JP2002536418A5 - - Google Patents
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- Publication number
- JP2002536418A5 JP2002536418A5 JP2000598175A JP2000598175A JP2002536418A5 JP 2002536418 A5 JP2002536418 A5 JP 2002536418A5 JP 2000598175 A JP2000598175 A JP 2000598175A JP 2000598175 A JP2000598175 A JP 2000598175A JP 2002536418 A5 JP2002536418 A5 JP 2002536418A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- mixture
- sequence
- loop
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 description 51
- 150000007523 nucleic acids Chemical group 0.000 description 44
- 108091028043 Nucleic acid sequence Proteins 0.000 description 23
- 239000012634 fragment Substances 0.000 description 19
- 210000004027 cell Anatomy 0.000 description 17
- 108020004707 nucleic acids Proteins 0.000 description 15
- 102000039446 nucleic acids Human genes 0.000 description 15
- 108010067390 Viral Proteins Proteins 0.000 description 14
- 108090000623 proteins and genes Proteins 0.000 description 14
- 239000013598 vector Substances 0.000 description 14
- 102000004169 proteins and genes Human genes 0.000 description 13
- 238000004519 manufacturing process Methods 0.000 description 12
- 239000013612 plasmid Substances 0.000 description 11
- 108020004414 DNA Proteins 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 108010041986 DNA Vaccines Proteins 0.000 description 7
- 229940021995 DNA vaccine Drugs 0.000 description 7
- 239000002773 nucleotide Substances 0.000 description 5
- 125000003729 nucleotide group Chemical group 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 229940023143 protein vaccine Drugs 0.000 description 5
- 229960005486 vaccine Drugs 0.000 description 5
- 102000053602 DNA Human genes 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 4
- 208000036142 Viral infection Diseases 0.000 description 3
- 239000013604 expression vector Substances 0.000 description 3
- 230000037432 silent mutation Effects 0.000 description 3
- 230000009385 viral infection Effects 0.000 description 3
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical group O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 2
- 229930010555 Inosine Natural products 0.000 description 2
- 229960003786 inosine Drugs 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 208000031886 HIV Infections Diseases 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- 108020005202 Viral DNA Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19907485A DE19907485B4 (de) | 1999-02-12 | 1999-02-12 | Virus-Vakzine |
| DE19907485.2 | 1999-02-12 | ||
| PCT/EP1999/009759 WO2000047223A2 (de) | 1999-02-12 | 1999-12-03 | Virus-vakzine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002536418A JP2002536418A (ja) | 2002-10-29 |
| JP2002536418A5 true JP2002536418A5 (https=) | 2006-10-26 |
Family
ID=7898389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000598175A Withdrawn JP2002536418A (ja) | 1999-02-12 | 1999-12-03 | ウイルスワクチン |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20060222665A1 (https=) |
| EP (1) | EP1149167B1 (https=) |
| JP (1) | JP2002536418A (https=) |
| CN (1) | CN1268748C (https=) |
| AT (1) | ATE260978T1 (https=) |
| AU (1) | AU1976100A (https=) |
| DE (2) | DE19907485B4 (https=) |
| DK (1) | DK1149167T3 (https=) |
| ES (1) | ES2216619T3 (https=) |
| PT (1) | PT1149167E (https=) |
| WO (1) | WO2000047223A2 (https=) |
| ZA (1) | ZA200106155B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7118874B2 (en) * | 1998-10-09 | 2006-10-10 | Variation Biotechnologies Inc. | Immunogenic formulation and process for preparation thereof |
| CA2417240A1 (en) * | 2000-08-07 | 2002-02-14 | Sloan-Kettering Institute For Cancer Research | Method and composition for immunization using mixed pools of mutated nucleic acids or peptides |
| DE10218129A1 (de) * | 2002-04-23 | 2003-11-20 | Univ Ruprecht Karls Heidelberg | Genetischer Impfstoff gegen RNA-Virus-Infektionen |
| BRPI0504117A (pt) | 2005-09-05 | 2007-05-22 | Fundacao De Amparo A Pesquisa | epìtopos, combinação de epìtopos, usos de epìtopos ou sua combinação, composição, usos da composição, vacinas profiláticas anti-hiv-1, vacinas terapêuticas, método para a identificação de epìtopos e métodos para o tratamento ou prevenção |
| ES2725450T3 (es) | 2007-07-02 | 2019-09-24 | Etubics Corp | Métodos y composiciones para la producción de un vector adenoviral para su uso en vacunaciones múltiples |
| CN101591379B (zh) | 2008-05-27 | 2017-01-18 | 中国疾病预防控制中心性病艾滋病预防控制中心 | 基于eiav减毒活疫苗的氨基酸突变而构建的抗hiv疫苗 |
| CN102146417B (zh) * | 2010-02-10 | 2014-04-02 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 利用tat核心肽段促进外源蛋白可溶性表达的方法及其专用表达载体 |
| WO2014031178A1 (en) | 2012-08-24 | 2014-02-27 | Etubics Corporation | Replication defective adenovirus vector in vaccination |
| US10245313B2 (en) * | 2014-10-24 | 2019-04-02 | Versitech Limited | DNA motif compounds and methods for inducing specific antibodies and cellular immunity |
| CN108026593A (zh) * | 2015-05-18 | 2018-05-11 | 卡琳缪恩股份有限公司 | 区分hiv-1与慢病毒载体的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL89118A0 (en) * | 1988-02-03 | 1989-08-15 | Microgenesys Inc | Vaccine containing polypeptides derived from the envelope gene of human immunodeficiency virus type 1 |
| US5851813A (en) * | 1990-07-12 | 1998-12-22 | President And Fellows Of Harvard College | Primate lentivirus antigenic compositions |
| FR2677363A1 (fr) * | 1991-06-07 | 1992-12-11 | Pasteur Institut | Compositions a base de peptides multiepitopiques, leur procede d'obtention et leurs applications, notamment en tant que vaccins. |
| WO1994022917A1 (en) * | 1993-04-05 | 1994-10-13 | University Of Massachusetts Medical Center | Cross-reactive influenza a immunization |
| WO1995004147A1 (en) * | 1993-08-02 | 1995-02-09 | Chiron Corp | Recombinant constructs using replacement sequences in hypervariable regions |
| US5741492A (en) * | 1996-01-23 | 1998-04-21 | St. Jude Children's Research Hospital | Preparation and use of viral vectors for mixed envelope protein vaccines against human immunodeficiency viruses |
-
1999
- 1999-02-12 DE DE19907485A patent/DE19907485B4/de not_active Expired - Fee Related
- 1999-12-03 AU AU19761/00A patent/AU1976100A/en not_active Abandoned
- 1999-12-03 DK DK99963478T patent/DK1149167T3/da active
- 1999-12-03 WO PCT/EP1999/009759 patent/WO2000047223A2/de not_active Ceased
- 1999-12-03 ES ES99963478T patent/ES2216619T3/es not_active Expired - Lifetime
- 1999-12-03 CN CNB998165611A patent/CN1268748C/zh not_active Expired - Fee Related
- 1999-12-03 EP EP99963478A patent/EP1149167B1/de not_active Expired - Lifetime
- 1999-12-03 PT PT99963478T patent/PT1149167E/pt unknown
- 1999-12-03 JP JP2000598175A patent/JP2002536418A/ja not_active Withdrawn
- 1999-12-03 AT AT99963478T patent/ATE260978T1/de not_active IP Right Cessation
- 1999-12-03 DE DE59908783T patent/DE59908783D1/de not_active Expired - Fee Related
-
2001
- 2001-07-26 ZA ZA200106155A patent/ZA200106155B/en unknown
-
2005
- 2005-11-14 US US11/271,889 patent/US20060222665A1/en not_active Abandoned
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