JP2003066049A - Reagent management method - Google Patents

Abstract

PROBLEM TO BE SOLVED: To precisely manage a reagent set in an optional position. SOLUTION: In this reagent management method for monitoring the residual test number of the reagent kit of an analyzer for dispensing the reagent solution of the reagent kit to a reaction vessel to measure a certain measurement item, identification information and position information for the reagent kit are acquired from the barcode of the reagent kit, the residual test number in the identification information of the reagent kit corresponding to the position information is subtracted by one every dispensing of reagent solution of the reagent kit, and an alarm is given when the residual test number is 0.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a reagent management method, and more particularly to a reagent management method used when analyzing an analysis item in an automatic chemical analyzer or an automatic immunoassay device.

[0002]

2. Description of the Related Art As a conventional technique related to the present invention, identification information of a used reagent liquid tank is registered in a storage unit, and the reagent liquid tank is installed when the reagent liquid tank is installed in a reagent installation unit. The determination unit determines whether or not the tank is registered in the storage unit, and outputs a warning when it is determined that the reagent liquid tank is already used. Known (eg, Patent No. 315655)
No. 0 publication).

[0003]

When analyzing a biological sample, a reagent corresponding to the measurement item in the sample is mixed with the sample to prepare a reaction solution, and the optical characteristics of the reaction solution are measured. It is common to calculate the concentration of a measurement item. Therefore, in order to measure multiple items, multiple types of reagents are required.Therefore, in an automatic analyzer, a container accommodating each type of reagent is installed at a specific position, and the reagents are set according to the installation position of the container. I try to identify the type.

The present invention has been made in consideration of such circumstances, and provides a management method capable of reliably managing reagents even if a plurality of types of reagent containers are installed at arbitrary installation positions. It is a thing.

[0005]

The present invention provides a reagent management method for monitoring the number of remaining tests of a reagent kit of an analyzer for dispensing a reagent solution of a reagent kit into a reaction container to measure a certain measurement item, The identification information and the position information of the reagent kit are acquired from the barcode of the reagent kit, and the remaining test number of the identification information of the reagent kit corresponding to the position information is subtracted by 1 for each reagent solution dispensing of the reagent kit to obtain the remaining test. The present invention provides a reagent management method characterized by outputting a warning when the number becomes 0.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The reagent kit in the present invention means a set of a plurality of reagents required for measurement of one item, for example, a sample diluent, a latex reagent and a buffer. To do. The position information of the reagent kit is information indicating the position of the reagent kit in the reagent installation place where a plurality of reagent kits can be installed in any order.

In the management method of the present invention, the number of remaining tests is 0.
For the reagent kit, the dispensing operation by the reagent dispenser may be disabled. The identification information and the position information of the reagent kit are acquired from the barcode of the reagent kit, and the expiration date after opening of the identification information of the reagent kit corresponding to the position information is the expiration date of the identification information and the number of remaining tests. May be set when is the maximum number of usable tests.

The identification information and the position information of the reagent kit are acquired from the barcode of the reagent kit, and the expiration date of the identification information of the reagent kit corresponding to the position information is within the deadline.
A calibration instruction may be output when the remaining test number is the maximum usable test number and the manufacturing number is new.

After obtaining the identification information and the position information of the reagent kit from the barcode of the reagent kit and creating the identification information file of the reagent kit, the reagent kit information file corresponding to the position information and the identification information file is created. However, the remaining test number in the reagent kit information file may be subtracted by 1 for each dispensing of the reagent solution of the reagent kit, and a warning may be output when the remaining test number becomes 0.

By opening the cover of the reagent installation place, installing the reagent kit in the reagent installation place, and closing the cover, the identification information and the position information of the reagent kit are automatically acquired from the barcode of the reagent kit, After creating the identification information file of the reagent kit, create a reagent kit information file in which the position information corresponds to the identification information file, and set the number of remaining tests of the identification information file and the reagent kit information file as the reagent liquid content of the reagent kit. It is also possible to subtract 1 for each note and output a warning when the number of remaining tests becomes 0.

Embodiments The present invention will be described in detail below based on the embodiments shown in the drawings. This does not limit the invention.
FIG. 1 is a perspective view showing the configuration of an automatic analyzer to which the present invention is applied. As shown in the figure, in the automatic analyzer 80, a sample container (not shown) containing blood as a sample is placed on the sample setting section 51.

A plurality of reaction plates 62 as shown in FIG. 2 are installed in the reaction plate installation section 53. The reaction plate 62 has a liquid storage portion 6 capable of storing a liquid.
A plurality of 4 are provided. And the reaction plate 62
Are transferred to the sample mixing section 52 by the reaction plate transfer section 57.

The reagent rack 4 and the bar code reader installation section 50 are arranged as shown in FIG. The pipette drive unit 100 moves the pipette 56 up and down, moves in the directions of arrows A and B, and performs suction / discharge operations. From the input unit 58, the user
Enter the information for the measurement. When the measurement information is input, the pipette 56 moves, sucks blood from the sample container installed in the sample installation part 51, and discharges it to the liquid storage part 64 of the reaction plate 62 transferred to the sample mixing part 52.

The pipette 56 moves to the cleaning tank 42,
After washing, a necessary reagent is sucked from the reagent container kit 2 (FIG. 5) installed in the reagent rack 4 and is discharged to the liquid storage portion 64 from which blood has been discharged previously. Thereby, the blood and the reagent are mixed and reacted.

After the pipette 56 is washed again in the washing tank 42, the mixed liquid previously mixed is sucked from the liquid container 64 and discharged to the sample measuring unit 41. Then, the sample measuring unit 41 measures the amount of light absorption, the amount of scattered light, and the like, and after the arithmetic control unit 101 performs a predetermined arithmetic operation, the measurement result is displayed on the display unit 102. The reaction plate 62 of the sample mixing section 52 is
It is discarded in the discard unit 54.

FIG. 3 is a plan view showing the bar code reader 103 installed in the bar code reader installation section 50 and reagent holders H1 to H7 installed in the reagent rack 4, and FIG. 4 is a front view of the bar code reader 103. .

As shown in these figures, in the bar code reader 103, the bar code reading section 10 has a base 20.
It is placed in. The reflection mirror 11 is mounted on the base 20 at an angle shown in FIG. The light emitted from the barcode reading unit 10 is reflected by the reflection mirror 11, changes its direction, and is emitted in the direction of arrow C. Therefore, the barcode reading unit 10 can read the barcode in the direction of arrow C.

The base 20 is connected to a belt 14 suspended between a drive pulley 14a and a driven pulley 14b, and is slidably mounted on a guide rail 13 in the direction of arrow D. Then, by rotating the drive pulley 14a by the stepping motor 12, the base 20, that is, the bar code reader 10 can be moved in the arrow D direction.

On the other hand, the three reagent container kits 2 containing the reagents are placed on the reagent holders H1 to H3 of the reagent rack 4, respectively. The reagent container 2 is shown in FIG.
The reagent container kit 2 is configured by connecting three containers 2a by the connecting portion 32. Further, the barcode attaching portion 34 is connected to one end of the connecting portion 32. A barcode is attached to the barcode attaching unit 34. Information such as the type of reagent contained in the reagent container kit 2 and the lot number is entered in the barcode.

Then, the reagent container kit 2 is attached to the reagent rack 4
The operation cover 104 that covers the reagent rack 4 when the reagent rack 4 is placed on
Is opened, the reagent container kit 2 is installed so that the bar code faces the bar code reader installation section 50, and then the operation cover 104 is closed. The opening / closing of the operation cover 104 is detected by the cover opening / closing sensor 105.

FIG. 6 is a block diagram showing an electric circuit of the automatic analyzer 80 shown in FIG. The arithmetic control unit 101 is a CP
The input unit 58, the bar code reading unit 10, and the microcomputer including U, ROM, and RAM,
Upon receiving output signals from the sample measuring unit 42 and the cover opening / closing sensor 105, the stepping motor 12, the pipette driving unit 100, and the reaction plate transfer unit 57 are driven based on a predetermined program, and signal processing is performed to perform the processing result. Is output to the display unit 102.

The main operation of the bar code reader having such a configuration will be described with reference to the flowchart shown in FIG.

First, the reagent kit 2 is set in each of the reagent holders H1, H2 and H3, and the operation cover 104 is closed (step S1). The barcode reader 103 reads the "barcode information" of each reagent kit 2 set in the reagent holders H1 to H3 (step S2).

Next, the reagent history file (identification information file) provided in the RAM of the arithmetic control unit 106 is the reagent information which is the same as the "bar code information" of each reagent kit 2 set in the reagent holders H1 to H3. ) Is determined (step S3). If there is, the history information of the corresponding reagent is read (step S4). If not, the read “bar code information” is replaced with new “reagent history information”.
Is recorded in the reagent history file as (step S5).

FIG. 8 shows the bar code information read from the reagent kit 2. This bar code information includes the measurement items to which the reagent kit is applied, the manufacturing lot number of the reagent kit, and the number of tests (maximum test that can be measured with a new reagent kit. (Number of times), expiration date, serial number, etc.

FIG. 9 shows the contents of the reagent history file (identification information file). In this file, the bar code information of FIG. 8 shows the expiration date (30 days after opening) of the reagent and the number of remaining tests. Information in which (remaining amount of reagent) is added is recorded.

Next, the reagent history information obtained in step S4 or S5 is used as the reagent holder information registration section (reagent kit information file) provided in the RAM of the arithmetic control section 101.
Is registered as shown in FIG. 10 (step S6). In other words, looking at the reagent holder information registration section, the reagent holder H
It is possible to determine what kind of history the reagent kit 2 is currently set to 1 to H7.

Therefore, for each of the reagents set in the reagent holders H1 to H7, the measurement item, the number of remaining tests, the expiration date, the lot number, etc. are displayed on the display unit 102 (FIGS. 1 and 6) as shown in FIG. It is displayed (step S7).
In this display, if the number of remaining tests is checked and if it is 0, that column is displayed in red, and it is warned that the reagent kit cannot be used for measurement. Similarly, the expiration date and the expiration date after opening the reagent (30 days after opening) are compared, and the earlier expiration date is displayed as the expiration date. If the expiration date has expired, that column is displayed in red to warn that it cannot be used. (Steps S8, S9, S13).

In the display example shown in FIG. 11, the reagent holder H2
The remaining reagent test number 0 is unusable and the reagent kit 2 set in the reagent holder H3 has expired and is unusable. In this case, the measurement is performed using the reagent kit 2 of the usable reagent holder H1 (steps S10 and S1).
1), the number of remaining tests of the used reagent kit 2 is shown in FIG. 9 and FIG.
Only one is subtracted from the number of tests indicated by 0 (step S1
2).

The processing operations of steps S6 to S12 are repeated until the operation cover 104 is opened again.
When the operation cover 104 is opened, the reagent holder H
It is determined that one of the reagent kits 2 of 1 to H7 has been newly replaced or moved to a different reagent holder, and the processing operation is started from step S1.

As for the reagent kit 2 for which the use prohibition is warned, even if the user gives an instruction from the input section 58 to perform a measurement using the reagent kit 2, the arithmetic control section causes the pipette drive section 100 to detect the pipette 56. Dispensing operation is prohibited.

Regarding the reagent kit 2 set in any of the reagent holders H1 to H7, the expiration date is within the expiration date, the remaining test number is the maximum usable test number, and the manufacturing lot number is new (used until now). It is determined that the sensitivity calibration (calibration) of the sample measuring unit 42 is necessary for the reagent, and the fact is displayed in the other columns of FIG. 11. It

[0033]

According to the present invention, since the position information of the reagent kit is obtained and the identification information is obtained from the barcode of the reagent kit, the reagent kit installed at an arbitrary position can be accurately managed. can do.

[Brief description of drawings]

FIG. 1 is a perspective view showing an automatic analyzer to which the present invention is applied.

FIG. 2 is a perspective view showing a reaction plate of the automatic analyzer of FIG.

3 is a plan view showing a barcode reader and a reagent rack of the automatic analyzer of FIG.

FIG. 4 is a front view of a barcode reader of the automatic analyzer of FIG.

5 is a perspective view of a reagent kit used in the automatic analyzer of FIG.

FIG. 6 is a block diagram of an electric circuit of the automatic analyzer of FIG.

7 is a flowchart showing a main part of an operation of the automatic analyzer of FIG.

8 is an explanatory diagram showing the read contents of the barcode reader of the automatic analyzer of FIG. 1. FIG.

9 is an explanatory diagram showing recorded contents of the automatic analyzer of FIG.

10 is an explanatory diagram showing registered contents of the automatic analyzer of FIG.

11 is an explanatory diagram showing display contents of the automatic analyzer of FIG. 1. FIG.

[Explanation of symbols]

4 reagent rack 41 Sample measurement section 42 cleaning tank 50 Bar code reader installation section 51 Sample setting section 52 Sample Mixing Section 53 Reaction plate installation section 54 Disposal Department 56 pipette 57 Reaction plate transfer section 58 Input section 80 Automatic analyzer 100 Pipette drive 101 arithmetic control unit 102 display

Claims (6)

[Claims] 1. A reagent management method for monitoring the number of remaining tests in a reagent kit of an analyzer for dispensing a reagent solution of a reagent kit into a reaction container to measure a certain measurement item, and identifying information from a barcode of the reagent kit. And the position information of the reagent kit are acquired, the remaining test number of the identification information of the reagent kit corresponding to the position information is subtracted by 1 for each reagent liquid dispensing of the reagent kit, and a warning is output when the remaining test number becomes 0. A reagent management method comprising: 2. The reagent management method according to claim 1, wherein the dispensing operation by the reagent dispenser is disabled for a reagent kit having a remaining test number of 0. 3. A reagent management method for dispensing a reagent solution of a reagent kit to a reaction container to measure a certain measurement item and monitoring the expiration date of the reagent kit of an analyzer after opening the reagent kit. The information and the position information of the reagent kit are obtained, and if the identification information is not in the identification information file accumulating the identification information, the identification information is registered in the identification information file, and the expiration date after opening is set. Reagent management method. 4. A reagent management method for monitoring the number of remaining tests in a reagent kit of an analyzer for dispensing a reagent solution of a reagent kit into a reaction container to measure a certain measurement item, and identifying information from a barcode of the reagent kit. And the position information of the reagent kit are acquired, the expiration date of the identification information of the reagent kit corresponding to the position information is within the deadline, the remaining test number is the maximum usable test number, and the manufacturing lot number is new. At this time, a reagent management method characterized by outputting a calibration instruction. 5. A reagent management method for monitoring the number of remaining tests of a reagent kit of an analyzer for dispensing a reagent solution of a reagent kit into a reaction container to measure a certain measurement item, and identifying information from a barcode of the reagent kit. After obtaining the position information of the reagent kit and the identification information file of the reagent kit, a reagent kit information file that corresponds to the identification information file with the position information is created, and the number of remaining tests of the reagent kit information file Is subtracted for each dispensing of the reagent solution of the reagent kit, and a warning is output when the number of remaining tests becomes 0. 6. In a reagent management method for monitoring the number of remaining tests of a reagent kit of an analyzer for dispensing a reagent solution of a reagent kit into a reaction container to measure a certain measurement item, a cover of a reagent installation place is opened, After installing the reagent kit in the reagent installation location and closing the cover, automatically obtain the identification information and the position information of the reagent kit from the barcode of the reagent kit, and after creating the identification information file of the reagent kit, A reagent kit information file that corresponds to the identification information file with the position information is created, and the remaining test number of the identification information file and the reagent kit information file is subtracted by 1 for each reagent liquid dispensing of the reagent kit. A reagent management method, wherein a warning is output when the value becomes 0.