BRPI0504117A - epìtopos, combinação de epìtopos, usos de epìtopos ou sua combinação, composição, usos da composição, vacinas profiláticas anti-hiv-1, vacinas terapêuticas, método para a identificação de epìtopos e métodos para o tratamento ou prevenção - Google Patents

epìtopos, combinação de epìtopos, usos de epìtopos ou sua combinação, composição, usos da composição, vacinas profiláticas anti-hiv-1, vacinas terapêuticas, método para a identificação de epìtopos e métodos para o tratamento ou prevenção

Info

Publication number
BRPI0504117A
BRPI0504117A BRPI0504117-1A BRPI0504117A BRPI0504117A BR PI0504117 A BRPI0504117 A BR PI0504117A BR PI0504117 A BRPI0504117 A BR PI0504117A BR PI0504117 A BRPI0504117 A BR PI0504117A
Authority
BR
Brazil
Prior art keywords
epitopes
composition
combination
hiv
vaccines
Prior art date
Application number
BRPI0504117-1A
Other languages
English (en)
Inventor
Edecio Cunha Neto
Jorge Elias Kalil Jr
Simone Goncalves Da Fonseca
Original Assignee
Fundacao De Amparo A Pesquisa
Fundacao Zerbini
Univ Sao Paulo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacao De Amparo A Pesquisa, Fundacao Zerbini, Univ Sao Paulo filed Critical Fundacao De Amparo A Pesquisa
Priority to BRPI0504117-1A priority Critical patent/BRPI0504117A/pt
Priority to PCT/BR2006/000175 priority patent/WO2007028219A1/en
Priority to EP11180972A priority patent/EP2397489A1/en
Priority to EP06775031.5A priority patent/EP1937711B1/en
Publication of BRPI0504117A publication Critical patent/BRPI0504117A/pt
Priority to US12/073,401 priority patent/US8338582B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"EPìTOPOS, COMBINAçãO DE EPìTOPOS, USOS DE EPìTOPOS OU SUA COMBINAçãO, COMPOSIçãO,USOS DA COMPOSIçãO, VACINAS PROFILáTICAS ANTI-HIV-1, VACINAS TERAPêUTICAS, MéTODO PARA A IDENTIFICAçãO DE EPìTOPOS E MéTODOS PARA O TRATAMENTO OU PREVENçãO" A presente invenção refere-se a novos epítopos reconhecidos por linfócitos T CD4+. Ainda, a presente invenção refere-se ao usos de ditos epítopos e suas combinações, particularmente no tratamento ou prevenção de distúrbios causados pelo vírus HIV-1. A presente invenção refere-se também a uma composição que compreende ditos epítipos e aos usos de dita composição, particularmente no tratamento ou prevenção de distúrbios causados pelo HIV-1. Outro objeto da presente invenção são vacinas, profiláticas anti-HIV-1 ou terapêuticas. Adicionalmente, a presente invenção trata de um método para a identificação de epítopos e métodos de tratamento ou prevenção de uma infecção causada pelo vírus HIV-1.
BRPI0504117-1A 2005-09-05 2005-09-05 epìtopos, combinação de epìtopos, usos de epìtopos ou sua combinação, composição, usos da composição, vacinas profiláticas anti-hiv-1, vacinas terapêuticas, método para a identificação de epìtopos e métodos para o tratamento ou prevenção BRPI0504117A (pt)

Priority Applications (5)

Application Number Priority Date Filing Date Title
BRPI0504117-1A BRPI0504117A (pt) 2005-09-05 2005-09-05 epìtopos, combinação de epìtopos, usos de epìtopos ou sua combinação, composição, usos da composição, vacinas profiláticas anti-hiv-1, vacinas terapêuticas, método para a identificação de epìtopos e métodos para o tratamento ou prevenção
PCT/BR2006/000175 WO2007028219A1 (en) 2005-09-05 2006-09-04 Epitopes, combined epitopes, use of epitopes or their combination, composition, uses of the composition, anti- hiv-i prophylactic vaccines, therapeutic vaccines, method for the identification of epitopes and methods for treatment and prevention
EP11180972A EP2397489A1 (en) 2005-09-05 2006-09-04 Epitopes, combined epitopes, use of epitopes or their combination, composition, uses of the composition, anti-HIV-I prophylactic vaccines, therapeutic vaccines, method for the identification of epitopes and methods for treatment and prevention
EP06775031.5A EP1937711B1 (en) 2005-09-05 2006-09-04 Epitopes, combined epitopes, use of epitopes or their combination, composition, uses of the composition, anti- hiv-i prophylactic vaccines, therapeutic vaccines, method for the identification of epitopes and methods for treatment and prevention
US12/073,401 US8338582B2 (en) 2005-09-05 2008-03-05 Anti-HIV immunogens and methods for inducing an immune response

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0504117-1A BRPI0504117A (pt) 2005-09-05 2005-09-05 epìtopos, combinação de epìtopos, usos de epìtopos ou sua combinação, composição, usos da composição, vacinas profiláticas anti-hiv-1, vacinas terapêuticas, método para a identificação de epìtopos e métodos para o tratamento ou prevenção

Publications (1)

Publication Number Publication Date
BRPI0504117A true BRPI0504117A (pt) 2007-05-22

Family

ID=37835320

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0504117-1A BRPI0504117A (pt) 2005-09-05 2005-09-05 epìtopos, combinação de epìtopos, usos de epìtopos ou sua combinação, composição, usos da composição, vacinas profiláticas anti-hiv-1, vacinas terapêuticas, método para a identificação de epìtopos e métodos para o tratamento ou prevenção

Country Status (4)

Country Link
US (1) US8338582B2 (pt)
EP (2) EP1937711B1 (pt)
BR (1) BRPI0504117A (pt)
WO (1) WO2007028219A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008068765A2 (en) * 2006-12-07 2008-06-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions and methods for inhibiting hiv-1 replication and integrase activity
US20130195904A1 (en) * 2010-01-04 2013-08-01 National University Of Singapore Human immunodeficiency virus (hiv-1) highly conserved and low variant sequences as targets for vaccine and diagnostic applications
EP2444101A1 (en) * 2010-10-21 2012-04-25 Universitätsklinikum Freiburg Selective targeting of the CD40L/Mac-1 interaction by small peptide inhibitors and its use for the treatment of inflammation and atherogenesis
EP2620446A1 (en) 2012-01-27 2013-07-31 Laboratorios Del Dr. Esteve, S.A. Immunogens for HIV vaccination
CN104163857B (zh) * 2014-08-12 2017-02-15 中国人民解放军军事医学科学院微生物流行病研究所 一种hiv‑1多表位重组蛋白及其编码基因与应用
BR112021024925A2 (pt) * 2019-06-10 2022-01-18 Andrea Savarino Método para a definição de uma vacina personalizada contra o hiv/aids
EP4058058A1 (en) 2019-11-14 2022-09-21 Aelix Therapeutics S.L. Dosage regimens for vaccines

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FR2591227B1 (fr) * 1985-12-06 1988-11-10 Pasteur Institut Peptides capables d'inhiber les interactions entre les virus lav et les lymphocytes t4, produits qui en sont derives et leurs applications
US5221610A (en) * 1988-05-26 1993-06-22 Institut Pasteur Diagnostic method and composition for early detection of HIV infection
US5516657A (en) 1992-05-11 1996-05-14 Cambridge Biotech Corporation Baculovirus vectors for expression of secretory and membrane-bound proteins
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US6413517B1 (en) * 1997-01-23 2002-07-02 Epimmune, Inc. Identification of broadly reactive DR restricted epitopes
PT1011720E (pt) 1997-09-11 2005-04-29 Us Health Respostas de linfocitos t citotoxicos nas mucosas
DE19907485B4 (de) 1999-02-12 2008-01-17 Strathmann Ag & Co. Virus-Vakzine
EP1225907A4 (en) 1999-10-05 2005-06-22 Epimmune Inc INDUCTION OF CELLULAR IMMUNE RESPONSES TO HUMAN IMMUNODIC VIRUS-1 (HIV-1) BY MEANS OF PEPTIDE AND NUCLEIC ACID COMPOUNDS
ES2303513T3 (es) 1999-11-16 2008-08-16 Geneart Ag Genoma del intersubtipo (c/b') de vih-1 y sus aplicaciones.
US7655774B2 (en) * 2000-02-18 2010-02-02 University Of Washington Ancestral and COT viral sequences, proteins and immunogenic compositions
FR2806727A1 (fr) * 2000-03-23 2001-09-28 Pf Medicament Molecule d'interet pharmaceutique comprotant en son extremite n-terminale un acide glutamique ou une glutamine sous forme de sel d'addition d'acide fort physiologiquement acceptable
EP1455816A4 (en) 2000-10-19 2007-03-28 Epimmune Inc HLA CLASS I AND II BINDING PEPTIDES AND THEIR USE
US20030077826A1 (en) 2001-02-02 2003-04-24 Lena Edelman Chimeric molecules containing a module able to target specific cells and a module regulating the apoptogenic function of the permeability transition pore complex (PTPC)
ES2605445T3 (es) * 2001-11-26 2017-03-14 Hivih Interacciones proteína-proteína en el virus de la inmunodeficiencia humana
AU2003245729A1 (en) 2002-06-27 2004-01-19 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating a cytotoxic t lymphocyte immune response
DE10257771A1 (de) 2002-12-10 2004-07-08 Ruprecht-Karls-Universität Heidelberg Inhibierung der HIV Replikation durch Expression von 'late domain' Peptiden in Zielzellen
EP1605972A2 (en) * 2003-03-26 2005-12-21 Cytos Biotechnology AG Hiv-peptide-carrier-conjugates
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GB0323840D0 (en) 2003-10-10 2003-11-12 Ist Superiore Sanita Vaccines

Also Published As

Publication number Publication date
EP1937711A1 (en) 2008-07-02
EP1937711B1 (en) 2014-06-11
EP2397489A1 (en) 2011-12-21
EP1937711A4 (en) 2009-07-01
WO2007028219A1 (en) 2007-03-15
US20080260766A1 (en) 2008-10-23
US8338582B2 (en) 2012-12-25

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]