JP2003137747A - Hair growth suppressor - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair growth suppressor having excellent suppressing effect on growth of body hair of the hands, the feet, the breast, or the like, and whiskers, or the like, no anxiety about skin troubles such as irritation, rash and is extremely highly effective and safe. SOLUTION: This hair growth suppressor is obtained by mixing blackberry lily with one or more kinds of plant extracts having antiandrogenic action, one or more kinds of essential oils having antiandrogenic action and one or more kinds of plant extracts having skin astringing action/capillary vasoconstrictive action with one or more kinds of naturally or chemically modified phospholipids.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an agent for suppressing hair growth of body hair and beard such as hands, feet, chest, etc., which is mainly composed of plant extract and essential oil and has high efficacy and safety.

[0002]

2. Description of the Related Art Hair growth suppressive agents have been used in the past for treating hirsutism,
It was used by some women who suffer from unwanted hair on their legs, but nowadays it is fashionable to shave or remove body hair such as hands, feet, chest etc. among young men who are highly clean.
In addition, it has become popular as etiquette, and hair growth inhibitors are used as daily care products after shaving or hair removal treatment. Currently, commercially available hair suppressors are
Female hormones such as estradiol, estrone and ethinyl estradiol are blended as the main agents for the purpose of alleviating the action of male hormones that promote the growth of hair and beard such as feet and chest.

[0003]

The skin that has been shaved or dehaired, especially the skin that has been chemically treated with thioglycolic acids or that has been treated with electricity, is extremely sensitive. The use of a hair growth inhibitor containing female hormones on the skin in such a state has a problem that not only the hair growth inhibitory effect is insufficient but also skin troubles such as irritation and rash occur easily.

The object of the present invention is to solve the above-mentioned problems of the prior art and to have an excellent effect of suppressing hair growth of hair such as hands, feet and chest and hair.
Moreover, it is to provide a hair growth inhibitor that is extremely effective and safe without fear of skin trouble such as irritation or rash.

[0005]

In order to achieve the above object, the hair growth-suppressing agent according to the present invention is a herb that suppresses the growth of body hair and beard such as hands, feet, and chest whose growth is promoted by male hormone. And one or more other plant extracts having antiandrogenic activity, essential oil having antiandrogenic activity 1
Extraction of plants that have the effect of contracting the capillaries and skin around the hair follicles, which are the nutrient supply channels required for growth of hairs and beards such as seeds and hands, legs, chest, etc., and inhibiting nutrient supply to hair roots One or more products, and one or more naturally or / and chemically modified phospholipids that enhance the permeability and affinity to the skin are characterized by being contained. In addition, by liposomeizing these, the permeability and affinity to the skin are further enhanced, the hair growth suppression effect is dramatically improved, and the long-term stable maintenance of the formulation is ensured by using the water-soluble polymer. You can do it.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION Next, embodiments of the present invention will be described. In the hair growth-suppressing agent according to the present invention, Hyogi is a perennial plant that grows naturally from western Honshu, Shikoku, Kyushu to Taiwan, China and India. The extract of the Japanese cedar tree, the extract, is the cedar tree (Belamcanda chinensis).
D. C. ) Is an anti-androgen agent that suppresses the activity of 5α-reductase that activates androgen, which is an extract extracted from the rhizome of (1). 0.001 to 50.0% by weight, preferably 0.01 to 20.0% by weight, of the above-mentioned Hyogi extract having anti-androgen action is added.

The plant extract having an anti-androgen action other than Hyogi can be arbitrarily selected without any particular limitation. For example, a preferred example is Arnica, aloe, sorghum, sorghum, ginseng,
Hypericum, Kina, mulberry, salamander, dioxin, ce
Examples thereof include those prepared by combining at least one selected from the group consisting of Di, Senri, Soybean, Thyme, Clove, Button, Hop, Yokuinin, Logwood, Rosemary and the like. The plant extract having the anti-androgen action may be one or more kinds in an arbitrary combination of 0.
005-30.0% by weight, preferably 0.01-20.
Add 0% by weight.

The essential oil having an anti-androgen action can be arbitrarily selected without any particular limitation. For example, orange oil and caraway are given as suitable examples.
Examples include oils, jujua oils, spearmint oils, eucalyptus oils, mugwort oils, lavender oils, rosemary oils, and the like, which are combined and combined. The essential oil having the anti-androgen action is 0.001-30.
0% by weight, preferably 0.005 to 20.0% by weight is added.

The plant extract having skin astringent action and capillary contractile action can be arbitrarily selected without any particular limitation. For example, if a suitable example is shown,
Examples thereof include a mixture of at least one selected from the group consisting of Acacia yak, kiwi, horsetail, horse mackerel, horsetail, spruce, tormentilla, horse chestnut, mugwort, rose, and waremoko.
The plant extract having the skin astringent action and the capillary contractile action may be used in an amount of 0.005 or more in any combination.
50.0% by weight, preferably 0.01-30.0% by weight
Added. Furthermore, it is preferable to add ethanol or a lower monovalent alcohol such as isopropanol or butanol as a penetrant.

The phospholipid can be arbitrarily selected without any particular limitation. For example, a preferable example is a plant-derived phospholipid such as soybean and / or hydrogenated soybean phospholipid, egg yolk phospholipid. In addition to lipids and / or hydrogenated egg yolk phospholipids, diacylphosphatidylcholine, diacylphosphatidylethanolamine, diacylphosphatidylinositol, diacylphosphatidylglycerol, enzymatically decomposed lysolecithin, hydroxylated lecithin Among these, one kind or a combination of two or more kinds can be mentioned. Further, the phospholipid can be blended as it is, but a high pressure homogenizer and / or a homogenizer such as an ultrasonic homogenizer.
A more effective preparation can be prepared by liposomal treatment with.

The water-soluble polymer is not particularly limited and can be arbitrarily selected, but it is preferable to select it depending on the feeling of use, application and dosage form. For example, as a preferred example, a natural plant-based water-soluble polymer such as sodium alginate, carrageenan, agar, guar gum, quince seed, tamarind gum, locust bean gum, gum arabic, tragacanth gum. , Pectin, quince, tu
Natural animal-based water-soluble polymers such as beloose polysaccharides, for example, albumin, gelatin, collagen, chitosan, sodium chondroitin sulfate, etc., microbial natural water-soluble polymers, for example, xanthan gum, gellan gum, pullulan, hyaluronic acid Natural polymer derivatives such as sodium, sclerotium gum, and Alcaligenes producing polysaccharides, for example, crystalline cellulose, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose Sodium, starch phosphate, starch gluco-
Synthetic water-soluble polymers such as sodium acetate, cationized guar gum, carboxymethyl hydroxypropylated guar gum, etc., for example, carboxyvinyl polymer, polyacrylic acid amide, sodium polyacrylate, polyvinyl alcohol, polyvinyl Examples thereof include pyrrolidone, polyethylene glycol, polymethacryloyloxyethylphosphorylcholine, 2-methacryloyloxyethylphosphorylcholine / butyl methacrylate copolymer and the like. In addition to these, an inorganic water-soluble thickener, for example, bentonite, laponite, aluminum / magnesium silicate or the like can be added. Among the above water-soluble polymers, as a result of the examination by the present inventors, locust bean gum, carrageenan, sclerotium gum, alkaligenes-producing polysaccharide, carboxyvinyl polymer, alone or in combination of two or more kinds. When used, a more stable formulation can be prepared, which is consistent with the gist of the present invention.

In addition, the hair growth-suppressing agent according to the present invention usually contains components, such as oils, surfactants, wetting agents, preservatives and sequestering agents, which are usually added to cosmetics, quasi drugs, pharmaceuticals and the like. The antioxidant, flavoring agent, colorant, active ingredient, powder and the like may be optionally selected and blended.

The hair growth inhibitor of the present invention is a mixture of the above components,
The dosage form may be cream-like, liquid-like, gel-like, aerosol-like or the like, but is not limited to these dosage forms.

[0014]

The following is a description of examples of practical use, but the present invention is not limited to these examples.

Example 1, Comparative Example 1 A having a blending ratio shown in Table 1 was dissolved by stirring at 80 ° C., and then B was mixed at room temperature to prepare a hair growth inhibitor.

[0016]

[Table 1]

Safety Test 1 (Primary Skin Irritation Test) For each hair growth-suppressing agent prepared in Example 1 and Comparative Example 1 above, a heart-type guinea pig (female, 1 It was applied (open state) to the skin of 5 animals in a group (body weight: about 300 g) for 24 hours, and after 24, 48 and 72 hours, the skin was evaluated by the primary irritation scoring method. No erythema or edema was observed in any of the subjects, and it was determined to be negative.

Safety Test 2 (Cumulative Skin Irritation Test) For each of the hair growth-suppressing agents prepared in Example 1 and Comparative Example 1 above, a hair-treating guinea pig (female, 1 It is applied to the skin of 5 animals in a group (body weight: about 300 g) once a day for 5 consecutive days.
After 8 and 72 hours, the presence or absence of erythema and edema was determined. No erythema or edema was observed in any of the subjects, and it was determined to be negative.

Safety Test 3 (Human Cumulative Irritation Test) Each hair growth inhibitor prepared in Example 1 and Comparative Example 1 above was prepared as a stock solution from 25 healthy men in their 20s to 30s. It was continuously applied to the arm once a day for 5 days, and 24 hours, 48 hours, and 72 hours after the application, the presence or absence of erythema and edema was determined. No erythema or edema was observed in any of the 25 subjects. No symptoms such as itching or tingling were observed.

Hair growth suppression test 1 5 cm of both shins and legs of 25 healthy men in their 20s to 30s
10 cm was shaved with an electric shaver, and each hair growth inhibitor prepared in the above Example 1 and Comparative Example 1 was once a day for 5 times a week.
The application was performed for 20 days a day. The judgment was made visually. The results obtained are summarized in Table 2 below.

[0021]

[Table 2]

As shown in Table 2, according to the hair growth-suppressing agent of the present invention prepared in Example 1, a remarkable hair growth-suppressing effect on the foot hair was observed.

Example 2 A having a mixing ratio shown in Table 3 was dissolved by stirring at 80 ° C., treated with a high-pressure homogenizer, and cooled to room temperature to prepare a hair growth inhibitor. Comparative Example 2 A having a blending ratio shown in Table 3 was dissolved by stirring at 80 ° C. and then cooled to room temperature to prepare a hair growth inhibitor.

[0024]

[Table 3]

Hair Growth Inhibition Test 2 Using the hair growth inhibitors prepared in Example 2 and Comparative Example 2 above, the same test as in Hair Growth Inhibition Test 1 was carried out. The results obtained are summarized in Table 4 below.

[0026]

[Table 4]

As shown in Table 4, the hair growth-suppressing agent of the present invention prepared in Example 2 was found to have a dramatic hair growth-suppressing effect on the foot hair. The hair growth-suppressing agent of the present invention of Example 2 was tested for hair growth-suppressing effect on body hair in the same manner as in the above test, and a dramatic hair growth-suppressing effect was similarly observed for body hair. It was

Hair Growth Inhibition Test 3 An electric shake was applied to the jaws of 30 healthy men in their 20s to 40s.
The hair growth inhibitor of Example 2 was shaved on the left side of the chin with a bar.
It was applied once a day for 7 days. For comparison, the hair growth inhibitor of Comparative Example 2 was similarly applied to the right side of the jaw. The effect of suppressing hair growth was evaluated visually. The results obtained are summarized in Table 5.

[0029]

[Table 5]

As shown in Table 5, according to the hair growth-suppressing agent of the present invention prepared in Example 2, a dramatic hair growth suppressing effect on beard hair was observed.

Example 3 A having a mixing ratio shown in Table 6 was dissolved by stirring at 80 ° C., treated with a high pressure homogenizer, and cooled to room temperature. Separately heated and dissolved B was mixed with this at room temperature to prepare a hair growth inhibitor. Comparative Example 3 A having a blending ratio shown in Table 6 was dissolved by stirring at 80 ° C., treated with a high pressure homogenizer, and cooled to room temperature to prepare a hair growth inhibitor.

[0032]

[Table 6]

Stability Test 1 Regarding the hair growth-suppressing agents prepared in Example 3 and Comparative Example 3 above, they were stored in a thermostatic chamber at room temperature, 5 ° C. and 40 ° C., and their changes with time in appearance were observed. The results are shown in Table 7.

[0034]

[Table 7]

As is clear from the results in Table 7, Example 3
It was confirmed that the hair growth-suppressing agent of the present invention prepared in (1) provided a stable preparation for a long period of time.

[0036]

As described above, the hair growth-suppressing agent according to the present invention is a plant extract 1 having an action of smelt and anti-androgen.
At least one species, at least one essential oil having anti-androgen action, and at least one plant extract having skin astringent / capillary contracting action, and further one or more natural or / and chemically modified phospholipids By increasing the permeability and affinity to the skin by blending them, a more effective preparation can be prepared by liposomally converting these with a high-pressure homogenizer and / or a homogenizer such as an ultrasonic homogenizer. it can. The hair growth inhibitor according to the present invention is
It is excellent in the effect of suppressing hair growth of body hair such as chest and beard, and has very high efficacy and safety without concern about skin trouble such as irritation and rash. In addition, a long-term stable maintenance of the preparation is possible by adding a water-soluble polymer.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61P 17/00 A61P 17/00 (72) Inventor Kenichi Numata 1-5-9 Kanda Izumi-cho, Chiyoda-ku, Tokyo No. Ein Co., Ltd. F term (reference) 4C076 AA19 BB31 CC18 DD63F FF16 4C083 AA111 AA112 AA122 AC122 AC432 AC482 AD572 4C088 AB72 AC13 BA08 CA03 MA07 MA16 NA14 ZA89 ZA92 ZB22

Claims (3)

[Claims] 1. At least one plant extract having an anti-androgenic effect, and an essential oil 1 having an anti-androgen effect.
Or more, and one or more plant extracts having skin astringent action / capillary contraction action, and further natural or /
And a hair growth inhibitor containing one or more chemically modified phospholipids. 2. The hair growth inhibitor according to claim 1, which is prepared by liposomal preparation with a high pressure homogenizer and / or a homogenizer such as an ultrasonic homogenizer. 3. The hair growth inhibitor according to claim 2, wherein a water-soluble polymer is incorporated.