JP2003164290A5 - - Google Patents
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- Publication number
- JP2003164290A5 JP2003164290A5 JP2001367093A JP2001367093A JP2003164290A5 JP 2003164290 A5 JP2003164290 A5 JP 2003164290A5 JP 2001367093 A JP2001367093 A JP 2001367093A JP 2001367093 A JP2001367093 A JP 2001367093A JP 2003164290 A5 JP2003164290 A5 JP 2003164290A5
- Authority
- JP
- Japan
- Prior art keywords
- dna
- complementary strand
- cell
- polypeptide
- recombinant vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 108020004414 DNA Proteins 0.000 claims description 46
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 30
- 229920001184 polypeptide Polymers 0.000 claims description 25
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 25
- 230000000295 complement effect Effects 0.000 claims description 21
- 210000004027 cell Anatomy 0.000 claims description 18
- 239000013612 plasmid Substances 0.000 claims description 16
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 13
- 230000009711 regulatory function Effects 0.000 claims description 11
- 230000017455 cell-cell adhesion Effects 0.000 claims description 7
- 210000002744 extracellular matrix Anatomy 0.000 claims description 7
- 208000024827 Alzheimer disease Diseases 0.000 claims description 6
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims description 6
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims description 6
- 230000006870 function Effects 0.000 claims description 6
- 239000011159 matrix material Substances 0.000 claims description 4
- 238000007792 addition Methods 0.000 claims description 3
- 230000037430 deletion Effects 0.000 claims description 3
- 238000012217 deletion Methods 0.000 claims description 3
- 230000035772 mutation Effects 0.000 claims description 3
- 238000006467 substitution reaction Methods 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000010998 test method Methods 0.000 claims 3
- 238000012360 testing method Methods 0.000 claims 3
- 230000030833 cell death Effects 0.000 claims 2
- 238000007689 inspection Methods 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000003449 preventive effect Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000016273 neuron death Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 101100075438 Rattus norvegicus Lrrc15 gene Proteins 0.000 description 6
- 210000004556 brain Anatomy 0.000 description 4
- 230000014509 gene expression Effects 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000002299 complementary DNA Substances 0.000 description 3
- 101001039113 Homo sapiens Leucine-rich repeat-containing protein 15 Proteins 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 102000043361 human LRRC15 Human genes 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 210000004498 neuroglial cell Anatomy 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 206010003571 Astrocytoma Diseases 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 238000000636 Northern blotting Methods 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 210000001130 astrocyte Anatomy 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 108010054624 red fluorescent protein Proteins 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000010474 transient expression Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001367093A JP2003164290A (ja) | 2001-11-30 | 2001-11-30 | βアミロイド誘導Lib遺伝子 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001367093A JP2003164290A (ja) | 2001-11-30 | 2001-11-30 | βアミロイド誘導Lib遺伝子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003164290A JP2003164290A (ja) | 2003-06-10 |
| JP2003164290A5 true JP2003164290A5 (enExample) | 2005-05-26 |
Family
ID=19176891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001367093A Pending JP2003164290A (ja) | 2001-11-30 | 2001-11-30 | βアミロイド誘導Lib遺伝子 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2003164290A (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7399469B2 (en) * | 2004-03-26 | 2008-07-15 | Pdl Biopharma, Inc. | Anti-LFL2 antibodies for the diagnosis, prognosis and treatment of cancer |
| JP2006075152A (ja) * | 2004-08-09 | 2006-03-23 | Dai Ichi Seiyaku Co Ltd | 細胞移動阻害剤 |
-
2001
- 2001-11-30 JP JP2001367093A patent/JP2003164290A/ja active Pending
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