JP2002543173A5 - - Google Patents
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- Publication number
- JP2002543173A5 JP2002543173A5 JP2000615370A JP2000615370A JP2002543173A5 JP 2002543173 A5 JP2002543173 A5 JP 2002543173A5 JP 2000615370 A JP2000615370 A JP 2000615370A JP 2000615370 A JP2000615370 A JP 2000615370A JP 2002543173 A5 JP2002543173 A5 JP 2002543173A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- cycloalkyl
- alkyl
- compound
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 description 29
- 239000001257 hydrogen Substances 0.000 description 29
- 150000001875 compounds Chemical class 0.000 description 25
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 description 24
- 150000002431 hydrogen Chemical group 0.000 description 21
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 13
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 12
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 12
- 125000001624 naphthyl group Chemical group 0.000 description 12
- 125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 description 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
- 241000124008 Mammalia Species 0.000 description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 229940121896 radiopharmaceutical Drugs 0.000 description 4
- 239000012217 radiopharmaceutical Substances 0.000 description 4
- 230000002799 radiopharmaceutical effect Effects 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- 125000001309 chloro group Chemical group Cl* 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- -1 methoxyethoxymethyl Chemical group 0.000 description 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 description 1
- WUAPFZMCVAUBPE-NJFSPNSNSA-N 188Re Chemical compound [188Re] WUAPFZMCVAUBPE-NJFSPNSNSA-N 0.000 description 1
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- WUAPFZMCVAUBPE-IGMARMGPSA-N rhenium-186 Chemical compound [186Re] WUAPFZMCVAUBPE-IGMARMGPSA-N 0.000 description 1
- 229910052713 technetium Inorganic materials 0.000 description 1
- 229940056501 technetium 99m Drugs 0.000 description 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1999/009344 WO2000066537A1 (en) | 1999-04-30 | 1999-04-30 | Spect imaging agents for serotonin transporters |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002543173A JP2002543173A (ja) | 2002-12-17 |
| JP2002543173A5 true JP2002543173A5 (https=) | 2006-06-22 |
Family
ID=22272656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000615370A Pending JP2002543173A (ja) | 1999-04-30 | 1999-04-30 | セロトニン輸送体のためのｓｐｅｃｔ画像化剤 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1175388B1 (https=) |
| JP (1) | JP2002543173A (https=) |
| AU (1) | AU780725B2 (https=) |
| CA (1) | CA2372481A1 (https=) |
| DE (1) | DE69930381T2 (https=) |
| ES (1) | ES2264259T3 (https=) |
| WO (1) | WO2000066537A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002102250A1 (en) * | 1999-10-22 | 2002-12-27 | Glaxo Group Limited | $g(in vivo) imaging |
| US7041851B2 (en) * | 2002-03-14 | 2006-05-09 | The Trustees Of The University Of Pennsylvania | Fluorinated phenyl thiophenyl derivatives and their use for imaging serotonin transporters |
| WO2003096978A2 (en) * | 2002-05-17 | 2003-11-27 | The Trustees Of Columbia University In The City Of New York | Carbon-11 and fluorine-18 labeled radioligands for positron emission tomography (pet) imaging for the brain serotonin transporters |
| WO2004087156A1 (en) | 2003-04-04 | 2004-10-14 | H. Lundbeck A/S | 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors |
| TWI347183B (en) | 2003-12-23 | 2011-08-21 | Lundbeck & Co As H | 2-(1h-indolylsulfanyl)-benzyl amine derivatives |
| PL1701940T3 (pl) | 2003-12-23 | 2008-11-28 | H Lundbeck As | Pochodne 2-(1H-indolilosulfanylo)benzyloaminy jako SSRI |
| AR052308A1 (es) | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| AR054393A1 (es) | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
| US7629473B2 (en) | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0322876A3 (en) * | 1987-12-29 | 1990-09-05 | Nihon Medi-Physics Co., Ltd. | Chelating compounds and their use |
| GB8912971D0 (en) * | 1989-06-06 | 1989-07-26 | Wellcome Found | Halogen substituted diphenylsulfides |
| US5783171A (en) * | 1989-06-16 | 1998-07-21 | Neorx Corporation | Radionuclide metal N2 S2 chelates substituted with glucose and biotin moieties |
| US5320825A (en) * | 1991-05-01 | 1994-06-14 | Trustees Of The University Of Pennsylvania | Serotonin reuptake inhibitors for S.P.E.C.T. imaging |
| DE4128183C1 (en) * | 1991-08-24 | 1993-01-14 | Forschungszentrum Juelich Gmbh, 5170 Juelich, De | New technetium complexes and corresp. complexing agents - useful for measurement of cerebral perfusion, diagnosis of Alzheimer's disease or epilepsy and localisation of tumours |
| GB9126311D0 (en) * | 1991-12-11 | 1992-02-12 | Wellcome Found | Substituted diphenylsulfides |
| US5688485A (en) * | 1992-12-31 | 1997-11-18 | The Dupont Merck Pharmaceutical Company | Radiolabelled complexes of ester-substituted diaminethiols |
-
1999
- 1999-04-30 CA CA002372481A patent/CA2372481A1/en not_active Abandoned
- 1999-04-30 WO PCT/US1999/009344 patent/WO2000066537A1/en not_active Ceased
- 1999-04-30 ES ES99918906T patent/ES2264259T3/es not_active Expired - Lifetime
- 1999-04-30 EP EP99918906A patent/EP1175388B1/en not_active Expired - Lifetime
- 1999-04-30 JP JP2000615370A patent/JP2002543173A/ja active Pending
- 1999-04-30 DE DE69930381T patent/DE69930381T2/de not_active Expired - Fee Related
- 1999-04-30 AU AU36712/99A patent/AU780725B2/en not_active Ceased
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