JP2003201246A - Antiinflammatory agent, and food and drink containing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an antiinflammatory agent having excellent antiinflammatory effects, especially effective for the whole symptom of allergic rhinitis, free from grave side effects observed in a medicine because a material which is not a medicine but a food is used, and having high safety, and to provide a food and drink containing the antiinflammatory agent. <P>SOLUTION: This antiinflammatory agent against inflammation contains a dried product of a leaf of Perilla frutescens, cacao and a fruit of Foeniculum vulgare, or an essence extracted from them with hot water. In other aspect, the antiinflammatory agent contains a dried product of the leaf of Perilla frutescens, the cacao, the fruit of the Foeniculum vulgare, a fenugreek seed, rosemary, a juniper berry and a celery seed, or an essence extracted from them with hot water. The food and drink contains the antiinflammatory agent. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an anti-inflammatory agent effective for allergic diseases such as pollinosis and foods and drinks containing the same. More specifically, the present invention relates to an anti-inflammatory agent having fewer side effects than a drug and safe for long-term use, and foods and drinks containing the same.

[0002]

BACKGROUND OF THE INVENTION Pollenosis, which is one of allergic rhinitis, is a disease that was rarely found in Japan more than 20 years ago, but is a disease whose prevalence has increased remarkably in recent years. Currently, 30% of the people are said to have some allergic symptoms.

Moreover, in recent years, not only do allergic reactions to typical "cedar pollen" occur, but there is a tendency to develop it in response to other pollens such as cypress and ragweed, and the onset period has been extended to multiple seasons. There is. In addition, the number of cases in which this symptom develops perennially in response to house dust and mites has increased.

Therefore, studies on the treatment of hay fever are now widely conducted, and several kinds of treatment methods have been developed and provided for treatment. However, there are merits and demerits, and a satisfactory treatment method is recognized. Not not. In addition, once affected, unpleasant symptoms such as sneezing, runny nose, nasal congestion, headaches, and persistent itching of the eyes are exhibited, and side effects such as drowsiness caused by therapeutic agents may reduce the productivity of the population and may even adversely affect the economy. Has been done.

Under these circumstances, antiallergic agents, steroid agents and the like are currently developed and used as medicines. These drugs have side effects such as symptom deterioration (rebound phenomenon) due to long-term administration, sleepiness due to action on the central nervous system, effects on the endocrine system, and strong antiallergic effects. It is necessary to use.

On the other hand, as an antiallergic material that is safe and has no side effects, one that has an antiallergic effect has been searched for in conventional foods, and development as a food material has been attempted (Japanese Patent Laid-Open No. 61-291524). Japanese Patent Laid-Open No. 1-1.
21217, and JP-A-7-215884).
For example, the well-known
bussuavissimus) tea leaves are extracted with hot water from perilla frutescens, and perilla frutescens leaves are extracted with hot water from perilla leaf extract.

As a result of clinical research on these materials,
It has been confirmed that beetroot extract alleviates and prevents cardiovascular allergies such as rhinitis, sneezing, and sore throat, and perilla leaf extract has been confirmed to alleviate and prevent allergic symptoms such as skin inflammation. ing.

Moreover, since these materials are made from ordinary foods that have a long eating experience, they are safe even after long-term ingestion and have no side effects, so they are used as functional ingredients of antiallergic foods. .

[0009]

However, in the case of the above-mentioned drugs, many side effects are obvious, and it is necessary to use them under the supervision of a doctor, which is not suitable for alleviation or prevention of allergic symptoms over a long period of time. is there. Further, when the above-mentioned ordinary food is used as a raw material, it is an excellent antiallergic material without side effects, but it only suppresses a part of the biological reaction leading to the development of allergy. Therefore, as a result, it is effective to alleviate or prevent some allergic symptoms, but it cannot be expected to alleviate or prevent all symptoms.

In view of such circumstances, the present invention is based on the inventor's 35 years of experience in oriental medicine, and the object of the present invention is to have an excellent anti-inflammatory effect, especially allergenicity. Providing highly safe anti-inflammatory agents and foods and drinks containing them, which are effective against all symptoms of rhinitis, and have no serious side effects such as those seen with drugs because they are made of non-drug foods To do.

[0011]

The above-mentioned object is achieved by an anti-inflammatory agent characterized by containing a dried product of soybean leaves, cacao and linseed or a hot water extract thereof, and having an anti-inflammatory effect on inflammation. To be done. Furthermore, in addition to the above-mentioned dried product or its hot water extract, by containing the dried product of fenugreek seeds, rosemary, juniper berries and / or celery seeds or its hot water extract, the anti-inflammatory action against inflammation is further improved. To do.

Further, the above object is also achieved by a food or drink containing the above anti-inflammatory agent.

On the other hand, regarding the antiallergic action of the extracts of Lamiaceae plants, Japanese Patent Application Laid-Open No. 9-87189 discloses the antiallergic action of extracts of perilla leaves, flowers, roots and the like. However, the fact that the above combination has an effect on all the symptoms of allergic rhinitis is not known so far, and is clarified by the present study.

[0014]

BEST MODE FOR CARRYING OUT THE INVENTION The weight ratio of dried leaves of soybean leaf, cacao and broth of the anti-inflammatory agent according to the present invention is 6 to 2: 6 to 2:
It is preferably 4 to 1, more preferably 3:
3: 2. Further, the dry weight ratio of the anti-inflammatory agent of the present invention such as Soyaba, cacao, scent, fenugreek seed, rosemary, juniper berry and celery seed is 6-2: 6-2: 4-1-1: 4-1. : 4 ~ 1: 4 ~
The ratio is preferably 1: 3 to 0.3, more preferably 3: 3: 2: 2: 2: 2: 1.

The dried products of the anti-inflammatory agent of the present invention such as soybean leaves, cacao, scent, fenugreek seeds, rosemary, juniper berries and celery seeds may be pulverized into a dry powder.

When the hot water extraction is carried out, it is preferable to carry out the extraction as it is or after pulverizing the dried product. Further, the ratio of the hot water used as the extraction solvent and the dried product is not particularly limited, but with respect to the dried product, hot water 10 to 10
It is preferably 100 times by weight, particularly 15 to 25 times by weight in terms of extraction operation and efficiency. The extraction temperature is preferably in the range of 90 to 100 ° C., and the extraction time is preferably in the range of 30 to 50 minutes.

The anti-inflammatory agent according to the present invention is prepared by mixing stevia as a sweetness with soybean leaf, cacao and scent in a ratio of 6 to 2: 6 to 2: 4 to 1 so that a patient can easily drink it. It may be added in a ratio of 3 to 0.3, and soy leaves, cacao, scent, fenugreek seeds, rosemary, juniper berries and celery seeds may be added in a ratio of 6 to 2: 6 to 2: 4.
˜1: 4˜1: 4˜1: 4˜1: 3˜0.3 may be added to the mixture in a ratio of 3˜0.3.

The anti-inflammatory agent according to the present invention may be taken as an extract granule by spray-drying or freeze-drying a hot water extract.

The dose of the anti-inflammatory agent according to the present invention depends on the medical condition,
Although it may vary depending on the age of the patient and the like, usually, a suitable weight of the dried product is 15 to 25 g per day.

The concentration of the active ingredient in the food or drink containing the anti-inflammatory agent can be appropriately changed depending on the kind of the food or drink, but it is usually about 1 to 20 wt%. It should be noted that the above-mentioned dose is an example, and can be appropriately changed according to various situations.

The food and drink of the present invention includes soups, beverages (juice, liquor, mineral water, coffee, tea, etc.), confectionery (gum, candy, chocolate, snacks,
Jelly, etc.), noodles (soba, udon, ramen, etc.) and other general foods, health foods, nutritional supplements (nutritive drinks, etc.) can be added. This makes it possible to take antiallergic substances without resistance, which helps prevent allergies. In addition, a long-term use of the food or drink according to the present invention can provide an excellent effect on improving allergic constitution.

[0022]

EXAMPLES Next, the present invention will be specifically described based on Examples.

[Example 1] Preparation of anti-inflammatory agent An anti-inflammatory agent was prepared by mixing each dry powder with the composition shown in Table 1 to give Example 1.

Comparative Example 1 Dry powders having the composition shown in Table 1 were mixed to give Comparative Example 1.

Comparative Example 2 An anti-inflammatory agent was prepared by mixing each dry powder with the composition shown in Table 1 to prepare Comparative Example 2.

Example 3 The dry powders having the composition shown in Table 1 were mixed to prepare an anti-inflammatory agent, which was set as Example 3.

[0027]

[Table 1]

[Test Example 1] A clinical test was carried out as follows. From mid-February to mid-May, runny nose, sneeze,
Of 42 patients with cedar pollinosis and perennial allergy who are experiencing peculiar symptoms such as nasal congestion, 31 of Example 1 is the anti-inflammatory agent of the present invention, and 5 are anti-inflammatory agents of the present invention. Example 3 is divided into 2 times a day, and the amount in Table 1 is 100 ° C.
Of hot water for 35 minutes to extract, take 3 of the 6 remaining cases, take Comparative Example 1 twice a day, take the same, and give the remaining 3 cases of Comparative Example 2. Divide into twice a day,
I took it as well. The determination was made according to the criteria in Table 2 after the 4-week administration period.

[0029]

[Table 2]

The results of the clinical tests are shown in Table 3.

[0031]

[Table 3]

From the above results, the effect on inflammation was recognized particularly in Example 1, and the effect in Example 3 was higher than that in Comparative Example. During the treatment period, no symptom that was considered to be a side effect was observed. On the other hand, the comparative examples had low effects on inflammation.

That is, in Comparative Example 1 consisting of soy leaves and rosemary and Comparative Example 2 consisting of scent and cacao, the anti-inflammatory effect was hardly recognized or partial, whereas in the present invention, it was obtained. It was clarified that the obtained anti-inflammatory agent was effective against all the symptoms of allergic rhinitis.

Regarding Example 1, 3 after the start of prescription.
From day one, improvement in symptoms was observed, and one week later, consciousness of symptom reduction began to become apparent, and two weeks later, the efficacy became clear.

Next, examples of foods and drinks containing the anti-inflammatory agent of the present invention will be shown.

[Example 2] Soup Using the anti-inflammatory agent obtained in Example 1, a soup was prepared by a conventional method according to the following formulation.

[0037] Anti-inflammatory agent 20wt% Mung bean 30wt% Stevia 1.5wt%, Salt 1wt%, Water 47.5wt%

The foods and drinks containing the anti-inflammatory agent of the above-mentioned examples can be easily ingested in daily life, effectively prevent allergic diseases, and easily improve the constitution. Is possible.

[0039]

INDUSTRIAL APPLICABILITY The anti-inflammatory agent of the present invention and foods and drinks containing the same have an excellent anti-inflammatory effect against allergic rhinitis such as pollinosis. Moreover, since it uses food materials as its raw materials, it has a high level of safety without the serious side effects of chemicals. Further, the food and drink of the present invention can prevent allergies in daily life and easily improve the constitution.

Front page continued (51) Int.Cl. ⁷ Identification code FI theme code (reference) A23L 1/30 A23L 1/30 B A61P 11/02 A61P 11/02 27/14 27/14 27/16 27/16 29 / 00 29/00 37/08 37/08 F term (reference) 4B018 MD61 ME07 MF01 4C088 AB03 AB12 AB38 AB40 AB59 AC01 BA09 CA05 CA11 MA07 MA08 MA41 MA44 MA52 ZA33 ZA34 ZB11 ZB13

Claims (12)

[Claims] 1. An anti-inflammatory agent, which comprises a dried product of soybean leaves, cacao and cocoon or a hot water extract thereof and has an anti-inflammatory action against inflammation. 2. The anti-inflammatory agent according to claim 1, wherein the weight ratio of the dried product of soybean leaves, cacao and scent is 6 to 2: 6 to 2: 4 to 1. 3. The anti-inflammatory agent according to claim 1, wherein the weight ratio of the dried product of soybean leaf, cacao and scent is 3: 3: 2. 4. An anti-inflammatory which comprises dried leaves of soy leaves, cacao, scent, fenugreek seeds, rosemary, juniper berries and celery seeds or a hot water extract thereof, and which has an anti-inflammatory effect on inflammation. Agent. 5. A dry product of soy leaves, cacao, scent, fenugreek seeds, rosemary, juniper berries and celery seeds in a weight ratio of 6 to 2: 6 to 2: 4 to 1: 4.
The anti-inflammatory agent according to claim 4, wherein the anti-inflammatory agent is from about 1: 4 to 1: 4 to 1: 3 to 0.3. 6. The weight ratio of dried leaves of soy leaves, cacao, scent, fenugreek seeds, rosemary, juniper berries and celery seeds is 3: 3: 2: 2: 2: 2: 1.
The anti-inflammatory agent according to claim 4, which is 7. The leaves of claim 1 as an anti-inflammatory agent,
A food or drink characterized by containing a dried product of cacao or cocoa or a hot water extract thereof. 8. The food or drink according to claim 7, wherein the weight ratio of dried products of soybean leaves, cacao and scent is 6 to 2: 6 to 2: 4 to 1. 9. The food and drink according to claim 7, wherein the weight ratio of the dried products of soy leaf, cacao and scent is 3: 3: 2. 10. An anti-inflammatory agent, which comprises the dried product of soybean leaf, cacao, cocoon, fenugreek seed, rosemary, juniper berry and celery seed according to claim 4, or a hot water extract thereof. Food and drink. 11. The dry product of soy leaf, cacao, scent, fenugreek seed, rosemary, juniper berry and celery seed has a weight ratio of 6 to 2: 6 to 2: 4 to 1: 1.
It is 4 to 1: 4 to 1: 4 to 1: 3 to 0.3.
The listed food and drink. 12. The weight ratio of dried leaves of soy leaf, cacao, scent, fenugreek seed, rosemary, juniper berry and celery seed is 3: 3: 2: 2: 2: 2 :.
The food or drink according to claim 10, which is 1.