, L-ascorbic acid-2-O-
Glucosides are particularly preferred. The amount of these components is 0.001 to 30% in the total amount of the whitening cosmetic (as a dry solid in the case of a plant extract).
% By mass, more preferably 0.1 to 10% by mass
It is. Within this range, a sufficient whitening effect can be obtained, as well as excellent usability and storage stability. Examples of the ultraviolet ray protective agent include inorganic and organic ultraviolet ray protective agents. Examples of inorganic systems include
For example, metal oxides such as titanium dioxide, lower titanium oxide, zinc oxide and cerium oxide; metal hydroxides such as iron hydroxide;
Metal flakes such as plate-like iron oxide and aluminum flake; and ceramics such as silicon carbide. These powders may be subjected to a conventionally known surface treatment, for example, a fluorine compound treatment (perfluoroalkyl phosphate treatment, perfluoroalkylsilane treatment, perfluoropolyether treatment, fluorosilicone treatment, fluorinated silicone resin treatment), silicone Treatment (preferably methylhydrogenpolysiloxane treatment, dimethylpolysiloxane treatment, vapor-phase tetramethyltetrahydrogencyclotetrasiloxane treatment), silicone resin treatment (preferably trimethylsiloxysilicic acid treatment), pendant treatment (vapor-phase silicone A method of adding an alkyl chain or the like after the treatment), a silane coupling agent treatment, a titanium coupling agent treatment, a silane treatment (preferably an alkylsilane or an alkylsilazane treatment), an oil treatment, a polyacrylic acid treatment, and gold. Soap treatment (stearic acid or myristic acid salts are preferred), acrylic resin treatment, preferably subjected to a surface treatment with a metal oxide treatment or the like, more preferably,
It is preferable to use a plurality of these processes in combination. Examples of the organic UV protective agent include, for example, 2-ethylhexyl paramethoxycinnamate (alias: octyl paramethoxycinnamate), 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone- 5-sulfuric acid, 2,2'-dihydroxy-4
-Methoxybenzophenone, p-methoxyhydrocinnamic acid diethanolamine salt, paraaminobenzoic acid (hereinafter abbreviated as PABA), ethyldihydroxypropyl P
ABA, glyceryl PABA, homomenthyl salicylate, methyl-O-aminobenzoate, 2-ethylhexyl-2-cyano-3,3-diphenyl acrylate,
Octyl dimethyl PABA, octyl salicylate, 2-
Phenyl-benzimidazole-5-sulfate, triethanolamine salicylate, 3- (4-methylbenzylidene) camphor, 2,4-dihydroxybenzophenine,
2,2 ′, 4,4′-tetrahydroxybenzophenone,
2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2-hydroxy-4-N-octoxybenzophenone, 4-isopropyldibenzoylmethane, butylmethoxydibenzoylmethane, octyltriazone,
4- (3,4-dimethoxyphenylmethylene) -2,5
-Dioxo-1-imidazolidine 2-ethylhexyl propionate, polymer derivatives thereof, and silane derivatives. These UV protective agents can be used alone or in combination of two or more. The amount of these components is preferably 0.1 to 40% by mass, particularly 0.1 to 30% by mass, and more preferably 1 to 20% by mass based on the total amount of the whitening cosmetic. Within this range, a sufficient whitening effect can be obtained, as well as excellent usability and storage stability. Among these ultraviolet inhibitors, particularly preferred are fine particle titanium oxide, fine particle zinc oxide, flaky zinc oxide, fine particle iron oxide, 2-ethylhexyl paradimethylaminobenzoate, 2-ethylhexyl paramethoxycinnamate, Benzophenone, 4-tert-butyl-4 '
-Methoxy-dibenzoylmethane, 2,4,6-trianilino-p- (carbo-2'-ethylhexyl-1'-
Oxy) 1,3,5-triazine, butylmethoxydibenzoylmethane, oxybenzone, benzophenone-based ultraviolet absorber and the like. Antioxidants include tocopherols such as α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol; α-carotene, β-tocopherol
Carotene, γ-carotene, lycopene, cryptoxanthin, lutein, zeaxanthin, isoseaxanthin,
Carotenoids such as rhodoxanthin, capsanthin and crocetin; flavonoids such as rutin; tannins such as tannic acid, epicatechin, epicarcatechin, epicatechin gallate, epicarocatechin gallate; , Carotropin, digitoxin,
And saponins such as digitonin, ziconin, digitalin and the like. These antioxidants can be used alone or in combination of two or more.
The amount is preferably 0.0001 to 5% by mass, more preferably 0.0001 to 3% by mass, based on the total amount of the whitening cosmetic (in the case of a plant extract, as a dry solid content). Within this range, a high whitening effect can be expected and a whitening cosmetic excellent in usability can be obtained. Furthermore, it is preferable to use these antioxidants together with ascorbic acid, citric acid, succinic acid, malonic acid, maleic acid, etc., which significantly improves the antioxidant properties, synergistically enhances the whitening effect, and improves usability and storage. A whitening cosmetic having good stability can be obtained. As humectants, glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, isoprene glycol,
Polyhydric alcohols such as POE methylglucoside; biopolymers such as sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, bovine submandibular gland mucin, hydrolyzed eggshell membranes; mixed isomerized sugar, trehalose, sulfated Sugars such as trehalose, pullulan and maltose; other amino acids, sodium lactate, urea,
And sodium pyrrolidonecarboxylate, trimethylglycine and the like. In addition, animal and vegetable oils and fats as oil components,
Hydrocarbons, esters, silicones, fluorinated oils, sebum components and intercellular lipid analogs (eg sphingolipids,
Ceramide, cholesterol and its derivatives, and phospholipids and its derivatives). Furthermore, anti-inflammatory agents such as ε-aminoaproic acid, glycyrrhizic acid, β-glycyrrhetinic acid, lysozyme chloride, guaiazulene, hydrocortidine and the like are also included. These humectants can be used alone or in combination of two or more. Among them, the amount of the humectant other than the polyhydric alcohol and the oil component is as follows (in the case of a plant extract, dry solids). 0.001 in the total amount of whitening cosmetics
The amount is preferably from 10 to 10% by mass, particularly preferably from 0.01 to 8% by mass, more preferably from 0.01 to 5% by mass, from the viewpoints of usability and storage stability. In the case of a polyhydric alcohol or an oil component, it is preferably used in an amount of 0.01 to 75% by mass based on the total amount of the whitening cosmetic, particularly 0.01 to 50% by mass, more preferably 0.05 to 20% by mass. It is more preferable in view of the properties and storage stability. Γ-oryzanol,
Vitamin E derivatives, tocopherol nicotinate, tocopherol acetate, and plant extracts include assembly extract, hypericum extract, ginkgo extract, arnica extract, china extract, hamamelis extract, calendula officinalis, malonier extract, emmeiso extract, salvia extract, and hamaboufu Extract, sansho extract, rice germ oil, bodhi extract, ginger tincture, clove extract and the like. These blood flow enhancers can be used alone or in combination of two or more.
The amount is preferably 0.001 to 10% by mass, particularly 0.01 to 5% by mass, more preferably 0.05 to 3% by mass in the total amount of the whitening cosmetic (in the case of a plant extract, as a dry solid content). A whitening cosmetic which can be expected to have a high whitening effect and is excellent in usability and storage stability is obtained. In the whitening cosmetic composition of the present invention, in addition to the above-mentioned raw materials, a surfactant, a tackifier, a powder, a pigment, a coloring agent, a preservative, a bactericide, a fragrance, etc. achieve the object of the present invention. It can be appropriately compounded within the range. Examples of the surfactant include fatty acid soap, sodium cetyl sulfate, N-stearoyl-L
An anionic surfactant such as sodium glutamate;
Polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene polyhydric alcohol fatty acid ester, polyoxyethylene hydrogenated castor oil,
Nonionic surfactants such as polyhydric alcohol fatty acid esters and polyglycerin fatty acid esters; cationic surfactants such as tetraalkylammonium salts; betaine type;
Amphoteric surfactants such as sulfobetaine type and sulfoamino acid type; and natural surfactants such as lecithin and lysophosphatidylcholine. These surfactants can be used alone or in combination of two or more. The amount of the surfactant is preferably 0.01 to 20% by mass, more preferably 0.1 to 5% by mass, based on the total amount of the whitening cosmetic. Within this range, the usability and storage stability are excellent, which is preferable. Examples of the above-mentioned adhesives include gum arabic, tragacanth, arabinogalactan, locust bean gum (carob gum), guar gum, karaya gum, carrageenan, pectin, agar, quince seed (quince), starch (rice, corn, potato). , Wheat), alge colloid, tranto gum, locust bean gum, etc .; plant macromolecules; xanthan gum, dextran, succinoglucan, pullulan, etc .; microbial macromolecules; collagen, casein, albumin, etc .; animal macromolecules; carboxymethyl starch , Starch-based polymers such as methyl hydroxypropyl starch; methyl cellulose, ethyl cellulose, methyl hydroxypropyl cellulose, carboxymethyl cellulose, hydroxymethyl cellulose, hydroxy Cellulose polymers such as propyl cellulose, nitrocellulose, sodium cellulose sulfate, sodium carboxymethyl cellulose, crystalline cellulose and cellulose powder; alginic acid polymers such as sodium alginate and propylene glycol alginate; polyvinyl methyl ether, polyvinyl pyrrolidone, carboxyvinyl polymer Vinyl polymers such as polyethylene glycol; polyoxyethylene polymers such as polyethylene glycol; polyoxyethylene polyoxypropylene copolymer polymers; acrylic polymers such as sodium polyacrylate, polyethyl acrylate, and polyacrylamide; Polyethyleneimine, cationic polymer, bentonite, aluminum magnesium silicate, laponite, smectite, saponite, hectorite, Inorganic viscosity agent such as water silicic acid and the like. Other viscosity agents include oil-soluble gelling agents, for example, metal soaps such as aluminum stearate, magnesium stearate and zinc myristate; N-lauroyl-L-glutamic acid, di-n-butylamine Dextrin fatty acid esters such as dextrin palmitate, dextrin stearate, dextrin 2-ethylhexanoate palmitate; sucrose fatty acid esters such as sucrose palmitate and sucrose stearate; monobenzylidene Benzylidene derivatives of sorbitol such as sorbitol and dibenzylidene sorbitol; dimethylbenzyl dodecylammonium montmorillonite clay, dimethyldioctadecyl ammonium montmorillonite, octane Organically-modified clay minerals such as decyl dimethyl benzyl ammonium montmorillonite and the like. These tackifiers can be used alone or in combination of two or more. The compounding amount of these adhesives is 0.01 to 30% by mass, especially 0.1 to 30% by mass based on the total amount of the whitening cosmetic.
The content is preferably set to 1 to 15% by mass. Within this range, the moisturizing effect, the usability and the storage stability are excellent, which is preferable. The powder is not particularly limited and may be any of an inorganic fine powder and an organic fine powder, and may have any shape such as a spherical shape, a flat shape, a granular shape, a needle shape, a rod shape, and an amorphous shape. As the inorganic powder, titanium oxide, zirconium oxide, zinc oxide, cerium oxide, magnesium oxide, barium sulfate, calcium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, silicic acid, silicic anhydride,
Aluminum silicate, magnesium silicate, aluminum magnesium silicate, calcium silicate, barium silicate, strontium silicate, metal tungstate,
Hydroxyapatite, vermiculite, heidilite, bentonite, montmorillonite, hectorite,
Zeolite, ceramic powder, dicalcium phosphate, alumina, aluminum hydroxide, boron nitride, silica, etc .; as organic powder, polyamide powder, polyester powder, polyethylene powder, polypropylene powder, polystyrene powder, polyurethane powder, benzoguanamine powder, polymethyl Benzoguanamine powder, polytetrafluoroethylene powder, polymethyl methacrylate powder, cellulose, silk powder, nylon powder, 12 nylon, 6 nylon, styrene / acrylic acid copolymer, divinylbenzene / styrene copolymer, vinyl resin, urea resin, Phenol resin, fluorine resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, microcrystalline fiber powder, starch Etc. The. These powders can be used alone or in combination of two or more. Further, even those which have been subjected to surface treatment such as fluorine treatment by silicone treatment, metal soap treatment, amino acid treatment, fatty acid treatment, alkyl phosphate ester treatment, N-acyl glutamic acid treatment, perfluoroalkyl phosphate ester treatment, etc. Good.
The mixing amount of these powders is 0.001 in the total amount of the whitening cosmetic.
It is preferable to set it to 50 mass%, especially 0.005-30 mass%. Within this range, the usability and the storage stability are excellent, which is preferable. Specific examples of the pigments and coloring agents include, as colored pigments, inorganic red pigments such as iron oxide, iron hydroxide and iron titanate; inorganic brown pigments such as γ-iron oxide; Inorganic yellow pigments such as loess; inorganic black pigments such as black iron oxide and carbon black; inorganic purple pigments such as manganese violet and cobalt violet; inorganic green pigments such as chromium hydroxide, chromium oxide, cobalt oxide, and cobalt titanate Inorganic blue pigments such as navy blue and ultramarine blue; tar-based pigments raked, natural pigments raked, and synthetic resin powders obtained by combining these powders; fine titanium oxide, fine particles Fine powders of zinc oxide, fine cerium oxide, fine silicon dioxide, etc .; aluminum powder, copper powder, stainless steel powder, etc. as metal powder pigments; tar As arsenide, Red No. 3, Red 104
No., Red No. 106, Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red No. 220, Red No. 226
No., Red No. 227, Red No. 228, Red No. 230, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Yellow No. 2
No. 04, Blue No. 1, Blue No. 2, Blue No. 201, Green No. 3
No., Green No. 201, Green No. 204, Green No. 205, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 206
No. 207, etc .; natural pigments include carminic acid,
Raccaic acid, calsamine, bradylin, crocin and the like. These pigments and coloring agents can be used alone or in combination of two or more. The amount of these pigments and coloring agents is 0.001% of the total amount of the whitening cosmetic.
It is preferable to set it to 50 mass%, especially 0.005-30 mass%. Within this range, the usability and the storage stability are excellent, which is preferable. Examples of the preservative include paraoxybenzoic acid esters such as methylparaben, ethylparaben, propylparaben and butylparaben, phenoxyethanol, ethanol, dehydroacetic acid and the like. These can be used alone or in combination of two or more. As fungicides, benzalkonium chloride,
Isopropylmethylphenol, triclosan, trichlorocarbanilide, chlorhexidine hydrochloride, benzethonium chloride and the like. These can be used alone or in combination of two or more. The whitening cosmetic of the present invention can be produced according to a conventional method. Further, the whitening cosmetic of the present invention is not limited to general whitening cosmetics, but also includes quasi-drugs, and the dosage form can be arbitrarily selected according to the purpose. It can be in the form of cream, ointment, emulsion, lotion, solution, gel, pack, powder, stick, etc. The present invention will be described below in detail based on examples and comparative examples. The fragrance used in the following examples is as follows. [Table 1] Preparation Method The method for preparing the plant extract used in the following examples is as follows, but the scope of the present invention is not limited only to these. (Preparation method of Panax ginseng extract) 100 mL of a mixture of water and ethanol (50:50) was added to 10 g of ground Panax ginseng, and the mixture was extracted at room temperature with occasional stirring for 24 hours. Filter this,
After concentration under reduced pressure, the residue was freeze-dried to obtain 2.5 g of a dry powder. (Preparation of Wheat Germ Extract) Wheat Germ 50
g is immersed in 1 L of water and left for one day while stirring. The obtained liquid was concentrated and then filtered. As a result, 15.7 g (0.16 g in terms of solid matter) of a wheat germ extract was obtained. (Preparation method of fire spine extract) 5.00 g of dried fire spine fruit was immersed in 50 mL of hot water at 90 ° C., boiled for 3 hours and filtered, and the obtained extract was treated with Diaion HP-
20 [Mitsubishi Kasei Kogyo] column (Φ3cm × 11c)
(m, Vt = 80 mL) and washed with 800 mL of a 10% aqueous ethanol solution. Then 400 mL of 40
The eluate was concentrated under reduced pressure and lyophilized to give 1.04 g of a solid. (Preparation method of olive leaf extract) 50 g of olive branches and leaves were extracted by refluxing with 50 vol% ethyl alcohol, filtered, concentrated under reduced pressure, and freeze-dried to obtain 2.1 g of a solid. (Preparation method of apricot extract)
unus armeniaca L.) was squeezed, and the resulting juice was concentrated under reduced pressure to obtain 10.2 g of apricot juice (in terms of solid matter: 1.2 g). (Preparation of Geoscoria Composite Extract) A dried Geoscoria composite (Dioscorea
composita) was placed in a water / ethanol (1: 1, volume ratio) solvent (1 liter), extracted with stirring at room temperature for 24 hours, filtered, and the filtrate was collected and lyophilized to obtain a powder. 28 g of a solid were obtained. The skin color lightness recovery test method and sensory test (whitening effect) described in the examples are as follows. (1) Skin Color Brightness Recovery Test The back skin of 20 subjects was irradiated with ultraviolet rays in the UV-B region twice as much as the minimum erythema dose, a sample application site and a non-application site were set, and each skin was examined. The reference lightness (V0 value, V0 'value) was measured. Subsequently, the sample was applied twice a day to the application site.
After continuous application for 5 weeks, the lightness (Vn value, Vn) of the skin at the application site and the non-application site after 3, 6, 9, 12, and 15 weeks
n ′ value) was measured, and the recovery of skin color was evaluated according to the following criteria. The lightness of the skin (Munsell color system V
Values) were calculated from the X, Y, and Z values obtained by measuring with a high-speed spectral colorimeter. The evaluation was shown as an average value of the evaluation points after 3 weeks for 20 subjects. Evaluation Point Judgment Criteria Samples whose difference in skin lightness recovery value for each week satisfies the following formula: 5 ΔV−ΔV ′ ≧ 0.12 4 0.12> ΔV−ΔV ′ ≧ 0.08 3 0.08> ΔV− ΔV ′ ≧ 0.04 2 0.04> ΔV−ΔV ′ ≧ 0 10> ΔV−ΔV ′ ΔV ... Recovery value of applied part (Vn-V0) ΔV '... Recovery value of non-applied part (Vn'-V0) (2) Sensory test Twenty test subjects evaluated the characteristics of the sample after continuously using the sample for 10 days. The evaluation was shown by the number of respondents who answered "the whitening effect was felt" to the questionnaire item of the whitening effect. Examples 1 to 5 and Comparative Examples 1 to 6 Skin creams were prepared according to the formulation shown in Table 2 by a conventional method. The above test was performed for each, and the results are shown in Table 3.
It was shown to. [Table 2] [Table 3] Characteristics The skin creams of Examples 1 to 5 of the present invention showed good results in the above tests. In addition, the skin cream was placed in a thermostat at 0 ° C. and 45 ° C., and daily observation was performed. No abnormalities such as discoloration, odor, and phase separation were observed even after 4 months. Furthermore, no side effects were observed in the subjects, and the skin irritation and sensitization were excellent. On the other hand, the skin creams of Comparative Examples 1 to 6 did not show a sufficient effect, and were inferior to the examples of the present invention. Example 6 (Skin lotion) A skin lotion was prepared according to the formulation shown in Table 4 by a conventional method. [Table 4] Properties The skin lotion of Example 6 showed good results in the above-mentioned tests, and was also excellent in storage stability at low and high temperatures and in usability. Example 7 (Day Essence) According to the formulation shown in Table 5, a day essence (daytime serum) was prepared by a conventional method. [Table 5] Properties The de-essence of Example 7 showed good results in the above-mentioned tests, and was also excellent in storage stability at low and high temperatures and in usability. Example 8 (Two-layer lotion) A two-layer lotion was prepared according to the formulation shown in Table 6 by a conventional method. [Table 6] Properties The two-layer lotion of Example 8 exhibited a good whitening effect in the above-mentioned tests, and was also excellent in storage stability at low and high temperatures and in usability. Example 9 (Sunscreen) A sunscreen was prepared according to the formulation shown in Table 7 by a conventional method. [Table 7] Properties The sunscreen cream of Example 9 exhibited a good whitening effect in the above-mentioned tests, and was also excellent in storage stability at low and high temperatures and in usability. Example 10 (Pack) A pack was prepared according to the formulation shown in Table 8 by a conventional method. [Table 8] Characteristics The pack of Example 10 exhibited a good whitening effect in the above-mentioned tests and was excellent in usability. As described above, the whitening cosmetic composition of the present invention comprises (A) a dioscorea compositor (Dioscorea).
composita), (B) Panax ginseng CAMeyer, wheat germ, fire spikes (P
yracantha fortuneana), olives (Olea europaea)
L.), in combination with one or more selected from the group consisting of plant extracts obtained from apricots, prevents inflammation due to ultraviolet rays, suppresses melanin production due to ultraviolet damage, and promotes excretion of melanin pigments. It exhibits an excellent whitening effect in a short period of time, and is excellent in usability and storage stability.

Continuation of front page    F term (reference) 4C083 AA082 AA111 AA112 AB242                       AC022 AC102 AC122 AC172                       AC182 AC242 AC422 AC442                       AC482 AC662 AD092 AD152                       AD172 AD222 AD352 AD492                       CC01 CC02 CC04 CC05 CC07                       CC19 DD05 DD23 DD31 EE01                       EE03 EE05 EE10 EE16 EE17

Claims (1)

[Claim 1] (A) Geoscoria composite (Di)
oscorea composita), (B) Panax ginseng CAMeyer, wheat germ, fire spikes (Pyracantha fortuneana), olives (Olea)
europaea L.), and one or more selected from the group consisting of plant extracts obtained from apricots.