JP2003231684A - Cholesterol metabolism improving agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a new cholesterol metabolism improving agent. <P>SOLUTION: The cholesterol metabolism improving agent contains one or more kinds of condensed polyphenol compounds. Thereby, the cholesterol metabolism improving agent containing the condensed polyphenol compounds is capable of remarkably reducing cholesterol contained in serum, the liver and whole living bodies, has actions of maintaining the amount of a high-density lipoprotein cholesterol and exhibits excellent improving actions on cholesterol metabolism. Prophylaxis and amelioration of arteriosclerosis can be carried out by ingesting the cholesterol metabolism improving agent in the form of a medicine, a quasi- drug, a food, or the like, in usual eating habits, or the like. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to application to pharmaceuticals, quasi drugs, and foods as a cholesterol metabolism improving agent utilizing the cholesterol metabolism improving action of a condensed polyphenol compound.

[0002]

BACKGROUND OF THE INVENTION Sterols and their derivatives are essential constituents of the living body. Triacylglycerol, which is called neutral fat, plays a role of supplying and storing energy used in the living body.
Cholesterol and its fatty acid ester are important constituents of cell membranes, and at the same time, they are precursors of bile acids, steroid hormones, vitamin D, and other compounds that perform various important functions in vivo.

However, cholesterol, which has an important function in the living body, is one of the causes of arteriosclerosis, which is currently cited as a typical example of lifestyle-related diseases. It is said that this is because the cholesterol content in blood is excessive.

Cholesterol forms a complex with a protein of a specific species in blood and exists as a lipoprotein. Among these lipoproteins, cholesterol-protein complexes classified as low-density lipoprotein cholesterol and ultra-low-density lipoprotein cholesterol promote arteriosclerosis, and conversely cholesterol-protein complexes classified as high-density lipoprotein cholesterol. It is said that the body suppresses arteriosclerosis.

Therefore, in treating arteriosclerosis, it is generally considered that reducing the content of lipids in blood vessels, particularly low-density lipoprotein (including ultra-low density lipoprotein) cholesterol, can be an effective means. It is considered that, as a method, a diet therapy in which intake is restricted from the diet itself in order to prevent excessive intake of lipids, especially cholesterol, or a method of applying a substance that inhibits cholesterol absorption from the small intestine, or Methods such as activating cholesterol-degrading metabolism in the body have been implemented.

[0006] However, arteriosclerosis cannot be reliably treated by only reducing the excessive content of low-density lipoprotein in the blood vessel, and maintains the content of high-density lipoprotein at the normal level. Only then can arteriosclerosis be treated.

[0007]

In view of the above circumstances, the present inventors have studied a method for reducing lipids in the living body, particularly cholesterol, and as a result, ingested condensed polyphenol compounds We have found that cholesterol is reduced. After further detailed study, ingestion of condensed polyphenol compounds specifically reduced the low-density lipoprotein (including ultra-low-density lipoprotein) cholesterol content in blood,
It was also found that it does not affect the content of high density lipoprotein cholesterol. Therefore, it was found as a result of the study that the condensed polyphenol compound has an action of improving the metabolism of cholesterol in the living body.

[0008]

[Means for Solving the Problems] That is, the present invention provides a cholesterol metabolism improving agent containing one or more condensed polyphenol compounds.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION The condensed polyphenol compound used in the present invention is a compound having a structure represented by Formula 1.

[0010]

[Formula 6] [R ₁ = H or OH, R ₂ = H or OH, R ₃ = H or OH, R ₄ = H or a benzyl group represented by the formula 2, R ₅ =
H or OH, R ₆ = H or OH, R ₇ = H or OH, R
₈ = H or a benzyl group represented by the formula 3, and R ₉ = H or OH. It is arbitrarily selected from n = 10 to 50. X in Formula 1 has the structure shown in Formula 4. The n structural formulas of X may all be the same or different. ]

[Formula 7] Formula 2 [R ₁₀ = H or OH, R ₁₁ = H or OH, R ₁₂ =
It is arbitrarily selected from H or OH. ]

[Formula 8] [R ₁₃ = H or OH, R ₁₄ = H or OH, R ₁₅ =
It is arbitrarily selected from H or OH. ]

[Formula 9] [R ₁₆ = H or OH, R ₁₇ = H or OH, R ₁₈ =
Optionally selected from H or OH, R ₁₉ = H or a benzyl group of formula 5. ]

[Formula 10] [R ₂₀ = H or OH, R ₂₁ = H or OH, R ₂₂ =
It is arbitrarily selected from H or OH. ]

As the condensed polyphenol compound used in the present invention, a compound having the above structure can be arbitrarily selected. As the condensed polyphenol compound, those obtained by chemical synthesis and those obtained from extracts of natural products can be arbitrarily applied.

Among the condensed polyphenol compounds used in the present invention, it is particularly preferable to use persimmon tannin because it has a sufficient effect of improving cholesterol metabolism and is industrially very easy to obtain.

Persimmon tannin is a plant belonging to the genus Diospyros of the family Scutellariae, Persimmon (Diospyros kaki) or Meganoki (Diospyro).
(slotus) matured or overripe fruits, leaves, petals, scallions, etc. The extraction is mainly performed by solvent extraction using a specific solvent. The extraction solvent may be selected in consideration of the purpose of use of the product to be provided, the type, or the processing to be performed later, but usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol,
1 selected from lower alcohols such as butanol and isobutanol or hydrous lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin or hydrous polyhydric alcohols, and various organic solvents such as acetone and ethyl acetate 1 It is preferable to use one kind or a mixed solution of two or more kinds. However, when the content of the organic solvent is not preferable depending on the purpose of use, water alone is used, or the solvent is easily removed after extraction, extraction is performed using a highly volatile solvent, and water is removed after removing the solvent. A method of dissolving is also possible.

As the persimmon tannin, the above-mentioned extract or extract can be applied as it is. However, in order to increase the persimmon tannin content in the extract or extract, it is preferable to further carry out a purification operation. Purification operations include decomposition by addition of acid (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, organic acid, etc.) or alkali (sodium hydroxide, calcium hydroxide, ammonia, etc.), fermentation or metabolic conversion by microorganisms, ion exchange resin or activated carbon. , Component adsorption by diatomaceous earth, fractionation using chromatography with various separation modes (ion exchange, hydrophilic adsorption, hydrophobic adsorption, size exclusion, ligand exchange, affinity, etc.), filter paper and membrane filter Examples include filtration using an ultrafiltration membrane, pressurization or depressurization, heating or cooling, drying, concentration, distillation, pH adjustment, deodorization, decolorization, and storage for a long period of time. These can be arbitrarily selected. It is possible to perform combined processing.

The condensed polyphenol compound used in the present invention may be in the form of liquid, solid, powder, granules,
Any shape such as paste or gel may be used, and the optimum shape for constructing the final product can be arbitrarily selected.

The cholesterol metabolism improving agent used in the present invention is used in medicines, quasi drugs, foods and the like. The dosage form is not particularly limited as long as it can be taken orally, and liquid,
The dosage form can be any of solid, powder, suspension, paste, gel, granule, capsule and the like. As the form, pharmaceuticals or quasi-drugs having the above-mentioned dosage form, food, and further oral compositions (gum, candy, tablets, etc.), processed fish paste products such as kamaboko, chikuwa, sausage, ham, etc. Livestock products, Western confectionery,
Japanese sweets, raw noodles, Chinese noodles, boiled noodles, noodles such as buckwheat, sauce, soy sauce, sauce, sugar, honey, powdered candy,
Seasonings such as starch syrup, spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, greens, sprinkles, or processed vegetables and fruits such as canned and bottled vegetables and fruits, Dairy products such as cheese, butter, yogurt, processed cereal products, fermented foods, miso soup, soups, fruit juices, vegetable juices, whey drinks,
It can be added to soft drinks, alcoholic beverages, etc.

The content of the condensed polyphenol compound used in the present invention in the cholesterol metabolism-improving agent is appropriately adjusted depending on its usage, form, sex and age of the subject, health condition of the subject, etc. Usually, it is preferably in the range of about 0.001 to 80% by mass, and particularly in the range of 0.1 to 30% by mass, based on the total amount of the cholesterol metabolism improving agent, the safety to human body and the effect of improving cholesterol metabolism. Is preferable in terms of strength of expression.

The cholesterol metabolism-improving agent of the present invention and pharmaceuticals, quasi-drugs, and foods containing the same, in addition to the above-mentioned essential components, may be supplemented with nutrition, recovery from fatigue, tonicity, cell activation (prevention of cell senescence). ) Etc., the effects of the present invention for the purpose of improving taste, improving the taste, imparting color tone, aroma, gloss, stabilizing, adjusting viscosity increasing, adjusting sustained release, assisting solubility, preserving, etc. The components and additives exemplified below can be arbitrarily selected and used in combination within a range that does not impair the production. The content of cholesterol metabolism improver is
Although not particularly specified, 0.0001 to 50% is usually preferable. The following components or additives may be added in advance in the manufacturing process of the cholesterol metabolism-improving agent of the present invention and pharmaceuticals, quasi drugs, and foods containing them, or may be added during the manufacturing process. Therefore, it may be selected as appropriate.

(1) Various oils and fats Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange lafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed Oil, Persic oil, Castor oil, Cottonseed oil, Peanut oil, Turtle oil, Mink oil, Egg yolk oil, Palm oil, Palm kernel oil, Owl, Palm oil, Beef tallow, Lard, Squalene,
Squalane, pristane or hydrogenated products of these oils (hardened oil, etc.), etc.

(2) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid,
Docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, natural fatty acids such as lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexane Acids, synthetic fatty acids such as isopentanoic acid.

(3) Alcohols ethanol, isopropyl alcohol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, 2-
Hexyldecanol, isostearyl alcohol, 2-octyldodecanol and other synthetic alcohols.

(4) Polyhydric alcohols ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(5) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, etc.

(6) Gum, sugar or water-soluble polymer compound gum arabic, benzoin gum, dammar gum, guaiac butter, Irish moss, karaya gum, tragacanth gum,
Carob gum, quince seed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) with alkylene (C2-C4) oxide such as ethylene oxide added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose , Carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose and the like.

(7) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acid,
Nicotinic acid, Pantothenic acid, Biotin, Choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxosterol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K)
2), menadione (vitamin K3), menadiol (vitamin K4), and others, essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamins P (eriocitrin), vitamin U and the like.

(8) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Alternatively, amino acid derivatives such as pyrrolidonecarboxylic acid.

(9) Various ingredients or additives derived from plant-based raw materials, animal-based raw materials, microbial-based raw materials, other natural raw materials, etc. These are generally carried out according to the product type and form to be added. Processing (e.g., crushing, milling, washing, hydrolysis, fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc., selected arbitrarily, Combined processing) is performed, and various materials may be arbitrarily selected and provided.

The solvent used for the extraction may be selected in consideration of the purpose of use, the type of product to be provided, the processing to be performed later, etc. Usually, water, methanol,
Lower alcohols such as ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol or lower alcohols containing water, propylene glycol, 1,
3-butylene glycol, 1,2-butylene glycol, 1,4-
Butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, polyethylene glycol (molecular weight 100 to 100,000) ) Or other polyhydric alcohols or hydrous polyhydric alcohols, acetone, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, various organic solvents such as toluene, One or two selected from acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.) adjusted to an appropriate normality It is desirable to use the above mixture. However, when the inclusion of a solvent is not preferable depending on the application, water alone may be used, or ethanol which is easy to remove after extraction may be used and used alone or in any mixture with water. You can use the extracted one.

Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, and the extraction time are also
Each of the various raw materials and the solvent used can be arbitrarily set. The temperature of the solvent is from -4 ° C to 1
The temperature can be arbitrarily set within the range of 00 ° C, but from the viewpoint of stability of the components contained in the raw material, it is preferably around 10 to 40 ° C.
Also, the weight ratio of the solvent to the raw material can be arbitrarily set within the range of 4: 1 to 1:10, for example, raw material: solvent, and the weight ratio of 1: 1 to 1: 5 is particularly preferable.

The decomposition mainly includes decomposition by acid, decomposition by alkali, decomposition by enzyme, decomposition by high temperature and high pressure. For acid decomposition, for example, hydrochloric acid, sulfuric acid, nitric acid,
Phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid,
It is preferable to use an inorganic acid such as periodate or an organic acid. In the decomposition with alkali, it is preferable to use, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate or the like. In the decomposition with acid or alkali, the concentration, reaction time, reaction temperature, etc. can be arbitrarily set for the target raw material. In the enzymatic decomposition, it is preferable to use an enzyme having a function of decomposing a protein or polysaccharide having an important function particularly with respect to a cell structure or a tissue structure, a lipid or a complex thereof, for example, aminopeptidase, dipeptidase, dipeptidase, Peptidyl peptidase, tripeptidyl peptidase,
Carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, aspartate endopeptidase, metalloendopeptidase, promeline, thermolysin, pronase, pepsin, rennin, pancreatin, chymopapain, ficin, collagenase, Proteolytic enzymes (proteases) such as elastase, polysaccharide degrading enzymes such as amylases, takaamylases, cellulases, hemicellulases, pectinases, polygalacturonases, dextranases, pralanases, hen egg white-derived lysozyme, human-derived lysozyme, papaya. Origin lysozyme, turnip origin lysozyme, barley origin lysozyme, zymolyce, lysozyme chloride, glucanase, glucouron Over Ze, chitinase, cell wall lytic enzymes such as Kirosanaze. In the enzymatic decomposition, the concentration, reaction time, reaction temperature, pH of the solution and the like can be arbitrarily set, but it is particularly preferably set to an optimum value for the enzyme used.

Fermentation or metabolic conversion by a microorganism can be carried out by inoculating at least one or more kinds of microorganisms on a raw material as a substrate and growing the same. Microorganisms can be inoculated into the substrate by directly adding the microorganisms into the substrate, or by adsorbing them on a carrier such as alginic acid, polyvinyl, gelatin, etc., for example, in the form of fine beads composed of the microorganisms and the carrier. Further, it can be used by fixing it to the tube wall of the bioreactor. In the fermentation or metabolic conversion by microorganisms, the microorganisms to be used are not particularly specified, but can be defined as microorganisms other than pathogenic microorganisms that generally show remarkable toxicity to the living body. Examples of microorganisms used include Aciculoconid as microorganisms classified as yeast.
ium, Actonia, Aessosporon, Ambrosiozyma, A
Genus mphierna, Genus Anthomyces, Genus Apiotrichum, Arthroasc
Us, Arxula, Ascotrichosporon, Ashbia, Ashb
genus ya, genus Asporomyces, genus Atelosaccharomyces, Azymoca
ndida, Azymohansenula, Azymomyces, Azymoproc
andida, Babjevia, Ballistosporomyces, Basidi
otrichosporon, Bensingtonia, Blastobotrys, B
genus lastodendrion, genus Blastoderma, Blastoschizomyces
Genus, Botryoascus, Botryozyma, Brettanomyces (Brettanomyces bruxellensis, Brettanomyces anomal
us, etc.), Bullera genus, Bulleromyces genus, Candida genus (Cand
ida albicans, Candida amylolenta, Candida anomal
a, Candida boidinii, Candida entomaea, Candida etc
hellsii, Candida famata, Candida fermentati, Candi
da guilliermondii, Candida halophila, Candida inte
rmedia, Candida krusei, Candida lactosa, Candida l
ipolytica, Candida mogii, Candida parapsilosis, Ca
ndida sake, Candida tropicalis, Candida versatili
s, Candida vulgaris, etc.), Castellania sp., Chlamydozy
ma genus, Chromotorula genus, Citeromyces genus, Cladosporium
Genus, Clavispora, Crebrothecium, Cryptococcus
Genus Debaryomyces (Debaryomyces delbrueckii, Deba
ryomyces halotolerans, Debaryomyces hansenii, etc.),
Debaryozyma, Dekkera, Dekkeromyces, Dematium
Genus, Dipodascus, Eeniella, Enantiothamnus, En
genus doblastoderma, genus Endoblastomyces, genus Endomyces, E
Genus ndomycopsis, Genus Endyllium, Genus Entelexis, Eremascus
Genus, Eremothecium, Eutorula, Eutorulopsis, Fa
bospora, Fellomyces, Fermentotrichon, Filoba
sidium, Galactomyces, Geotrichoides, Geotric
hum, Guilliermondella, Hanseniaspora, Hansen
ula genus (Hansenula anomala, Hansenula kluyveri, Hans
enula miso, Hansenula polymorpha, Hansenula wicker
hamii etc.), Hypomyces spp., Issatchenkia spp., Kloeckera
Genus (Kloeckera brevis, Kloeckera fluorescens, Kloec
kera japonica, etc.), genus Kloeckeraspora, Kluyveromyc
es genus (Kluyveromyces bulgaricus, Kluyveromyces marx
ianus, Kluyveromyces thermotolerans, etc.), Kockovael
genus la, genus Kurtzmanomyces, genus Leucosporidium, Lipomyce
s, Magnusiomyces, Metschnikowia, Microanthom
genus yces, genus Monilia, genus Monospora, genus Monosporella, Mr
Genus akia, Genus Myceloblastanon, Genus Mycocandida, Mycoderm
a genus, Mycotorula genus, Mycokluyveria genus, Mycotoruloides
Genus, Myxozyma, Nadsonia, Nectaromyces, Nemato
spora, Octosporomyces, Ogataea, Oidium, Oo
spora, Oosporidium, Pachysolen, Parasaccharo
genus myces, genus Paratorulopsis, genus Parentomyces, Petasos
genus pora, genus Pichia (Pichia amylophila, Pichia farino
sa, Pichia guilliermondii, Pichia membranifacien
s, Pichia mogii, etc.), Pityrosporum, Procandida
Genus, Procandida, Prosporobolomyces, Proteomyces
Genus, Pseudohansenula, Pseudomonilia, Pseudomyco
derma, Pseudosaccharomyces, Pseudozyma, Rhod
omyces, Rhodosporidium, Rhodotorula, Sacchar
omyces (Saccharomyces aceti, Saccharomyces ceras
i, Saccharomyces cerevisiae, Saccharomyces exiguu
s, Saccharomyces unisporus, Saccharomyces fibulige
ra etc.), Saccharomycodes, Saccharomycopsis, Sat
genus urnispora, genus Schizoblastosporion, Schizosaccharo
myces, Schwanniomyces, Selenotila, Selenozym
Genus a, Smithiozyma, Sporidiobolus, Sporobolomyce
s genus, Sporothrix genus, Stephanoascus genus, Sterigmatomyce
Genus s, genus Sympodiomyces, genus Syringospora, Tetrapisispo
genus ra, genus Torula, genus Torulaspora, genus Torulopsis, Trich
genus osporon, genus Udeniomyces, genus Vanrija, Waltomyces
Genus, Willia, Williopsis, Wingea, Xanthophyllo
genus myces, genus Yamadazyma, genus Zendera, Zygofabospora
Genus, Zygopichia, Zygohansenula, Zygorenospora
Genus, Zygosaccharomyces, Zymodebaryomyces, Zymon
Examples include the genus ema. Microorganisms classified as bacteria include the genus Acetobacter (Acetobacter aceti, etc.), Achromob
genus acter, genus Acidianus, genus Acidobacterium, Acidithiob
genus acillus, genus Acrocarpospora, genus Actinoalloteichus,
Actinocorallia, Actinokineospora, Actinomadura
Genus, Actinoplanes, Actinopolyspora, Actinosynne
ma genus, Aerococcus genus, Aeromicrobium genus, Agrobacterium
Genus, Agromyces, Ahrensia, Alcaligenes, Alicyc
lobacillus, Alloiococcus, Alteromonas, Amorp
hosporangium, Ampullariella, Amycolata, Amyc
olatopsis, Aquaspirillum, Arcanobacterium, A
rthrobacter, Aureobacterium, Azotobacter, Ba
cillus genus (Bacillus brevis, Bacillus subtilis, etc.),
Bacteroides, Beneckea, Bifidobacterium (Bifi
dobacterium bifidum, Bifidobacterium longum, Bifid
obacterium breve, Bifidobacterium infantis, etc.), Br
achybacterium, Brevibacillus, Brevibacterium
Genus, Brevundimonas, Burkholderia, Carnobacteriu
m genus, Catellatospora genus, Cellulomonas genus, Chainia genus,
Chromobacterium, Chryseobacterium, Citrobacter
Genus, Clavibacter, Corynebacterium, Couchioplane
s genus, Cryptosporangium genus, Curtobacterium genus, Dactylo
sporangium, Deinococcus, Delftia, Demetria
Genus, Dermacoccus, Dermatophilus, Elytrosporangi
um, Enterobacter, Erwinia, Escherichia, Eu
bacterium genus, Excellospora genus, Exiguobacterium genus, Fa
genus enia, genus Flammeovirga, genus Flavobacterium, Flexibac
ter, Geodermatophilus, Globicatella, Glucona
cetobacter genus, Gluconoacetobacter genus, Glycomyces genus,
Gordona, Gordonia, Halobacterium, Halococcus
Genus, Herbidospora, Hydrogenophilus, Hyphomicrob
ium, Hyphomonas, Intrasporangium, Janibacter
Genus, Jonesia, Kibdelosporangium, Kineococcus
Genus, Kineospora, Kitasatoa, Kitasatospora, K
genus itasatosporia, genus Klebsiella, genus Kocuria, Kurthia
Genus Lactobacillus (Lactobacillus rimae, Lactobac
illus divergens, Lactobacillus carnis, Lactobacill
us piscicola, Lactobacillus acidophilus, Lactobaci
llus amylophilus, Lactobacillus animalis, Lactobac
illus brevis, Lactobacillus casei, Lactobacillus c
urvatus, Lactobacillus bulgaricus, Lactobacillus d
elbrueckii, Lactobacillus fermentum, Lactobacillus
fructivorans, Lactobacillus fructosus, Lactobacil
lus helveticus, Lactobacillus hilgardii, Lactobaci
llus homohiochii, Lactobacillus kefiri, Lactobacil
lus malefermentans, Lactobacillus murinus, Lactoba
cillus paracasei, Lactobacillus paracasei subsp.t
olerans, Lactobacillus parakefiri, Lactobacillus p
entosus, Lactobacillus plantarum, Lactobacillus re
uteri, Lactobacillus rhamnosus, Lactobacillus sake
i, Lactobacillus confusus, Lactobacillus viridesce
ns, Lactobacillus johnsonii, Lactobacillus viscosu
s, Lactobacillus bunchneri, Lactobacillus fermenta
tae, Lactobacillus acidophil-aerogenes, Lactobacil
lus leichmannii, Lactobacillus gasseri, Lactobacil
lus bifidus, Lactobacillus jugurt, Lactobacillus c
aucasicus, Lactobacillus arabinosus, Lactobacillus
kunkeei, Lactobacillus nagelii, Lactobacillus for
nicalis, Lactobacillus pentoaceticus, Lactobacillu
s xylosus, Lactobacillus minutus, etc.), Leuconostoc
Genus (Leuconostoc lactis, Leuconostoc dextranicum, L
euconostoc mesenteroides, Leuconostoc oenos, Leuco
nostocparamesenteroides, Leuconostoc cremoris, Leu
conostoc citrovorum, etc.), Listonella, Lucibacteri
um, Luteococcus, Magnetospirillum, Marinilab
Genus ilia, Marinospirillum, Mesorhizobium, Metallos
phaera, Methylobacterium, Microbispora, Micr
ococcus, Microellobosporia, Micromonospora,
Mycobacterium, Mycoplasma, Nocardia, Nocardi
Genus oides, Genus Nonomuraea, Genus Nonomuria, Oceanospirillu
genus m, genus Ochrobactrum, genus Oerskovia, genus Oligella, Paen
genus ibacillus, genus Pediococcus (Pediococcus halophili
s, Pediococcus acidilactis, Pediococcus cerevisia
e, Pediococcus pentosaceus, Pediococcus urinae-equ
i etc.), Pedobacter genus, Peptococcus genus, Peptostreptoco
ccus, Pilimelia, Pimelobacter, Planobispora
Genus, Planococcus, Planomonospora, Prevotella
Genus, Propionibacterium, Proteus, Protomonas,
Pseudomonas, Pseudonocardia, Rahnella, Rarob
Acter genus, Rathayibacter genus, Rhizobium genus, Rhizomonas
Genus, Rhodobacter, Rhodococcus, Rhodopseudomonas
Genus, Rhodospirillum, Rothia, Rubrobacter, Rue
geria, Saccharomonospora, Saccharothrix, Ser
genus ratia, genus Sinorhizobium, genus Sphingobacterium, Sphi
Genus ngomonas, Sporolactobacillus, Stenotrophomonas
Genus, Streptoalloteichus, Streptococcus (Strepto
coccus durans, Streptococcus faecalis, Streptococ
cus faecium, Streptococcus bovis, Streptococcus eq
uinus, Streptococcus mutans, Streptococcus salivar
ius, Streptococcus thermophilus, Streptococcus aga
lactiae, Streptococcus mitis, Streptococcus pyogen
es, Streptococcus pneumoniae, Streptococcus lacti
s, Streptococcus dysgalactiae, Streptococcus sangu
is, Streptococcus acidominimus, Streptococcusaviu
m, Streptococcus uberis, Streptococcus cremoris, S
treptococcus diacetilactis etc.), Streptomyces, St
Reptosporangium, Streptoverticillium, Terrabac
ter, Thermoactinomyces, Thermobifida, Thermo
genus bispora, genus Thermocrispum, genus Thermomonospora, The
genus rmoplasma, genus Thiobacillus, genus Thiomonas, Thiospha
era, Weissella, Xanthobacter, Xanthomonas
Genus, genus Zymomonas and the like. Ascomycetes other than yeast, microorganisms classified as basidiomycetes or imperfect fungi include Allomyces, Amoebidium, Amorphotheca, Art
hroderma, Ascoidea, Ascobolus, Ascodesmis
Genus, Aspergillus, Aureobasidium, Botryosphaeria
Genus, Botryotinia, Brachybasidium, Byssochlamys
Genus, Capnodium, Ceratocystis, Ceratomyces, Ch
aetomium, Chrysella, Chrysocelia, Chytridium
Genus, Claviceps, Cochliobolus, Coemansia, Cole
Genus osporium, genus Coniochaetidium, genus Cordyceps, Cronar
genus tium, genus Cyttaria, genus Dasyspora, genus Derchslera, Dic
homyces, Dothidea, Endogone, Entomophthora
Genus, Emericella, Eupenicillium, Eurotium, Exo
basidium, Gibberella, Glomus, Graphiola, G
ymnoascus, Harpella, Helicomyces, Helvella
Genus, Hemicarpenteles, Hyphochytrium, Hypocrea
Genus, Laboulbenia, Labyrinthula, Leptosphaeria
Genus, Leptosphaerulina, Lophodermium, Melanotaen
ium, Microascus, Microstroma, Medeolaria,
Melampsora, Melamsporella, Morchella, Monasc
us, Monilinia, Monoblephalis, Mycospharella
Genus, Nannizzia, Nectria, Neolecta, Neurospora
Genus, Nodulosphaeria, Olpidium, Peziza, Penici
llium, Perenospora, Pestalotiopsis, Phomopsi
s genus, Phragmidiella genus, Pneumocystis genus, Preussia genus,
Pleospora, Puccinia, Pythium, Ravenelia, R
ickia, Rhinocladiella, Rhizidiomyces, Rhizoc
tonia, Sclerocleista, Saprolegnia, Satioella
Genus, Sclerotinia, Sclerotum, Septobasidium, S
genus ordaria, genus Sporidiobolus, genus Stibella, stigmatomy
ces, Sydowiella, Talaromayces, Taphrina, T
hraustochytrium, Tolyposporium, Trichoglossum
Genus, Trichoma, Ustilago, Verticillium, Xylari
a genus and the like.

In the fermentation or metabolic conversion by microorganisms, in addition to various raw materials such as plant-based raw materials, animal-based raw materials or other natural product-based raw materials, the growth and metabolism of microorganisms are regulated or activated, and further special biosynthesis or decomposition is performed. In order to induce the pathway, various compounds and the like can be further added to the raw material.For example, sugars such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerol and starch can be used as a carbon source. Quality or ethane,
Hydrocarbons such as methane, propane, butane, formic acid, acetic acid,
Propionic acid, lauric acid, palmitic acid, oleic acid, linoleic acid, fatty acids such as linolenic acid, nitrogen sources, ammonium sulfate, ammonium chloride, ammonium salts such as ammonium phosphate and urea, uric acid, or amino acids, etc., Compounds containing vitamins and potassium, calcium, magnesium, sodium, sulfur, phosphorus, chlorine, etc. required in various microorganisms in the composition, further,
Iron, copper, zinc, cobalt, nickel, boron, manganese,
Molybdenum, tin, selenium, silicon, arsenic, vanadium,
It is possible to further add compounds such as chromium and fluorine contained in the composition. Further, the optimum temperature, the amount of oxygen supplied, the pH, the pressure, etc. that affect the growth and metabolic activity of various microorganisms can be arbitrarily set according to the characteristics peculiar to various microorganisms. Is 10
The pH can be arbitrarily set within the range of 50 ° C., and the pH can also be arbitrarily set within the range of 1 to 14.

In the fractionation or purification, generally known techniques can be appropriately used, and in addition to solvent extraction, for example, liquid chromatography (ion exchange chromatography, ion exclusion chromatography, affinity chromatography, gel filtration chromatography, Size exclusion chromatography, hydrophilic adsorption chromatography,
Fractionation by hydrophobic adsorption chromatography, ligand exchange chromatography, etc.), dialysis by semipermeable membrane, crystallization and recrystallization of components, filter paper, membrane filter, ultrafiltration membrane, activated carbon, filter aid, etc. And a density gradient separation method such as a red zone centrifugation method and a density gradient sedimentation equilibrium method.

As a concrete plant (crude drug) used as a raw material,
For example, almonds, ai, blue vines
(Seifufuji), Aoki (Aoki), Aogiri or Kenashiaogiri
(Goji paulownia), Aotsutsurafuji (Kibo), Aotenma, Acacia, Red capsicum (Akasoma), Redcurrant `` fruit '', Red clover, Red grapes, Red amber (Logwood), Red algae (Red bud), Red pine or Red madder or Red madder (Akane) (Grassroots), Akagia jiou or jiou (ground yellow),
Agi (A Wei), Aki Larch, Akinire (Resin), Aguay Gua Su, Aguahe (Omi Tenguyashi), Akebei
(Ki-dori), Asa (Asakojin), Malva Morning Glory or Morning Glory
(Gagushi), Hydrangea (hydrangea), Ashitaba (tomorrow leaf), Azuki (red azuki bean), Asunaro, Acerola, Athira (Shokuyoukanna), anise, abiu, abiurana, canola,
Abemaki `` fruit '', avocado, flax, flaxseed, flaxseed, flaxseed, amana (amaranthus), amaranthus (Hiyu, Hagatetou, Himogeito, Senninkoku, Sugimorigateu, Hosohaogeito, Aogaytou, Haribiyuakon, Aozuran, Ausazuran, Aozuranu, Aozuran, Aozuran, Aozuran , Algae lily or fritillaria (shellfish), aristromelia (Yurizuisen), arcana (Arcanna), algarovo (Cabbage), Altea, Arnica, Alpinia or Katsumidai (Sawzuku), aloe (蘆 舆 舆), aloe vera, Angelica, apricot or hon apricot (apricot kernel). ), Ansokkou
(Benzoic incense), yellow sapote, igakouzorina (geijutsu),
Epimedium or Echinacea chinensis (Indian cabbage), rush (wick wick), knotweed (tiger cane root), yew (first place), strawberry, fig (flowerless fruit "fruit, leaf"), fig (first),
Ichibi (Winter Aoi), Ichiyakuso (one medicinal herb), Ginkgo (Ginkgo `` seed, leaf ''), Itohimehagi (Denshi), carob,
Inunazuna (Taylex), Inubiyu (Honagainubiyu),
Rice `` Seeds, seed coats '', Inondo `` Seeds '', Pleurotus cornucopiae, Nettle, Ylang-ylang, Ylang tobacco (Iwabiwaen), Iwahiba or Iwamatsu (Makihashi), Oolong tea, Fennel (Incense), Wheat (Chibana), Ukiyagara (Sanryaki) ), Uguisu Kagura `` fruit '', Scallops, Turmeric (Pleistocene), Duckweed (Ukiwa), Usubasaishin or Keirinsaishin or Sengokusaishin (spicy), Usbania mallow, Usbenitaiai, Utsuchiran, Nepenthes
(Summer hay), Udo or Shishido (Kou-Katsu, Koku-Katsu, Katsu-Koku), Unyadegato (Uncaria, Cat's Claw), Uba Tea, Ume (Karaume "seed, pulp"), Owarushi (Rubiaceae),
Unshu mandarin (Chen skin), Unbok, Estragon, Eleuthero (Ezo Goka), Ezo Suzuran, Echinashi (Hosobamurasakibarengiku), Enishida, Enokitake (enokitake),
Ebisugusa or Cassia tora (Keiko), Elcampre, Elderberry "fruit", Elemi, Eringii or Pre-lotus ernge, Enju (Mulberry, Sophoraceae rice), Ougi or Kibanana (Yellow 耆), Narukoyuri or Kagikarumabanarukoyuri (Yellow spirit), Spruce sasayuki or Sasanoyuki, Ouren (Yellow), Ogatha Houken, Giant crow (Calocon), Ooguruma (Civil incense), Otsutsurafuji
(Self-defense), psyllium (carp, carp grass), plantain thistle
(Yuzhou Leopard, Bald Ear), Toucan Hazel (Haruko), Toucan Cactus, Obana Okera or Okera (White Barley), Obana Salvage (Banaba), Obayashishabushi "Fruits", Oohoshigusa (Osaka citrus), Omiami, Oomimi Hawthorn (mountain scum), barley (barley), oca, Okazeri (snake bed), okra "fruit", oguruma (overturning), okururigogotai (bamboo stinking, indigo piercing), ginseng or ginseng (carrot), St. John's wort or Stinkweed St. John's wort or St. John's wort (younger brother cut grass), Onamomi
(Blue ear), Onidokoro or Tokoro or Nagadokoro (Haikai), Oninoyagara (Tenma), Oniyuri or Sasayuri or Hakatayuri (Yuri), Onoelan, Ononis, Oh leopard
(Striped leaf), Ominaeshi (soy sauce), Oyuko, Dutch mustard (cresson), Dutch jelly, Dutch bieu, Dutch honeywort, olive "fruit, seed, leaf", oregano, orange "fruit, fruit skin", kaijyou Yellow), cacao `` fruit, peel, seed '', Kagizura (fishing hook), Kakidoshi or Kantorisou (Lotus grass), Kakiran, Gaku hydrangea, Cassia, Casinoki (楮 berries "fruits"), Gajutsu (muddle), Kashiwa (Leopard tree, Camellia leaf), Cascarilla, Cascara Grada, Gypsophila, Kasengou, Crabgrass (Kinshato), Kaniwa, Carnation, Valerian root, Hippopotamus,
Birch or weeping birch (white birch), gerbera, pumpkin, kapok cypress `` seed '', kahokusansho (shusho),
Cattail, chamomile or Roman chamomile, chamomile
(Grass), camu camu (duck), color, larva, mantle or crow cucumber (sea melon), crow bischak (half summer), oats, guarana "seed", callahoo
(Koboku), Karaya, Gallu, Karin (Cucurbita), Garcinia, Kawamidori, Kawara Psycho (Koryosai, White-floured grass), Kawajisha, Kawaratake, Kawara-nadeshiko (stone bamboo) or Ezokawaranadeshiko (barley, tannin), Kawaraninjin (Kawaraninjin) (Blue ginger),
Kawamoyogi (Chinese cabbage), Kansui (Asaito), Kanzo
(Licorice), cantara, candelilla, canto, canna, canlan, raspberry (ezo strawberry, dutch strawberry, shrimp strawberry, nawairo strawberry, maple strawberry,
European raspberries), kiwi "fruits, leaves", cichlids (melon roots), kyokyo (bellflowers, bellflowers), chrysanthemums (chrysanthemums,
Crested knapweed, Amaranthaceae, Amaranthaceae, Catalpa (Azusa fruit), Rumex japonicum (Amugi root), Kizitsu (Apricot fruit), Kizuta, Kidachi aloe, Kidachihaka, Quercus chinensis (Shinkona, Akakinanoki), Quinua (quinoa), Kakiha (yellow oak) Gymnema Sylvester, Kimenkaku, cabbage,
Cabbage "immature fruit", caraway, cucumber, goryu (Nishikawayanagi, Teiyanagi), Kiraja Saponaria, Kiraya, Kiranso (Kenshi Kobayashi), Kumquat "Fruit", Ginsengkai, Kimbusen, Kimma, Kinmizuhiki (Senkusa), Kinran, Ginran, Kinryohen, Guapaba Vermelha, Guava "Fruit", Guayule, Quercus Infectria (Galler), Kukui Nut, Kugenumaran, Cuco (Bleed, Bleed, Leopard, cicada), Kusagikazura Camphor tree, gooseberry "fruit", carrot (yellow flower), kutiti river, gardenia (yamashiko), kunugi (brassica), cupuas, cubebaba, kumazasa, pine vine (horse whiskers), clara (bitterness), cranberry ""Fruits", chestnut "seed, fruits, astringent skin", Curculigo latifolia "fruits", grapefruit Roots "fruits and leaves",
Black buckthorn, black squirrel (necessity of rescue), Kamehiba hikoshi or Kurobana hikoshi or Hiki o koshi (extended life grass),
Cloves (cloves, cloves), gumbai nazuna (sekimei, sekimeishi), kei gai (a sage, sagebrush), keito (corow flowers, corolla), geckavidin, bay (laurel),
Kenashisarutoriibara (Tsukuryo rye, mountain return), Gentian,
Kemponashi (Kyugushi), Kouki Sekokuku, Kishikankan
(Koji, Tachibana, Ovenimikan, Fukuromican,
Sagami Koji, Ponkan, Santara (Tachibana peel), Kosimbara (Monthly flower), Kosuihakka, Kozo `` fruit '', Kocha (black tea), Kouhone (river bone), Kouhon (straw book, Karamoto book), Koryan, Koryokyo ( Takara ginger), cilantro `` fruit '', kouren (huhokuren), scarabana (yellow gon), cowberry (overgrowth), coco coconut `` fruit '', goshuyu (wheat 萱 萸), gosho strawberry (covered bonito), pepper (pepper), cosmos, Copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (spicy pepper), burdock (burdock, burdock), kobotsuduru, sesame (sesame), sesame seed (ginseng), gojishiza (vinegar), honeysuckle or vinegar or pine wilt, wheat. (Wheat), rice or rice bran "Red bran, Shiran bran", rice oil, cola acminata "seed", cola vera "seed", colony lya, fenugreek "fruit", colombo, co Nslango,
Kelp, konjac, comfrey (final grass), sisal
(Sisal Asa), Sai Hairan, Sakaneran (Ezosakaneran), Saxima Button Crane or Shina Button Crane or Shina Senninsou (Wei Sen), Sakura (Oshima Sakura,
Yamazakura, Oyamayamazakura, Ed Higashi, Mamezakura, Miyamazakura, Somei Yoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura "Leaf,
`` Flowers, fruits, bark (cherry bark) ''), cherries, sasa, sasabaginran, sasanqua, sage modaka (sawaki), sweet potatoes, sugar cane, sugar beet, rapeseed jujube (saccharin seeds), saffron (safflowers), sapodilla, sapotemariyo. , Pomelo "fruits", Sorbourn, Salmon berry "fruits", Prunus communa
(Sand indigo stab), salvia (sage), swordfish (spinach), sour walnut (mountain walnut), sanctum cactus, sangre degrado (croton), citrus ginseng, sanshini ginseng (37 ginseng), sanshyu (salmon mushroom) ), Sansho
(Sansho), Sandscon (Mountain bean root), Shea (Carite), Cyanoki `` fruit '', Shiitake (Shiitake), Zion (Shien), Digitalis, Shikunshi (Kushikunshi), Perilla or Aojizo or Chimenjiso or Catamenjiso (Shiso leaf, (Shiso), rosewood, linden, cypress, syringa (ream), shimeji
(Hinjimeji, Shakamejime, Hatakejimeji, Oshirojimeji, Beech Mejime, Honjimeshi, Shimotake mushroom),
Shimokuren (spicy), spirea, potato, peony (peony), shajin (sasan), jasmine (matsurya), janohigaku (wheat gate winter), skukonkasumiso, shukushamitsu (sand kernel, curd sand), juzdama, palm `` Fruits '', Shunlan, ginger (ginger), hydrangea hydrangea (Tsuneyama), ginger (iris, iris root), shozuku `` fruit '', white oak `` seed '', silane (butterfly), white-billed butterfly `` seed '', white clover (clover), White adzuki bean (chicken bone grass), white bean iris (smelly squirrel), white flower ivy "flower", shirominanten (southern natural fruit), cinchona sakusula bra, ginkgo biloba (mizuka, scented flower, shicho flower),
Cinnamon, Cinnamomum cassia, watermelon
(Watermelon), honeysuckle (gold and silver flower, Shinobi winter), sorrel (acidic), swim berry `` fruit '', star apple, stevia, strawberry `` fruit '', Suzuko (Lord Xu), horsetail (question), purslane (horse toothpaste,) Horse tooth Kenko), plum "fruit", sulgalan (orang), red pine "cone", Japanese larch, western quintet, walnut, hawthorn, hornbill, dandelion, horse chestnut (malonie), pear "fruit" ], Natsumiyukiso, Sambucus nigra
(Elder), Pacific jelly (Juniper, Juniper), Yarrow (Millfoil), Rose, Astragalus vulgaris, Mistletoe, Peppermint or Peppermint, Horseradish, Budgerigar
(Ishikon), Ginkgo (Cherry Blossom, Kouki Ginkgo, Oanabashi Ginkgo, Okinawa Ginkgo, Hon Ginkgo, Ginkgo Ginkgo, Shikaku Ginkgo, Kibanano Ginkgo) (Dendrobium, Ishibuchi), Cedron (Boshishuboku), Henasei, Henosei, Henosei, Henosei, Heisei Oise, Hire Celery, senkyu (river kyu), senshinren (shinshinren), sendan, sennin cactus, senna "fruit, leaves", ninninsou (daiba), senburi (this medicine), senboku, souka
(Grass fruit), Elephants, soy sauce, buckwheat "seed fruit", some potatoes, rhubarb (daikon), radish, daidai
(Orange skin, Minami), Takasago Rurihigotai (South indigo stab), Takasaburo (Dragon lotus), Takatodai (Oogi), Takawarabi
(Inui), dark sweet cherry "fruit", hollyhock, pearl oyster (thyme, Hyorika), tachidokoro
(Haikai), Tachiyanagi, Tamarind "seed", onion, tamshiba (spicy), Taranoki "fruit, leaf, root bark", Tarayou (Obayu winter blue, single-leaf tea, chincho tea, dacha tea), dahlia
(Tenjiku Button), Tarwi, Tanchiwachi, Tanjin
(Danshen), dandelion (brown glutinous) or white dandelion or moco dandelion, dammar, cherry "fruit", chigaya "fruit, root, sprout", ginseng ginseng (bamboo ginseng), chicory, chanka piedra (red ginger), tulip, Choco-no-Stay, Gypsophila (Dahlia), Ginseng (Mushroom), Ginseng (Agar leaf), Choreimaitake (Boar), Chologi, Tsukisou, Tsukusakaneran, Tsukuritake (Mushrooms), Tsuchihabi, Camellia, Tsubasaki, Tsubasaki, Tsubaki, Tsubasaki. Lacquer grass), communis (Duck rush), Azuki bean (Red adzuki bean), Pleurotus cornucopiae, Pleurotus cornucopia L. (Horchid crow), Tsuruna (Apricot), Ginseng (Folia ginseng),
Tsuwabuki, Deiko, Ganoderma lucidum, Duberry "Fruits", Agar Tree, Tencha (Tenshi Tea), Tendaiyaku (Crow Herb), Pepper (Winter Gourd), Pepper-Peer (Pancho), Pepper (Tourki) (Tueki), Peanut (Marigold) ), Touna Bena (river cut), corn or corn hair (nanban hair), squirrel mochi (Sadako), gentian or daffodil (dragon gall), horsetail (tree bandit), dokudami (drug), konjac (root), Toshishi or Maedaoshi or Nenshikazura, Eucommia (Musaka "bark, leaves, roots"), Ash (Hata peel), tomato, tragacanth, Triacanthus "seed", eustoma, Tormentilla, Doronoki, Tororooi, Tonka bean, Nigeria berry "fruit", Chinese yam or yam (mountain drug), Nagikadada (Butcher Bloom), Naginata Koju, Nazuna, Nata Ne, ground bean or vertical stick (sword bean), nut mandarin, jujube (Oju),
Naniwaibara (Kinzako), Navena (interrupted), Nameko, Peanut (peanut), Nanten (Namitenmi), Nanban Karamushi
(Cara hemp), bittern (Bitterwood), sagebrush (bitterness), nutmeg,
Kei or Nikkei or Ceylon Nikkei or Yab Nikkei (cinnamon bark) or Keishi (Keishi), Nyoro shorebird, Chinese chive (Nishi), elderberry (Grafted tree "fruit, flower, stem, leaf"), garlic (daigar), Nurude (quintile) , Leek, alveolum or nebu or nebi or nemur or digokubana (celebration), thistle
(Oyagi), Noibaru (Fruit), Nozomi Kazura (Ryosaku), Nogetou, Yarrow, Nodake (Maehu), Novara, Peach, Pineapple `` fruit '', Hibiscus (Busouge, Furinbusouge, Roselle), Hyelindo,
Hachiwa, Pau Dose, Hakamaurabosi (bone fracture supplement), Hakukayumato, Hakusan Chidori, Hakusen (tinea versicolor), Hakulberry `` fruit '', Hakobe (prosperous), Hazel (Haruko),
Hasiridokoro (roth root), basil, lotus (lotus, lotus meat, lotus root), parsley (netherlands jelly), hadakamugi, batata, bee or madake (boiled bamboo), patchouli, peppermint (light load, light load leaf), pearl barley (yokuinin). , Hananasuge (familiar mother), banana, hanahakka, hanabinshi (shitsuri, shitsuri), vanilla bins, papaya, hacogusa (mouse koji), pahalobobo, hub "whole grass, stems, leaves", paprika, hamacakiran,
Hamago or Mitsuba hamago (vine vine), pearl hemlock (kazushi), hamabishi (shitsuriko), hamaboufu (hama windbreak), hamamelis, palm, rose (rose), balata, balata rubber, agaricus (aratake mushroom, white oyster mushroom) , Haran, Pariurus (Piscus vulgaris), Parietalia, Harkanlan, Balsamina (Tsurureishi, Nigauri), Harunire (black skin, black hide, yellow leaf),
Barbasco, Harlin Dou, Handaikai (Yutakaumi), Breadfruit, Carrot, Carrots, Pecan nuts,
Higanbana (stone garlic, iris flower), hygrumadaria, higotai, hishi (hishimi), pistachio, beet, hibiscus (ishii), hibiscus japonica, daisies (daisies), hinako no kozuchi (cow knee), chickpeas, cypress , Hiba, castor, sunflower, bell pepper, Himeuzu (Aoi), himejima
(Incense), Himematsutake (Kawariharatake, Hiromatsutake), Himemu orchid, Pimenta "fruit", juniper,
Sandalwood, Amaranthus "fruit", Biroia mallow, Broadbrush (Balance), Loquat "fruits, leaves, stems", areca
(Large skin, 榳 抔 子), Pu'er tea (Fu-cha), Futokazura (nantan), butterbur, butterbur dandelion (subsistence winter flower, subsistence winter leaf), wisteria bud (Ranso), wisteria beans (flat bean), wisteria wisteria (butterfly cherry, persimmon flower) ), Grape "fruit, peel, seed, leaf",
Beech, Fuyusuminatsutake (Coleoptera: Cordyceps), Brazilian licorice, Brazilian carrot, Black currant "fruit", Blackberry, Branjeen, Plum "fruit", Frucellaria, Blueberry (Himesuhime), Prunes, Floral Blanca, Blonde psyllium, Bundou (mung bean), hazelnuts, loofah, hetkaran, safflower (safflower), Henneken, belladonna, berry "fruit", Persea, Perbianberg, Pereschia grandifolia, red quince or duckweed (beautiful), boysenberry "fruit", houkigi Or sage, or Nendou or Hahagigi Kochia (ground syrup), Hosairan, Pouteria sapota, Pouteria lucuma, honoki, bowfu (windbreak), spinach, physalis (Torone), honoki (Japanese abundance, magnolia), boke ( Gourd ), Hosoba Abragiku (Bitter Yoku), Hosoba Ogura, Hosobanaokera (Soshu), Hosobanokirinsou (Keitensanchi), Hosobabarengiku, Bodaiju (Bodhi tree), button (peony `` flower, leaf, stem,
Bark ''), button peony (peony skin), hops, jojoba, boriji
(Ruricha), Bordeaux, white berry “fruit”,
Hongonik (Meat Juyo, Daiei), Hongsekoku (Iron Crustacea, Suzuyama Ishien), Maizuru Tennan Show (Tennansei), Maitake (Maitake), Maou (Maho), Maca, Macadamia nuts, Margaret (Mokshungik), Macri (Aquatic grass),
Magwa (mulberry bark "bark, leaves"), Magnolia splengeri, Masaranduba, Masalanzuva de Ceara,
Masheira de Boi, Mashua (Tamanouzenhalen, Kyukonkinrenka), Matatabi (Kiten Tate), Matsukasa, pine "leaves, bark, roots", Matta Orho, Matsuhodo (peel flesh), Matico (Cordon sillo), Mayoram (Hanahakka), Malvanojazin (Ginseng), Mulberry "fruit", Quince, Malaine (Biludomouzuika), Mango, Mangosteen, Manzania (Andes chamomile), Manshu Gurmi, Mandarin "fruit", Mantake mushroom (Ganoderma lucidum), Pheasant (Mimomi "Fruit"), Mishima Psycho
(Saiko), Water plantain or Water morning glory (Rhinoglossus), Water stag beetle (Harenbei lotus), Misohagi (Centropina), Michiyanagi or Niwayanagi (Hen), Mitsugashiwa, Mitsuba, Midori sapote,
Green mint, mimosa, mioga, miracle fruit "fruit", myrrh, milobalan, wheat straw, sagebrush
(Kaki), Mukunoki, Mukuroji (prolonged skin), Munya, purple (purple root), purple corn, purple azalea
(Kunming chicken blood widow), Megakansa opuntica, swordfish
(Profit mother grass), Memou grass, Melaleuca, Melissa, Melon "fruit", Mokoyomogi, Mosouchi, Mokkirin,
Mojé (pepper), holly, mokko (woody incense), maple peach, peach (peach "leaf, seed, flower, fruit"), coconut, morello cherry "fruit", morohaya (burlap), Yawakawamurasaki, Yakuchi (Yasuchi), cornflower (cornflower), cornflower, yacon, yashabushi (arrow wheel) or himeyashabushi or hagayashabushi `` fruit,
`` Pericarp, Kaho '', willow, yamde (octagonal metal plate), mistletoe (willow parasite), willow (kawayanagi, weeping willow, weeping willow, red willow, willow willow, willow dog,
(Willow, cory willow, unryan willow, willow willow, palm, willow willow, willow willow, willow willow, fox willow, doronoki), willow tree `` leaf,
"Stem", Pepper, Yabkoji (purple gold bull), Yab tobacco
(Tsugar, Tenmeisei), pokeweed (Shokuryoku), yamahanoki (Yamaharu), sagebrush, yucca or flavifolia, yuzu `` fruit '', lily, yorogusa, sagebrush (leaf bud), rygan
(Raimaru), lime "fruit", rye, lakanka "fruit", raspberry "leaves, fruit", latania (clamellia), rakkyo or shallot (seed white), lavender, agave (Aonogure azure, fukurin agave), ryokcha (green tea). ), Apple "fruit,
Seed, leaf, root ", gentian, rubus or Suabisimus
(Tsuyo Ryo), Ruritama thistle (Varadigo higotai, Xinjiang stab head), Reishi (Lichie, Lichia nucleus), Lettuce (Chisha), Red currant `` fruit '', Red pitaya, Lemon `` fruit '',
Lemongrass, Forsythia or Forsythia (Forsythia),
Astragalus, Rhizoma, Waxy, Locon, Reed, Rhizoma, Loganberry "Fruit", Rosemary (mannen wax), Rosehip (Novara), Wasabi, Cottonweed (Japanese sage flower), Waremoko (Small ground) Etc.

Examples of seaweeds include seaweed [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, aonori (usubaaonori, sujiaonori, hiraaonori, bowaonori, hosoedaonori), anaosaa (sea algae), Kind: kelp (Macombus, liquorice, Hosomekonbu, Mitsuishikonbu), wakame, hirome, aowakame, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitrus ruetokeana), hijiki, hibamata, sea uchiwa, usubaumiu Kirebanoumiuchi, Akabatumiuchi, Konaumiuchiwa, Okuchiuchiwa, Usuyukiuchiwa, Echiukiumiuchiwa], Seaweed [Red algae: Hijirimen, Hakusa, Hirakusa, Onik , Obakusa, Kataobakusa,
Yatabegusa, Yukigiri, Amanita, Tosakanori, Togekirinsai, Amaxakirinsai, Giraffe, Jakushinkirinsai, Tsunomata, Obatatsunomata, Tochaka (Nyakuzuna-no-Tomashita), Ezotsunomatsuta, Togenomata, Hirasakonotoma, Kotobuki, Kotobuki, Kotobushi
[Yaleus Banori, Kagious Banori, Suzius Banori, Haius Banori, Akamomijinori] and the like.

In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Qualmomim: Quanonimo, Volvox: Ohigewawari, Volbox, Palmera, Yotsumeu, Genus Aomizu: Hizaori, Ao-shiro, Tsurugi-Midoro, Hibi-Midoro: Hibi-Midoro, Aosa Genus: Anaaosa, Amiosa, Nagahaosa, Kawanori: Kawanori,
Fruicula genus, Shiogusa genus: Oenothera genus, Asamidoriushigusa, Kawashiogusa, Marimo, Baronia genus: Tamagobalonia, Tamabaronia, Magatagum genus: Magata, Iwachia genus: Fusaiwaduta, Black squirrel, Mildewer, Black millet, Nematoda, Hagemonia, Nematoda. Sakibutimir, Nagamir, Hiramiru, and Kasanori:
Casanori, genus genus: Futozuzumo, Tamazuzumo,
(Mizujuzumo, Mikadzuki genus, Colecaete genus, Tsudumimo genus, Kikkokusa genus: Kikkokusa, Astragalus genus: Hitogusa, Hirohanohitohegusa, Usutoegusa, Motukihitoe, Sayamidoro, etc.

Blue-green algae (genus Suizenjinori: genus Suizenjinori, genus Algae, genus Nostoc: Kawatake, Nostoc commune,
Hassai, genus Yuremo, racenmo (spirulina) genus: spirulina, trichodesmium (aiacacio), etc.).

Brown algae (Pyraera: Pyraera, Shiomidoro: Nagamisio Midoro, Isogrape: Isogrape,
Genus Isogawara: Isogawara, Kurogashira: Gunsen Kurogashira, Kasakizaki: Kazakizaki, Muchimo: Muchimo, Hiramuchimo, Keperigusa, Astragalus: Astragalus, Sakibirohajiza, Sanyuhajihadosa, Azagusa saga: Common sage: Common clover, Common clover Prickly squirrel, Ulaboshihaha, Symphalida: Symphologus, Cyperus genus: Cyperus cypress, Konaumi uchiwa, Akabayumi uchiwa, Namikura genus: Prunus chinensis, Somexaceae genus: Somenaceae
Pinus genus: Matsumo, Nagamatsu genus: Nagamatsu moth, Okinawa mozuku genus: Okinawa mozuku, Niceft mozuku genus: Physcomit genus, Physmozuku genus: Physcomitum genus: Genus mosquito: Genus mosquito: Genus moss, Genus moss Isige, Iroro, Ichimegasa: Ichimegasa, Calligraphy: Calli, Umibosu: Umibosu, Urushigusa: Urushigusa,
Black cypress, Tobacco bug, Genus: Haemorium, Haberdoki: Haberodoki, Havanori: Havanori, Habernori: Hazelnut, Common genus: Common butterbur, Ezoburo genus: Nematode: Nephila, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Pleurotus vulgaris Genus Kagomenori: genus Kagomenori, genus Muralis: murachidori, genus Phalaenopsis: shark
Sardine: Sardine, Asclepias: Asclepias, Kayamonori: Kayamonori, Fennel genus: Fennel, Tsurumo: Tsurumo, Anata: Squirrel, Susume: Aedes albopictus, Missus konjac, Miscanthus, Aedes radisculent, konjac beetle, konjac beetle, scutella conserved , Onikonbu, Goheikonbu, Nagakombu, Pea kombi, Otojijimokubu, Tororokonbu genus: Tororocombu, Antocume: Antokume, Kajime: Kajime, Tsuruarame, Kurume, Chrysanthemum genus: Chrysanthemum genus: Necrochamus genus, Black konjac genus, Black locust, Black civet, : Catfish,
Genus Alame: Alame, Ainu Wakame, Ainu Wakame, Chigaiso, Oniwaka Ezo Ishige: Ezo Ishige, Yabanemoku: Yabanemoku, Rappamok: Rappamok, Jolomok: Ugananomoku, Jolomok, Hiemoku, Honduramaku, Isamanidae, Tamanashira Akamoku, Shidamok, Hondawara, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yasumatamok, Umitranano, Obamamok, Fushizushimok, Hahamok, Togemoku, Yoremoku, Sugimurakoku, Sugimurakoku, Sugimurakoku, Sugimoku, Sugimoku, Sugimoku
Burukkimo, genus Kayamonori: Kayamonori, etc.).

[0039] Red algae (genus: Kensuke Nori, Funori Nousuke, genus Magnolia: Asakusanori, Susabinori,
Upruinori, Onia manori, Tasa, Fuiritha, Benitasa, Rhodocorton: Milnobeni, Akebono Mozuku: Akebono Mozuku, Konahada genus: Hikonahada, Yogorekonahazukuni Azukuniboku, Azusa konjac, Azusa konjac, Azurus chinensis, Azurus chinensis, Azulina serrata, Azurus serrata, Scorpionaceae. : Pine pine, Fusanori genus: Fusanori, False genus: False genus,
Genus Sodegari: Sodegarami, Rattle Genus: Rattle, Rattle, Hilotatamaidae: Hirohatamai Taki, Tamai Taki: Tamai Tadaki, Kagenokiri: Kagaminori, Kaburi, Hibachi, Hibachi, Hibachi, Hibachi, Hitenagao, Hitengusa, Hitenagasa, Hitenagasa, Hitenagai Genus: Hihibiroud, Hibihibiroud,
Rhododendron: Rhododendron spp .:
Scorpionaceae, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekaregususa: Nisekarekigusa, Okitsubara genus: Psyllium genus: Acacia genus: Abaca, Malva Aqaba, Naminohana mosquito: Anemoneaceae: Anemoneaceae: Prunus vulgaris Etsukiiwanokawa, Kainokawa genus: Kainokawa, Kaninote genus: Kaninote, Coral genus: Coral moth, Centipede genus: Centipede, Shimejikade, Katanori, Hiramukade, Kyounohimo, Sakuranori, Nikumukade, Tanbanori, Tsurutsuru,
Fudaraku, Maruba Hudarak, Isonohana: Nurakusa,
Black knuckle, Ginkgo biloba, Japanese quince: Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese pine tree, Japanese pine tree Nagaobane genus: Nagaobane,
Genus: Hanafunori, Fukurofunori, Mafunori, Kaligukisa: Pachydermia japonicum, Podocarpus genus: Hosobanotokaomodoki, Hirohanotosakadoki, Yatsudegatatokadoki, Kurotosakatodoki, Katodoki, Katodoki, Katodoki, Katodoki Doki,
Himetosakadoki, Kinuhada genus: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hichinagenasu, Nihonbunio, Nihonburonoo Pleurotus cornucopia, Okamuragusa:
Yamadagusa, Mirin: Mirin, Hosobamirin, Tosakanori: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomokka, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kadikio Nori, Phytophthora alba Spodoptera litura, genus Astragalus: Astragalus,
Genus Ogonori: Ogonori, Cranegrass, Shiramo, Ozonori, Mizookonori, Cabana Nori, Beniogonori, Fukuroshinonori, Muranosakinogoonori, Scorpionaceae, Scutellariae, Scorpionoris , Amanita genus: Nectaria vulgaris, Fushiklenori genus: Fushiklenori, Namibia genus: Pleurotus cornucopiae, Cyprinidae: Pleurotus genus, Periwinkle genus: Periwinkle, Prunus genus: Pleurotus genus: Simi, Hedgehog, Lotus japonicus
Lotus japonicus, Scutellaria: squid reeds,
Novonori, Black-headed genus: Black-headed ginsou, Red-headed genus: Red-headed ginsou, Rhizoma genus: Hishibukuro, Madaragusa: Scutellaria, Etsukimadara, Taogo-nagien: Taogosou, Hanasakura, Haduna, sugi , Hiratao goat genus: Hiratao goat, dalus genus: dalus, scorpionfish, anadalus, weebagsa genus: weebagsa, benifukuronori genus: benifukuronori, fushuna genus: fushunagi, himefusutsunagi,
Broadbill, Salix genus: Spodoptera cinerea, Usbawa vulgaris, squid genus: squid, caygis, squid squid, haneigis, axusa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chirimomimushi: Chirimomiji, Konohanori family: Hatabenoori, Konohanori, Suzuronori, Usubini: Usbeni, Hasugiginu: Hasujiginu, Nagausaginohagi, Hausaginohagi, Hausaginohaji, Niusakonohaji, sugi-nosagi, sugi, sugi Yaleus Banori, Suzius Banori, Haius Banori, Usbanorimodoki: Usbanorimodoki, Ayanishiki: Ayanishiki, Agianu:
Ayaginu, Dasia genus: Enashidasia, Shimadsia genus: Isohagi, Shimadaia, Dagimodi: Dagimodoki, Itogusa: Moroitogusa, Futoigusa, Makuri: Makuri, Yanaginori genus: Hana-yanagia, sagiyunayunayunayunayunayunayunayunabenyi, benna : Crosozo, Cobosozo, Hanesoso, Sozonohana, Amaranthus: Ranunculaceae, Raponica, Cozanemo: Cozanemo, Imurasaki, Hosocozanemo, Genus: Mesothraceae, Black-spotted dragonfly, Anemoneaceae, Anemoneaceae, Anemoneaceae, Anemoneaceae, Angustiaceae, Angustiaceae, Angustiformes Astragalus, Rhizophora: Rhizopus, Fujimatsumo: Fujimatsumo, Sawtooth genus: Toothbrush Mushrooms, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome genus: Ideyukogome, Ochiimozuku genus: Ochiimozuku, Otomogusa, Chichinorimo: Chinorimo, Chisujinori: Chisujinori and the like).

Axis algae (genus Chara, genus Citra,
The genus Rhizopus: Rhizophyllum, the genus Lichnotamnus, the genus Flamus: Himaflamus, Chaboflamus, Tripera, etc.), the yellow algae (Genus Hikarimo: Hikarimo, etc.), etc.

The material derived from animal-derived raw materials includes chicken cob extract, bovine, porcine or human placenta extract, porcine or bovine stomach, duodenum, intestine, spleen extract or its decomposed product, beef or pig. Brain tissue extract, water-soluble collagen, collagen derivative such as acylated collagen, collagen hydrolyzate,
Elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its degradation product or their derivatives,
Silk protein and its degradation products or their derivatives, pig or bovine blood cell protein degradation products (globin peptides), cattle or pig hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and its Degradation products or their derivatives, skim milk powder and its degradation products or their derivatives, lactoferrin or its degradation products, chicken egg components, fish meat degradation products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid)
etc.

As the active ingredient or the ingredient derived from a microbial material used as an additive, yeast metabolites, yeast extract, bacterial metabolites, bacterial extract, metabolites such as mold or mushroom, actinomycete metabolites, mold or Extracts of mushrooms, actinomycetes extract, natto metabolites, natto extract, fermented rice extract, fermented rice bran (red bran, white bran), euglena extract or its decomposition product or water-soluble derivative thereof, raw milk or skim milk powder Lactic acid fermentation product, trehalose or its derivative.

In addition, as a plant or animal or microbial material, any site, cell, tissue, organ, metabolite derived from a transgenic body or cell fusion can be used. Further, obtained by culturing cells at any site, cell, tissue, organ, etc., for example, cultured cells derived from each tissue (embryonic stem cells, fibroblasts, Langerhans cells,
Animal-derived cultured cells such as macrophages, epidermal cells, and hepatocytes), undifferentiated cell groups, in-differentiating cell groups, and metabolites thereof can also be used.

As a component of a natural product raw material used as an active ingredient or an additive, seawater such as deep sea water, for example, seawater salt,
Marine components such as dried seawater, inorganic salts (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the Dead Sea or the seas of the Atlantic Ocean or the Pacific Ocean.

(10) α-hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.

(11) Pigmentation inhibitor p-aminobenzoic acid derivative, salicylic acid derivative, benzenesulfonamide derivative, imidazole derivative, naphthalene derivative, hydroxyanthranilic acid or its salt and their derivatives, anthranilic acid derivative, coumarin derivative, Amino acid derivative (2-amino-3- [1-carboxyl-
2- (1H-Imidazol-4-yl) ethyl] aminobutanoic acid, 2-amino-3- [1-carboxyl-2- (1H-imidazo-
Lu-4-yl) ethyl] aminobutanoic acid hydrochloride, 2-amino-
3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid sodium salt, 2-amino-3- [1-
Carboxyl-2- (1H-imidazol-4-yl) ethyl]
Aminobutanoic acid potassium salt, etc.), benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative,
Furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, ascorbic acid or salts thereof and their derivatives (phosphoric acid-L-ascorbate magnesium, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyprophosphate Ester, 5-o-α-D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphoric acid sodium salt, L-ascorbic acid phosphoric acid potassium salt, L-ascorbic acid phosphoric acid magnesium salt, L-ascorbin Acid phosphoric acid ester calcium salt, L-ascorbic acid phosphoric acid aluminum salt, L-ascorbic acid sulfuric acid sodium salt, L-ascorbic acid sulfuric acid potassium salt, L-ascorbic acid sulfuric acid magnesium salt, L-ascorbic acid sulfuric acid Steal calcium salt,
L-ascorbic acid sulfate aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-
o-α-D-galactopyranosyl-L-ascorbic acid, 2-o-β
-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphoric acid ester magnesium salt, L-ascorbic acid phosphoric acid sodium salt, L-ascorbic acid sulfuric acid sodium salt, 6-o-acyl ascorbic acid phosphorous Acid ester sodium salt, 6-o-acyl ascorbic acid phosphoric acid ammonium salt, 6-o-acyl ascorbic acid phosphoric acid ester isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkylascorbic acid Phosphoric acid potassium salt, 6-o-alkyl ascorbic acid phosphoric acid calcium salt, 6-o-alkyl ascorbic acid phosphoric acid barium salt, 6-o-alkyl ascorbic acid phosphoric acid ammonium salt, 6-o-alkyl Ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl phosphorus ascorbate Acid ester diethanolamine salt, 6-o-alkylascorbic acid phosphoric acid ester triethanolamine salt, 6-o-alkylascorbic acid phosphoric acid ester monoisopropanolamine salt, 6-o-alkylascorbic acid phosphoric acid ester diisopropanolamine salt, 6-o-alkyl ascorbic acid phosphoric acid ester triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphoric acid cholesterol ester , Palmitic acid-L-ascorbyl, isopalmitic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid- L-Ascorbyl, Diisostearic Acid-L-Ascorbyl, Mi Styric acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexanoic acid- L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α
-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-
Ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, L-
Ascorbic acid tetraisopalmitate, L-
Ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol ester, L- Ascorbic acid-DL-tocopherol phosphate, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid triphosphate , 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferulate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6
-Palmitoyl ascorbyl] -4'-acetoxy ferulate, DL-α-tocopherol-2-L-ascorbic acid phosphoric acid diester, ascorbic acid inositol-bonded derivative,
Ascorbic acid phosphoramide derivative, ascorbic acid arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), tocopherol or a salt thereof and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ) -Tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate ester, tocopherol acetate, tocopherol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL -α-tocopheryl glucoside, DL
-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL
-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-
Tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α -Tocopheryl maltoside, L
-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-
Tocopheryl maltoside, 1- (sulfoethylamino) -3
-(Α-tocopheryl-6-yloxy) propan-2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-yloxy) propan-2-ol hydrochloride, S- [ 3-
(Α-tocopheryl-6-yloxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N -[3- (α-Tocopheryl-6-yloxy) -2-hydroxypropyl] aspartic acid, N-
[3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienols or salts thereof and their derivatives (α-tocotrienol,
β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate, etc., kojic acid or its derivative (2-methoxymethyl-hydroxy-4H-pyran- 4-one, 2-ethoxymethyl
-5-Hydroxy-4H-pyran-4-one, 2-benzolyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H-pyran-4-one , 2-
Phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate , Kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), oxybenzone, benzophenone, guaiazulene, shikonin, isoflavone glycoside (6-o-apiosylpuerarin-4'-o -Glucoside, 6-o-glucosylpuerarin, 3'-hydroxypuerarin-4'-o-glucoside, 6-o-apiosyl-3'-hydroxypuerarin, etc., γ-pyrone glycoside (maltol-
3-o- (6'-o-apiosyl) -glucoside, maltol-3-o
-(6'-o-apiosyl) -glucoside etc.), isononyl ferulate, ellagic acid or salts thereof and their derivatives (5,4-dimethylellagic acid, 3,3'-dimethylellagic acid, 3,
3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-
Methoxyellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid, amrittoside, etc.), lucinol, ondisaponin, bakumondusaponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, anilide benzoate (4- Hydroxy-N- (2-hydroxyphenyl) benzoic acid amide, 4-hydroxy-N- (3-hydroxyphenyl) benzamide, 4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t- Butyl-4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5
-Di-t-butyl-4-hydroxy-N- (3-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N-
(2-hydroxyphenyl) benzamide, etc.), diphenylpyraline, cyproheptadine, triprolidine, dimethindene, ozagrel, isothipendyl, iproheptin, homochlorcyclidine, alimemazine, bucillamine, oxtosamide, vidarabine, xanthoxol,
Placenta (from bovine, porcine, equine, ovine, etc.)
Extract, almond extract, ammalok extract, euphoria extract, lichen extract, okera extract, corn extract, uncaria extract, geijicha extract, coconut extract, licorice extract, gardenia extract, krani Gean extract, Clara extract, Scutellaria baicalensis (Sweet) extract, Wheat
(Wheat) extract, rice (rice) extract, koriaria extract,
Sidowaya extract, Sanyukyu extract, San Vitro extract, Sunpens extract, Silane (Juniperia) extract,
Senkyu (river cucumber) extract, senna extract, senkukuka extract, senkatsusai extract, squirtingine extract,
Nodake (pre-hu) extract, adlay (Yokuinin) extract,
Hamago extract, honeysuckle extract, hamamelis extract, palm extract, Parietaria extract, safflower extract, magwa extract, malvanojazin extract, purple iris extract, and white iris extract. , Muco mugwort extract, Yashajitsu extract, Hong Kong extract, Waremoko extract, Yuzuriha extract, Yakutou extract, Yatsude extract, etc.

(12) Tyrosinase activity inhibitor ascorbic acid or salts thereof and derivatives thereof (phosphate-L-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyproline ascorbate, 5-o- α-D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphoric acid sodium salt, L-ascorbic acid phosphoric acid potassium salt, L-ascorbic acid phosphoric acid magnesium salt, L-ascorbic acid phosphoric acid calcium salt L-ascorbic acid phosphoric acid aluminum salt, L-ascorbic acid sulfuric acid sodium salt, L-ascorbic acid sulfuric acid potassium salt, L-ascorbic acid sulfuric acid magnesium salt, L-ascorbic acid sulfuric acid calcium salt, L-ascorbin Acid sulfate Teraluminum salt, L-ascorbate sodium salt, L-ascorbate potassium salt, L-ascorbate magnesium salt, L-ascorbate calcium salt, L-ascorbate aluminum salt, 6-o-α-D-galactopyrano Syl-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphoric acid ester magnesium salt, L-ascorbic acid phosphoric acid ester sodium salt,
L-ascorbic acid sulfuric acid sodium salt, 6-o-acyl ascorbic acid phosphoric acid sodium salt, 6-o-acyl ascorbic acid phosphoric acid ammonium salt, 6-
o-Acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6-o
-Alkyl ascorbic acid phosphate potassium salt, 6
-O-alkyl ascorbic acid phosphoric acid ester calcium salt, 6-o-alkyl ascorbic acid phosphoric acid ester barium salt, 6-o-alkyl ascorbic acid phosphoric acid ester ammonium salt, 6-o-alkyl ascorbic acid phosphoric acid ester monoethanol Amine salt, 6-o-alkylascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphoric acid ester triethanolamine salt, 6-o-alkylascorbic acid phosphoric acid ester monoisopropanolamine salt, 6-o- Alkyl ascorbic acid phosphoric acid ester diisopropanolamine salt, 6-o-Alkyl ascorbic acid phosphoric acid ester triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-
β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphoric acid cholesterol ester, palmitic acid-L
-Ascorbyl, Isopalmitic acid-L-Ascorbyl, Dipalmitic acid-L-Ascorbyl, Diisopalmitic acid-L-
Ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid-L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L -Ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D- Glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-
o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl
-L-ascorbic acid, L-ascorbic acid tetraisopalmitic acid ester, L-ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6 -Isopropylidene-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-
Tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid triphosphate, 2-o- Ascorbyl cinnamate, 2-o-ascorbyl ferulate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl] -4'-
Acetoxy ferulate, DL-α-tocopherol-2-L-
Ascorbic acid phosphoric acid diester, ascorbic acid inositol bond derivative, ascorbic acid phosphoramide derivative, ascorbic acid arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc., hydroquinone or salts thereof and derivatives thereof ( Hydroquinone α-D-glucose, hydroquinone β-D-glucose, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose, hydroquinone α-L-galactose, hydroquinone Hexacarbon glycosides such as β-L-galactose, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-ribose, hydroquinone β-L-ribose, hydroquinone -D-arabinose, hydroquinone β-D-arabinose, hydroquinone α-L-arabinose, hydroquinone β-L-arabinose and other pentose glycosides, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α -L-glucosamine, hydroquinone β-L-glucosamine, hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-
Aminoglycosides such as galactosamine, hydroquinone β-L-galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β-D-glucuronic acid, hydroquinone α-L-glucuronic acid, hydroquinone β-L-glucuronic acid, hydroquinone α Hydroquinone glycosides such as uronic acid glycosides such as -D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L-galacturonic acid, hydroquinone benzyl ether, 4-β -D-glucopyranosyloxy-
1- (4-hydroxyphenoxy) butane, 5-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) pentane, 6-β-D-glucopyranosyloxy-1- (4-hydroxy Phenoxy) hexane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propane, 2-β-D-
Hydroquinone hydroxyalkyl ether glycosides such as glucopyranosyloxy-1- (4-hydroxyphenoxy) butane and 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propan-3-ol Etc.), kojic acid or its salts and their derivatives (2-methoxymethyl)
-Hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-
Hydroxy-4H-pyran-4-one, 2-benzolyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H-pyran-4-one, 2- Phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate , Kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), tocopherol or salts thereof and derivatives thereof (α-tocopherol,
β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, tocopherol succinate, Tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-
Tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-
Tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ -Tocopheryl maltoside, D
-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β
-Tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, L- (sulfoethylamino) -3- (Α-tocopheryl-6-yloxy) propan-2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-yloxy) propane-2-
All hydrochloride, S- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] cysteine, S- [3-
(Α-tocopheryl-6-yloxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3-
(Α-tocopheryl-6-yloxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-
6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienols or salts thereof and their derivatives (α-tocotrienol, β-tocotrienol, γ-
Tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate, etc.), N-acetyltyrosine or its salts and their derivatives, glutathione or its salts and their derivatives, ellagic acid Or salts thereof and their derivatives (3,4-dimethylellagic acid, 3,3′-
Dimethyl ellagic acid, 3,3 ', 4-trimethyl ellagic acid, 3,3',
4,4'-Tetramethyl-5-methoxyellagic acid, 3-ethyl-4-
Methyl-5-hydroxyellagic acid, amritside, etc.), isonitrine A, isonitrine B, isonitrine C, isonitrine D, isonitrinic acid E, isonitrinic acid F, dermadein, tricobilidenine and other isonitrile antibiotics, orseric acid derivative (orseric acid, Orcenic acid ethyl ester orcinol, p-geranyl orceric acid, p-geranyl orceric acid ethyl ester geranyl orcinol, p-farnesyl orceric acid, p-farnesyl orceric acid ethyl ester farnesyl orcinol, p-dodecanyl or Seric acid, p-dodecanyl orceric acid ethyl ester dodecanyl orcinol, p-tetradecanyl orcelinic acid, p-tetradecanyl orcelinic acid ethyl ester tetradecanyl orcinol, p-hexadecanyl orcelinic acid , P- Hexadecanyl Orcelinic Acid Ethyl Ester Hexadecanyl Orcinol, p-Undecanyl Orcelinic Acid, p-Undecanyl Orcelinic Acid Ethyl Ester Undecanyl Orcinol, p-Tridecanyl Orcelinic Acid, p-Tri Decanyl orceric acid ethyl ester Undecanyl orcinol, p-pentadecanyl orserine acid, p-pentadecanyl orserine acid ester pentadecanyl orcinol, ethylhexyl orserine acid, p-ethylhexyl orserine ester Ethylhexyl orcinol, p-Cyclohexylmethyl orserine acid, p-Cyclohexylmethyl orserine acid ethyl ester cyclohexylmethyl orcinol, p-
Hydroxyethylhexyl orserine acid methyl ester, p-hydroxyethylhexyl orserine acid hydroxyethylhexyl orcinol, etc.), umberic acid, brefeldin, oxydesveratrol, resorcinol derivative (4-cyclohexylresorcinol), 3-hydroxyketone compound (1 , 5-bis (p-hydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (o, p-dihydroxyphenyl) -2-hydroxypentan-4-one,
1,5-bis (p-hydroxyphenyl-m-methoxyphenyl) -2-hydroxypentan-4-one etc.), 1,3-diketone compounds (1,5-bis (p-hydroxyphenyl) -2,4 -Pentanedione, 1,5-bis (o, p-dihydroxyphenyl)-
2,4-pentanedione, 1,5-bis (p-hydroxyphenyl
-m-Methoxyphenyl) -2,4-pentanedione), bishydroxybenzyl amides, γ-aminobutyric acid or its derivatives (N-methyl-γ-aminobutyric acid, N-dimethyl-γ-aminobutyric acid, γ- Aminobutyric acid oleyl ester, etc.), placenta extract, lucinol, silk extract, acacia extract,
Acerola extract, Abutilon (winter aquatic) extract, Weeping birch extract, Quellus (gallicus) extract, chestnut extract, Kamehiba hikoshi extract, Kurobana hikikoshi extract, Hikiokoshi extract, Seri extract, buckwheat extract,
Darbylia extract, Nazuna extract, Fujibacama (Orchid)
Extract, chamomile extract, mulberry extract, gardenia extract, Touki extract, oleander extract, Clara extract,
Artemisia extract, honeysuckle extract, yellow bud extract, Dokudami extract, matsuhod extract, adlay extract, hop extract, hawthorn extract, yarrow extract, althea extract, keihi extract, mankaishi extract, hamamelis extract, yamawawa extract, bellflower extract,
Toshishi extract, succulent extract, irrigation extract, mahuang extract, senkyu extract, dokutsu extract, psycho extract, bow-fu extract, hama-bofu extract, sardine extract, peony skin extract, peony extract, kakkon extract,
Licorice extract, quintile extract, aloe extract, ginger extract, safflower extract, green tea extract, black tea extract, Asenyaku extract, etc.

(13) Melanocyte melanin production inhibitor lobeline or lobeline derivative, liquiritin derivative (liquiritin-α-glucoside, liquiritin-α-maltoside, etc.), phenylchroman derivative, chromone derivative (2-
Butyl chromone, 2-pentyl chromone, 2-heptyl chromone, 2-nonyl chromone, 2-hexadecyl chromone, 2-
(1-Ethylpentyl) chromone, 2-butyl-7-methoxychromone, 2-pentyl-7-methoxychromone, 2-heptyl-7-methoxychromone, 2-nonyl-7-methoxychromone, 2-pentadecyl-7- Methoxychromone, 2- (1-ethylpentyl) -7-methoxychromone, 7-hydroxy-2-methylchromone, 7-hydroxy-2-butylchromone, 7-hydroxy-2-pentylchromone, 7-hydroxy-2- Heptyl chromone, 7-hydroxy-2-nonyl chromone, 7-hydroxy-2-pentadecyl chromone, 7-hydroxy-2- (1-
Ethylpentyl) chromone, etc.), azelaic acid derivatives (azelaic acid monoalkyl ester, azelaic acid dialkyl ester, etc.), phosphatidylglucosamine
Lysophosphatidylglucosamine, phenylhydroquinone, 3-β-D-glucopyranosylmanur, 3-β-D-maltopyranosylmanur, substituted amino acid derivative (DL-N-formyl-3- (1-naphthyl) alanine, DL-N-acetyl-3- (1
-Naphthyl) alanine, DL-N-propionyl-3- (1-naphthyl) alanine, DL-N-butyryl-3- (1-naphthyl) alanine, DL-N-isobutyryl-3- (1-naphthyl) alanine,
DL-N-valeryl-3- (1-naphthyl) alanine, DL-N-isovaleryl-3- (1-naphthyl) alanine, DL-N- (2-methylvaleryl) -3- (1-naphthyl) alanine, DL -N- (3-methylvaleryl) -3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-t-
Butylacetyl-3- (1-naphthyl) alanine, DL-N-pivaloyl-3- (1-naphthyl) alanine, DL-N-caproyl-3
-(1-naphthyl) alanine, DL-N- (2-ethylhexanoyl) -3- (1-naphthyl) alanine, DL-N- (2-methylhexanoyl) -3- (1-naphthyl) alanine, DL-N-heptanoyl-3- (1-naphthyl) alanine, DL-N-octanoyl-3
-(1-naphthyl) alanine, DL-N- (2-propylpentanoyl) -3- (1-naphthyl) alanine, DL-N-nonanoyl-3
-(1-naphthyl) alanine, DL-N-decanoyl-3- (1-naphthyl) alanine, DL-N-undecanoyl-3- (1-naphthyl) alanine, DL-N-dodecanoyl-3- (1-naphthyl) ) Alanine, DL-N-tridecanoyl-3- (1-naphthyl) alanine, DL-N-tetradecanoyl-3- (1-naphthyl) alanine, DL-N-pentadecanoyl-3- (1-naphthyl) Alanine, DL-N-hexadecanoyl-3- (1-naphthyl) alanine, DL-N-heptadecanoyl-3- (1-naphthyl) alanine, DL-N-octadecanoyl-3- (1-naphthyl) alanine , DL-N-nonadecanoyl-DL-3- (1-naphthyl) alanine, DL-N-icosanoyl-3- (1-naphthyl) alanine, DL
-N-acroyl-3- (1-naphthyl) alanine, DL-N-crotoniloyl-3- (1-naphthyl) alanine, DL-N-methacryloyl-3- (1-naphthyl) alanine, DL-N-vinylacetyl -3- (1-naphthyl) alanine, DL-N-cyclopropanoyl-3- (1-naphthyl) alanine, DL-N- (2-pentenoyl) -3- (1-naphthyl) alanine, DL-N- (4-Pentenoyl) -3- (1-naphthyl) alanine, DL-N- (2-hexenoyl) -3- (1-naphthyl) alanine, DL-N- (3-hexenoyl) -3- (1-naphthyl ) Alanine, DL-N- (2-methyl-3-
Pentenoyl) -3- (1-naphthyl) alanine, DL-N-Cyclohexenoyl-3- (1-naphthyl) alanine, DL-N-
(10-Undecenoyl) -3- (1-naphthyl) alanine, DL
-N-linoleyl-3- (1-naphthyl) alanine, DL-N-hydroxyacetyl-3- (1-naphthyl) alanine, DL-N- (6-
Hydroxycaproyl) -3- (1-naphthyl) alanine, D
LN- (8-hydroxyoctanoyl) -3- (1-naphthyl)
Alanine, DL-N- (9-hydroxynonanoyl) -3- (1-naphthyl) alanine, DL-N- (10-hydroxydecanoyl)
-3- (1-naphthyl) alanine, DL-N- (11-hydroxyundecanoyl) -3- (1-naphthyl) alanine, DL-N- (12
-Hydroxydecanoyl) -3- (1-naphthyl) alanine,
DL-N-benzoyl-3- (1-naphthyl) alanine, DL-N- (2
-Hydroxybenzoyl) -3- (1-naphthyl) alanine,
DL-N- (3-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (4-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (o-toluyl)- 3- (1-naphthyl) alanine, DL-N- (m-toluyl) -3- (1-naphthyl)
Alanine, DL-N- (p-toluyl) -3- (1-naphthyl) alanine, DL-N- (1-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-naphthoyl)- 3- (1-naphthyl) alanine, DL-N- (2-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-carboxybenzoyl) -3-
(1-naphthyl) alanine, DL-N- (4-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (2-picoryloyl) -3- (1-naphthyl) alanine, DL-N- (3-picolinloyl) -3- (1-naphthyl) alanine, DL-N- (4-picolinloyl) -3- (1-naphthyl) alanine, DL-N-phenylacetyl-3- (1-naphthyl) alanine, DL-N- (2-phenylpropanoyl) -3- (1-naphthyl) alanine, DL-N- (3-phenylbutyryl) -3- (1-naphthyl) alanine, DL-N-
(4-methylvaleryl) -3- (1-naphthyl) alanine, DL-
N-valeryl-3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine amide, DL-N-
(4-methylvaleryl) -3- (1-naphthyl) alanine methyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine ethyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine propyl ester, DL-
N- (4-methylvaleryl) -3- (1-naphthyl) alanine-N
-Butyl ester, DL-N- (4-methylvaleryl) -3- (1-
Naphthyl) alanine pentyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine isopropyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine isobutyl ester, DL- N- (4-methylvaleryl) -3- (1-naphthyl) alanine-t-butyl ester, etc.), benzolactam derivative, indolactam derivative,
Cedrol, guaiol, 1- (4-hydroxyphenythio) -2-propanol, β-lactoglobulin, 2-methoxy-5-methylphenol, 5-ethyl-2-methoxyphenol, 5-N-propyl-2-methoxy Phenol, 5-N-butyl-2-methoxyphenol, 5-N-hexyl-2-methoxyphenol, 5-N-heptyl-2-methoxyphenol, 5-N
-Decyl-2-methoxyphenol, 5- (1,1-dimethylpropyl) -2-methoxyphenol, 5- (1,1-dimethylbutyl) -2-methoxyphenol, 5- (1,1-dimethylethyl) -2-methoxyphenol, 2-methoxy-5- (1-methylpentyl) phenol, 2-methoxy-5- (1-methylhexyl) phenol, 2-methoxy-5- (3-methylhexyl) phenol, 2- Methoxy-5- (6-methylheptyl)
Phenol, 5- (1,3-dimethylheptyl) -2-methoxyphenol, marberine, ferguinol, sugiol, cryptojaponol, 1,5-bis [p-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [o-hydroxyphenyl] -1,4-pentadiene-3-one, 1,5-
Bis [2,4-dihydroxyphenyl] -1,4-pentadiene-3-one, 1,5-bis [3-methoxy-4-hydroxyphenyl] -1,4-pentadiene-3-one, haginine, agrimofol , Aglimol, hydrangenol or its derivatives, alkylresorcinol or its derivatives (4-N-butylresorcinol, etc.), Aristolone, caramenenes (caramenene, 7-hydroxycarbamenene, 5-hydroxycarbamenene, 7-methoxycaramene) Nene etc.), trans-umbellic acid, N-α-benzoyl-L-arginine, N-α-benzoyl-L-arginine ethyl ester or N-α-benzoyl-L-arginine ethyl ester, 5-methyl-2 (3H ) -Furanone, 2-butene-4-olide, 2-hydroxymethylfuran, 2,5-dimethyl-4-hydroxy-3 (2H) -furanone, 2-formylfuran, 3-formylfuran, methyl α-furyl ketone, F Furyl acetate, 2-hydroxy-3-methyl -
2-cyclopenten-1-one, 2-hydroxy-3,5-dimethyl
-2-cyclopenten-1-one, 2,5-dimethyl-4-hydroxy-3 (2H) -thiophenone, 2-hydroxy-3-ethyl-2-cyclopenten-1-one, tetronic acid, pentanedione,
Iminodibenzyls (2,2'-iminodibenzyl, imipramine, imipramine hydrochloride, desipramine, desipramine hydrochloride, chlorimipramine, trimipramine, etc.),
Dibenzocycloheptadienes (amitriptyline, amitriptyline hydrochloride, nortriptyline, noxiptyline, etc.), tetrahydrocoparol glycosides (ketotifen fumarate, labda-8 (17), 13-diene-15-ol, tetrahydromannur, tetrahydrocopa Roll, tetrahydrocoparol glucoside, tetrahydrocoparol galactoside, tetrahydrocoparol maltoside, tetrahydrocoparol cellobioside, tetrahydrocoparol maltotrioside, etc.), spiro ether compound, piochelin, phenothiazine compound, promethazine, alimemazine, alimemazine tartrate, Triflupromazine,
Levomepromazine, chlorpromazine, cyclanderate, 4-carboxymethyloxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- ( 3-
Carboxypropyl-1-oxy) benzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4-
(3-carboxypropyl-1-oxy) -2-methoxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2 -
Hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, 4- (10-carbamoyldecane- 1-oxy) -2-hydroxybenzoic acid, 4-
(4-hydroxybutyl-1-oxy) benzoic acid, 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid, 4-
(4-acetoxybutyl-1-oxy) benzoic acid, 4- (4-acetoxybutyl-1-oxy) -2-hydroxybenzoic acid, 4-
(3-Ethoxycarbonylpropyl-1-oxy) -2-hydroxybenzoic acid, 3- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-methoxybutyl-1-
Oxy) -2-hydroxybenzoic acid, 4- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl- 1-oxy) -2-hydroxybenzoic acid,
4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-
Carboxydecane-1-oxy) -2-hydroxybenzoic acid,
Hydroxytrimethylcyclohexanes (2-hydroxy-4- (2,2,6-trimethyl-1-yl-cyclohexane)
Butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -1-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-butene, 4- (2 , 2,6-Trimethyl-1-yl-
Cyclohexane) butane, 3-methyl-3-hydroxy-5-
(2,2,6-Trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1
-Yl-cyclohexane) pentane, 3-methyl-5- (2,2,6
-Trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -3-pentene, 3-methyl-3-hydroxy
-5- (2,2,6-Trimethyl-1-yl-cyclohexane) -1-pentene, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -2 -Pentene, 2-hydroxy-4- (2,2,6-trimethyl-1-yl-cyclohexane)
Monosaccharides such as butane, disaccharides or trisaccharide glycosides), escinol, para-hydroxycinnamic acid-4- (2,2,6-trimethyl-yl)
-Cyclohexane) -2-butyl ester monosaccharide, disaccharide or trisaccharide glycoside, ondisaponin, bakumondosaponin,
Ruscogenin, sericoside, asiaticoside, hederin, senegin, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-keto-butane, 4- (2,2,6-trimethyl-1)
-Yl-6-cyclohexene) -2-keto-butane, 4- (2,2,6-
Trimethyl-1-yl-cyclohexane) -2-keto-3-butene, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene)
-2-keto-3-butene (β-ionone), Lp-hydroxyphenylglycine, Dp-hydroxyphenylglycine, N-
Benzyloxycarbonyl-Lp-hydroxyphenylglycine, N-benzyloxycarbonyl-Dp-hydroxyphenylglycine, N-benzoyl-Lp-hydroxyphenylglycine, N-benzoyl-Dp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Dp
-Hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine, N-
Acetyl-Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine ethyl ester, N
-Acetyl-Dp-hydroxyphenylglycine ethyl ester, N-acetyl-Lp-hydroxyphenylglycineamide, N-acetyl-Dp-hydroxyphenylglycineamide, Lp-methoxyphenylglycine, Dp-methoxyphenylglycine, Lp-methoxyphenylglycine Hydrochloride, Dp-methoxyphenylglycine hydrochloride, 4-hydroxy-3-methoxy-L-phenylglycine, 4-hydroxy-3-
Methoxy-D-phenylglycine, Lp-hydroxyphenylglycine ethylamide, Dp-hydroxyphenylglycine ethylamide, N-tert-butoxycarbonyl-Lp-hydroxyphenylglycine, N-tert-butoxycarbonyl-Dp-hydroxyphenylglycine, N -tert-butoxycarbonyl-Lp-methoxyphenylglycine, N-tert-butoxycarbonyl-Dp-methoxyphenylglycine, N-9
-Fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine benzyl ester hydrochloride Salt, N-9-fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine benzyl ester hydrochloride, Lp-hydroxyphenylglycineamide, Dp-hydroxyphenylglycineamide, Lp-
Hydroxyphenylglycine allyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine benzyl ester
p-toluenesulfonate, Lp-hydroxyphenylglycine ethyl ester, Dp-hydroxyphenylglycine ethyl ester, Lp-hydroxyphenylglycine ethyl ester hydrochloride, Dp-hydroxyphenylglycine ethyl ester hydrochloride, Lp-hydroxyphenylglycine methyl ester , Dp-hydroxyphenylglycine methyl ester, etc., 1,3-diallylindan-2-carboxylic acid, stachybosin, pheophorbide derivative, eleucerin, isoeleucerin or 4-β-hydroxyisoeleucerin, eleucerinol, spiroketal derivative (2- (2,4-hexadiynylidene) -1,6-dioxaspiro [4.5] dec-3-ene, 2- (2-hexynylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-(( 4-Methylphenyl) methylidene) -6,6-dioxaspiro [4.4] nona-3
-Ene, 2- (2-hexenylidene) -6,6-dioxaspiro [4.5] deca-3-ene, 2- (2-hexenylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-hexyl -1,6-Dioxaspiro [4.4] nonane, 2- (2-hexenyl) -1,6-
Dioxaspiro [4.4] nonane, 2- (2-hexynyl) -1,
6-dioxaspiro [4.4] nonane, 2-pentyl-1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [4.4]
Nonane, 1,6-dioxaspiro [4.5] decane, 1,7-dioxaspiro [5.5] undecane, 2,3-benzo-4,4-dimethyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo- 2-
Pentyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-hexyl-1,6-dioxaspiro [4.4] nonane, 3,4
-Benzo-2-octyl-1,6-dioxaspiro [4.4] nonane, 2-hexyl-9,9-dimethyl-1,6-dioxaspiro [4.
4] Nonane, 2- (2,4-hexadiynylidene) -1,6-dioxaspiro [4.4] non-3-ene, etc.), malvalic acid, phosphonic acid derivatives or salts thereof, aspergylomalasmin, aminophosphonic acid Derivative or salt thereof, diphenhydramine or salt thereof, pregnenolone or derivative thereof, lutein, farnesyl isopropanol derivative, hexahydrofarnesyl acetone, 4-benzoylamino-2-hydroxybenzoic acid, 5-benzoylamino-2-hydroxybenzoic acid, 4- Benzoylaminobenzoic acid, 4- (1-naphthoylamino) -2-hydroxybenzoic acid, 5- (1-naphthoylamino) -2-hydroxybenzoic acid, 4- (2-naphthoylamino) -2-hydroxy Benzoic acid, 5- (2-naphthoylamino) -2-hydroxybenzoic acid, 4- (1-naphthoylamino) benzoic acid, 4- (2-naphthoylamino) benzoic acid, 4 -
Phenylaminocarbonylbenzoic acid, 4-phenylaminocarbonyl-2-hydroxybenzoic acid, 5-phenylaminocarbonyl-2-hydroxybenzoic acid, 4- (1-naphthylaminocarbonyl) benzoic acid, 4- (1-naphthylaminocarbonyl) ) -2-Hydroxybenzoic acid, 5- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 4- (2-naphthylaminocarbonyl) benzoic acid, 4- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid Acid, 5- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, hexahydrofarnesyl isopropanol derivative, borneol-p-hydroxycinnamic acid ester glucoside, borneol-p-hydroxycinnamic acid ester maltoside, borneol-p -Hydroxycinnamic acid ester maltotrioside, cinnamic acid-4- (2,2,6-trimethyl-yl-cyclo Hexane) -2-butyl ester derivative, 2,4-dihydroxybenzophenone, 1- (2,4-dihydroxyphenyl) - ethanone (2 ', 4'-dihydroxy acetophenone), 1- (2,
4-dihydroxyphenyl) -1-propanone (2 ', 4'-dihydroxypropiophenone), 1- (2,4-dihydroxyphenyl) -1-butanone, 1- (2,4-dihydroxyphenyl) -1- Pentanone, 1- (2,4-dihydroxyphenyl)-
1-hexanone, 1- (2,4-dihydroxyphenyl) -1-heptanone, 1- (2,4-dihydroxyphenyl) -1-octanone, 1- (2,4-dihydroxyphenyl) -1-nonanone, 1
-(2,4-Dihydroxyphenyl) -1-decane, 1- (2,4-
Dihydroxyphenyl) -1-undecanone, 1- (2,4-dihydroxyphenyl) -1-dodecanone, 1- (2,4-dihydroxyphenyl) -1-tetradecanone, 1- (2,4-dihydroxyphenyl) -1 -Hexadecanone, 1- (2,4-dihydroxyphenyl) -1-octadecanone, 1- (2-hydroxy-4-methoxyphenyl) -ethanone (2'-hydroxy-4 '
-Methoxyacetophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-propanone (2'-hydroxy-4'-methoxypropiophenone), 1- (2-hydroxy-4-methoxyphenyl) -1 -Butanone, 1- (2-hydroxy-4-methoxyphenyl) -1-pentanone, 1- (2-hydroxy-4-methoxyphenyl) -1-hexanone, 1- (2-hydroxy-4-methoxyphenyl)- 1-heptanone, 1- (2-hydroxy-4-
Methoxyphenyl) -1-octanone, 1- (2-hydroxy-
4-methoxyphenyl) -1-nonanone, 1- (2-hydroxy-
4-methoxyphenyl) -1-decanone, 1- (2-hydroxy-
4-methoxyphenyl) -1-undecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-dodecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-tetradecanone, 1-
(2-Hydroxy-4-methoxyphenyl) -1-hexadecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octadecanone, 1- (4-hydroxy-2-methoxyphenyl) -ethanone (4'- Hydroxy-2'-methoxyacetophenone), 1- (4-hydroxy-2-methoxyphenyl) -1-propanone (4'-hydroxy-2'-methoxypropiophenone), 1- (2,4-dimethoxyphenyl) -Ethanon (2 ', 4'
-Dimethoxyacetophenone), 1- (2,4-dimethoxyphenyl) -1-propanone (2 ', 4'-dimethoxypropiophenone), lactone derivative (1,6-dioxaspiro [4.
4) nonane-2,7-dione, 1,6-dioxaspiro [4.5] decane-2,7-dione, 4-tridecanolide, 4-dodecanolide, 4-undecanolide, 4-decanolide, 4-nonanolide,
4-octanolide, 4-heptanolide, 5-dodecanolide, 5-
Undecanolide, 5-decanolide, 5-nonanolide, 5-octanolide, 2-undecene-4-olid, 2-decene-4-olid, 2-nonene-4-olid, 2-heptene-4-olid, 2-undecene- 5-Olido, 2-decene-5-olid, 2-nonene-5-olid, 2-octene-5-olid, 4-methyl-4-dodecanolide, 4-methyl-4-undecanolide, 4-methyl-4- Decanolide, 4-methyl-4-nonanolide, 4-methyl-4-heptanolide, 5-methyl-5-dodecanolide, 5-methyl-5-undecanolide, 5-methyl-5-decanolide, 5-methyl-5-nonanolide, 5-methyl-5-octanolide, 2-methoxycarbonyl-
4-dodecanolide, 2-methoxycarbonyl-4-undecanolide, 2-methoxycarbonyl-4-decanolide, 2-methoxycarbonyl-4-nonanolide, 2-methoxycarbonyl-4-
Heptanolide, 2-methoxycarbonyl-5-undecanolide, 2-methoxycarbonyl-5-decanolide, 2-methoxycarbonyl-5-nonanolide, 2-methoxycarbonyl-5-octanolide, 2-allyl-4-undecanolide, 2-allyl- Five-
Decanolide, 2-allyl-4-nonanolide, 2-pentyl-4-undecanolide, 2-pentyl-4-nonanolide, 2-methyl-4-
Undecanolide, 2-methyl-4-nonanolide, 2- (4-hydroxybutyl) -4-undecanolide, 2- (4-hydroxybutyl) -4-nonanolide, 2- (4-hydroxybutyl) -5-
Decanolide, 5-propyloxy-4-pentanolide, 5-allyloxy-4-pentanolide, 5- (2-hydroxyethoxy) -4-pentanolide, 8-hydroxy-4-octanolide,
6-Propyloxy-5-hexanolide, 6-allyloxy-5-
Hexanolide, 6- (2-hydroxyethoxy) -5-hexanolide, 9-hydroxy-5-nonanolide, etc.), ethynomycin, iriflorenthal, iripalidal, 2'-8-C-
Glucosyl-7-methyl aloesol coumaroyl ester, 2'-8-C-glucosyl-7-methyl aloesol cinnamoyl ester, chloropyramine, anise extract, aloe extract, knotweed (tiger cane root) extract, lobster extract, Ebisugusa extract , Ketsumeishi extract,
Astragalus (Astragalus) extract, Astragalus membranaceus extract, Crowed melon (Calocon) extract, Ona fir (Blue ear) extract,
Oninagara (Tenma) extract, Japanese oyster extract, Japanese knotweed extract, oyster extract, pumpkin extract, cattail
(Guangxi) extract, Kansu (sweetening) extract, Quercus versicolor
(Sengakurusaku) extract, kuromoji extract, black-and-white extract, sisal (sisal) extract, saxima button vine extract, cinna button vine extract, chinensenso (weapon) extract, oshimazakura extract, oyamazakura extract, beanzakura extract, takanezakura extract,
Kohigan extract, Satozakura extract, Zion (purple garden) extract, Palm extract, White squirrel extract, Senninsou (Large sardine) extract, Tamshiba extract, Daimonjiso extract, Tsukisou extract, Toshishi extract, Pleurotus cornucopia extract, Nashiwamugi extract,
Yarrow extract, Chinese cabbage extract (dimple ring), dill extract, honeydew extract, sardine extract,
Hitotsuba (Ishimushi) extract, Himegashima (incense) extract, juniper extract, floral blanka extract, hamula extract, sagebrush extract, bindweed extract, sandalwood extract, ganoderma lucidum extract, swordfish
(Esophago herbaceous) extract, willow tree extract, red willow extract, pussy willow extract, dog cory willow extract, willow tree extract, cory willow extract, unryow willow extract, miyayama willow extract, willow willow extract, sage willow extract, foxtail willow extract, foxtail willow extract Extract, mid-autumn agave, Aono agave extract, Fukurin agave extract, Mitsumata extract, Aonori extract, Usubaaonori extract, Sujiaonori extract, Hiraaoniori extract, Boaonori extract, Hosoedahonori extract, konbu extract, mackerel syrup extract, reconcile syrup extract, reconcile syrup extract Extract, Mitsuishikonbu extract, wakame extract, hirome extract, blue seaweed extract, hijiki extract, hibamata extract, sea urchin Wa extract, Usubaumiuchiwa extract, Kirebanoumiuchiwa extract, Akabasumiuchiwa extract, Konaumiuchiwa extract, Okinawan extract, Usuyukichiwa extract, Etsuukiuuchiwa extract, Togekirinsai extract, Akusakinakirinsai extract, Ginseng extract, Japanese juniper radix extract. , Ibottsunomata extract, Marubatsunomata extract, shirakotoji extract, Japanese cedar extract, Shikinori extract, Kainori extract, Yakuzusa extract, Uraboshiyahaz extract, Sea urchin extract, Ishimozuku extract, Missjim kelp extract, Atamisukumoku extract, Nagamokumaku extract, Nagashimamaku extract, Nagashimamaku extract. Shidamoku Extract, Nejimoku Extract, Narasamo Extract, Mametha Walla Extract, Tatukuri Extract, Yatsumata Moku Extract, Umitranooe Kiss, ovamoku extract, sisujimoku extract, hahakimoku extract, yoremoku extract, saw rimoku extract, psyllium lime extract, centipede extract, nurakusa extract,
Black knuckle extract, bark sardine extract, pine tree extract, scorpion leaf extract, sea squirt extract, poplar extract, himefusumitsu extract, hirohafutsutsunagi extract, kurososo extract, kobusozo extract, haezozo extract, sozonohana extract, shiranoha kirihiraba extract. Extract, Camote de Azafran extract, Hamica extract, Poleo Verde extract, Naboneguro extract, etc.

(14) Melanin production accelerator salicylic acid or a salt thereof and derivatives thereof (salicylic acid glucoside, salicylic acid fatty acid ester, salicylic acid alcohol ether, salicylic acid amides, etc.), salicyl alcohol or a salt thereof and derivatives thereof, apigenin, and ament Flavone, salamander extract, udo extract, cypress extract, gassho extract, oak extract, ox root extract, cuckoo thistle extract, Rumex
(Yotei root) extract, Gymnema sylvestre extract, Carooo extract, Gyokin kinka extract, Konronka extract, Sabinryo extract, Jasmine (matsurika) extract, Tachiaoi extract, Shoreito extract, Arabidopsis extract, Lizard extract, Saw extract, Deico extract, Eucommia ulmoides extract, Nagi-kada extract (Butcher bloom) extract, Teppouuri extract, Tokiwamansaku extract, Nankin goby extract, Sambucus extract, Nadeshiko extract, Michiyanagi extract, Willow tree extract, Morohaya (burlap) extract, Tachiyanagi extract, Weeping willow extract. Extract, Yahazusou Extract, Tamaki Fujishime Extract, Ryo Kaou Extract,
Astragalus sinensis extract, shellfish extract (cockle extract, green mussel extract, European oyster extract, scallop extract, clam extract, clam extract, bacillus extract, mussel extract, red mussel extract, abalone extract, bait extract, etc.) and the like.

(15) Humectant ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene Glycol, 1,3-butylene glycol, pentyl glycol, glycerin, erythritol, pentaerythritol, dipentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol, cititol, laminitol, varianamine, Multivalent Al such as validamine and validator Lumpur ethers, gum arabic, benzoin rubber, Danmarugomu,
Guaiac fat, Irish moss, karaya gum, tragacanth gum, carob gum, quince seed, agar, casein,
Glucose, galactose, mannose, xylose,
Fructose, maltose, isomaltose, cellobiose, gentiobiose, trehalose, kojibiose, laminaribiose, nigerose, cellobiose, sambibiose, neohesperidose, apiose, hamamelose, streptose, hydroxystreptose, dihydrostreptose or 2-methylerythrose. Derivatives, 2-methylerythronolactone, mycarose, cladinose, axenose, alkanose, olivomycose, chromose, evamicose, vinerose, nogarose, virenose, noviose, moenuronic acid, galosamine, sibilosamine, N-acylcansosamine, vancosamine , Evanitrose, rubranitrose, tetronitrose, pyralose, α-octose,
Trioxacalcinose, aldogallose, saccharides such as blastomyosin or esters thereof, trehalose or its derivatives, D-mannosamine and its derivatives, primeverose or its derivatives, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, Alkylene such as ethylene oxide
(C2-C4) Oxidized hydroxyalkyl (C
2 ~ C4) chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethyl cellulose, Methylcellulose, carboxymethylcellulose, carboxyethylcellulose, carboxyethylcellulose sodium, hydroxyethylcellulose, hydroxypropylcellulose, nitrocellulose, crystalline cellulose, hydroxypropylmethylcellulose, dermatan sulfate, water-soluble polymers such as keratan sulfate, glycerin fatty acid pyrrolidone carboxylic acid esters, Glycerin fatty acid acetyl amino acid esters, pyrrolidone carboxylic acid or its salt, polyaspartic acid or its salt, poly Glutamic acid or its salt, polylysine or its salt, sodium lactate, hydantoin and its derivatives, Np-vinylbenzyl-D-cellobione amide, N
-p-vinylbenzyl-D-lactonamide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-gluconamide, glucosyloxyethyl methacrylate, galactosyloxypropyl acrylate, mannosyloxyethyl methacrylate, glutamyllysine, glutaurine , 1,2,4-butanetriol, carane-3,4-diol, azoxaponin (3-o- [β-D-glucopyranosyl-β
-D-glucuronopyranosyl] -sophoradiol, 3-o- [β
-D-glucopyranosyl-3-D-glucuronopyranosyl] -soya sapogenol B, 3-o- [β-D-glucopyranosyl-β
-D-glucuronopyranosyl] -azuxapogenol, 3-o-
[Β-D-glucopyranosyl] -28-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -dypogenic acid, 3-o-
(Α-L-rhamnopyranosyl-β-D-glucopyranosyl-β-D
-Glucuronopyranosyl] -Soya sapogenol B, 3-o-
[Β-D-glucopyranosyl-β-D-glucuronopyranosyl] -29-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -azuxapogenol), Aoki (Aoki) extract, Aogiri Extract, kenashia ogiri (green paulownia) extract, red ginger (red sardine) extract, red clover extract, red pine extract, aguahe (Amaranthus palm) extract,
Maraba morning glory extract, morning glory (chocolate) extract, Achira (Cannabis spp.) Extract, rapeseed extract, Amaranthus vulgaris extract, Amana (Hikari) extract, Amaranthus esculentaum extract, Hagatetow extract, Pleurotus cornucopiae extract, Sugimorigatetou Extract, Chinese cabbage extract, Chinese cabbage extract, Herbium extract, Aozulan extract, Amaranthus hypochondriacus extract, Aristoloemeria extract, Arcana
(Arcanna) extract, arugarobo (cabbage) extract, aloe vera extract, rush (wick-plant) extract, yew (first place)
Extract, strawberry extract, carob extract, Aedes
(Taylex) extract, rice extract, mint extract,
Strawberry (Iwabuchi) extract, Strawberry extract, Strawberry
(Makiashi) extract, Wheat (Chibana) extract, duckweed
(Ukiwa) extract, Usbenita mallow extract, Usbania mallow extract, Unyadegato (Uncaria) extract, Enokitake mushroom (Enokitake) extract, Eryngii extract, Pre-Lotus eryngii extract, Oogata Houken extract, Ooguruma
(Civil incense) extract, Primrose herb extract, Oca extract, Okazeri (Snake bed) extract, Okra extract, Onidocho extract, Tokoro extract, Nagadokoro (Hikai) extract, Ononisu extract, Eucommia extract, Pleurotus ostreatus extract, Kantorisou (Rensen) (Grass) extract, hydrangea extract, Cascala sagrada extract, gypsophila extract, Panax ginseng extract, kaniwa extract, carnation extract, gerbera extract, camu camu (duck) extract, color extract, oat extract, karin (melon) extract,
Kawara Psycho (Koryosai, White Herb) Extract, Kawajisha Extract, Kawara Dashiko (Ishitake) Extract, Ezo Kawara Dashiko
(Bran barley, Barley bark) extract, Cantara hemp extract, Chrysanthemum extract, Quinoa (quinoa) extract, cabbage extract,
Kiwi extract, cucumber extract, gouryu (Nishikawayanagi,
Teiyanagi) extract, Kiransou (Kenshi Kobayashi) extract, Guayule extract, Chrysanthemum vine (Tenmen winter) extract, Ginseng (Yellow lance) extract, Cupuas extract, Gumbai Nazuna
(Sekimei, Sekimeishi) extract, Kemponashi (Kikushi) extract, Gekkavidin (Beauty of the moon) extract, Kouren (Pink yellow) extract, Coconut extract, Cosmos extract, Kobodzu extract, Rice oil extract, Konjac extract, Saffron (Safflower, West) Safflower extract, sapodilla extract, sangre degrad (croton) extract, carrot carrot
(37 ginseng) extract, shea (karite) extract, cyanoki extract, shiitake mushroom (shiitake mushroom) extract, shimeji mushroom extract, hinshimeji extract, shakashimeji extract, matsutake shimeji extract, oishiromushishimeji extract, beech shimeji extract, honjimeshi extract, shirotake mushroom mushroom extract, shimokurene ) Extract, saishin extract, cactus extract, january bean (bakumon winter) extract, gypsophila paniculata extract, hydrangea hydrangea (tsuneyama) extract, white morrow butterfly extract, white adzuki bean (chicken bone grass) extract, ginkgo biloba (mizuka, mizuka, Chinkeng flower) extract, watermelon (watermelon) extract, sycamore
(Lord Xu) extract, purslane (horse toothpaste, horse toothbrush) extract, ginkgo extract, cherry ginseng extract, ginkgo gem extract, lavender ginseng extract, ginseng ginseng extract, ginseng ginger extract, ginkgo ginkgo extract, shikaku ginkgo extract, gibbon Nosekkokku Extract, Cedron (Boushuboku) Extract, Mallow Extract, Celery Extract, Senshinren Extract (Daikon) Extract, Japanese Radish Extract, Takasaburo Extract, Tadachikoro (Hikai) Extract, Dahlia (Tenjiku Button) Extract , Talwi extract, Chinese cabbage extract, Amaranthaceae extract, Chanka piedra (Kidachikansou) extract,
Tulip extract, Chologi extract, Tsukuri mushroom (mushroom) extract, camellia extract, clover (lacquer grass) extract, Tounabena (river cutting) extract, corn extract, corn hair (nanban hair) extract, horse mackerel (tree bandit) extract, ash (Hata peel) ) Extract, Eustoma grandiflorum extract,
Wild bean extract, Tatehaki (sword bean) extract, jujube (Oju)
Extract, navena (intermittent) extract, nameko extract, namban columbine (ramix) extract, nutmeg extract, nembus extract, nebu extract, nevi extract, neem tree extract, sycamore extract (salmon) extract, cornflower extract, linden extract, honeysuckle extract, honey bean extract, Papaya extract, Pahalobobo extract, Balata gum extract, Agaricus extract, Agaricus extract, White-bellied Agaricus extract, Usukimorinokasa extract, Haran extract, Paliurus (Prunus vulgaris) extract, Balsamina (Tsurureishi, Nigauri) extract, Harlindough extract, Kandaikai ) Extract, Higerum dahlia extract, beet extract, Hiba extract, sunflower extract, bell pepper extract, Himeuzu (Aoi) extract, Himematsutake (Kawariharatake, Hiromatsutake) extract, Fuyushinsakutake (caterpillar) extract, Brazilian licorice extract, hazelnut extract, loofah extract, red citrus extract, duckweed (Keiten) extract, broomwood extract, elder extract,
Nendou extract, Hahakiki / Kokia (ground syrup) extract, Futamata hakobe extract, Rhododendron japonicum (Kageten Sanchi) extract, Jojoba extract, Borage (Rurichisha) extract, Bordeaux extract, Hongonik (Meat Juice, Daiei) extract, Hongsekokuk (Tempered Citrus, Suzuyama Sekisui) Extract, Maca Extract, Macadamia Nut Extract, Margaret (Mokshungik)
Extract, Tamano Zen Haren Extract, Kyukonkinrenka Extract, Matatabi Extract, Matsukasa Extract, Matsuhod Extract, Matico (Cordon Sillo) Extract, Quince Extract, Malaine Extract, Manzanya (Andes) Chamomile) extract, water psyllium extract, water morning glory (dragon tongue grass) extract, green mint extract, wheat straw extract, munya extract, muramurasakisikib (purple) extract, purple fuji wisteria (Kunmei chicken blood wisteria) extract, moje (red pepper) extract, Molex extract, Cornflower extract, Yacon extract, Palm extract, Yabu Tobacco (Tsuru, Tenmei) extract,
Horse chestnut extract, mocca extract, lily extract, ligan
(Thunder pill) extract, lime extract, rye extract, lacquer extract, shallot extract (apple white) extract, apple extract, gentian extract, litchi (lean branch, leek nuclei) extract, astragalus extract, minnow essence extract, minisasaniki extract, chlorella vulgaris Extract, Chlorella pyrenoidosa extract, Chlorella ellipsoidia extract, Macrocystis pyrifera extract, Yukiri extract,
Tosakanori extract, Onyx extract, Amakusanori extract, Amukuro extract, Kawanori extract, Marimo extract, Motchihito extract, Ezohahaz extract, Habanori extract, Habanori extract, Cottonweed extract, Aname extract, Shimeji extract, Tororokonbu extract, Antokume extract, Tsurumerame extract, Black-necked extract. Extract, Neko-shikkonbu extract, Ainu seaweed extract, Chigaiso extract, Ezo shige extract, Yabanemoku extract, Rappa Moku extract, Uganomo Moku extract, Jolo Moku extract, Hiemoku extract, Tamanashi Moku extract, Honda Wara extract,
Sugimoku extract, Ushikenori extract, Susabinori extract, Akebono-mozuku extract, Sea urchin extract, Fusanori extract, Hosobananaminohana extract, Hanafunori extract, Itofunori extract, Kaginori extract, Mirin extract, Hosobamirin extract, Kikutosaka extract, Ezonameri extract, Ibaranoiri extract. , Kagui Baranori Extract,
Saidaibara extract, Tachiibara extract, Porphyra chinensis extract, Cercis chinensis extract, Pleurotus chinensis extract, Periwinkle extract, Acacia chinensis extract, Bacillus subtilis natto culture metabolite, natto extract, loofah water, white birch, or red pine sap.

(16) Cell activating agent / metabolic activator Vitamin A group: retinol or its salt and derivatives thereof (retinyl linoleate, retinyl linolenate, retinyl oleate, retinyl arachidate, etc., retinol unsaturated fatty acid ester) Etc.), retinal or a salt thereof and a derivative thereof, dehydroretinal or a salt thereof and a derivative thereof, retinoic acid or a salt thereof and a derivative thereof, a retinoic acid analogue compound (4-[[[8- (3,
5-dimethylphenyl) -2-naphthalenyl] carbonyl]
Amino] benzoic acid, 4-[[[8- (3-methylphenyl) -2
-Naphthalenyl) carbonyl] amino] benzoic acid, 4-
[[[8- (4-Methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-Methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4- [[[8- (3,4-Dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2,
4-dimethylphenyl) -2-naphthalenyl] carbonyl]
Amino] benzoic acid, 4-[[[8- (2-isopropylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-Ethylphenyl) -2-naphthalenyl] carbonyl] Amino] benzoic acid, 4-[[[8- (2-fluorophenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methoxyphenyl) -2-
Naphthalenyl] carbonyl] amino] benzoic acid, 4-
[[(8-Benzyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[(E) -2- (8-phenyl-2-naphthalenyl) propenyl] benzoic acid), retinol acid derivative (4-hydroxyphenyl) Retinamide), retinoid analogue (4-[[(5,6-dihydro-5,5-dimethyl-8-ethyl
-2-Naphthalenyl) amino] carbonyl] benzoic acid, 4-
[[(5,6-Dihydro-5,5,8-trimethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2 -Naphthalenyl) amino] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,
5-dimethyl-8-ethyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) -carbonyl] amino] benzoic acid, 4- (E)-[2- (5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) -1-propenyl] benzoic acid, 4-
[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) oxy] carbonyl] benzoic acid, 4-[[(5,
6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2- ( Naphthalenyl) carbonyl] oxy] benzoic acid, 4-[[5,6-dihydro-5,
5-dimethyl-8- (2-fluorophenyl) -naphthalenyl]
Carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro
-5,5,6-Trimethyl] -8-phenyl-2- (naphthalenyl)
Carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro
-5,5,7-Trimethyl-8-phenyl-2-naphthalenyl) carbonyl] benzoic acid, 4-[[(E)-(5,6-dihydro-5,5-
Dimethyl-8-phenyl) -2-naphthalenyl] vinyl] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] sulfamyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] sulfamyl] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl- 8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4-
[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-
Naphthalenyl] thiocarbonyl] amino] benzoic acid, 4-
[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-
Naphthalenyl] carbonyl] methyl] benzoic acid, 4-
[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-
Naphthalenyl] methyl] oxy] benzoic acid, 4-
[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-
Naphthenyl] oxy] methyl] benzoic acid, 4-[[[(5,
6-dihydro-5,5-dimethyl-8- (2,4-dimethylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl -8- (4-Methylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-
Phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4-
[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-
Naphthalenyl] sulfamyl] methyl] benzoic acid, 4-
[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] amino] benzoic acid, 4-[[[(5,
6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] amino] thiocarbonyl] benzoic acid, 4-[[[((5,
6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] sulfamyl] benzoic acid, 4-[[[(5,6-
Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl]
Amino] methyl] benzoic acid, 4-[[[(5,6-dihydro-
5,5-Dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-hydroxybenzoic acid, 4-[[[(5,6-
Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-nitrobenzoic acid, 4-
[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-
Naphthalenyl] carbonyl] amino] -2-fluorobenzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] carbonyl] amino] -2-methoxybenzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-
(2-Naphthalene)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-8-phenyl-2-
Naphthalenyl) carbonyl] aminobenzoic acid, 4-
[[(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3-fluorobenzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl -8-phenyl-2
-Naphthalenyl) carbonyl] amino] -3-methylbenzoic acid, 4-[[(5,8,10,10a-tetrahydro-10,10-dimethyl
-9-Phenyl-2-anthracenyl) carbonyl] amino]
Benzoic acid, 4-[[(1,1-dimethyl-3-phenyl-1H1-inden-5-yl) amino] carbonyl] benzoic acid, 4-
[(1,1-Dimethyl-3-phenyl-1H-inden-5-yl-oxymethyl) benzoic acid, 4- [2- (1,1-dimethyl-3-phenyl-1H-inden-5-yl) Vinyl] benzoic acid, 4-
[(1,1-dimethyl-3-phenyl-1H-indene-5-carbonyl) amino] benzoic acid), carotene or a salt thereof and derivatives thereof (α-carotene, β-carotene, γ-carotene,
Carotenoids such as lycopene, cryptoxanthin, lutein, zeaxanthin, isozeaxanthin, rhodoxanthin, capsanthin, crocetin), lycopene or its salts and their derivatives, vitamin B group: thiamine or its salts and their derivatives (thiamine hydrochloride, thiamine) Disulfide, bisbentamine, bisbutyamine, thiamine monophosphate disulfide, benfotiamine, shicotiamine, octotiamine, disetiamine, fursultiamine, prosultiamine, astaxanthin thiamine phosphate diester), thiamine sulfate, riboflavin or its Salts and their derivatives (flavin adenine dinucleotide, flavin mononucleotide, riboflavin phosphate diester, 1-β-D-ribofuranosyl nicotinamide Pyrophosphate diester, 1-β-D
-Ribofuranosyl nicotinic acid, etc.), pyridoxine or salts thereof and derivatives thereof (3,4-dipalmitic acid pyridoxine, 3,4-dicaprylic acid pyridoxine, pyridoxine sulfate diester, etc.), pyridoxal or salts thereof and derivatives thereof, Pyridoxamine or its salts and their derivatives, cyanocobalamin or its salts and their derivatives, cobalamins (methylcobalamin, adenosylcobalamin, hydroxocobalamin, aquacobalamin, etc.), folic acid or its salts and their derivatives, nicotinic acid or its salts And derivatives thereof, pantothenic acid or salts thereof and derivatives thereof, biotin or salts thereof and derivatives thereof, choline or salts thereof and derivatives thereof, inositol or salts thereof and derivatives thereof, vitamin C group: as Rubin acid or salts and derivatives thereof, vitamin D group: ergocalciferol or salts thereof and derivatives thereof, cholecalciferol and its salts and their derivatives (1.alpha.-hydroxy-2
2-[(1-hydroxy-1-methyl) -2-cyclopentene-4-
Ile-oxy] -23,24,25,26,27-pentanolcolecalciferol, [1R, 4R] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopentene-4- Il-oxy]
-23,24,25,26,27-Pentanorcolecalciferol,
[1R, 4S] -1α-Hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,2
6,27-Pentanorcolecalciferol, [1S, 4R] -1α
-Hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanocholecalciferol, [1S, 4S] -1α -Hydroxy-2
2-[(1-hydroxy-1-methyl) -2-cyclopentene-4-
-Oxy] -23,24,25,26,27-pentanolcholecalciferol, etc.), dihydrotaxosterol or salts thereof and derivatives thereof, vitamin E group: tocopherol or salts thereof and derivatives thereof, tocotrienol or salts thereof And derivatives thereof, ubiquinone or salts thereof and derivatives thereof, vitamin K group: phytonadione or salts thereof and derivatives thereof, menaquinone or salts thereof and derivatives thereof, menadione or salts thereof and derivatives thereof, menadiol or salts thereof and Derivatives thereof, vitamin F group: linoleic acid or a salt thereof and derivatives thereof, linolenic acid or a salt thereof and derivatives thereof, arachidonic acid or a salt thereof and derivatives thereof, and the like,
Carnitine or its salts and their derivatives, ferulic acid or its salts and their derivatives, γ-oryzanol or its salts and their derivatives, orotic acid or its salts and their derivatives, Vitamin P group: eriocitrin or its salts and Derivatives thereof, vitamin L group: anthranilic acid or a salt thereof and derivatives thereof, adenylthiomethylpentose or a salt thereof and derivatives thereof, vitamin U group: methylmethionine sulfonium chloride or a derivative thereof, valine, leucine, isoleucine,
Threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine,
Glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid,
Glutamic acid, hydroxylysine, arginine, ornithine, histidine or derivatives thereof (N-octyloxycarbonyl-β-alanyl-L-histidine, N-dodecyloxycarbonyl-β-alanyl-L-histidine, N- (12-amino-1 -Oxododecyl) -L-histidine, N-2-ethylhexyloxycarbonyl-β-alanyl-L-histidine hydrochloride, N-hexadecyloxycarbonyl-β-alanyl-L-
Histidine, N-octylaminocarbonyl-β-alanyl
-L-histidine, N-dodecylaminocarbonyl-β-alanyl-L-histidine, N-dodecylsulfonyl-β-alanyl-L-histidine, N-dodecylamino-oxalyl-β-alanyl-L-histidine, etc. , Their amino acids such as sulfates, phosphates, nitrates, citrates, or amino acid derivatives such as pyrrolidonecarboxylic acid, and α-hydroxy acids such as glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, and succinic acid , 2-hydroxycarboxylic acids (methyl lactic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hydroxyheptanoic acid, 2-hydroxyoctanoic acid, 2-hydroxynonanoic acid,
2-hydroxydecanoic acid, 2-hydroxyundecanoic acid, α
-Hydroxylauric acid, α-hydroxymyristic acid,
α-hydroxypalmitic acid, α-hydroxystearic acid, α-hydroxyarachidonic acid, cerebronic acid, α-hydroxynervonic acid, mandelic acid, benzylic acid, phenyllactic acid, atrolactic acid, 2- (4'-hydroxyphenyl) -2 -
Hydroxyethanoic acid, 2- (4'-chlorophenyl) -2-hydroxyethanoic acid, 2- (3'-hydroxy-4'-methoxyphenyl) -2-hydroxyethanoic acid, 2- (4'-hydroxy-3 ' -
Methoxyphenyl) -2-hydroxyethanoic acid, 3- (2'-hydroxyphenyl) -2-hydroxypropanoic acid, 3- (4'-
Hydroxyphenyl) -2-hydroxypropanoic acid, 2-
(3 ', 4'-dihydroxyphenyl) -2-hydroxyethanoic acid, glyceric acid, erythronic acid, ribbon acid, arabinonic acid, xylonic acid, lyxonic acid, aroic acid, altronic acid, gluconic acid, mannonic acid, gulonic acid, Idonic acid, galactonic acid, talonic acid, glucoheptonic acid, galactoheptonic acid, tartronic acid, muticic acid, etc.), polyhydroxycarboxylic acid or hydroxypolycarboxylic acids (gluconolactone, galactonolactone, glucuronolactone, galacturonolactone, Glonolactone, ribonolactone, sugar acid lactone, pantoyl lactone, glucoheptonolactone, mannonolactone, galactoheptonolactone, etc., 2-keto acids (glyoxylic acid, methyl 2-ketoethanoate, benzoylformate, methyl benzoylformate, benzoyl) Ethyl formate, Phenylpyruvate, methyl phenylpyruvate, ethyl phenylpyruvate, 2-
Ketobutanoic acid, 2-ketopentanoic acid, 2-ketohexanoic acid,
2-ketoheptanoic acid, 2-ketooctanoic acid, 2-ketododecanoic acid, methyl 2-ketooctanoate, etc.), quinic acid, isocitric acid, tropic acid, tretocanoic acid, 3-chlorolactic acid, cerebronic acid, citramalic acid, agaricinic acid, aloyritin acid,
Pantoic acid, lactobionic acid, hexulosonic acid, Photosensitizer No. 301, hinokitiol, pantothenic acid or its derivative, allantoin, pentadecanoic acid glyceride, linolenic acid or its derivative, eicosapentaenoic acid or its derivative, docosahexaenoic acid or its derivative, estradiol, e Tenylestaradiol, antiallol or its glycosides, lionilecinol or its glycosides, rhododendrol or its glycosides, platiphylonol or its glycosides, lactone compounds (D-glucurono-6,3-
Lactone, α-D-glucoheptonic-γ-lactone, δ-
Glucuronolactone, α, β-glucooctonic-γ-
Lactone, L-glonic-γ-lactone, γ-D-galactonolactone, D-saccharic-1,4-lactone, D-saccharic-3,6-lactone, D-ribonic-γ-lactone, α-
Butyrolactone, γ-butyrolactone, α-octanoic lactone, γ-octanoic lactone, nonanoic lactone, γ-valerolactone, D-mannoic-δ-
Lactone, D-xyloic-δ-lactone, D-arabinoic-δ-lactone, stearoyl-δ-gluconolactone, DL-pantolactone, palmitoyl-DL-pantolactone, etc.), 3-hydroxy-3,4-dicarboxyl -1,4-butanolide or its derivative, 6-benzylaminopurine or its derivative, 1,4-diazadicyclooctane, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3 -Diphenylisobenzofuran, rutin, tectorigenin 7-
Xylosyl glucoside, captopril, alacepril, lisinopril, enalapril, delapril, benazepril, cilazapril, imidapril, quinapril, transelapril, perindopril, temocapril, losartan, endoserine, galactomannan saccharide polymer, mucin aglycan, trimethylglycine, trimethylglycine, trimethylglycine , Luteolin, acasetin, diosmethine, baicalein, kaempferol, quercetin, morin, myricetin, datiscetin, quercetagetin, rhamnetin, isorhamnetin, gardenin A type, gardenin B type, gardenin C type, gardenin D
Type, gardenin type E, pectorinariginin, oupatrin, fisetin, scutellarein, galangin, homoeriodictyol, pinsembrine, naringenin, hesperetin, eriodictyol, pinobanksin, aromadendrin, taxifolin, amperopsin, sacranetin, fustin, daustine, daustin, feustine ,
Genistein, prunetin, aflomocin, irigenin, glycitin, baptigenin, platencein, lactic acid bacterium extract, lactic acid bacterium culture liquid extract, lactic acid bacterium fermented milk extract,
Bifidobacteria extract, Bifidobacterium culture extract, Bifidobacterium fermented milk extract, placenta extract, Reishi extract, spleen extract, thymus extract, yeast extract, yeast culture extract,
Fermented yeast extract, filamentous fungus extract, filamentous fungus culture solution extract,
Basidiomycete extract, Basidiomycete culture extract, bacterial cell crush extract, bacterial culture extract, cultured human dermal cell crush extract, Red ash (ground yellow) extract, Fennel (Incense)
Extract, eleuthero (Ezo Goka) extract, barley (barley)
Extract, occluhrigotai (Usuzhou Leopard, Indigo Sap) extract,
Red-breasted essence extract, Hypericum perforatum extract, Dutch jelly extract, Dutch honeysuckle extract, Calyx radix extract, Roman chamomile extract, Garcinia extract, Kawara carrot (blue-green) extract, Kakiran extract, Quillaja extract, Quinlan extract, Ginglan extract,
Calendula Extract, Sakanelan (Ezosakanelan) Extract, Sasabaginlan Extract, Soiled Walnut (Yellow Walnut) Extract, Spirea Extract, Shajin Extract, Plum Extract, Gourmet Extract, Horsetail Extract, Pineapple Extract, Chinese Plover Extract, Beech Extract,
Physalis (Torone) extract, Maitake mushroom (maitake mushroom) extract, Misohagi (Cendula spp.) Extract, Mukge (Kaki) extract, Makujiji
(Prolonged skin) extract, bean sprout extract, eucalyptus extract, Suavesimus extract, lettuce (chisha) extract, aloe extract, sardine extract, lentil extract, gentian extract, burdock extract, shikon extract, carrot extract, hamamelis extract, hops Extract, Yokuinin extract, Odori Koso extract, Senburi extract, Touki extract, Calendula officinalis extract, Hypericum extract, Cucumber extract, Pleurotus cornucopia extract, Rosemary extract, Parsley extract, Sanadagusa extract, Fukurinamiji extract, Gatsugakonbu extract, mosquito extract Phellinus linteus extract, kelp kelp extract, Gohei kelp extract, Naga kelp extract, pea kelp extract, pearl radish kelp extract, rattle extract, rattle rattle extract, red bean moth extract, Hosobeni Zukuekisu, opera seaweed extract,
Ezotosaka extract, sillamo extract, birch extract, etc.

(17) Antioxidant ascorbic acid or its salt and derivatives thereof (phosphate-magnesium L-ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyproline phosphate, 5-o- α-D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphoric acid sodium salt, L-ascorbic acid phosphoric acid potassium salt, L-ascorbic acid phosphoric acid magnesium salt, L-ascorbic acid phosphoric acid calcium salt , L-ascorbic acid phosphoric acid aluminum salt, L-ascorbic acid sulfuric acid sodium salt, L-
Ascorbic acid sulfuric acid potassium salt, L-ascorbic acid sulfuric acid magnesium salt, L-ascorbic acid sulfuric acid calcium salt, L-ascorbic acid aluminum sulfate, L-ascorbic acid sodium salt, L-
Ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyranosyl-L-
Ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphoric acid ester magnesium salt, L-ascorbic acid phosphoric acid sodium salt, L-ascorbic acid sulfuric acid sodium salt, 6-o-
Acyl ascorbic acid phosphate sodium salt, 6-
o-Acyl ascorbic acid phosphoric acid ammonium salt, 6-o-acyl ascorbic acid phosphoric acid ester isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkyl ascorbic acid phosphoric acid potassium salt, 6 -O-alkyl ascorbic acid phosphoric acid ester calcium salt, 6-o-alkyl ascorbic acid phosphoric acid ester barium salt, 6-o-alkyl ascorbic acid phosphoric acid ester ammonium salt, 6-o-alkyl ascorbic acid phosphoric acid ester monoethanol Amine salt, 6-o-alkylascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphoric acid ester triethanolamine salt, 6-o-alkylascorbic acid phosphoric acid ester monoisopropanolamine salt, 6-o- Alkyl ascorbic acid phosphate diisopropanol Amine salt, 6-o-
Alkyl ascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6
-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphoric acid cholesterol ester, palmitic acid L-ascorbyl, isopalmitic acid L-ascorbyl,
Dipalmitate L-ascorbyl, diisopalmitate L-
Ascorbyl, L-ascorbyl stearate, L-Ascorbyl isostearate, L-Ascorbyl distearate, L-Ascorbyl diisostearate, Myristic acid
L-ascorbyl, isomyristic acid L-ascorbyl, dimyristic acid L-ascorbyl, diisomyristic acid L-ascorbyl, 2-ethylhexanoic acid L-ascorbyl, di2-
Ethyl hexanoate L-ascorbyl, oleic acid L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-
o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl
-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, etc., L-ascorbic acid tetraisopalmitate, L -Ascorbic acid tetralaurate, L-
Ascorbic acid tetra-2-ethylhexanoate, L
-Ascorbic acid tetraoleate, 5,6-isopropylidene-L-ascorbic acid, le, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid , L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferulate,
2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxy ferulate, DL-α-tocopherol-2-L-ascorbic acid phosphate diester, Ascorbic acid inositol bond derivative, ascorbic acid phosphoramide derivative, ascorbic acid arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative,
Ascorbic acid sialic acid derivatives, etc.), stearic acid esters, tocopherols or salts thereof and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α
-Tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate ester, tocopherol acetate, tocopherol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL -α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-
β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-
α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D -δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L
-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfoethylamino) -3- (α-tocopheryl- 6-Iroxy) propan-2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-
Iloxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-yloxy) -2
-Hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-yloxy) -2-
Hydroxypropyl] aspartic acid, N- [3- (α-
Tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienols or salts thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, Tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate, etc.), dihydropyridine derivative (methyl-3-phenyl-2-
Propenyl 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) pyridine-3,5-dicarboxylate and its salts), benzochroman derivative, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT ), Butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol, maritimine, sulfretin, xanthene-2,7-diols, caffeoylquinic acid, propolis, carotenoids ( α-carotene, β-
Carotene, γ-carotene, lycopene, lutein, violaxanthin, spirilloxanthin, spheroidene, astaxanthin, etc.), phlorotannin, akebi (wooden tree) extract, amacha (sweet tea) extract, oolong tea extract, netherlands extract, citrus extract, kumquat extract,
Gobaishi extract, genoderma lucidum extract, sesame extract, sesame cultured cell extract, sesame cypress (genus) extract, rice bran extract, salamander (sansho) extract, pear extract, rhubarb extract, tomato extract,
Nanten (nantenmi) extract, thistle (daikon) extract, noibaru (yomi) extract, paprika extract, pistachio extract, loquat extract, betel nut (dairy skin, calyx) extract, butterbur extract, bokeh (wood melon) extract, buckwheat glutinous extract ,
Mahou (mao) extract, mimosa extract, barley extract,
Oyster bear willow extract, willow bud extract, cottonweed extract (Chrysanthemum vulgaris) extract, Chlamydomonas extract, Akayukimo extract, Astragalus membranaceus extract, Acabas mellifera extract, Hypericum perforatum extract, Hamamelis extract, Clove extract, Melissa extract, Trillium vulgaris extract, White birch extract, Salvia extract, rosemary extract, southern natural extract, ginkgo extract, green tea extract, clove extract, etc.

(18) Active oxygen scavenger / radical scavenger Superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin,
Quercitrin, catechin, catechin derivatives, rutin or its derivatives, gallic acid or its salts and their derivatives, curcumin or its salts and their derivatives, transferrin, ceruloplasmin, coenzyme Q, uric acid, bilirubin, metallothionein, stilbengalloyl Glycoside (3,5,4'-trihydroxystilbene 4'-o-β-D
-(6 "galloyl) glucopyranoside, 3,5,4'-trihydroxystilbene 4'-o-β-D- (2" galloyl) glucopyranoside, etc.), chlorogenic acid phospholipid ester, chlorogenic acid sphingosine ester and its derivatives, Chlorogenic acid glycolipid ester, chlorogenic acid sugar ester, chlorogenic acid sterol ester, thiazole derivative or its salt (2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-
Hydroxyphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- [3-carboxy-4-hydroxy-5- (2-methyl-2-propenyl) phenyl] thiazole and 2- (3,4
-Diethoxyphenyl) -4- (3-carboxy-4-hydroxy-5-methylphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- (3-carboxy-5-methoxyphenyl)
Thiazole,), hydroxymatairesinol, allohydroxymatairesinol, hydantoin derivative, red pine (logwood) extract, red megalois (red bud) extract, red pine rape extract, madder pine extract, madder (madder root) extract, hydrangea (hydrangea) ) Extract, abemaki extract, fig extract, ginkgo (gingko) extract, asparagus extract, plum (crow plum) extract, Japanese lacquer extract (Lepidoptera esculenta) extract, estragon extract, Enju (camellia flower, camellia rice) extract, oak tree (camellia tree, (Mulberry leaf) extract, Kasen extract, birch extract, birch extract, kunugi
(Kou-sou) extract, oleander extract, Kishikankan (Koji, Tachibana, Ovenimikan, Fukulemican, Sagamikouji, Ponkan, Santara extract, coffee extract, Comfrey (final herb) extract, Sasa (bamboo) extract, perilla extract, Aojizo extract, Chili Menjiso extract, Catamajiso extract, Peony extract, Quercus extract, Mizunara extract, Crape myrtle extract, Zikoppi extract, White Oak extract, White clover extract, Horseradish extract, Black tea extract, Green tea extract, Tsuwabuki extract, Tencha ( Beetroot tea extract, Tendaiyaku extract, Naniwaibara (Kinzaiko) extract, peanut (peanut) extract, Kay extract, Nikkei extract, Ceylon Nikkei extract, Yabunikei (cinnamon) extract, Keishi extract, Nousenka La extract, Lotus lotus extract, Chinese cabbage extract, Chinese cabbage extract, Hanasage extract, Rose extract, Barbasco extract, Spinach extract, Beech extract, American beech extract, Beech extract, European beech extract , Convolvulus vulgaris extract, Hosobana okera extract, button (peony) extract, mayorum (hanahakka) extract, melon extract, evening primrose extract, snow willow extract, orchid extract, lacanca extract, rooibos extract, Naminohana extract, yukari extract, Hosoyukari extract, Azusa extract, basil extract, mokko extract, etc.

(19) Fat metabolism promoter phthalazine derivative (4-ethyl-1- (β-hydroxyethylamino) phthalazine, 4-N-propyl-1- (β-hydroxyethylamino) phthalazine, 4-N-butyl -1- (β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (β-
Hydroxypropylamino) phthalazine etc.), xanthine derivatives (caffeine, theophylline, theobromine,
Xanthine, aminophylline, choline theophylline, diprophylline, proxyphylline and oxstrifylline), Aotsu rafuji (Kibo) extract, thistle extract, holly thistle extract, nia thistle extract, thistle extract, thistle extract, milk thistle extract, cacao extract , Ercampuri extract, Otsutsurafuji (self-defense) extract, banyan syrup extract, Karaxakeman extract, Kikyo (Kikyo, Kikyo root) extract, Kizita extract,
Pepper extract, cola acminata extract, Sagemodaka extract, pomelo extract, saushuyu
(Yamatake mushroom) extract, Tsutsurafuji extract, Otsutsurafuji extract, Choreimaitake (Boletus) extract, Centella asiatica extract, Astragalus extract, Ginseng extract, Ginseng extract (Nagado) extract, Naginata kouju extract, Banana extract, Pu'er tea (general) ? Tea) extract, plum extract, bow-fu (windproof) extract, etc.

(20) Anti-inflammatory agent / interleukin production inhibitor / anti-inflammatory agent Quinolinone derivative, dibenzoxepin derivative, thiotroposine, phthalimide derivative, flurbiprofen,
Felbinac, bufexamac, suprofen, 1,4-diphenylpropylpiperazine derivative, calxin compound, chromanol glycoside (2- (α-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol) , Ictamol, indomethacin, kaolin, diphenhydramine hydrochloride, d-camphor, DL-camphor, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, hydrocortisone, guaiazulene, chamazulene, chlorpheniramine maleate, diphenhydramine hydrochloride, clemastine fumarate, cyproheptine hydrochloride. , Promethazine hydrochloride, piperazine derivative,
α-D-phenylglycoside derivative, glycyrrhizic acid or a salt thereof, and derivatives thereof (α-glycyrrhizinic acid, β-glycyrrhizinic acid, α-glycyrrhizinic acid methyl ester, β-glycyrrhizinic acid methyl ester, α-glycyrrhizinic acid trisodium, α -Monopotassium glycyrrhizinate, dipotassium α-glycyrrhizinate, monoammonium α-glycyrrhizinate, trisodium β-glycyrrhizinate, monopotassium β-glycyrrhizinate, dipotassium β-glycyrrhizinate, β-glycyrrhizinate monoammonium, etc.), glycyrrhetinic acid Or its salts and their derivatives (α-glycyrrhetinic acid, β-glycyrrhetinic acid, α-glycyrrhetinic acid stearyl, β-
Stearyl glycyrrhetinate, α-glycyrrhetinic acid pyridoxine, β-glycyrrhetinic acid pyridoxine, α-glycyrrhetinic acid glycerin, β-glycyrrhetinic acid glycerin, 3-succinyloxyglycyrrhetinic acid disodium, etc.), mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, Allantoin, calcium pantothenate, panthenol such as pantothenyl ethyl ether and its salts and their derivatives, ε-aminocaproic acid, diclofenac sodium, tranexamic acid or its derivatives (trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans -4-p
-Nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-bromobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-m-
Chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-benzyloxycarbonylamino Sodium methylcyclohexanecarboxylate, trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylate ammonium, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylate potassium, trans-4-p-bromobenzyloxycarbonyl Aminomethylcyclohexanecarboxylate potassium, trans-4-m-chlorobenzyloxycarbonyl aminomethylcyclohexanecarboxylate calcium, Lance -4-p-
Methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid magnesium, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylic acid monoethanolamine, trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4- ( 2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid,
Trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-methylphenylisopropyloxy) Carbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylic acid sodium salt, trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid potassium salt, trans-4- (p- Biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate calcium, trans-4- (3,5
-Dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate magnesium,
Trans-4- (p-Methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid monoethanolamine, trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-methylsulfonylethyloxy Carbonylaminomethylcyclohexanecarboxylic acid, trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid sodium salt, trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylic acid potassium salt, trans
-4- (Pyridine-4'-methyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2,2,2-
Trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, potassium trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate, sodium trans-4- (pyridine-4′-methyloxycarbonylaminomethyl) cyclohexanecarboxylate, Trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylate potassium, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate calcium, etc.), sulfatide, astaxanthin fatty acid diester (astaxanthin Dilauric acid ester, astaxanthin dimyristic acid ester, astaxanthin dipentadecanoic acid ester, astaxanthin dipalmitic acid ester Astaxanthin dipalmitooleate, astaxanthin diheptadecanoate, astaxanthin dielaidate, astaxanthin diricinoleate, astaxanthin petroselinate, astaxanthin vaccenate, astaxanthin eleostearate, astaxanthin punicinate , Astaxanthin licanoic acid ester, astaxanthin parinaric acid ester, astaxanthin gadoleic acid ester, astaxanthin 5-eicosenoic acid ester, astaxanthin 5-docosenoic acid ester, astaxanthin cetolic acid ester, astaxanthin erucic acid ester, astaxanthin 5,13-docosadienoic acid Ester, Astaxanthin Ceracholate, As Taxanethine decenoic acid ester, astaxanthin steric acid ester, astaxanthin dodecenoic acid ester, astaxanthin dioleic acid ester, astaxanthin distearic acid ester, astaxanthin dieicosapentaene, acid ester, astaxanthin didocosahexaenoic acid ester, astaxanthin dilinoleic acid ester, astaxanthin dilinolene Acid ester, astaxanthin diarachidonic acid ester, etc.),
Astaxanthin diglycerophosphate (astaxanthin diglycerophosphate, astaxanthin glycerophosphate palmitate, astaxanthin glycerophosphatidyl choline palmitic acid, astaxanthin glycerophosphatidyl choline DHA, astaxanthin glycerophosphatidyl inositol palmitate, astaxanthin glycerophosphite Inositol DHA, astaxanthin glycerophosphatidyl inositol linoleic acid, astaxanthin glycerophosphatidyl choline linoleic acid, etc.), steviol glycoside, benzimidazole derivative (1- (2-ethoxyethyl) -2- [1- (2- ( 4- (1- (4,4-Dimethyl-2-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzi Imidazole, 2- [4
-(2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-
Methyl propanoic acid, ethyl 2- [4- (2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidine-
1-yl) ethyl) phenyl] -2-methylpropanate, 1-
(2-Ethoxyethyl) -2- [1- (2- (4- (1,1-dimethyl-
2-hydroxyethyl) phenyl) ethyl) piperidine-4
-Yl] -1H-benzimidazole, 1- (2-hydroxyethyl) -2- [1- (2- (4- (1- (4,4-dimethyl-oxazoline
-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- (4-
(1- (2-hydroxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid), an alanine derivative or a salt thereof (N- {3-isopentyl-4-) Methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -L-alanine, N- {3-isopentyl-4-methyl
-2- [4- (3-Trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -2-methylalanine, N- {3-isopentyl-4-methyl-2- [4- (3 -Trifluoromethylbenzamido) benzoylimino] -3
H-thiazoline-5-carbonyl} -N-methyl-L-alanine etc.), thiazoline derivatives or salts thereof (3-isopentyl-4
-Methyl-2- [4- (3-trifluoromethylbenzamide)
Benzoylimino] -3H-thiazoline-5-carboxylic acid, 4-
Isobutyl-3-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid, etc.), chlorpheniramine maleate, diphenhydramine hydrochloride, diphenylpyraline hydrochloride, carbinoxamine maleate , Hydrocortisone butyrate, sulfated acidic mucopolysaccharide or a salt thereof, sulfated dextran or a salt thereof, licorice extract, shikon extract, ages extract, propolis, eye (indigo leaf) extract, avocado extract, amadocolo (jam bamboo) extract, algae lily extract , Bimo (shellfish) extract, Igakouzolina (gebiliary head) extract, Ibukitoranoo extract, Turmeric (depressive) extract, Echinashi (Hosobamurasakibarenjiku) extract, Auren (Yellow) extract, Oguruma (overturning) extract, Hypericum Younger brother cut grass extract, orange extract, cassia extract, kamiya De (grass) extract, Kawamidori extract, Kawamoyogi (Chinese peony root) extract, Watercress extract, Kensaisartoriibara (Earth peony, mountain return) extract, Gentiana extract, Koukisekokuku extract, Kouhon (Straw book, Karamoto book) extract, Koryo Ryokyo (Takayoshi). (Ginger)
Extract, Gosho Strawberry (Okabonko) Extract, Sai Hiran Extract, Cherry Extract, Salvia (Sage) Extract, Digitalis Extract, Cinnamon Extract, Saladou Extract, Indian Bodice Extract, Shukshamitsu (Sandin,
(Condensed sand) extract, juzudama extract, shirominanten (southern natural fruit) extract, Astragalus membranaceus extract, Salix mellifera extract, Achillea millefolium (Milfoil) extract, Hirohase Nega extract, Takasago Rurihigotai (South indigo spine) extract, Takara bracken (Inu). Spine) extract, Pleurotus cornucopiae extract (100 scent), Tamasakitsuduraji extract, Tonin extract, Chigaya extract, Touga (winter melon) extract,
Dokudami (ten drug) extract, parsley (Dutch jelly) extract,
Hanabishi (Shitsuri, Shitsuri) extract, Chinese nutsedge (Kashiko) extract, Hisashi (Hishimi) extract, Birodoaoi extract, Futokazura (Nantan) extract, Bundou (mung bean) extract, Sandalwood extract, Butcher bloom extract, Pansy extract, Hosoba Abragiku (Bittersweet) Extract, Mizuru Tennansho (Tennansei) Extract, Pheasant (Boomerum) Extract, Miracle Fruit Extract, Mulk Tree Extract, Peach
(Peach) extract, cornflower extract, willow extract,
Mistletoe (willow-parasitic) extract, Aedes kouji (purple gold beef) extract,
Japanese sagebrush extract, sagebrush extract, rosemary
(Mannen wax) extract, Hitohimehagi extract, Piscus japonicus extract, Tamazuzumo extract, Mizojuzumo extract, Urushigusa extract, Keshigurusa extract, Iwahigashi extract, Akamoku extract, Togemoku extract, Aqaba extract, Malva aqaba extract, Harigane extract, Darus extract, Yuna extract, Belladonna extract, Honoki extract,
Harunire (black skin, white skin, black leaf) extract, etc.

(21) Blood Flow Promoter / Vascular Stimulator Tocopherol or its salts and their derivatives, tocotrienols or their salts and their derivatives, cepharanthin, carpronium chloride, eugenol derivatives (acetyleugenol, methyleugenol, methylisoeugenol, ethyl Eugenol, ethylisoeugenol, eugenol salicylate, etc.), minoxidil,
Capsicum tincture, Nonyl acid vanilamide, Cantharis tincture, Ginger tincture, peppermint oil, L-menthol, camphor, benzyl nicotinate, cinnarizine, tolazoline, acetylcholine, verapamil, ictamol, α-borneol, cyclanderate, nonyl acid warenylamide, Capsaicin, Zingerone, Assemblage extract, Garlic extract, Carrot extract, Aloe extract, Gentiana extract, Touki extract, Ashitaba (Tomorrow leaf) extract, Arnica extract, Prickly peony (Sanryu) extract, Pleurotus cornucopia extract, Unshiu mandarin orange (Citrus) extract, Toucan hazel extract, oyster extract, persimmon extract, kina extract, ryehen extract, bear vine
(Hipparden grass) extract, Kubijinso extract, Kohone (river bone)
Extract, burdock (burdock root, burdock root) extract, swordfish
(Yamakage greens) extract, Chinese cabbage extract, ginger (ginger) extract, ginger extract (iris, iris root) extract, hawthorn extract, senburi (our drug) extract, daidai (orange peel) extract, tanjin (tanseng) extract, thyme Extract, Ginseng extract (Ginseng ginseng) extract, Ginkgo biloba extract, Ginseng extract (Folia ginseng) extract, Capsicum
(Pepper) extract, Touki (toki) extract, Sciurus vulgaris
(Sadako) extract, Natsumikan extract, elderberry (bone grafting)
Extract, Hazel (Haruko) extract, Hasiridokoro (Roth root) extract, Mint (Light load, Light load leaf) extract, Hamabofuu (Hamaboshi) extract, Higotai extract, Fujimodoki (Cherry blossom, Kashiwa) extract, Black currant extract, Bodaiju (Bodhi) Daiki) extract, Yuzu extract, Japanese cabbage extract
(Waume) extract, Yamajeri extract, Hibiscus extract,
Rosehip extract etc.

(22) Antiandrogen Estrogen (estron, estradiol, ethinyl estradiol, etc.), isoflavone, oxendron, 4 ', 5,7-trihydroxy-8-prenylflavanone,
4 ', 5,7-trihydroxy-8-prenylflavone, 3,3', 4 ',
5,7-pentahydroxy-8-prenylflavone, nicorandil, cyclosporic acid and the like.

(23) Structural proteolytic enzyme (matrix metalloprotease such as elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme) Carbostyryl derivatives or their salts, dicarboxylic acids (glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, 1,9-nonamethylenedicarboxylic acid,
1,10-Decamethylenedicarboxylic acid), rosmarinic acid, ursolic acid, oleanolic acid, hydroxamic acid derivative,
Esculetin derivative, anthocyanidins, nordihydroguaiaretec acid, 20-carboxy-16-hydroxy-21-nor-5α-7,9 (11) -lanostadiene-3,24-dione, ubiquinone, plastaquinone, juglone, Shikonin, quinizarin, alizarin, abietin, levopimar, betulin, α-amyrin, catechin compound (catechin, epigallococaekin, epigallocatechin gallate, epicatechin, epicatechin gallate, catechin rhamnopyranoside catechin, etc.), diisopropyl fluorophosphate, (2R, 6R) -2,6-Dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate dimethyl, N, N'-bis [(1S, 2R)- 2-hydroxyindane-
1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptanedicarboxylic acid-1,7-diamide, (2R, 6R) -2,6-dihydroxy-4- (tert-butyl Dimethylsilyloxy) heptane-1,7-dicarboxylate dimethyl, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy)
Dimethyl heptane-1,7-dicarboxylic acid, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [ (1S, 2R)-
2-Hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R)-
2-Hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [(1S, 2R)- 2-Hydroxyindan-1-yl]-(2R, 6R) -2,4,6-trihydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxy Indan-1-yl]-(2S, 6S) -2,6-dibenzyloxy-4-
Hydroxyheptane-1,7-dicarboxylic acid diamide, (2S, 6
S) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate dimethyl,
Dimethyl (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2
S, 6S) -2,6-Dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate dimethyl,
(2S, 6S) -2,6-Dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [(1S, 2R) -2-hydroxyindane -1-yl]-(2S, 6S)-
2,6-Dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'-
Bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6
R) -2,6-Dibenzyloxy-4-hydroxyheptane-1,7-
Dicarboxylic acid diamide, 3-[[4- (4-Fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclopentyl) -amino] -propionic acid, 4- [4-
(4-Fluorophenoxy) -benzenesulfonylamino] -tetrahydropyran-4-carboxylic acid hydroxyamide, 4- [4- (4-chlorophenoxy) -benzenesulfonylmethyl] -tetrahydropyran-4-carboxylic acid hydroxyamide, 3 -[[4- (4-Fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclobutyl) -amino] -propionic acid, 4- (4'-chlorobiphenyl-4-yl) -2- [2- (1,3-Dioxo-1,3-dihydroisoindol-2-yl) -ethyl] -4-oxobutyric acid, {1-
[4- (4-Fluorobenzyloxy) -benzenesulfonyl] -2-hydroxycarbamoylpiperidin-3-yl)-
Carbamic acid isopropyl ester, 2- [4- (4-Fluorophenoxy) -benzenesulfonylamino] -N-hydroxy-2-methylfuropionamide, 3- [4- (4-Fluorophenoxy) -benzenesulfonyl] -2 , N-Dihydroxyfropionamide, 3- (4-phenoxybenzenesulfonyl) -7-oxabicyclo [2.2.1] heptane-2-carboxylic acid hydroxyamide, (4-benzylbenzyl)-[2-
(2,2-Dimethyl-1-methylcarbamoylpropylcarbamoyl) -4- (4'-fluorobiphenyl-4-yl) -butyl] -phosphinic acid, 2-amino-3- [4- (4-fluorophenoxy) -Benzenesulfonyl] -N-hydroxypropionamide, and N-hydroxy-2- (4-phenylpiperidine-1-sulfonyl) -acetamide, Pleurotus cornucopia extract, Nepenthes extract Hawthorn extract, hawthorn
(Yamageko) extract, Karahoo (Park) extract, Guava extract, Gomishi (Gomiza) extract, Charcoal extract, Rose bud extract, Hypericum perforatum extract, Chickweed
(Historical) extract, Hinako no Kochi (cow knee) extract, honoki (Japanese magnolia, magnolia) extract, American grape extract, European grape extract, Yama grape extract, mandarin extract, Mishima Psycho (Saiko) extract, Astragalus extract, Hypericum extract, Clara extract, mulberry extract, cinnamon syrup extract, ginkgo biloba extract, comfrey extract, salvia extract, Sambucus nigra extract, bodige extract, button pipi extract, etc.

(24) Structural Protein Synthesis Promoter Ethanolamine derivative, pentoxifylline, serine derivative, geraniol, crocetin, methyl 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-4- (3 , 5,5-Trimethylhexyloxy) methyl benzoate, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4- (3,7-dimethyl- Methyl 6-octenyloxy) -2-hydroxybenzoate, ethyl 3- (2-ethylhexyloxy) -5-hydroxybenzoate, 5-
Methyl (2-ethylhexyloxy) -2-hydroxybenzoate, methyl 2-hydroxy-5- (3,5,5-trimethylhexyloxy) benzoate, methyl 5- (2-cyclohexylethoxy) -2-hydroxybenzoate Methyl 4-N-hexyloxy-2-hydroxybenzoate, methyl 2-hydroxy-4-N-octyloxybenzoate, methyl 4-N-decyloxy-2-hydroxybenzoate, 5-N-hexyloxy-2 -Methyl hydroxybenzoate, 4- (2-ethylhexyloxy)
-2-Hydroxybenzoic acid, 2-hydroxy-4- (2,5,5-trimethylhexyloxy) benzoic acid, 4-cyclohexylmethoxy-2-hydroxybenzoic acid, 4- (2-cyclohexylethoxy) -2-hydroxy Benzoic acid, 4- (3,7-dimethyl-
6-octenyloxy) -2-hydroxybenzoic acid, 3- (2-
Ethylhexyloxy) -5-hydroxybenzoic acid, 5- (2
-Ethylhexyloxy) -2-hydroxybenzoic acid, 5-
(2-Ethylhexyloxy) -2-hydroxybenzoic acid, 2
-Hydroxy-5- (3,5,5-trimethylhexyloxy) benzoic acid, 5- (2-cyclohexylethoxy) -2-hydroxybenzoic acid, 4-N-hexyloxy-2-hydroxybenzoic acid, 5-N -Hexyloxy-2-hydroxybenzoic acid, 2-hydroxy-4-N-octyloxybenzoic acid, 4-N-decyloxy-2-hydrobenzoic acid, N- (2-hydroxyethyl) -4- (2-ethylhexyl) Oxy) -2-hydroxybenzamide, N-ethyl-4- (2-ethylhexyloxy) -2-
Hydroxybenzamide, 2-acetoxy-4-cyclohexylmethoxybenzoic acid, 4- (2-ethylhexyloxy)
2-Hydroxybenzoic acid sodium salt, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid methyl ester, 4-{(2E) -3,7-dimethyl Ethyl -2,6-octadienyloxy} -2-hydroxybenzoate, 5-{(2E) -3,7
Dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate ethyl, 3-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate ethyl, 3 -{(2E)-
Ethyl 3,7-dimethyl-2,6-octadienyloxy} -5-hydroxybenzoate, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -3-methoxybenzoic acid Ethyl acid, 4-{(2
E, 6E) -3,7,11-Trimethyl-2,6,10-dodecatrienyloxy} -2-hydroxymethyl benzoate, 4-{(2E) -3,7-dimethyl-2,6-octa Dienyloxy} -2-hydroxybenzoic acid (2E) -3,7-dimethyl-2,6-octadienyl, 4-{(2E)
-3,7-Dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid, 5-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid Acid, 3-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid, 3-{(2E) -3,7-dimethyl-2,6-octadi Enyloxy} -5-hydroxybenzoic acid, 2-hydroxy-4-{(2E, 6
E) -3,7,11-Trimethyl-2,6,10-dodecatrienyloxy} benzoic acid, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -3- Methoxybenzoic acid, 2-acetoxy-4-
{(2E) -3,7-Dimethyl-2,6-octadienyloxy} benzoic acid, N- (2-hydroxyethyl) -4-{(2E) -3,7-dimethyl-2,6-octa Dienyloxy} -2-hydroxybenzamide, 4-{(2E) -3,7-dimethyl-2,6-octadienylamino} -2-hydroxybenzoic acid, dimethyl-2,6-octadienyloxy} Benzoic acid, N- (2-hydroxyethyl) -4-
{(2E) -3,7-Dimethyl-2,6-octadienyloxy} -2-
Hydroxybenzamide, 4-{(2E) -3,7-dimethyl-2,6-
Octadienylamino} -2-hydroxybenzoic acid, 3-dodecyloxybenzoic acid, 3- (12-hydroxydodecyloxy) benzoic acid, 4-dodecyloxybenzoic acid, 4- (12-
Hydroxydodecyloxy) benzoic acid, 3- (12-hydroxyoctadecyloxy) benzoic acid, 4- (12-hydroxyoctadecyloxy) benzoic acid, 3- (11-hydroxyundecyloxy) benzoic acid, 4- (11-hydroxy Undecyloxy) benzoic acid, 3-[(2E) -3,7-dimethyl-2,6-
Octadienyloxy] benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 3-[(2E, 6
E) -3,7,11-Trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10
-Dodecatrienyloxy] benzoic acid, 4- [3,7-dimethyl-9- (2,6,6-trimethyl-1-cyclohexen-1-yl)-
2,4,6,8-Nonatetraenyloxy] benzoic acid, 4- [3,4-
Dihydro-2,5,7,8-tetramethyl-2- (4,8,12-trimethyltridecyl) -2H-1-benzopyran-6-oxy] benzoic acid, 4-[(2E, 6E) -3 , 7,11-Trimethyl-2,6,10-dodecatrienyloxy] benzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzamide, 4- (2-
Methyl-2-butenyloxy) benzamide, 4- (2-ethylhexyloxy) benzamide, 4-dodecyloxybenzamide, 4- (12-hydroxydodecyloxy) benzamide, 4- (12-hydroxyoctadecyloxy) benzamide, 4- (11 -Hydroxyundecyloxy) benzamide, 4- (10-hydroxydecyloxy) benzamide, 4-isostearyloxybenzamide, N- (2-
Hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-
2,6,10-dodecatrienyloxy] benzamide, N, N-
Dimethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzamide, N, N-di [(2E) -3,7
-Dimethyl-2,6-octadienyl] -4-aminobenzamide, 4- [N'-methoxycarbonyl-N-[(2E) -3,7-dimethyl-2,6-octadienylamino] benzamide, 4- 〔N-
Acetyl-N-[(2E) -3,7-dimethyl-2,6-octadienyl]] aminobenzamide, N- (2-hydroxyethyl)
-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, N, N-diethyl-4-[(2E, 6E)- 3,7,11-Trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, pea extract, sugar beet extract, squid reed extract, Phellinus linteus extract, Novonori extract, squid extract, caygis extract, squid squid extract, honey extract Squid extract, Scutellaria sinensis extract, Moroitogusha extract, Fusarium vulgaris extract, Hanayanagi extract, Salix radix extract, Motuyurena extract, Porphyra chinensis extract, Mosayanagi extract, Sasabayanaginori extract, Wasabi extract and the like.

(25) Mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitor anacardic acid or its derivative (6-pentadecatrienylsalicylic acid methyl ether, 6-pentadecatrienylsalicylic acid ethyl ether, 6-penta Decatrienyl salicylate propyl ether, 6-Pentadecatrienyl salicylate butyl ether, 6-Pentadecatrienyl salicyl alcohol methyl ether, 6-Pentadecatrienyl salicyl alcohol ethyl ether, 6-Pentadecatrienyl salicyl alcohol propyl ether, 6 -Pentadecatrienyl salicyl alcohol butyl ether, 6-
Pentadecatrienylsalicylaldehyde methyl ether, 6-Pentadecatrienylsalicylaldehyde ethyl ether, 6-Pentadecatrienylsalicylaldehyde propyl ether, 6-Pentadecatrienylsalicylaldehyde butyl ether, 2-Methylether-6-pentadeca Trienyl cinnamic acid, 2-ethyl ether-6-pentadecatrienyl cinnamic acid, 2-propyl ether-6-pentadecatrienyl cinnamic acid, 2-butyl ether-6-pentadecatrienyl cinnamic acid, 2-Methyl ether-6-pentadecatrienyl cinnamate, 2-ethyl ether
-6-Pentadecatrienyl cinnamic alcohol, 2-propyl ether-6-pentadecatrienyl cinnamic alcohol, 2-butyl ether-6-pentadecatrienyl] cinnamic alcohol, etc.), polyisoprenylated benzophenone derivative ( Garcinol, isogarcinol, xanthothymol, isoxanthomol, Gucciferon, etc.),
Epimedium extract, Yachimataikarisou (Indian cabbage)
Extract, Narco lily extract, Kaguruma Banaruco Lily
(Yellow essence) extract, oregano extract, oshida extract, oji extract, spruce extract, crow shrimp (half summer) extract,
Phellinus linteus extract, wolfberry (Pinus chinensis, linden, linseed leaf, skeleton) extract, Goshuyu (Glutinous broth) extract, Senega extract, Sendan extract, Tamarind extract, Taragon extract, Snapdragon daikon extract, Hachiku (bamboo extract) Boiled) extract, daisy (daisy) extract, myrobalan extract,
Scutellaria aspen extract, mockin extract, laurel extract, yab sotto extract, smelt extract, Macrocystis integrifolia extract, Neocitys ruetokeana extract, nettle extract, pacific extract, caterpillar extract, yagweed extract, cactus serrata extract, ezo nonomata extract, Scutellaria extract, Fusawa ivy extract, Hanemo extract, Mill extract,
Chromyl extract, Sakibutimir extract, Nagamil extract, Hiramir extract, Matsumo extract, Okinawa mozuku extract, Mozuku extract, Fukuronori extract, Kajime extract, Fukurofunori extract, Mahunori extract, etc.

(26) Mucopolysaccharide synthesis accelerator stilbene derivative or its salt, morphine or its salt and their derivatives, N-acetylglucosamine, flax extract, casino extract (kozo fruit) extract, kozo extract, hana mint extract, breadfruit extract, Hirakotoji extract, Kotoji-no-nomata extract, Yaleus banori extract, Kagious banori extract, Suzius banori extract, Amiosa extract, Nagaosaosa extract, Rhodophyllum vulgaris extract, Pleurotus chinensis radix extract, Yatsudegatato sycamore extract, Kurosaka extract Japanese Polygonum extract, Nezashinotosakaki extract, Yusora extract, Etsukinotosakaki extract,
Nankaitokimono extract, Himetosakakidoki extract, etc.

(27) Intercellular Lipid Formation Promoter / Intercellular Lipid Conditioning Agent Phospholipids (phosphatidylethanol, phosphatidylcholine, phosphatidyltriethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylglycerol, phosphatidylinositol, diacylphosphatidylcholine, diacylphosphatidyl) Ethanolamine, diacylphosphatidylinositol, diacylphosphatidylserine, 1-cysteinylphosphatidic acid, 2-cysteinylphosphatidic acid, 1-glutathionylphosphatidic acid, 2-glutathionylphosphatidic acid, 1-azelaoylphosphatidic acid, 2 -Azela oil phosphatidic acid, 1-hydroxyacylphosphatidic acid, 2-hydroxyacylphosphatidic acid, ceramide, glucosi Ceramide, galactosylceramide, cerebroside, phosphatidylglucosylacylglycerol, N-oleoyl sphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, N-salicyloyl phytosphingosine, Sphingomyelin, soybean lecithin, egg yolk lecithin, etc.), N-acetylneuraminic acid (sialic acid), N-glucosorneuraminic acid, gangliosides (galaose, ganglitriaose, ganglitetraose, globotetraose, neolactotetra) Aus, neolactohexaose, neolactooctaose, etc.), oligosulfated hyaluronic acid, hydroxy tamoxifen compound, glyceroglycolipids, pentoxyferrin, 3-deazaadenosine, carboxysamide Conductor,
Inositol polyamines, sialic acid, triterpenic acid derivatives, lactose, lactosamine derivatives, sulfated chitin derivatives, albumin, ginseng extract, ginseng ginseng extract, lily lily extract, sasayuri extract,
Hakata lily extract, poppy extract, etc.

(28) Maillard reaction inhibitor aminoguanidine, flavanones (naringin, naringenin, naringin, naringenin, liquiritin, liquiritigenin, digallic acid, luteoic acid, ellagic acid, chlorogenic acid, glucogarin, tetralin, hamamelitannin, gallic acid Acid tannin, tannic acid, geraniin, gallic acid, galloyl gallic acid, ellagutanin, hexagalloyl glucose, heptagalloyl glucose, tetragalloyl glucose, triggeroyl glucose, pentagalloyl glucose, digalloyl quinic acid, triggeroyl quinic acid) , 2-hydroxyphenylalkylamine derivatives or salts thereof, phenylpropenoic acid derivatives (3- [2,3-
Bis (methoxymethoxy) phenyl] propenoic acid, 7- (4-hydroxy-3-methoxyphenyl) hepta-2,4,6-trienoic acid, 3- (3,5-dimethoxy-4-hydroxyphenyl) propenohydrazide , N'-isopropylidene-3- (2-methoxyphenyl) propenohydrazide, etc.), broomweed (Ishikon root) extract, juniper garlic extract, etc.

(29) Testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter γ-amino-β-hydroxybutyric acid esters (γ-amino-
β-Hydroxybutyric acid methyl ester, γ-amino-β-hydroxybutyric acid ethyl ester, γ-amino-β-hydroxybutyric acid propyl ester, γ-amino-β-hydroxybutyric acid butyl ester, γ-amino-β-hydroxybutyric acid ethylhexyl ester , Γ-amino-β-hydroxybutyric acid hexadecyl ester, γ-amino-β-hydroxybutyric acid lauryl ester, γ-amino-β-hydroxybutyric acid stearyl ester, γ-amino-β-hydroxybutyric acid oleyl ester, γ-amino- β-hydroxybutyric acid benzyl ester, γ-amino-β-hydroxybutyric acid phenyl ester,
γ-amino-β-hydroxybutyric acid ethyl glycol ester, γ-amino-β-hydroxybutyric acid sorbitol ester, γ-amino-β-hydroxybutyric acid polyoxyethylene glycol ester, γ-amino-β-hydroxybutyric acid glycerin ester, etc.), Amine oxides (oleyldimethylamine oxide, stearyldimethylamine oxide, palmityldimethylamine oxide, myristyldimethylamine oxide, lauryldimethylamine oxide, dimethyllaurylethoxyamine oxide, dihydroxyethyllaurylamine oxide, coconut oil alkyldimethylamine oxide, etc.) , Alkyl betaines (coconut oil fatty acid amide propyl betaine, coconut oil alkyl betaine, lauryl dimethylamino acetic acid betaine, lauric acid amide propyl betaine, Lauryl hydroxysulfobetaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, etc.), pyrimidine N-oxide derivative (2-amino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-6- (1-
Pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-6-morpholinopyrimidine-3-oxide, 2-amino
-4-methyl-6- [1- (4-methylpiperazinyl)] pyrimidine-3-oxide, 2-amino-4- (1-hexahydroazepinyl) -6-methylpyrimidine-1-oxide, 2-Amino-4-dimethylamino-6-methylpyrimidine-1-oxide, 2-amino-4-allylamino-6-methylpyrimidine-1-oxide, 2
-Amino-4-benzylamino-6-methylpyrimidine-1-oxide, 2-amino-4,5-methyl-6-piperidinopyrimidine-3
-Oxide, 2-amino-4-ethyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-5-nitro-6-piperidinopyrimidine-3-oxide, 2,5-diamino- 4-methyl
-6-Piperidinopyrimidine-3-oxide, 2-amino-4-methyl-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-5-piperidino-6- (1-Pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-6-
Piperidinopyrimidine-3-oxide, 2-methyl-4-amino
-5-Bromo-6- (1-pyridinyl) pyrimidine-3-oxide, 2-methyl-4-amino-5-nitro-6-piperidinopyrimidine-3-oxide, 2-methyl-4,5-diamino -6-Piperidinopyrimidine-3-oxide, 2-Methyl-4-amino-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-Amino-4-methyl-6-piperidinopyrimidine -3-oxide monohydrochloride, 2-acetylamino-4-methyl-6-piperidinopyrimidine-3-oxide, 2,4-diamino-6-phenoxypyrimidine-3-oxide, 2,4-diamino-6 -(2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-6- (2,4,
6-Trichlorophenoxy) pyrimidine-3-oxide, 2,4
-Diamino-5-nitroso-6- (2,4-dichlorophenoxy)
Pyrimidine-3-oxide, 2,4-diamino-5-nitro-6-
(2,4,6-Trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4,5-triamino- 6- (2,
4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-
Diamino-5-bromo-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, etc.), p-menthane-3,8-diol, monoglyceryl-D-glucoside monotridecanoate, 1- o
-N-pentadecylglycero-D-glucoside, glyceride sulfate such as monopentadecanoic acid glyceride sulfate ester salt, monopentadecylglyceryl ether sulfate ester salt, 1-o-hexadecyl-2-o-methylglycero- Le, 1
-o-octadecyl-2-o-methylglycerol, 1-o-oleyl-2-o-methylglycerol, acetylcarnitine or a salt thereof, geranylgeranylacetone, a hydroxamic acid derivative or a salt thereof, zingerone glycoside, Benzeneoxyacetic acid derivative ([5- [2- [1-phenyl-1- (3-pyridyl)
Methylideneaminooxy] ethyl] -7,8-dihydronaphthalen-1-yloxy] acetic acid, etc.), isorhamnetin-3-robinobioside, xanthone derivatives, proanthocyanidins (grape seed extract proanthocyanidins, apple-derived proanthocyanidins, pine-derived) Proanthocyanidins, Purified procyanidin oligomers, Procyanidins
B-1, procyanidin B-2, procyanidin B-3, procyanidin C-1 etc.), Arakashi extract, Angelica extract, Anse (almond kernel) extract, Hong Apricot extract, Prickly pear extract, Enishida extract, Plantain (car) Foremen, Carpinaceae extract, Pleurotus japonicus extract, Olive extract, Scutellaria barbata extract, Ginseng extract, Crowseed extract, Cinnamon cucumber extract (Chrysanthemum) extract, Chrysanthemum extract, Zebra daisy extract, Knotweed extract,
Catalpa extract, kukui nut extract, camphor extract, cubaba extract, buckthorn extract, mussel
(Purple syrup, Panax syrup) extract, pearl nut extract, snapdragon extract, kippi extract, citrus extract, cilantro extract, kobushi extract, magnolia extract, rapeseed vine extract, vinca vine extract, matsubusa extract, colombo extract, konzulango extract, sasanqua extract. Sweetpotato extract, Sanaebu jujube (Acari seed) extract, Sansukon (yamazu root) extract, potato extract, Shishigashira extract, Sanshishi extract, coriander extract, Stevia extract, Takatodai (Omugi) extract, Tarayou (Ohayu winter blue, single leaf tea, bitter tea) , Bitter lantern extract, Taranoki extract, Nigaki (Bitterwood) extract, Nurude (quintet) extract, Hakamaurabosi (Osteolysis) extract, Magnolia magnolia extract, Nile iris extract, Dermatophyta extract, Hacogusa (Musclegrass) extract, Lizard Ginseng extract, Mangosteen extract, Myoga extract, Melaleuca extract, Yashabushi (arrow wheel) extract, Himeyashabushi extract, Obayashishabushi extract, Yakusou extract, Yamanoki (Yamaharu) extract, Locon (Reed, root) extract, log Wood extract, lantana extract, etc.

(30) Hair mother cell growth inhibitor / hair growth inhibitor phthalazinones, benzoxazinones, phosphonic acid derivatives, cyproterone, 5α-androstene-3α, 17β-
Diols, medroxyprogesterone, norethisterone, mestanolone, citrus extract (first), kashi extract, kanto extract, sanjiko extract, syra extract, syrup extract, dwarf citrus extract, hydrangea extract, motu yak extract, oleander extract, oleumoku extract and the like.

(31) Odorant-eliminating agent Inondo extract, eremi extract, dammar extract, vanilla bins extract, pine extract and the like.

(32) Fragrances Natural animal fragrances such as musk, civet, catrium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black character essential oil, cinnamon essential oil, ginnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mint essential oil, large scented essential oil, tuberose essential oil, Choji essential oil, orange essential oil, winter green essential oil, true balsam essential oil, butchery essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, hiba essential oil,
Sandalwood essential oil, petitgrain essential oil, bay essential oil, vetiver essential oil, bergamot essential oil, Peruvian balsam essential oil, boad rose essential oil, scented essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary Vegetable oils such as essential oils and Japanese peppermint oil, and other synthetic flavors.

(33) Dye / colorant Red cabbage dye, red rice dye, madder dye, annatto dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, whole buckwheat pigment, cherry pigment, seaweed pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment and the like.

(34) Sweetener Sugar, sweet tea, fructose, arabinose, galactose, lactitol, maltitol, xylose, stevia, mannose, maltose, honey, glucose, miraculin, monerin, licorice extract and the like.

(35) Nutrient enhancer shell-baked calcium, cyanocholamine, yeast, wheat germ, egg yolk powder, hemicellulose, heme iron, etc.

(36) Capsules Agar capsules, pectin capsules, gelatin capsules,
Capsules of cellulose and its derivatives, chitin and its derivatives, capsules of chitosan and its derivatives, shellac capsules, polylysine capsules, polyaspartic acid capsules, polyglutamic acid capsules, collagen capsules and the like.

(37) Excipients Potato starch, wheat starch, pectin, corn starch, rice starch, lactose, sucrose, glucose, mannitol, sorbitol, calcium phosphate, calcium sulfate, calcium carbonate, calcium hydrogen carbonate, calcium citrate, cellulose and Derivatives, talc, clay, diatom, dextrin, stearic acid, agnesium stearate, dimethylsiloxane,
Macrogol, polyvinylpyrrolidone, polyvinyl ether, tragacanth, etc.

In addition, hormones, sequestering agents,
pH adjuster, chelating agent, antiseptic / antifungal agent, cooling agent, stabilizer, emulsifier, animal / vegetable protein and its decomposed product, animal / vegetable polysaccharide and its decomposed product, animal / vegetable glycoprotein and Degradation products, anti-inflammatory / anti-allergic agents, wound healing agents,
It is also possible to use a foaming agent, a thickening agent, an enzyme, purified water (electronic water, small clusters, etc.), a deodorant / deodorant, etc. in combination.

[0074]

[Examples] Production examples, test examples, and prescription examples of the cholesterol metabolism improving agent used in the present invention will be shown below, which will be described in more detail, but the present invention is not limited thereto.

(Production Example 1) Method for producing persimmon tannin which is a condensation type polyphenol compound 10 kg of mature fruit containing pericarp (Diospyros kaki) pericarp, which is a raw material, was ground, and 20 L of 50% ethanol aqueous solution was added to the mixture, followed by 3 at room temperature. Soaked for a day. After filtering the immersion liquid,
The filtrate is passed through a column filled with an adsorbent (Diaion HP, manufactured by Mitsubishi Kasei Co., Ltd.), the column is washed with purified water, and then adsorbed on the adsorbent using a 50% ethanol aqueous solution. The components were eluted. The eluate was concentrated under reduced pressure and then freeze-dried to obtain 500 g of a persimmon tannin which was a condensed polyphenol compound.

Test Example 1 Cholesterol Metabolism Improving Action Test Male Wistar rats were divided into 3 groups (1 group is composed of 6 rats), and a high cholesterol diet having the composition shown in Table 1 was given for 14 days. Reared. One group was used as a control and was fed with a feed composition containing no condensed polyphenol compound.
Group 2 was used to study the effect of improving cholesterol metabolism, and the feed used was the persimmon tannin obtained in Production Example 1 as a condensed polyphenol compound in one group at 2.0% by mass and in the other group at 4%. It was added so as to be 0.0% by mass. After breeding for 13 days, they were fasted for 24 hours, after which the rats were sacrificed by heart blood sampling, and the blood was centrifuged at 3000 rpm for 15 minutes to obtain serum. The total serum cholesterol and high density lipoprotein cholesterol contained in the obtained serum were quantified. The quantification method is an enzyme method, specifically, the total cholesterol content is cholesterol E-test Wako (manufactured by Wako Pure Chemical Industries, Ltd.), and the high density lipoprotein cholesterol content is HDL-cholesterol test Wako (Wako Jun Yaku Kogyo Co., Ltd.) was used. The low density lipoprotein cholesterol content was calculated from the measured total cholesterol content and high density lipoprotein cholesterol content. The measurement results of total cholesterol content in serum, high-density lipoprotein cholesterol content, low-density lipoprotein (including ultra-low-density lipoprotein) cholesterol content in ingested or non-ingested condensed polyphenol compounds Shown in 1. The total cholesterol content in the liver obtained after slaughter was
Liver lipids were extracted and cholesterol E
-Measured using Test Wako (manufactured by Wako Pure Chemical Industries, Ltd.). FIG. 2 shows the measurement results of total cholesterol content in the liver with or without ingestion of the condensed polyphenol compound. Also, the total cholesterol content in 100 g of rat body weight was determined by the same method as described above,
FIG. 3 shows the measurement results of the total cholesterol content in 100 g of body weight with or without ingestion of the condensed polyphenol compound. The various quantitative values obtained in these tests are all shown as the average value in each group.

[0077]

[Table 1] Test feed composition (g / 1000g feed) * 1: (Ca 5000mg, P 1561mg, K 3600mg, S 300mg, Na
1019mg, Cl 1571mg, Mg507mg, Fe 35mg, Zn 30mg, Mn
10mg, Cu 6mg, I 0.2mg, Mo 0.15mg, Se 0.15mg, Si 5m
g, Cr 1.0mg, F 1.0mg, Ni 0.5mg, B 0.5mg, Li 0.1mg,
V 0.1mg) / 1000g mineral mixture * 2: (thiamin hydrochloride 6.36mg, riboflavin 6.0mg,
Pyridoxine hydrochloride 7.29 mg, nicotinic acid 3.0 mg, calcium pantothenate 16.31 mg, folic acid 2.0 mg, cyanocobalamin 0.025 mg, biotin 0.2 mg, phylloquinone 0.75 m
g, retinyl palmitate 4000IU, cholecalciferol 1000IU, tocopherol acetate 751IU) / 1000g vitamin mixture

(Results of Test Example 1) As shown in FIG. 1, by ingesting a condensed polyphenol compound, the total cholesterol content in serum and low-density lipoprotein (including ultra-low-density lipoprotein) cholesterol were obtained. The content was significantly reduced as compared to the non-ingested group. On the other hand, the high density lipoprotein cholesterol content was maintained. Further, as shown in FIG. 2, the total cholesterol content in the liver was remarkably reduced in the 4.0 mass% condensed polyphenol compound-added group. Further, as shown in FIG. 3, the total cholesterol content in the whole rat living body was decreased by ingesting the condensed polyphenol compound, as compared with the non-intake group. From these test results, it was revealed that ingestion of the condensed polyphenol compound reduced cholesterol in serum, liver and whole body, and further maintained the high density lipoprotein cholesterol content in serum. became. Therefore, it was revealed that the condensed polyphenol compound has an excellent cholesterol metabolism improving effect.

(Prescription example) Pharmaceuticals, quasi-drugs, and foods containing cholesterol metabolism improving agents The following are prescription examples according to the above-mentioned evaluation results. Each prescription example is manufactured by a conventional method for manufacturing each product. The blended amount was shown. Further, the present invention is not limited to these.

(Formulation Example 1) Capsule 1. Magnesium ascorbate 0.5g 2. Persimmon tannin 5.0g 3. DL-α-tocopherol acetate 0.5g 4. Silicone oil 30.0g 5. Tween 80 0.05g 6. Corn starch 63.95g 100g in total 1 to 6 were mixed according to the above recipe, 200mg
Was filled into capsules.

(Formulation Example 2) Capsule 1. Macrogol 64.0 g 2. Glycerol 8.0 g 3. Persimmon tannin 2.0 g 4. Diphenhydramine hydrochloride 0.1 g 5. Thiamine hydrochloride 0.5 g 6. Purified water 10.0 g 7. Corn starch 12.4 g Total 100g 1 to 7 are mixed according to the above recipe, 200mg
Was filled into capsules.

(Formulation Example 3) Capsule 1. Starch 65.0 g 2. Persimmon tannin 3.0 g 3. Condensation type polyphenol compound (catechin: epicatechin: catechin gallate = 4: 5: 1) 3.0 g 4.mannitol 10.0 g 5 Calcium hydrogen carbonate 5.0g 6. Polyvinylpyrrolidone 14.0g Total 100g 1 to 6 were mixed uniformly according to the above recipe, and 200mg
Was filled into capsules.

(Formulation Example 4) Tablet 1. Persimmon tannin 100.0 mg 2. Corn starch 50.0 mg 3. Hydroxypropyl methylcellulose 150.0 mg 4. Carboxymethyl chitin 30.0 mg Total 330 mg

(Formulation Example 5) Tablet 1. Persimmon tannin 50.0 mg 2. Condensation type polyphenol compound (gallocatechin: catechin gallate: catechin = 2: 4: 4) 50.0 mg 3. Corn starch 80.0 mg 4. Methylcellulose 40.0 mg 5. Stearin Magnesium acid 20.0 mg 6. Talc 10.0 mg Total 250 mg

(Formulation Example 6) Tablet 1. Persimmon tannin 20.0 mg 2. Condensation type polyphenol compound (gallocatechin gallate: epicatechin: catechin = 4: 3: 3) 20.0 mg 3. Polyvinyl alcohol 160.0 mg 4. Carboxymethyl cellulose 50.0 mg 5. Magnesium stearate 5.0 mg Total 255 mg

(Formulation Example 7) Granules 1. Persimmon tannin 50.0 mg 2. Carboxymethyl cellulose 180.0 mg 3. Propylene glycol 20.0 mg 4. Sodium alginate 30.0 mg 5. Sucrose 10.0 mg Total 290 mg

(Formulation Example 8) Granules 1. Persimmon tannin 30.0 mg 2. Condensation type polyphenol compound (Epicatechin gallate: Epicatechin: Catechin = 1: 5: 4) 30.0 mg 3.Carboxymethyl cellulose 180.0 mg 4.Sodium alginate 30.0mg 5. Erythritol 10.0mg 6. Citric acid 5.0mg Total 285mg

(Formulation Example 9) Syrup mass% 1. Persimmon tannin 2.0 2. Condensation type polyphenol compound (catechin gallate: gallocatechin gallate: catechin = 3: 3: 4) 2.0 3. Sucrose 5.0 4. Sorbitol 1.0 5. Sodium citrate 0.5 6. Sodium glutamate 0.5 7. Fragrance suitable amount 8. Purified water 100 Residue

(Formulation Example 10) Syrup mass% 1. Persimmon tannin 1.0 2. Persimmon tannin fermentation product 1.0 3. Ascorbic acid glucoside 0.5 4. Silk extract 0.2 5. Scutellaria extract 0.2 6. Sucrose 2.0 7. Alginic acid Sodium 0.2 8. Perfume Suitable amount 9. Purified water 100 Residue

[0090] (Prescription example 11) Mentsuyu mass%     1. Soy sauce 80.0     2. Black vinegar 2.0     3. Glucose 13.0     4. Sodium glutamate 2.0     5. Persimmon tannin 1.5     6. Salix extract 1.5

[0091] (Prescription example 12) Udon or buckwheat mass%     1. Wheat flour or buckwheat flour 90.0     2. Salt 1.0     3. Persimmon tannin 4.0     4. Birch extract 4.0     5. Horse chestnut extract 1.0

[0092] (Prescription example 13) Beverage mass%     1. Glucose liquid sugar 30.0     2. Grapefruit juice 50.0     3. Pomegranate extract 3.0     4. Persimmon tannin 4.0     5. Sodium hyaluronate 2.0     6. Sodium chondroitin sulfate 2.0     7. Mandarin orange juice 6.0     8. Fragrance suitable amount     9. Acidulant

[0093] (Prescription example 14) Bread mass%     1.flour 80.0     2. Salt 1.0     3. Glucose 8.0     4. Persimmon tannin 3.0     5. Salvia extract 2.0     6. Perilla extract 2.0     7. Carboxymethyl chitin 2.0     8. Tocopherol succinate 0.5     9.β-carotene 0.5     9. Heme iron 1.0

[0094] (Formulation example 15) Sausage mass%     1. Ground meat 85.0     2. Chicken egg 5.0     3. Spice 1.0     4. Seasoning 1.0     5. Persimmon tannin 4.0     6. Capsicum extract 4.0

[0095] (Prescription example 16) Gum mass%     1.Menthol Micron 30.0     2. Grapefruit flavor 50.0     3. Persimmon tannin 3.8     4. Mint extract 2.0     5. Artemisia extract powder 2.0     6. Ellagitannin 1.0     7. Xylitol 10.0     8. Remaining amount of sorbitol

[0096] (Prescription example 17) Miso soup mass%     1. Tofu 30.0     2. Deep fried 5.0     3. carrot 5.0     4. Burdock 5.0     5. Chinese cabbage 5.0     6. Red miso 20.0     7. Persimmon tannin 6.0     8. The remaining amount of bonito dashi 100

[0097] (Prescription example 18) Cookie mass%     1.milk 62.0     2. Whole egg 14.5     3. Sugar 12.0     4. Constarch 5.0     5. Salt 0.5     6. Persimmon tannin 2.0     7. Fragrance suitable amount

The pharmaceuticals and foods shown in Formulation Example 4 and Formulation Examples 13 and 18 were routinely ingested by a total of 37 adult women and men in a normal diet, and as a result, the cholesterol content in blood was 23 in 23 patients. Was confirmed to have decreased.

[0099]

The cholesterol metabolism-improving agent containing the condensed polyphenol compound of the present invention remarkably reduces cholesterol contained in serum, liver and whole body,
It has a function of maintaining the amount of high-density lipoprotein cholesterol and exhibits an excellent effect of improving cholesterol metabolism.
Furthermore, by ingesting the cholesterol metabolism-improving agent of the present invention in the form of medicines, quasi-drugs, foods, etc. in a normal diet, it is possible to prevent and improve arteriosclerosis.

[Brief description of drawings]

FIG. 1 is a diagram showing measurement results of total cholesterol content, high-density lipoprotein cholesterol content, and low-density lipoprotein cholesterol content in rat serum in a state of ingesting or not ingesting a condensed polyphenol compound. .

FIG. 2 is a diagram showing the results of measurement of total cholesterol content in rat liver with or without ingestion of a condensed polyphenol compound.

FIG. 3 is a diagram showing the results of measurement of total cholesterol content in the living body of a rat with or without ingestion of a condensed polyphenol compound.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61P 3/06 A61P 3/06 9/10 101 9/10 101 (72) Inventor Toshi Nagaoka Kaifu-gun, Aichi prefecture 1 Livable Yatomi 4B, 137, Uomariura Nishimaeda, Yatomi-cho 472 (72) Inventor Sowa Iinuma, 1-1 Naka-Fudooka, Kakamigahara City, Gifu Prefecture Gifu Prefectural Institute for Health and Environmental Studies (72) Junichi Hasegawa Motosu-gun, Gifu Prefecture No. 1, 318, Asagi, Shinsei-machi, Ichimaru Falcos Co., Ltd. (72) Inventor Hiroyuki Kojima No. 1, 318, Asagi, Masaki-cho, Motosu-gun, Gifu F-Term, No. 1 Farucos Co., Ltd. 4B018 MD08 MD48 MD52 ME04 MF01 4C062 FF44 4C086 AA01 AA02 BA08 FA02 MA01 MA02 MA03 MA04 MA23 MA35 MA37 MA52 NA14 ZA45 ZC33 4C088 AB24 AC03 AC04 AC05 BA08 BA14 BA21 BA32 CA04 CA14 MA23 MA35 MA37 MA5 2 ZA45 ZC33

Claims (3)

[Claims] 1. A cholesterol metabolism-improving agent comprising one or more selected from the condensed polyphenol compounds represented by the formula 1. [Formula 1] Formula 1 [R ₁ = H or OH, R ₂ = H or OH, R ₃ = H or OH, R ₄ = H or a benzyl group represented by the formula 2, R ₅ =
H or OH, R ₆ = H or OH, R ₇ = H or OH, R
₈ = H or a benzyl group represented by the formula 3, and R ₉ = H or OH. It is arbitrarily selected from n = 10 to 50. X in Formula 1 has the structure shown in Formula 4. The n structural formulas of X may all be the same or different. ] Formula 2 [R ₁₀ = H or OH, R ₁₁ = H or OH, R ₁₂ =
It is arbitrarily selected from H or OH. ] Formula 3 [R ₁₃ = H or OH, R ₁₄ = H or OH, R ₁₅ =
It is arbitrarily selected from H or OH. ] Formula 4 [R ₁₆ = H or OH, R ₁₇ = H or OH, R ₁₈ =
Optionally selected from H or OH, R ₁₉ = H or a benzyl group of formula 5. ] Formula 5 [R ₂₀ = H or OH, R ₂₁ = H or OH, R ₂₂ =
It is arbitrarily selected from H or OH. ] 2. The cholesterol metabolism improving agent according to claim 1, wherein the condensed polyphenol compound is persimmon tannin. 3. The cholesterol according to claim 1 or 2, wherein the content of low-density lipoprotein (including ultra-low-density lipoprotein) cholesterol in human or animal blood is specifically reduced. Metabolism improver.